The shear stress-induced transcription factor klf2 affects dynamics and angiopoietin-2 content of weibel-palade bodies

PLoS ONE

Volumn 7, Issue 6, 2012, Pages

  van Agtmaal, Ellen L ^a   Bierings, Ruben ^a,b   Dragt, Bieuwke S ^a   Leyen, Thomas A ^c   Fernandez Borja, Mar ^a   Horrevoets, Anton J G ^c   Voorberg, Jan ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; ANGIOPOIETIN 2; CYCLIC AMP; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; KRUPPEL LIKE FACTOR 2; ANGPT2 PROTEIN, HUMAN; CYTOKINE; KLF2 PROTEIN, HUMAN; KRUPPEL LIKE FACTOR;

ARTICLE; BLOOD; CELL NUCLEUS; CELL STIMULATION; CELL STRUCTURE; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; ENDOTHELIUM CELL; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; LENTIVIRINAE; PROTEIN EXPRESSION; REGULATORY MECHANISM; SHEAR STRESS; UPREGULATION; WEIBEL PALADE BODY; BIOSYNTHESIS; CELL CULTURE; CLINICAL TRIAL; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PHYSIOLOGICAL STRESS; SECRETION (PROCESS); SHEAR STRENGTH;

ANGIOPOIETIN-2; CELLS, CULTURED; CYTOKINES; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION; HUMANS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; SHEAR STRENGTH; STRESS, PHYSIOLOGICAL; WEIBEL-PALADE BODIES;

EID: 84862001096     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0038399     Document Type: Article

References (45)

