Reduced amygdalaprefrontal coupling in major depression: Association with MAOA genotype and illness severity

International Journal of Neuropsychopharmacology

Volumn 12, Issue 1, 2009, Pages 11-22

  Dannlowski, Udo ^a   Ohrmann, Patricia ^a   Konrad, Carsten ^a   Domschke, Katharina ^a   Bauer, Jochen ^a   Kugel, Harald ^a   Hohoff, Christa ^a   Schöning, Sonja ^a   Kersting, Anette ^a   Baune, Bernhard T ^a,b   Mortensen, Lena S ^a   Arolt, Volker ^a   Zwitserlood, Pienie ^a   Deckert, Jrgen ^a,c   Heindel, Walter ^a   Suslow, Thomas ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b JAMES COOK UNIVERSITY   (Australia)

^c UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Amygdala; FMRI; Genetics; Major depression; Monoamine oxidase A

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; AMINE OXIDASE (FLAVIN CONTAINING); ANTIDEPRESSANT AGENT;

ADULT; ALLELE; AMYGDALOID NUCLEUS; ANTERIOR CINGULATE CORTEX; ARTICLE; BRAIN MAPPING; CINGULATE GYRUS; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; DOSOLATERAL PREFRONTAL CORTEX; EMOTIONALITY; FACIAL EXPRESSION; FEMALE; GENE; GENETIC ASSOCIATION; GENOTYPE; HUMAN; IMAGE ANALYSIS; MAJOR DEPRESSION; MALE; MAOA GENE; NERVE CELL NETWORK; ORBITAL CORTEX; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROMOTER REGION; TASK PERFORMANCE; VARIABLE NUMBER OF TANDEM REPEAT; VARIANCE; CHRONIC DISEASE; CLUSTER ANALYSIS; EMOTION; GENETICS; NERVE TRACT; NEUROPSYCHOLOGICAL TEST; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PHYSIOLOGY; PSYCHOLOGICAL RATING SCALE; TREATMENT OUTCOME;

ADULT; ALLELES; AMYGDALA; ANTIDEPRESSIVE AGENTS; CHRONIC DISEASE; CLUSTER ANALYSIS; DEPRESSIVE DISORDER, MAJOR; EMOTIONS; FEMALE; GENOTYPE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MONOAMINE OXIDASE; NEURAL PATHWAYS; NEUROPSYCHOLOGICAL TESTS; PREFRONTAL CORTEX; PSYCHIATRIC STATUS RATING SCALES; TREATMENT OUTCOME;

EID: 61949266789     PISSN: 14611457     EISSN: 14695111     Source Type: Journal    
DOI: 10.1017/S1461145708008973     Document Type: Article

References (64)

