ATP-induced relaxation of porcine retinal arterioles in vitro depends on prostaglandin E synthesized in the perivascular retinal tissue

Investigative Ophthalmology and Visual Science

Volumn 51, Issue 10, 2010, Pages 5168-5175

  Holmgaard, Kim ^a   Bek, Toke ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; PROSTACYCLIN; PROSTAGLANDIN D2; PROSTAGLANDIN E; PROSTAGLANDIN E2; PROSTAGLANDIN F2 ALPHA; THROMBOXANE A2; ADENOSINE; AMINO ACID RECEPTOR STIMULATING AGENT; IBUPROFEN; N METHYLASPARTIC ACID; PROSTAGLANDIN; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN SYNTHASE INHIBITOR; PROSTANOID RECEPTOR EP1;

ANIMAL TISSUE; ARTERIOLE; ARTICLE; BLOOD VESSEL TONE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN ANALYSIS; PROTEIN FUNCTION; RETINA ARTERY; VASODILATATION; ANIMAL; BIOSYNTHESIS; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; MYOGRAPHY; PHYSIOLOGY; SWINE; VASCULAR SMOOTH MUSCLE;

ADENOSINE; ADENOSINE TRIPHOSPHATE; ANIMALS; ARTERIOLES; CYCLOOXYGENASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID AGONISTS; IBUPROFEN; MUSCLE, SMOOTH, VASCULAR; MYOGRAPHY; N-METHYLASPARTATE; PROSTAGLANDINS; PROSTAGLANDINS E; RECEPTORS, PROSTAGLANDIN E; RETINAL ARTERY; SWINE; VASODILATION;

EID: 77958116639     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.09-4608     Document Type: Article

References (33)

