Treatment with histone deacetylase inhibitor attenuates MAP kinase mediated liver injury in a lethal model of septic shock

Journal of Surgical Research

Volumn 163, Issue 1, 2010, Pages 146-154

  Finkelstein, Robert A ^a,b   Li, Yongqing ^a   Liu, Baoling ^a   Shuja, Fahad ^a   Fukudome, Eugene ^a   Velmahos, George C ^a   Demoya, Marc ^a   Alam, Hasan B ^a  

^a Division of Trauma   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

acetylation; ERK; histone; IL 10; IL 6; liver; LPS; MAP kinase; p38; septic shock; suberoylanilide hydroxamic acid

Indexed keywords

BIOLOGICAL MARKER; HISTONE DEACETYLASE INHIBITOR; INTERLEUKIN 10; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; MYELOPEROXIDASE; PHOSPHOPROTEIN; SYNAPTOPHYSIN; TOLL LIKE RECEPTOR; VORINOSTAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; C57BL 6 MOUSE; CONFERENCE PAPER; CONTROLLED STUDY; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; INFLAMMATION; LIVER; LIVER INJURY; MALE; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEPTIC SHOCK; WESTERN BLOTTING;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; HYDROXAMIC ACIDS; INTERLEUKIN-10; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; LIVER; MALE; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASES; PEROXIDASE; SHOCK, SEPTIC; TOLL-LIKE RECEPTORS; UP-REGULATION;

EID: 77955926548     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2010.04.024     Document Type: Conference Paper

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