1. Davids N, (1981) Finite element methods of studying mechanical factors in blood flow. Neurol Res 3: 83-105.
2. Chiu JJ, Chien S, (2011) Effects of disturbed flow on vascular endothelium: pathophysiological basis and clinical perspectives. Physiol Rev 91: 327-387.
3. Dekker RJ, Boon RA, Rondaij MG, Kragt A, Volger OL, et al. (2006) KLF2 provokes a gene expression pattern that establishes functional quiescent differentiation of the endothelium. Blood 107: 4354-4363.
4. Parmar KM, Larman HB, Dai G, Zhang Y, Wang ET, et al. (2006) Integration of flow-dependent endothelial phenotypes by Kruppel-like factor 2. J Clin Invest 116: 49-58.
5. Zarins CK, Giddens DP, Bharadvaj BK, Sottiurai VS, Mabon RF, et al. (1983) Carotid bifurcation atherosclerosis. Quantitative correlation of plaque localization with flow velocity profiles and wall shear stress. Circ Res 53: 502-514.
6. Dekker RJ, van Soest S, Fontijn RD, Salamanca S, de Groot PG, et al. (2002) Prolonged fluid shear stress induces a distinct set of endothelial cell genes, most specifically lung Kruppel-like factor (KLF2). Blood 100: 1689-1698.
7. Jain MK, Ridker PM, (2005) Anti-inflammatory effects of statins: clinical evidence and basic mechanisms. Nat Rev Drug Discov 4: 977-987.
8. Kumar A, Lin Z, SenBanerjee S, Jain MK, (2005) Tumor necrosis factor alpha-mediated reduction of KLF2 is due to inhibition of MEF2 by NF-kappaB and histone deacetylases. Mol Cell Biol 25: 5893-5903.
9. Bhattacharya R, Senbanerjee S, Lin Z, Mir S, Hamik A, et al. (2005) Inhibition of vascular permeability factor/vascular endothelial growth factor-mediated angiogenesis by the Kruppel-like factor KLF2. J Biol Chem 280: 28848-28851.
10. Boon RA, Horrevoets AJ, (2009) Key transcriptional regulators of the vasoprotective effects of shear stress. Hamostaseologie 29: 39-40, 41-33.
11. Weibel ER, Palade GE, (1964) NEW CYTOPLASMIC COMPONENTS IN ARTERIAL ENDOTHELIA. J Cell Biol 23: 101-112.
12. Wagner DD, Olmsted JB, Marder VJ, (1982) Immunolocalization of von Willebrand protein in Weibel-Palade bodies of human endothelial cells. J Cell Biol 95: 355-360.
13. Valentijn KM, Sadler JE, Valentijn JA, Voorberg J, Eikenboom J, (2011) Functional architecture of Weibel-Palade bodies. Blood.
14. Bonfanti R, Furie BC, Furie B, Wagner DD, (1989) PADGEM (GMP140) is a component of Weibel-Palade bodies of human endothelial cells. Blood 73: 1109-1112.
15. McEver RP, Beckstead JH, Moore KL, Marshall-Carlson L, Bainton DF, (1989) GMP-140, a platelet alpha-granule membrane protein, is also synthesized by vascular endothelial cells and is localized in Weibel-Palade bodies. J Clin Invest 84: 92-99.
16. Vischer UM, Wagner DD, (1993) CD63 is a component of Weibel-Palade bodies of human endothelial cells. Blood 82: 1184-1191.
17. Fiedler U, Scharpfenecker M, Koidl S, Hegen A, Grunow V, et al. (2004) The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies. Blood 103: 4150-4156.
18. Utgaard JO, Jahnsen FL, Bakka A, Brandtzaeg P, Haraldsen G, (1998) Rapid secretion of prestored interleukin 8 from Weibel-Palade bodies of microvascular endothelial cells. J Exp Med 188: 1751-1756.
19. Wolff B, Burns AR, Middleton J, Rot A, (1998) Endothelial cell "memory" of inflammatory stimulation: human venular endothelial cells store interleukin 8 in Weibel-Palade bodies. J Exp Med 188: 1757-1762.
20. Oynebraten I, Bakke O, Brandtzaeg P, Johansen FE, Haraldsen G, (2004) Rapid chemokine secretion from endothelial cells originates from 2 distinct compartments. Blood 104: 314-320.
21. Zannettino AC, Holding CA, Diamond P, Atkins GJ, Kostakis P, et al. (2005) Osteoprotegerin (OPG) is localized to the Weibel-Palade bodies of human vascular endothelial cells and is physically associated with von Willebrand factor. J Cell Physiol 204: 714-723.
22. Sakamoto Y, Doi Y, Ohsato K, Fujimoto S, (1993) Immunoelectron microscopy on the localization of endothelin in the umbilical vein of perinatal rabbits. Anat Rec 237: 482-488.
23. Romani de Wit T, Rondaij MG, Hordijk PL, Voorberg J, van Mourik JA, (2003) Real-time imaging of the dynamics and secretory behavior of Weibel-Palade bodies. Arterioscler Thromb Vasc Biol 23: 755-761.
