GABA-induced relaxation of porcine retinal arterioles in vitro depends on inhibition from the perivascular retina and is mediated by GABA C receptors

Investigative Ophthalmology and Visual Science

Volumn 53, Issue 7, 2012, Pages 3309-3315

  Bek, Toke ^a   Holmgaard, Kim ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

1 ACETYL 2 (8 CHLORO 10, 11 DIHYDRODIBENZ [B, F] [1, 4] OXAZEPINE 10 CARBONYL) HYDRAZINE; 2 AMINO 5 PHOSPHONOVALERIC ACID; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID B RECEPTOR; 4 AMINOBUTYRIC ACID C RECEPTOR; 4 AMINOBUTYRIC ACID C RECEPTOR BLOCKING AGENT; 4 AMINOBUTYRIC ACID C RECEPTOR STIMULATING AGENT; ADENOSINE RECEPTOR; ADENOSINE RECEPTOR BLOCKING AGENT; ADENOSINE RECEPTOR STIMULATING AGENT; ADENOSINE TRIPHOSPHATE; ARECAIDINE; BACLOFEN; BENZYL [3 [[1 (3, 4 DICHLOROPHENYL) ETHYL] AMINO] 2 HYDROXYPROPYL] PHOSPHINIC ACID; BICUCULLINE; ECTONUCLEOTIDASE INHIBITOR; ENZYME INHIBITOR; IBUPROFEN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR STIMULATING AGENT; PICROTOXIN; PROSTAGLANDIN E RECEPTOR 2; PROSTAGLANDIN RECEPTOR STIMULATING AGENT; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTERY DILATATION; ARTICLE; BLOOD VESSEL TONE; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; RETINA ARTERY; SWINE;

ANIMALS; ARTERIOLES; GABA AGENTS; GABA ANTAGONISTS; GAMMA-AMINOBUTYRIC ACID; IMMUNOHISTOCHEMISTRY; MUSCLE, SMOOTH, VASCULAR; MYOGRAPHY; RECEPTORS, GABA; RETINA; RETINAL ARTERY; SWINE; VASODILATION;

EID: 84861970904     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.12-9838     Document Type: Article

References (21)

1. Russell TL, Werblin FS. Retinal synaptic pathways underlying the response of the rabbit local edge detector. J Neurophysiol. 2010;103:2757-2769.
2. Breceptors in the vertebrate retina. Prog Retin Eye Res. 1995;14:293-312.
3. Wässle H, Koulen P, Brandstätter JH, Fletcher EL, Becker C. Glycine and GABA receptors in the mammalian retina. Vision Res. 1998;38:1411-1430.
4. Creceptors in the vertebrate retina. Mol Neurobiol. 1996;12:181-194.
5. Creceptor-mediated inhibition in the retina. Vision Res. 2004; 44:3289-3296.
6. Holmgaard K, Aalkjaer C, Lambert JD, Hessellund A, Bek T. The relaxing effect of perivascular tissue on porcine retinal arterioles in vitro is mimicked by N-methyl-D-aspartate and is blocked by prostaglandin synthesis inhibition. Acta Ophthalmol. 2008;86:26-33.
7. Holmgaard K, Aalkjaer C, Lambert JD, Bek T. N-methyl-Daspartic acid causes relaxation of porcine retinal arterioles through an adenosine receptor-dependent mechanism. Invest Ophthalmol Vis Sci. 2008;49:4590-4594.
8. Holmgaard K, Bek T. ATP-induced relaxation of porcine retinal arterioles in vitro depends on prostaglandin E synthesized in the perivascular retinal tissue. Invest Ophthalmol Vis Sci. 2010;51:5168-5175.
9. Zheng W, Zhao X, Wang J, Lu L. Retinal vascular leakage occurring in GABA Rho-1 deficient mice. Exp Eye Res. 2010; 90:634-640.
10. Madsen C, Jensen AA, Liljefors T, et al. 5-Substituted imidazole-4-acetic acid analogues: synthesis, modeling, and pharmacological characterization of a series of novel c-aminobutyric acid(C) receptor agonists. J Med Chem. 2007;50:4147-4161.
11. Hessellund A, Jeppesen P, Aalkjaer C, Bek T. Characterization of vasomotion in porcine retinal arterioles. Acta Ophthalmol Scand. 2003;81:278-282.
12. Misfeldt M, Hessellund A, Simonsen U, Aalkjaer C, Bek T. Voltage-gated calcium channels are involved in the regulation of calcium oscillations in vascular smooth muscle cells from isolated porcine retinal arterioles. Exp Eye Res. 2010;91:69-75.
13. Peppiatt CM, Howarth C, Mobbs P, Attwell D. Bidirectional control of CNS capillary diameter by pericytes. Nature. 2006; 443:70-74.
14. Gordon GR, Howarth R, MacVicar BA. Bidirectional control of arteriole diameter by astrocytes. Exp Physiol. 2011;96:393-399.
15. Misfeldt MW, Aalkjaer C, Simonsen U, Bek T. Novel cellular bouton structure activated by ATP in the vascular wall of porcine retinal arterioles. Invest Ophthalmol Vis Sci. 2010;51: 6681-6687.
16. Vigh J, Vickers E, von Gersdorff H. Light-evoked lateral GABAergic inhibition at single bipolar cell synaptic terminals is driven by distinct retinal microcircuits. J Neurosci. 2011;31: 15884-15893.
17. Jones SM, Palmer MJ. Pharmacological analysis of the activation and receptor properties of the tonic GABA(C)R current in retinal bipolar cell terminals. PLOS One. 2011;6: e24892.
18. Hermann R, Heflin SJ, Hammond T, et al. Rod vision is controlled by dopamine-dependent sensitization of rod bipolar cells by GABA. Neuron. 2011;72:101-110.
19. Yang XL. Characterization of receptors for glutamate and GABA in retinal neurons. Prog Neurobiol. 2004;72:127-150.
20. Koulen P, Brandstätter JH, Kröger S, Enz R, Bormann J, Wässle H. Immunocytochemical localization of the GABA(C) receptor rho subunits in the cat, goldfish, and chicken retina. J Comp Neurol. 1997;380:520-532.
21. Zhang C, McCall MA. Receptor targets of amacrine cells. Vis Neurosci. 2012;1:11-29.