High-performance liquid chromatographic determination of (-)-β-D2-aminopurine dioxolane and (-)-β-D-2-amino-6-chloropurine dioxolane, and their metabolite (-)-β-D-dioxolane guanine in monkey serum, urine and cerebrospinal fluid

Journal of Chromatography B: Biomedical Applications

Volumn 691, Issue 2, 1997, Pages 425-432

  Chen, H ^a   Manouilov, K K ^a   Chu, C K ^a   Schinazi, R F ^b,c   McClure, H M ^c   Boudinot, F D ^a  

^a UNIVERSITY OF GEORGIA   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c EMORY UNIVERSITY   (United States)

Author keywords

2 Amino 6 chloropurine dioxolane; 2 Aminopurine dioxolane; Dioxolane guanine

Indexed keywords

1,3 DIOXOLANE DERIVATIVE; ANTIVIRUS AGENT; DRUG METABOLITE; NUCLEOSIDE ANALOG;

ARTICLE; CEREBROSPINAL FLUID; DRUG DETERMINATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MONKEY; NONHUMAN; PRIORITY JOURNAL; SERUM; URINE;

ANIMALS; ANTIVIRAL AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIOXOLANES; GUANOSINE; HAPLORHINI; PRODRUGS; PURINES; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 0031007924     PISSN: 15726495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4347(96)00473-2     Document Type: Article

References (6)

1. H.O. Kim, R.F. Schinazi, S. Nampalli, K. Shanmuganathan, D.L. Cannon, A.J. Alves, L.S. Jeong, J.W. Beach and C.K. Chu, J. Med. Chem., 36 (1993) 30.
2. R.F. Schinazi, H.M. McClure, F.D. Boudinot, Y. Jxiang and C.K. Chu, Antiviral Res., Suppl., 23 (1994) 81.
3. P. Rajagopalan, F.D. Boudinot, C.K. Chu, B.C. Tennant, B.H. Baldwin and R.F. Schinazi, Antiviral Chem. Chemother., 7 (1996) 65.
4. P. Rajagopalan, F.D. Boudinot, C.K. Chu, H.M., McClure and R.F. Schinazi, Pharm. Res. (Suppl.), 11 (1994) S-381.
5. K. Shanmaganathan, T. Koudriakova, S. Nampalli, J.M. Gallo and C.K. Chu, J. Med. Chem., 37 (1994) 821.
6. H. Chen, F.D. Boudinot, C.K. Chu, H.M., McClure and R.F. Schinazi, Antimicrob. Agents Chemother., 40 (1996) 2332.