24. Rondaij MG, Bierings R, Kragt A, Gijzen KA, Sellink E, et al. (2006) Dynein-dynactin complex mediates protein kinase A-dependent clustering of Weibel-Palade bodies in endothelial cells. Arterioscler Thromb Vasc Biol 26: 49-55.
25. van den Biggelaar M, Bouwens EA, Kootstra NA, Hebbel RP, Voorberg J, et al. (2009) Storage and regulated secretion of factor VIII in blood outgrowth endothelial cells. Haematologica 94: 670-678.
26. Dekker RJ, van Thienen JV, Rohlena J, de Jager SC, Elderkamp YW, et al. (2005) Endothelial KLF2 links local arterial shear stress levels to the expression of vascular tone-regulating genes. Am J Pathol 167: 609-618.
27. Bierings R, van den Biggelaar M, Kragt A, Mertens K, Voorberg J, et al. (2007) Efficiency of von Willebrand factor-mediated targeting of interleukin-8 into Weibel-Palade bodies. J Thromb Haemost 5: 2512-2519.
28. Rondaij MG, Bierings R, van Agtmaal EL, Gijzen KA, Sellink E, et al. (2008) Guanine exchange factor RalGDS mediates exocytosis of Weibel-Palade bodies from endothelial cells. Blood 112: 56-63.
29. Raines G, Aumann H, Sykes S, Street A, (1990) Multimeric analysis of von Willebrand factor by molecular sieving electrophoresis in sodium dodecyl sulphate agarose gel. Thromb Res 60: 201-212.
30. van Thienen JV, Fledderus JO, Dekker RJ, Rohlena J, van Ijzendoorn GA, et al. (2006) Shear stress sustains atheroprotective endothelial KLF2 expression more potently than statins through mRNA stabilization. Cardiovasc Res 72: 231-240.
31. Wu W, Xiao H, Laguna-Fernandez A, Villarreal G Jr, Wang KC, et al. (2011) Flow-Dependent Regulation of Kruppel-Like Factor 2 Is Mediated by MicroRNA-92a. Circulation 124: 633-641.
32. Fang Y, Davies PF, (2012) Site-Specific MicroRNA-92a Regulation of Kruppel-Like Factors 4 and 2 in Atherosusceptible Endothelium. Arterioscler Thromb Vasc Biol.
33. Gracia-Sancho J, Russo L, Garcia-Caldero H, Garcia-Pagan JC, Garcia-Cardena G, et al. (2011) Endothelial expression of transcription factor Kruppel-like factor 2 and its vasoprotective target genes in the normal and cirrhotic rat liver. Gut 60: 517-524.
34. Haberichter SL, Merricks EP, Fahs SA, Christopherson PA, Nichols TC, et al. (2005) Re-establishment of VWF-dependent Weibel-Palade bodies in VWD endothelial cells. Blood 105: 145-152.
35. Denis CV, Andre P, Saffaripour S, Wagner DD, (2001) Defect in regulated secretion of P-selectin affects leukocyte recruitment in von Willebrand factor-deficient mice. Proc Natl Acad Sci U S A 98: 4072-4077.
36. Lui-Roberts WW, Collinson LM, Hewlett LJ, Michaux G, Cutler DF, (2005) An AP-1/clathrin coat plays a novel and essential role in forming the Weibel-Palade bodies of endothelial cells. J Cell Biol 170: 627-636.
37. Tzima E, Kiosses WB, del Pozo MA, Schwartz MA, (2003) Localized cdc42 activation, detected using a novel assay, mediates microtubule organizing center positioning in endothelial cells in response to fluid shear stress. J Biol Chem 278: 31020-31023.
38. Michaux G, Pullen TJ, Haberichter SL, Cutler DF, (2006) P-selectin binds to the D'-D3 domains of von Willebrand factor in Weibel-Palade bodies. Blood 107: 3922-3924.
39. Harrison-Lavoie KJ, Michaux G, Hewlett L, Kaur J, Hannah MJ, et al. (2006) P-selectin and CD63 use different mechanisms for delivery to Weibel-Palade bodies. Traffic 7: 647-662.
40. Das H, Kumar A, Lin Z, Patino WD, Hwang PM, et al. (2006) Kruppel-like factor 2 (KLF2) regulates proinflammatory activation of monocytes. Proc Natl Acad Sci U S A 103: 6653-6658.
41. Augustin HG, Koh GY, Thurston G, Alitalo K, (2009) Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system. Nat Rev Mol Cell Biol 10: 165-177.
42. Fiedler U, Reiss Y, Scharpfenecker M, Grunow V, Koidl S, et al. (2006) Angiopoietin-2 sensitizes endothelial cells to TNF-alpha and has a crucial role in the induction of inflammation. Nat Med 12: 235-239.
43. Fiedler U, Augustin HG, (2006) Angiopoietins: a link between angiogenesis and inflammation. Trends Immunol 27: 552-558.
44. Goettsch W, Gryczka C, Korff T, Ernst E, Goettsch C, et al. (2008) Flow-dependent regulation of angiopoietin-2. J Cell Physiol 214: 491-503.
45. Starke RD, Ferraro F, Paschalaki KE, Dryden NH, McKinnon TA, et al. (2011) Endothelial von Willebrand factor regulates angiogenesis. Blood 117: 1071-1080.