The relaxing effect of perivascular tissue on porcine retinal arterioles in vitro is mimicked by N-methyl-D-aspartate and is blocked by prostaglandin synthesis inhibition

Acta Ophthalmologica

Volumn 86, Issue 1, 2008, Pages 26-33

  Holmgaard, Kim ^a   Aalkjær, Christian ^b   Lambert, John D C ^b   Hessellund, Anders ^a   Bek, Toke ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

Author keywords

aminobutyric acid (GABA); DL amino 5 phosphonovaleric acid (DL APV); N methyl D aspartate (NMDA); Perivascular tissue; prostaglandin synthesis inhibition; Retinal vascular tone

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 2 AMINO 5 PHOSPHONOVALERIC ACID; 4 AMINOBUTYRIC ACID RECEPTOR; IBUPROFEN; N METHYL DEXTRO ASPARTIC ACID; PICROTOXIN; PROSTAGLANDIN DERIVATIVE; 4 AMINOBUTYRIC ACID; AMINO ACID RECEPTOR BLOCKING AGENT; AMINO ACID RECEPTOR STIMULATING AGENT; N METHYLASPARTIC ACID; PROSTAGLANDIN RECEPTOR BLOCKING AGENT; VASOCONSTRICTOR AGENT;

ANIMAL TISSUE; ARTICLE; BLOOD VESSEL TONE; CONCENTRATION RESPONSE; CONTROLLED STUDY; IN VITRO STUDY; MUSCLE ISOMETRIC CONTRACTION; MYOGRAPHY; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS INHIBITION; RETINA ARTERY; RETINA BLOOD FLOW; SWINE; VASOCONSTRICTION; ANIMAL; ARTERIOLE; DOSE RESPONSE; DRUG EFFECT; PHYSIOLOGY; RETINA; RETINA BLOOD VESSEL; VASODILATATION;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; 2-AMINO-5-PHOSPHONOVALERATE; ANIMALS; ARTERIOLES; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; GAMMA-AMINOBUTYRIC ACID; N-METHYLASPARTATE; PROSTAGLANDIN ANTAGONISTS; RETINA; RETINAL VESSELS; SWINE; VASOCONSTRICTION; VASOCONSTRICTOR AGENTS; VASODILATION;

EID: 39349096387     PISSN: 1755375X     EISSN: 16000420     Source Type: Journal    
DOI: 10.1111/j.1600-0420.2007.01010.x     Document Type: Article

References (25)

1. Bormann J & Feigenspan A (1995): GABA C receptors. Trends Neurosci 18: 515-519.
2. Boussery K, Delaey C & Van de Voorde J (2004): Influence of adrenomedullin on tone of isolated bovine retinal arteries. Invest Ophthalmol Vis Sci 45: 552-559.
3. Boussery K, Delaey C & Van de Voorde J (2002a): Rat retinal tissue releases a vasorelaxing factor. Invest Ophthalmol Vis Sci 43: 3279-3286.
4. Boussery K, Delaey C & Van de Voorde J (2005a): The vasorelaxing effect of CGRP and natriuretic peptides in isolated bovine retinal arteries. Invest Ophthalmol Vis Sci 46: 1420-1427.
5. Boussery K, Franki AS, Delaey C & Van de Voorde J (2002b): A vasorelaxing factor is released from mouse retinal tissue. Ophthalmic Res 34: 172-177.
6. Boussery K, Lambrecht S, Delaey C & Van de Voorde J (2005b): Clozapine directly relaxes bovine retinal arteries. Curr Eye Res 30: 139-146.
7. Delaey C, Van Boussery K & Van de Voorde J (2000): A retinal-derived relaxing factor mediates the hypoxic vasodilation of retinal arteries. Invest Ophthalmol Vis Sci 41: 3555-3560.
8. Delaey C & Van de Voorde J (1998): Retinal arterial tone is controlled by a retinal-derived relaxing factor. Circ Res 83: 714-720.
9. Filosa JA, Bonev AD & Nelson MT (2004): Calcium dynamics in cortical astrocytes and arterioles during neurovascular coupling. Circ Res 95: E73-E81.
10. Grunwald JE, DuPont J & Riva CE (1996): Retinal haemodynamics in patients with early diabetes mellitus. Br J Ophthalmol 80: 327-331.
11. Hessellund A, Aalkjaer C & Bek T (2006): Effect of cyclic guanosine-monophosphate on porcine retinal vasomotion. Acta Ophthalmol Scand 84: 228-233.
12. Hessellund A, Jeppesen P, Aalkjaer C & Bek T (2003): Characterization of vasomotion in porcine retinal arterioles. Acta Ophthalmol Scand 81: 278-282.
13. Jeppesen P, Aalkjaer C & Bek T (2002): Adenosine relaxation in small retinal arterioles requires functional Na-K pumps and K(ATP) channels. Curr Eye Res 25: 23-28.
14. Jeppesen P, Aalkjaer C & Bek T (2003): Myogenic response in isolated porcine retinal arterioles. Curr Eye Res 27: 217-222.
15. Kobayashi N, Ishiguro S, Tomita H, Nishikawa S & Tamai M (1999): Changes of GABA metabolic enzymes in acute retinal ischaemia. Exp Eye Res 69: 91-96.
16. Kohner EM, Patel V & Rassam SM (1995): Role of blood flow and impaired autoregulation in the pathogenesis of diabetic retinopathy. Diabetes 44: 603-607.
17. Lukasiewicz PD, Eggers ED, Sagdullaev BT & McCall MA (2004): GABA C receptor-mediated inhibition in the retina. Vision Res 44: 3289-3296.
18. Mulligan SJ & MacVicar BA (2004): Calcium transients in astrocyte endfeet cause cerebrovascular constrictions. Nature 431: 195-199.
19. Mulvany MJ & Halpern W (1977): Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats. Circ Res 41: 19-26.
20. Napper GA & Kalloniatis M (1999): Neurochemical changes following postmortem ischaemia in the rat retina. Vis Neurosci 16: 1169-1180.
21. Pedersen DB, Eysteinsson T, Stefansson E, Kiilgaard JF, la Cour M, Bang K & Jensen PK (2004): Indomethacin lowers optic nerve oxygen tension and reduces the effect of carbonic anhydrase inhibition and carbon dioxide breathing. Br J Ophthalmol 88: 1088-1091.
22. PeppiattFC & Attwell D (2004): Neurobiology: feeding the brain. Nature 431: 137-138.
23. Thereza M, Perez R & Ehinger B (1989): Multiple neurotransmitter systems influence the release of adenosine derivatives from the rabbit retina. Neurochem Int 15: 411-420.
24. Zonta M, Angulo MC, Gobbo S, Rosengarten B, Hossmann KA, Pozzan T & Carmignoto G (2003a): Neuron-to-astrocyte signalling is central to the dynamic control of brain microcirculation. Nat Neurosci 6: 43-50.
25. Zonta M, Sebelin A, Gobbo S, Fellin T, Pozzan T & Carmignoto G (2003b): Glutamate-mediated cytosolic calcium oscillations regulate a pulsatile prostaglandin release from cultured rat astrocytes. J Physiol 553: 407-414.