Engineered troponin C constructs correct disease-related cardiac myofilament calcium sensitivity

Journal of Biological Chemistry

Volumn 287, Issue 24, 2012, Pages 20027-20036

  Liu, Bin ^a   Lee, Ryan S ^a   Biesiadecki, Brandon J ^a   Tikunova, Svetlana B ^b   Davis, Jonathan P ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b UNIVERSITY OF HOUSTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATP-ASE ACTIVITY; BIOCHEMICAL MODEL; CARDIAC DISEASE; CARDIAC MUSCLES; DILATED CARDIOMYOPATHY; FORCE GENERATION; GENETIC APPROACH; PATHOPHYSIOLOGY; PROTEIN MODIFICATIONS; RELATED FUNCTIONS; THERAPEUTIC STRATEGY; THIN FILAMENTS; TROPONIN C; TROPONIN I; TROPONIN T;

BIOCHEMISTRY; HEART; MUSCLE;

CALCIUM;

CALCIUM; CALCIUM ION; TROPONIN C; TROPONIN I; TROPONIN T;

ARTICLE; CARDIOMYOPATHY; CONTROLLED STUDY; DISEASE ASSOCIATION; HEART CONTRACTION; HEART FUNCTION; HEART MUSCLE; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN ENGINEERING; PROTEIN MODIFICATION; SENSITIVITY ANALYSIS; THIN FILAMENT;

ANIMALS; CALCIUM; CARDIOMYOPATHIES; HUMANS; MUTATION; MYOCARDIAL CONTRACTION; MYOFIBRILS; PROTEIN ENGINEERING; RATS; TROPONIN C;

EID: 84862023507     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.334953     Document Type: Article

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