Selective targeting of proteins within secretory pathway for endoplasmic reticulum-associated degradation

Journal of Biological Chemistry

Volumn 287, Issue 24, 2012, Pages 20007-20015

  Vecchi, Lara ^a   Petris, Gianluca ^a   Bestagno, Marco ^a   Burrone, Oscar R ^a  

^a INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING MOIETIES; CELLULAR QUALITY CONTROL; CYTOSOLS; FUSION PROTEINS; HIGH SPECIFICITY; KNOCK OUTS; MEMBRANE-BOUND; MISFOLDED PROTEINS; PROTEASOMAL DEGRADATION; RETROTRANSLOCATION; SECRETORY PATHWAYS; TARGET PROTEINS;

CELL MEMBRANES; DEGRADATION;

PROTEINS;

DEGRADIN; HYBRID PROTEIN; MEMBRANE PROTEIN; PROTEIN SEL1L; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CYTOSOL; EMBRYO; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM ASSOCIATED DEGRADATION; HUMAN; HUMAN CELL; IN VIVO STUDY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN TARGETING; PROTEIN TRANSPORT; SECRETORY PATHWAY;

ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM-ASSOCIATED DEGRADATION; HEK293 CELLS; HUMANS; PROTEIN FOLDING; PROTEIN TRANSPORT; PROTEINS; RECOMBINANT FUSION PROTEINS;

EID: 84862007841     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.355107     Document Type: Article

References (37)