1. Holmgaard K, Aalkjaer C, Lambert JD, Hessellund A, Bek T. The relaxing effect of perivascular tissue on porcine retinal arterioles in vitro is mimicked by N-methyl-D-aspartate and is blocked by prostaglandin synthesis inhibition. Acta Ophthalmol Scand. 2008;86: 26-33.
2. Holmgaard K, Aalkjaer C, Lambert JD, Bek T. ATP-induced relaxation of porcine retinal arterioles depends on the perivascular retinal tissue and acts via an adenosine receptor. Curr Eye Res. 2007;32:353-359.
3. Delaey C, Van D V. Retinal arterial tone is controlled by a retinalderived relaxing factor. Circ Res. 1998;83:714-720.
4. Boussery K, Delaey C, Van de Voorde J. Rat retinal tissue releases a vasorelaxing factor. Invest Ophthalmol Vis Sci. 2002;43:3279-3286.
5. Pournaras C, Tsacopoulos M, Chapuis P. Studies on the role of prostaglandins in the regulation of retinal blood flow. Exp Eye Res. 1978;26:687-697.
6. Biswas S, Bhattacherjee P, Paterson CA. Prostaglandin E2 receptor subtypes, EP1, EP2, EP3 and EP4 in human and mouse ocular tissues: a comparative immunohistochemical study. Prostaglandins Leukot Essent Fatty Acids. 2004;71:277-288.
7. Sharif NA, Davis TL, Williams GW. Ocular hypotensive DP-class prostaglandin receptor affinities determined by quantitative autoradiography on human eye sections. J Ocul Pharmacol Ther. 2005;21:121-132.
8. Hessellund A, Jeppesen P, Aalkjaer C, Bek T. Characterization of vasomotion in porcine retinal arterioles. Acta Ophthalmol Scand. 2003;81:278-282.
9. Gordon GR, Choi HB, Rungta RL, Ellis-Davies GC, MacVicar BA. Brain metabolism dictates the polarity of astrocyte control over arterioles. Nature. 2008;456:745-749.
10. Tang EH, Vanhoutte PM. Prostanoids and reactive oxygen species: team players in endothelium-dependent contractions. Pharmacol Ther. 2009;122:140-149.
11. Badejo AM Jr, Dhaliwal JS, Casey DB, Gallen TB, Greco AJ, Kadowitz PJ. Analysis of pulmonary vasodilator responses to the Rho-kinase inhibitor fasudil in the anesthetized rat. Am J Physiol Lung Cell Mol Physiol. 2008;295:L828-L836.
12. Matsuo T, Cynader MS. Localisation of prostaglandin F2 alpha and E2 binding sites in the human eye. Br J Ophthalmol. 1992;76:210-213.
13. Stjernschantz J, Selen G, Astin M, Resul B. Microvascular effects of selective prostaglandin analogues in the eye with special reference to latanoprost and glaucoma treatment. Prog Retin Eye Res. 2000; 19:459-496.
14. Kampf G, Ritter JM. Time-dependent inhibition by glyceryl trinitrate of platelet aggregation caused by U46619 (a thromboxane/ endoperoxide receptor agonist). Br J Clin Pharmacol. 1994;38: 80-82.
15. Nielsen PJ, Nyborg NC. Calcium antagonist-induced relaxation of the prostaglandin-F2 alpha response of isolated calf retinal resistance arteries. Exp Eye Res. 1989;48:329-335.
16. Pournaras CJ, Rungger-Brandle E, Riva CE, Hardarson SH, Stefansson E. Regulation of retinal blood flow in health and disease. Prog Retin Eye Res. 2008;27:284-330.
17. Bill A. Effects of indomethacin on regional blood flow in conscious rabbits: a microsphere study. Acta Physiol Scand. 1979; 105:437-442.
18. Mori A, Saito M, Sakamoto K, Narita M, Nakahara T, Ishii K. Stimulation of prostanoid IP and EP(2) receptors dilates retinal arterioles and increases retinal and choroidal blood flow in rats. Eur J Pharmacol. 2007;570:135-141.
19. Dorner GT, Zawinka C, Resch H, Wolzt M, Schmetterer L, Garhofer G. Effects of pentoxifylline and alprostadil on ocular hemodynamics in healthy humans. Invest Ophthalmol Vis Sci. 2007;48:815-819.
20. Goh Y, Nakajima M, Azuma I, Hayaishi O. Effects of prostaglandin D2 and its analogues on intraocular pressure in rabbits. Jpn J Ophthalmol. 1988;32:471-480.
21. Woodward DF, Hawley SB, Williams LS, et al. Studies on the ocular pharmacology of prostaglandin D2. Invest Ophthalmol Vis Sci. 1990;31:138-146.
22. Nakajima M, Goh Y, Azuma I, Hayaishi O. Effects of prostaglandin D2 and its analogue, BW245C, on intraocular pressure in humans. Graefes Arch Clin Exp Ophthalmol. 1991;229:411-413.
23. Matsugi T, Kageyama M, Nishimura K, Giles H, Shirasawa E. Selective prostaglandin D2 receptor stimulation elicits ocular hypotensive effects in rabbits and cats. Eur J Pharmacol. 1995;275:245-250.
24. Stiris T, Suguihara C, Hehre D, Goldberg RN, Flynn J, Bancalari E. Effect of cyclooxygenase inhibition on retinal and choroidal blood flow during hypercarbia in newborn piglets. Pediatr Res. 1992;31: 127-130.
25. Dodge AB, Hechtman HB, Shepro D. Microvascular endothelialderived autacoids regulate pericyte contractility. Cell Motil Cytoskeleton. 1991;18:180-188.
26. Hudes GR, Li WY, Rockey JH, White P. Prostacyclin is the major prostaglandin synthesized by bovine retinal capillary pericytes in culture. Invest Ophthalmol Vis Sci. 1988;29:1511-1516.
27. Burnette JO, White RE. PGI2 opens potassium channels in retinal pericytes by cyclic AMP-stimulated, cross-activation of PKG. Exp Eye Res. 2006;83:1359-1365.
28. Cai J, Boulton M. The pathogenesis of diabetic retinopathy: old concepts and new questions. Eye. 2002;16:242-260.
29. Clarke M, Dodson PM. PKC inhibition and diabetic microvascular complications. Best Pract Res Clin Endocrinol Metab. 2007;21: 573-586.
30. Frederiksen CA, Jeppesen P, Knudsen ST, Poulsen PL, Mogensen CE, Bek T. The blood pressure-induced diameter response of retinal arterioles decreases with increasing diabetic maculopathy. Graefes Arch Clin Exp Ophthalmol. 2006;244: 1255-1261.
31. Bek T, Hajari J, Jeppesen P. Interaction between flicker-induced vasodilatation and pressure autoregulation in early retinopathy of type 2 diabetes. Graefes Arch Clin Exp Ophthalmol. 2008;246: 763-769.
32. Johnson EI, Dunlop ME, Larkins RG. Increased vasodilatory prostaglandin production in the diabetic rat retinal vasculature. Curr Eye Res. 1999;18:79-82.
33. Ayalasomayajula SP, Amrite AC, Kompella UB. Inhibition of cyclooxygenase-2, but not cyclooxygenase-1, reduces prostaglandin E2 secretion from diabetic rat retinas. Eur J Pharmacol. 2004;498: 275-278.