Synthesis, pairing, and cellular uptake properties of C(6′)- functionalized tricyclo-DNA

Journal of Organic Chemistry

Volumn 77, Issue 10, 2012, Pages 4566-4577

  Lietard, Jory ^a   Leumann, Christian J ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BUILDING BLOCKES; CARBENES; CELLULAR UPTAKE; CYCLOPROPANE RING; DEPROTECTION; ESTER FUNCTIONS; FUNCTIONALIZED; IN-SITU; LABILE GROUPS; PHOSPHORAMIDITES; PRODRUGS; RADICAL REDUCTION; SELF AGGREGATION; SIDE-CHAINS; SUGAR UNITS; THERAPEUTIC APPLICATION; TRANSFECTION AGENTS;

AMIDES; BIOMOLECULES; CARBOXYLIC ACIDS; CELL MEMBRANES; CYTOLOGY; ESTERIFICATION; ESTERS; OLIGONUCLEOTIDES; PROPANE; RNA; SUGARS;

DNA;

AMIDE; CARBENE; CARBOXYLIC ACID; CYCLOPROPANE; DNA; DOUBLE STRANDED DNA; ESTER DERIVATIVE; MONOMER; NUCLEOSIDE; OLIGONUCLEOTIDE; PHOSPHORAMIDOUS ACID; PRODRUG; RADICAL; THYMINE; TRICYCLO DNA; UNCLASSIFIED DRUG;

ARTICLE; BASE PAIRING; CELL MEMBRANE PERMEABILITY; CELL STRAIN HEK293; CHEMICAL MODIFICATION; CONTROLLED STUDY; DEHALOGENATION; DEPROTECTION REACTION; DRUG SYNTHESIS; DRUG UPTAKE; ESTERIFICATION; FEMALE; HELA CELL; HUMAN; HUMAN CELL; HYDROLYSIS; LIPOPHILICITY; MOLECULAR STABILITY; OLIGONUCLEOTIDE THERAPY;

BASE PAIRING; BASE SEQUENCE; CIRCULAR DICHROISM; DNA; HEK293 CELLS; HELA CELLS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; OLIGODEOXYRIBONUCLEOTIDES; OLIGONUCLEOTIDES; ORGANOPHOSPHORUS COMPOUNDS; RNA; THERMODYNAMICS;

EID: 84862080993     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo300648u     Document Type: Article

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