1. Wickner, W., and Schekman, R. (2005) Protein translocation across biological membranes. Science 310, 1452-1456 (Pubitemid 41746334)
2. Ellgaard, L., and Helenius, A. (2003) Quality control in the endoplasmic reticulum. Nat. Rev. Mol. Cell Biol. 4, 181-191 (Pubitemid 36288040)
3. Vembar, S. S., and Brodsky, J. L. (2008) One step at a time: Endoplasmic reticulum-associated degradation. Nat. Rev. Mol. Cell Biol. 9, 944-957
4. Brodsky, J. L., and Wojcikiewicz, R. J. (2009) Substrate-specific mediators of ER associated degradation (ERAD). Curr. Opin. Cell Biol. 21, 516-521
5. Pickart, C. M., and Cohen, R. E. (2004) Proteasomes and their kin: Proteases in the machine age. Nat. Rev. Mol. Cell Biol. 5, 177-187 (Pubitemid 38325799)
6. Kamauchi, S., Nakatani, H., Nakano, C., and Urade, R. (2005) Gene expression in response to endoplasmic reticulum stress in Arabidopsis thaliana. Febs J. 272, 3461-3476 (Pubitemid 40979315)
7. Schäfer, A., and Wolf, D. H. (2009) Sec61p is part of the endoplasmic reticulum-associated degradation machinery. EMBO J. 28, 2874-2884
8. Carvalho, P., Goder, V., and Rapoport, T. A. (2006) Distinct ubiquitinligase complexes define convergent pathways for the degradation of ER proteins. Cell 126, 361-373 (Pubitemid 44092963)
9. Vashist, S., and Ng, D. T. (2004) Misfolded proteins are sorted by a sequential checkpoint mechanism of ER quality control. J. Cell Biol. 165, 41-52 (Pubitemid 38649175)
10. Gardner, R. G., Swarbrick, G. M., Bays, N. W., Cronin, S. R., Wilhovsky, S., Seelig, L., Kim, C., and Hampton, R. Y. (2000) Endoplasmic reticulum degradation requires lumen to cytosol signaling. Transmembrane control of Hrd1p by Hrd3p. J. Cell Biol. 151, 69-82
11. Kaneko, M., and Nomura, Y. (2003) ER signaling in unfolded protein response. Life Sci. 74, 199-205 (Pubitemid 37357051)
12. Mueller, B., Lilley, B. N., and Ploegh, H. L. (2006) SEL1L, the homologue of yeast Hrd3p, is involved in protein dislocation from the mammalian ER. J. Cell Biol. 175, 261-270 (Pubitemid 44631420)
13. Kikkert, M., Doolman, R., Dai, M., Avner, R., Hassink, G., van Voorden, S., Thanedar, S., Roitelman, J., Chau, V., and Wiertz, E. (2004) Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum. J. Biol. Chem. 279, 3525-3534 (Pubitemid 38140592)
14. Biunno, I., Cattaneo, M., Orlandi, R., Canton, C., Biagiotti, L., Ferrero, S., Barberis, M., Pupa, S. M., Scarpa, A., and Ménard, S. (2006) SEL1L a multifaceted protein playing a role in tumor progression. J. Cell. Physiol. 208, 23-38 (Pubitemid 43848986)
15. Christianson, J. C., Shaler, T. A., Tyler, R. E., and Kopito, R. R. (2008) OS-9 and GRP94 deliver mutant α1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD. Nat. Cell Biol. 10, 272-282 (Pubitemid 351331014)
16. Baker, B. M., and Tortorella, D. (2007) Dislocation of an endoplasmic reticulum membrane glycoprotein involves the formation of partially dislocated ubiquitinated polypeptides. J. Biol. Chem. 282, 26845-26856 (Pubitemid 47501903)
17. Kostova, Z., Tsai, Y. C., and Weissman, A. M. (2007) Ubiquitin ligases, critical mediators of endoplasmic reticulum-associated degradation. Semin Cell Dev. Biol. 18, 770-779 (Pubitemid 350138452)
18. Bernasconi, R., Galli, C., Calanca, V., Nakajima, T., and Molinari, M. (2010) Stringent requirement for HRD1, SEL1L, and OS-9/XTP3-B for disposal of ERAD-LS substrates. J. Cell Biol. 188, 223-235
19. Predonzani, A., Arnoldi, F., López-Requena, A., and Burrone, O. R. (2008) In vivo site-specific biotinylation of proteins within the secretory pathway using a single vector system. BMC Biotechnol. 8, 41
20. Vangelista, L., Cesco-Gaspere, M., Lorenzi, R., and Burrone, O. (2002) A minimal receptor-Ig chimera of human FcεRI α-chain efficiently binds secretory and membrane IgE. Protein Eng. 15, 51-57 (Pubitemid 34184342)
21. Pelham, H. R. (1990) The retention signal for soluble proteins of the endoplasmic reticulum. Trends Biochem. Sci. 15, 483-486
22. Vangelista, L., Soprana, E., Cesco-Gaspere, M., Mandiola, P., Di Lullo, G., Fucci, R. N., Codazzi, F., Palini, A., Paganelli, G., Burrone, O. R., and Siccardi, A. G. (2005) Membrane IgE binds and activates Fc ε RI in an antigen-independent manner. J. Immunol. 174, 5602-5611 (Pubitemid 40593201)
23. Vangelista, L., Laffer, S., Turek, R., Grönlund, H., Sperr, W. R., Valent, P., Pastore, A., and Valenta, R. (1999) The immunoglobulin-like modules Cε3 and α2 are the minimal units necessary for human IgE-FcεRI interaction. J. Clin. Invest. 103, 1571-1578
24. Sambrook, J., Fritsch, E. F., and Maniatis, T. (1989) in Molecular cloning. A Laboratory Manual. 2nd Ed., pp. 16.33-16.36, Cold Spring Harbor Laboratory Press, New York
25. Petris, G., Vecchi, L., Bestagno, M., and Burrone, O. R. (2011) Efficient detection of proteins retro-translocated from the ER to the cytosol by in vivo biotinylation. PLoS One 6, e23712
26. Vangelista, L., Cesco-Gaspere, M., Lamba, D., and Burrone, O. (2002) Efficient folding of the FcεRI α-chain membrane-proximal domain D2 depends on the presence of the N-terminal domain D1. J. Mol. Biol. 322, 815-825
27. Yoshida, H., Matsui, T., Yamamoto, A., Okada, T., and Mori, K. (2001) XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell 107, 881-891 (Pubitemid 34084979)
28. Iida, Y., Fujimori, T., Okawa, K., Nagata, K., Wada, I., and Hosokawa, N. (2011) SEL1L protein critically determines the stability of the HRD1- SEL1L endoplasmic reticulum-associated degradation (ERAD) complex to optimize the degradation kinetics of ERAD substrates. J. Biol. Chem. 286, 16929-16939
29. Paganetti, P., Calanca, V., Galli, C., Stefani, M., and Molinari, M. (2005) β-Site-specific intrabodies to decrease and prevent generation of Alzheimer Aβ peptide. J. Cell Biol. 168, 863-868 (Pubitemid 40397001)
30. Filesi, I., Cardinale, A., Mattei, S., and Biocca, S. (2007) Selective re-routing of prion protein to proteasomes and alteration of its vesicular secretion prevent PrP(Sc) formation. J. Neurochem. 101, 1516-1526 (Pubitemid 46848843)
31. Govaerts, C., Wille, H., Prusiner, S. B., and Cohen, F. E. (2004) Evidence for assembly of prions with left-handed β-helices into trimers. Proc. Natl. Acad. Sci. U.S.A. 101, 8342-8347 (Pubitemid 38736577)
32. McLear, J. A., Lebrecht, D., Messer, A., and Wolfgang, W. J. (2008) Combinational approach of intrabody with enhanced Hsp70 expression addresses multiple pathologies in a fly model of Huntington disease. FASEB J. 22, 2003-2011 (Pubitemid 351811476)
33. Beatty, W. L. (2006) Trafficking from CD63-positive late endocytic multivesicular bodies is essential for intracellular development of Chlamydia trachomatis. J. Cell Sci. 119, 350-359
34. Rathman, M., Barker, L. P., and Falkow, S. (1997) The unique trafficking pattern of Salmonella typhimurium-containing phagosomes in murine macrophages is independent of the mechanism of bacterial entry. Infect Immun. 65, 1475-1485 (Pubitemid 27146641)
35. Bernal-Bayard, J., Cardenal-Muñoz, E., and Ramos-Morales, F. (2010) The Salmonella type III secretion effector, salmonella leucine-rich repeat protein (SlrP), targets the human chaperone ERdj3. J. Biol. Chem. 285, 16360-16368
36. Giles, D. K., and Wyrick, P. B. (2008) Trafficking of chlamydial antigens to the endoplasmic reticulum of infected epithelial cells. Microbes Infect. 10, 1494-1503
37. Coffield, V. M., Jiang, Q., and Su, L. (2003) A genetic approach to inactivating chemokine receptors using a modified viral protein. Nat. Biotechnol. 21, 1321-1327 (Pubitemid 37356617)