Brain derived neurotrophic factor Val66Met polymorphism, the five factor model of personality and hippocampal volume: Implications for depressive illness

Human Brain Mapping

Volumn 30, Issue 4, 2009, Pages 1246-1256

  Joffe, Russell T ^a   Gatt, Justine M ^b,c   Kemp, Andrew H ^b,c   Grieve, Stuart ^d   Dobson Stone, Carol ^e,f   Kuan, Stacey A ^b,c   Schofield, Peter R ^e,f   Gordon, Evian ^b,c,d   Williams, Leanne M ^b,c  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b WESTMEAD HOSPITAL   (Australia)

^c UNIVERSITY OF SYDNEY   (Australia)

^d Brain Resource Company and the Brain Resource International Database   (Australia)

^e GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

^f UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

BDNF; Brain derived neurotrophic factor Val66Met polymorphism; Depression; Five factor model; Hippocampus; Neuroticism

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; METHIONINE; VALINE;

ADULT; ARTICLE; BRAIN SIZE; DEPRESSION; DISEASE PREDISPOSITION; FEMALE; GENETIC POLYMORPHISM; GENETIC TRAIT; GRAY MATTER; HETEROZYGOTE; HIPPOCAMPUS; HUMAN; HUMAN EXPERIMENT; MALE; NEUROSIS; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PERSONALITY; PRIORITY JOURNAL; TEMPORAL CORTEX;

ADULT; ANALYSIS OF VARIANCE; BRAIN-DERIVED NEUROTROPHIC FACTOR; COHORT STUDIES; CROSS-SECTIONAL STUDIES; DEPRESSIVE DISORDER; FEMALE; HIPPOCAMPUS; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; METHIONINE; MIDDLE AGED; PERSONALITY; PERSONALITY INVENTORY; POLYMORPHISM, GENETIC; QUESTIONNAIRES; STATISTICS AS TOPIC; VALINE; YOUNG ADULT;

EID: 63849327805     PISSN: 10659471     EISSN: None     Source Type: Journal    
DOI: 10.1002/hbm.20592     Document Type: Article

References (63)