1. Anand A, Li Y, Wang Y, Gardner K, Lowe MJ (2007). Reciprocal effects of antidepressant treatment on activity and connectivity of the mood regulating circuit: an FMRI study. Journal of Neuropsychiatry and Clinical Neuroscience 19, 274-282.
2. Anand A, Li Y, Wang Y, Wu J, Gao S, Bukhari L, Mathews VP, Kalnin A, Lowe MJ (2005a). Activity and connectivity of brain mood regulating circuit in depression: a functional magnetic resonance study. Biological Psychiatry 57, 1079-1088.
3. Anand A, Li Y, Wang Y, Wu J, Gao S, Bukhari L, Mathews VP, Kalnin A, Lowe MJ (2005b). Antidepressant effect on connectivity of the mood-regulating circuit: an fMRI study. Neuropsychopharmacology 30, 1334-1344.
4. Baxter Jr. LR, Schwartz JM, Phelps ME, Mazziotta JC, Guze BH, Selin CE, Gerner RH, Sumida RM (1989). Reduction of prefrontal glucose metabolism common to three types of depression. Archives of General Psychiatry 46, 243-250.
5. Beauregard M, Paquette V, Levesque J (2006). Dysfunction in the neural circuitry of emotional self-regulation in major depressive disorder. Neuroreport 17, 843-846.
6. Beck AT, Steer RA (1987). Beck Depression Inventory: Manual. Psychological Corporation Harcourt Brace Jovanovich: San Antonio, TX.
7. Bench CJ, Friston KJ, Brown RG, Frackowiak RS, Dolan RJ (1993). Regional cerebral blood flow in depression measured by positron emission tomography the relationship with clinical dimensions. Psychological Medicine 23, 579-590.
8. Bertolino A, Arciero G, Rubino V, Latorre V, De Candia M, Mazzola V, Blasi G, Caforio G, Hariri A, Kolachana B, et al. (2005). Variation of human amygdala response during threatening stimuli as a function of 5 'HTTLPR genotype and personality style. Biological Psychiatry 57, 1517-1525.
9. Brett M, Anton JL, Valabregue R, Poline JB (2002). Region of interest analysis using an SPM toolbox. Neuroimage 16, 497.
10. Brummett BH, Krystal AD, Siegler IC, Kuhn C, Surwit RS, Züchner S, Ashley-Koch A, Barefoot JC, Williams RB (2007). Associations of a regulatory polymorphism of monoamine oxidase-A gene promoter (MAOA-uVNTR) with symptoms of depression and sleep quality. Psychosomatic Medicine 69, 396-401.
11. Brown SM, Peet E, Manuck SB, Williamson DE, Dahl RE, Ferrell RE, Hariri AR (2005). A regulatory variant of the human tryptophan hydroxylase-2 gene biases amygdala reactivity. Molecular Psychiatry 10, 884-808.
12. Buckholtz JW, Callicott JH, Kolachana B, Hariri AR, Goldberg TE, Genderson M, Egan MF, Mattay VS, Weinberger DR, Meyer-Lindenberg A (2008). Genetic variation in MAOA modulates ventromedial prefrontal circuitry mediating individual differences in human personality. Molecular Psychiatry 13, 313-324.
13. Chen CH, Suckling J, Ooi C, Fu CH, Williams SC, Walsh ND, Mitterschiffthaler MT, Pich EM, Bullmore E (2007). Functional coupling of the amygdala in depressed patients treated with antidepressant medication. Neuropsychopharmacology. Published online: 7 November 2007. doi:10.1038/sj.npp.1301593.
14. Dannlowski U, Ohrmann P, Bauer J, Deckert J, Hohoff C, Kugel H, Arolt V, Heindel W, Baune BT, Kersting A, Suslow T (2008). 5-HTTLPR biases amygdala activity in response to masked facial expressions in major depression. Neuropsychopharmacology 33, 418-424.
15. Dannlowski U, Ohrmann P, Bauer J, Kugel H, Baune BT, Hohoff C, Kersting A, Arolt V, Heindel W, Deckert J, Suslow T (2007). Serotonergic genes modulate amygdala activity in major depression. Genes, Brain, and Behavior 6, 672-676.
16. Deckert J, Catalano M, Syagailo YV, Bosi M, Okladnova O, Di BellaD, Nöthen MM, Maffei P, Franke P, Fritze J, et al. (1999). Excess of high activity monoamine oxidase A gene promoter alleles in female patients with panic disorder. Human Molecular Genetics 8, 621-624.
17. Domschke K, Braun M, Ohrmann P, Suslow T, Kugel H, Bauer J, Hohoff C, Kersting A, Engelien A, Arolt V, et al. (2006). Association of the functional -1019C/G 5-HT1A polymorphism with prefrontal cortex and amygdala activation measured with 3 T fMRI in panic disorder. International Journal of Neuropsychopharmacology 9, 349-355.
18. Domschke K, Hohoff C, Mortensen LS, Roehrs T, Deckert J, Arolt V, Baune BT (2007). Monoamine oxidase A variant influences antidepressant treatment response in female patients with Major Depression. Progress in Neuropsychopharmacology and Biological Psychiatry. Published online: 19 August 2007. doi:10.1016/ j.pnpbp.2007.08.011.
