Scaleable processes for the synthesis of (-)-β-d-2,6-diaminopurine dioxolane (Amdoxovir, DAPD) and (-)-β-d-2-aminopurine dioxolane (APD)

Tetrahedron

Volumn 68, Issue 29, 2012, Pages 5738-5743

  Zhou, Longhu ^a   Coats, Steven J ^b   Zhang, Hongwang ^a   Shi, Junxing ^b   Bobeck, Drew R ^b   Schinazi, Raymond F ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b RFS Pharma LLC   (United States)

Author keywords

Amdoxovir; DAPD; Diaminopurine; Dioxolane; Glycosylation; Nucleoside

Indexed keywords

4 ACETOXY 2 ISOBUTYRYLOXYMETHYL 1,3 DIOXOLANE; ACETIC ACID; AMDOXOVIR; LEVO BETA DEXTRO 2 AMINOPURINE DIOXOLANE; NUCLEOSIDE; PURINE DERIVATIVE; TERT BUTYLCYANOACETATE; UNCLASSIFIED DRUG; WATER;

ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROLYSIS; PRIORITY JOURNAL; STEREOCHEMISTRY;

EID: 84862020421     PISSN: 00404020     EISSN: 14645416     Source Type: Journal    
DOI: 10.1016/j.tet.2012.05.039     Document Type: Article

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