Lipodepsipeptide empedopeptin inhibits cell wall biosynthesis through Ca2+-dependent complex formation with peptidoglycan precursors

Journal of Biological Chemistry

Volumn 287, Issue 24, 2012, Pages 20270-20280

  Müller, Anna ^a   Münch, Daniela ^a   Schmidt, Yvonne ^a   Reder Christ, Katrin ^a   Schiffer, Guido ^b   Bendas, Gerd ^a   Gross, Harald ^a   Sahl, Hans Georg ^a   Schneider, Tanja ^a   Brötz Oesterhelt, Heike ^c  

^a UNIVERSITY OF BONN   (Germany)

^b AiCuris GmbH   (Germany)

^c HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL MODEL; ANTI-BACTERIAL ACTIVITY; ANTIBACTERIAL ACTION; BACTERIAL CELLS; BACTERIAL INFECTIONS; BIOSYNTHETIC ENZYMES; CALCIUM IONS; CELL WALL BIOSYNTHESIS; CELL WALLS; COMPLEX FORMATIONS; GRAM-POSITIVE BACTERIUM; IN-VITRO; LATE STAGE; MECHANISM OF ACTION; MEMBRANE PREPARATION; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; N-ACETYLGLUCOSAMINE; PEPTIDOGLYCAN PRECURSORS; PEPTIDOGLYCANS; STREPTOCOCCUS PNEUMONIAE; STRUCTURAL SIMILARITY; TEICHOIC ACID;

ANTIBIOTICS; BACTERIA; BIOCHEMISTRY; BIOSYNTHESIS; CELLS; PHOSPHOLIPIDS; PURIFICATION; STOICHIOMETRY; SUGARS;

CYTOLOGY;

ANTIBIOTIC AGENT; CALCIUM ION; EMPEDOPEPTIN; N ACETYLGLUCOSAMINE; PEPTIDOGLYCAN; PLUSBACIN; PYROPHOSPHORIC ACID DERIVATIVE; RECOMBINANT ENZYME; TEICHOIC ACID; TRIPROPEPTIN; UNCLASSIFIED DRUG; UNDECAPRENYL PYROPHOSPHATE; UNDECAPRENYL PYROPHOSPHATE N ACETYLMURAMIC ACID(PENTAPEPTIDE) N ACETYLGLUCOSAMINE; URIDINE DIPHOSPHATE N ACETYLMURAMIC ACID; URIDINE DIPHOSPHATE N ACETYLMURAMIC ACID PENTAPEPTIDE;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL CELL WALL; BINDING AFFINITY; BINDING KINETICS; BIOSYNTHESIS; COMPLEX FORMATION; CYTOPLASM; ENZYME PURIFICATION; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; STOICHIOMETRY;

ACETYLGLUCOSAMINE; CALCIUM; CELL MEMBRANE; CELL WALL; DEPSIPEPTIDES; DRUG RESISTANCE, MULTIPLE, BACTERIAL; OLIGOPEPTIDES; PEPTIDOGLYCAN; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE; URIDINE DIPHOSPHATE N-ACETYLMURAMIC ACID; URIDINE DIPHOSPHATE SUGARS;

ANIMALIA; BACTERIA (MICROORGANISMS); METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; POSIBACTERIA; STREPTOCOCCUS PNEUMONIAE;

EID: 84862001926     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.369561     Document Type: Article

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