19. Drevets WC (1999). Prefrontal cortical amygdalar metabolism in major depression. Annals of the New York Academy of Science 877, 614-637.
20. Ekman P, Friesen WV (1976). Pictures of Facial Affect. Consulting Psychologists Press: Palo Alto, CA, USA.
21. Evans DL, Charney DS (2003). Mood disorders and medical illness: a major public health problem. Biological Psychiatry 54, 177-180.
22. Faul F, Erdfelder E, Lang AG, Buchner A (2007). G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behavior Research Methods 39, 175-191.
23. Fitzgerald PB, Laird AR, Maller J, Daskalakis ZJ (2007). A meta-analytic study of changes in brain activation in depression. Human Brain Mapping. Published online: 27 June 2007. doi:10.1002/hbm.20426.
24. Friston KJ (1994). Functional and effective connectivity in neuroimaging: a synthesis. Human Brain Mapping 2, 56-78.
25. Hamilton M (1960). A rating scale for depression. Journal of Neurology, Neurosurgery, and Psychiatry 23, 56-62.
26. Hariri AR, Drabant EM, Munoz KE, Kolachana BS, Mattay VS, Egan MF, Weinberger DR (2005). A susceptibility gene for affective disorders and the response of the human amygdala. Archives of General Psychiatry 62, 146-152.
27. Hariri AR, Drabant EM, Weinberger DR (2006). Imaging genetics: perspectives from studies of genetically driven variation in serotonin function and corticolimbic affective processing. Biological Psychiatry 59, 888-897.
28. Hariri AR, Mattay VS, Tessitore A, Kolachana B, Fera F, Goldman D, Egan MF, Weinberger DR (2002). Serotonin transporter genetic variation and the response of the human amygdala. Science 297, 400-403.
29. Hasler G, Drevets WC, Manji HK, Charney DS (2004). Discovering endophenotypes for major depression. Neuropsychopharmacology 29, 1765-1781.
30. Heinz A, Braus DF, Smolka MN, Wrase J, Puls I, Hermann D, Klein S, Grusser SM, Flor H, Schumann G, et al. (2005). Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter. Nature Neuroscience 8, 20-21.
31. Johnstone T, van Reekum CM, Urry HL, Kalin NH, Davidson RJ (2007). Failure to regulate: counterproductive recruitment of top-down prefrontal-subcortical circuitry in major depression. Journal of Neuroscience 27, 8877-8884.
32. Kersting A, Kroker K, Horstmann J, Baune BT, Hohoff C, Mortensen LS, Neumann LC, Arolt V, Domschke K (2008). Association of MAO-A variant with complicated grief in major depression. Neuropsychobiology 56, 191-196.
33. Kim SH, Hamann S (2007). Neural correlates of positive and negative emotion regulation. Journal of Cognitive Neuroscience 19, 776-798.
34. Lehrl S (1995). Mehrfachwahl-Wortschatz-Intelligenztest MWT-B [Multiple-choice Verbal Intelligence test]. Hogrefe: Göttingen, Germany.
35. Lévesque J, Eugène F, Joanette Y, Paquette V, Mensour B, Beaudoin G, Leroux JM, Bourgouin P, Beauregard M (2003). Neural circuitry underlying voluntary suppression of sadness. Biological Psychiatry 53, 502-510.
36. Maldjian JA, Laurienti PJ, Kraft RA, Burdette JH (2003). An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. Neuroimage 19, 1233-1239.
37. Malhotra AK, Goldman D (1999). Benefits and pitfalls encountered in psychiatric genetic association studies. Biological Psychiatry 45, 544-550.
38. Mayberg HS, Brannan SK, Tekell JL, Silva JA, Mahurin RK, McGinnis S, Jerabek PA (2000). Regional metabolic effects of fluoxetine in major depression: serial changes and relationship to clinical response. Biological Psychiatry 48, 830-843.
39. Mayberg HS, Liotti M, Brannan SK, McGinnis S, Mahurin RK, Jerabek PA, Silva JA, Tekell JL, Martin CC, Lancaste JL, Fox PT (1999). Reciprocal limbic cortical function and negative mood: converging PET findings in depression and normal sadness. American Journal of Psychiatry 156, 675-682.
40. Meyer JH, Ginovart N, Boovariwala A, Sagrati S, Hussey D Garcia A, Young T, Praschak-Rieder N, Wilson AA, Houle S (2006). Elevated monoamine oxidase a levels in the brain: an explanation for the monoamine imbalance o major depression. Archives of General Psychiatry 63, 1209-1216.
41. Meyer-Lindenberg A, Buckholtz JW, Kolachana B, Hariri AR, Pezawas L, Blasi G, Wabnitz A, Honea R, Verchinski B, Callicott JH, et al. (2006). Neural mechanisms of genetic risk for impulsivity and violence in humans. Proceedings of the National Academy of Sciences USA 103, 6269-6274.
42. Ni X, Sicard T, Bulgin N, Bismil R, Chan K, McMain S, Kennedy JL (2007). Monoamine oxidase a gene is associated with borderline personality disorder. Psychiatri Genetics 17, 153-157.
43. Ochsner KN, Gross JJ (2005). The cognitive control of emotion. Trends in Cognitive Sciences 9, 242-249.
44. Ochsner KN, Ray RD, Cooper JC, Robertson ER, Chopra S Gabrieli JD, Gross JJ (2004). For better or for worse: neura systems supporting the cognitive down- and up-regulation of negative emotion. Neuroimage 23, 483-499.
45. Ohira H, Nomura M, Ichikawa N, Isowa T, Iidaka T, Sato A Fukuyama S, Nakajima T, Yamada J (2006). Association o neural and physiological responses during voluntary emotion suppression. Neuroimage 29, 721-733.
46. Pezawas L, Meyer-Lindenberg A, Drabant EM, Verchinski BA, Munoz KE, Kolachana BS, Egan MF, Mattay VS, Hariri AR, Weinberger DR (2005). 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression. Nature Neuroscience 8, 828-834.
47. Phan KL, Fitzgerald DA, Nathan PJ, Moore GJ, Uhde TW, Tancer ME (2005). Neural substrates for voluntary suppression of negative affect: a functional magnetic resonance imaging study. Biological Psychiatry 57, 210-219
48. Phillips ML, Drevets WC, Rauch SL, Lane R (2003). Neurobiology of emotion perception II: Implications for major psychiatric disorders. Biological Psychiatry 54, 515-528.
49. Ramnani N, Behrens TE, Penny W, Matthews PM (2004). New approaches for exploring anatomical and functional connectivity in the human brain. Biological Psychiatry 56, 613-619.
50. Rauch AV, Ohrmann P, Bauer J, Kugel H, Engelien A, Arolt V, Heindel W, Suslow T (2007). Cognitive coping style modulates neural responses to emotional faces in healthy humans: a 3-T fMRI study. Cerebral Cortex 17, 2526-2535.
51. Robinson S, Windischberger C, Rauscher A, Moser E (2004). Optimized 3 T EPI of the amygdalae. Neuroimage 22, 203-210.
52. Sabol SZ, Hu S, Hamer D (1998). A functional polymorphism in the monoamine oxidase A gene promoter. Human Genetics 103, 273-279.
53. Sackeim HA (2001). The definition and meaning of treatment-resistant depression. Journal of Clinical Psychiatry 62, 1-17.
54. Schulze TG, Müller DJ, Krauss H, Scherk H, Ohlraun S, Syagailo YV, Windemuth C, Neidt H, Grässle M, Papassotiropoulos A, et al. (2000). Association between a functional polymorphism in the monoamine oxidase A gene promoter and major depressive disorder. American Journal of Medical Genetics 96, 801-803.
55. Siegle GJ, Steinhauer SR, Thase ME, Stenger VA, Carter CS (2002). Can't shake that feeling: event-related fMRI assessment of sustained amygdala activity in response to emotional information in depressed individuals. Biological Psychiatry 51, 693-707.
56. Siegle GJ, Thompson W, Carter CS, Steinhauer SR, Thase ME (2007). Increased amygdala and decreased dorsolateral prefrontal BOLD responses in unipolar depression. related and independent features. Biological Psychiatry 61, 198-209.
57. Smolka MN, Bühler M, Schumann G, Klein S, Hu XZ, Moayer M, Zimmer A, Wrase J, Flor H, Mann K, et al. (2007). Gene-gene effects on central processing of aversive stimuli. Molecular Psychiatry 12, 307-317.
58. Surguladze S, Brammer MJ, Keedwell P, Giampietro V, Young AW, Travis MJ, Williams SC, Phillips ML (2005). A differential pattern of neural response toward sad versus happy facial expressions in major depressive disorder. Biological Psychiatry 57, 201-209.
59. Surguladze S, Elkin A, Ecker C, Kalidindi S, Corsico A, Giampietro V, Lawrence N, Deeley Q, Murphy DG, Kucharska-Pietura K, et al. (in press). Genetic variation in the serotonin transporter modulates neural system-wide response to fearful faces. Genes, Brain, and Behavior.
60. Tzourio-Mazoyer N, Landeau B, Papathanassiou D, Crivello F, Etard O, Delcroix N, Mazoyer B, Joliot M (2002). Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. Neuroimage 15, 273-289.
61. WHO (2001). Mental Health: New Understanding, New Hope. Switzerland, World Health Organization: Geneva.
62. Wittchen HU, Wunderlich U, Gruschwitz S, Zaudig M (1997). SKID-I, Strukturiertes Klinisches Interview für DSM-IV [SCID-I, Structured Clinical Interview for DSM-IV]. Hogrefe: Göttingen.
63. Wong ML, Licinio J (2001). Research and treatment approaches to depression. Nature Reviews Neuroscience 2, 343-351.
64. Yu YW, Tsai SJ, Hong CJ, Chen TJ, Chen MC, Yang CW (2005). Association study of a monoamine oxidase a gene promoter polymorphism with major depressive disorder and antidepressant response. Neuropsychopharmacology 30, 1719-1723.