1. Antony MM, Bieling PJ, Cox BJ, Enns MW, Swinson RP (1998): Psychometric properties of the 42-item and 21-item versions of the depression anxiety stress scales in clinical groups and a community sample. Psychol Assess 10:176-181.
2. Ashburner J, Friston KJ (2000): Voxel-based morphometry - The methods. Neuroimage 11:805-821.
3. Baquet CC, Gorski JA, Jones KR (2004): Early striatal dendrite deficits followed by neuron loss with advanced age in the absence of anterograde cortical brain derived neurotrophic factor. J Neurosci 24:4250-4258.
4. Beck AT, Ward CH, Mendelsohn M, Mock J, Erbaugh J (1961): An inventory for measuring depression. Arch Gen Psychiatry 4: 561-571.
5. Beck AT, Epstein N, Brown G, Steer RA (1988): An inventory for measuring clinical anxiety: Psychometric properties. J Consult Clin Psychol 56:893-897.
6. Belmaker RH, Agam G (2008): Major depressive disorder. N Engl J Med 358:55-68.
7. Bueller JA, Aftab M, Sen S, Gomez-Hassan D, Burmeister M, Zubieta JK (2006): BDNF val66met allele is associated with reduced hippocampal volume in healthy subjects. Biol Psychiatry 59:812-815.
8. Cardon LR, Palmer LJ (2003): Population stratification and spurious allelic association. Lancet 361:598-604.
9. Costa PT, McCrae RR (1992): Normal personality assessment in clinical practice. The NEO Personality Inventory. Psychol Assess J Consult Clin Psychol 4:5-13.
10. Crawford JR, Henry JD (2003): The Depression Anxiety Stress Scales (DASS): Normative data and latent structure in a large non-clinical sample. Br J Clin Psychol 42:111-131.
11. Duman RS (2004): Depression: A case of neuronal life and death? Biol Psychiatry 56:140-145.
12. Duman R, Malberg J, Nakagawa S, D'sa C (2000): Neuronal plasticity and survival in mood disorders. Biol Psychiatry 48: 732-739.
13. Egan MF, Kajima M, Callicott JH, Goldberg TE, Kolachana BS, Bertolino A, Zaitsev E, Gold B, Goldman D, Dean M, Lu B, Weinberger DR (2003): The BDNF Val66met polymorphism affects activity dependent secretion of BDNF and human memory and hippocampal function. Cell 112:257-269.
14. Gatt JM, Clark CR, Kemp AH, Liddell BJ, Dobson-Stone C, Kuan S, Schofield PR, Williams LM (2007): A genotype-endophenotype-phenotype path model of depressed mood: Integrating cognitive and emotional markers. J Integr Neurosci 6:75-104.
15. Gonul AS, Akdeniz F, Taneli F, Donat O, Eker C, Vahip S (2003): Effect of treatment on serum brain-derived neurotrophic factor levels in depressed patients. Eur Neuropsychopharmacol 13(Suppl 4):S203.
16. Gordon E (2003): Integrative neuroscience in psychiatry: The role of a standardized database. Australas Psychiatry 11:156-163.
17. Gordon E, Cooper N, Rennie C, Hermens D, Williams LM (2005): Integrative neuroscience: The role of a standardised database. Clin EEG Neurosci 36:64-75.
18. Gorski JA, Zeiler SR, Tamowski S, Jones KR (2003): Brain derived neurotrophic factor is required for the maintenance of cortical dendrites. J Neurosci 23:6856-6865.
19. Grieve S, Clark CR, Williams LM, Gordon E (2005): Limbic and paralimbic preservation with aging. Hum Brain Mapp 25:391-401.
20. Hankin BL, Fraley RC, Lahey BB, Waldman ID (2005): Is depression best viewed as a continuum or discrete category? A taxometric analysis of childhood and adolescent depression in a population-based sample. J Abnorm Psychol 114:96-110.
21. Hariri AR, Goldberg TE, Mattay VS, Kolachana BS, Callicott JH, Egan MF, Weinberger DR (2003): Brain derived neurotrophic factor val66met polymorphism affects human memory related hippocampal activity and predicts memory performance. J Neurosci 23:6690-6694.
22. Henry JD, Crawford JR (2005): The short-form version of the Depression Anxiety Stress Scales (DASS-21): Construct validity and normative data in a large non-clinical sample. Br J Clin Psychol 44:227-239.
23. Hickie I, Hadzi-Pavlovic D, Scott E (1998): SPHERE: A National depression Project. Australas Psychiatry 6:248-250.
24. Ho B-C, Milev P, O'Leary DS, Librant A, Andreasen NC, Wassink TH (2006): Cognitive and magnetic resonance imaging brain morphometric correlates of brain-derived neurotrophic factor Val66Met gene polymorphism in patients with schizophrenia and healthy volunteers. Arch Gen Psychiatry 63:731-740.
25. Huang ZJ, Kirkwood A, Pizzorusso T, Porciatti V, Morales B, Bear MF, Maffei L, Tonegawa S (1999): BDNF regulates the maturation of inhibition and the critical period of plasticity in mouse visual cortex. Cell 98:739-755.
26. Hünnerkopf R, Strobel A, Gutknecht L, Brocke B, Lesch KP (2007): Interaction between BDNF Val66Met and dopamine transporter gene variation influences anxiety-related traits. Neuropsychopharmacology 32:2552-2560.
27. Hwang J-P, Tsai S-J, Hong C-J, Yang C-H, Lirng J-F, Yang YM (2006): The Val66Met polymorphism of the brain-derived neurotrophic factor gene is associated with geriatric depression. Neurobiol Aging 27:1834-1837.
28. Jacobson L, Sapolsky R (1991): The role of the hippocampus in feedback regulation of the hypothalamicpituitary-adrenocortical axis. Endocr Rev 12:118-134.
29. Jang K, Livesly WJ, Vernon PA (1996): Heritability of the big five personality dimensions and their facets. J Pers 64:577-591.
30. Jiang X, Xu K, Holberman J, Tian F, Marko AJ, Waheed JF, Harris CR, Marini AM, Enoch MA, Lipsky RH (2005): BDNF variation and mood disorders: A novel functional promoter polymorphism and val66met are associated with anxiety but have opposing effects. Neuropsychopharmacology 30:1353-1361.
31. Karege F, Perret G, Bondoiff G, Schwald M, Bertschy G, Aubry JM (2002): Decreased serum brain-derived neurotrophic factor levels in major depressed patients. Psychiatry Res 109:143-148.
32. Kaufman J, Yang B-Z, Douglas-Palumberi H, Grasso D, Lipschitz D, Houshyar S, Krystal JH, Gelernter J (2006): Brain-derived neurotrophic factor-5-HTTLPR gene interactions and environmental modifiers of depression in children. Biol Psychiatry 59:673-680.
33. Kendler KS, Neale MC, Kessler RC, Heath AC, Eaves LI (1993): A longitudinal twin study of personality and major depression in women. Arch Gen Psychiatry 50:853-862.
34. Kendler KS, Neale MC, Kessler RC, Heath AC, Eaves LI (1994): The clinical characteristics of major depression as indices of the familial risk to illness. Br J Psychiatry 165:66-72.
35. Kendler KS, Gardner CO, Prescott CA (1999): Clinical characteristics of major depression that predict risk of depression in relatives. Arch Gen Psychiatry 56:322-327.
36. Kroenke K, Spitzer RL (2002): The PHQ-9: A new depression and diagnostic severity measure. Psychiatr Ann 32:509-521.
37. Lange C, Irle E (2004): Enlarged amygdala volume and reduced hippocampal volume in young women with major depression. Psychol Med 34:1059-1064.
38. Lang UE, Hellweg R, Kalus P, Bajbouj M, Lenzen KP, Sander T, Kunz D, Gallinat J (2005): Association of a functional BDNF polymorphism and anxiety-related personality traits. Psychopharmacology 180:95-99.
39. Lewin GR, Barde YA (1996): Physiology of the neurotrophins. Annu Rev Neurosci 19:289-317.
40. Lovibond SH, Lovibond PF (1995): Manual for the Depression Anxiety Stress Scales, 2nd ed. Sydney: Psychology Foundation.
41. MacQueen GM, Campbell S, McEwen BS, MacDonald K, Amano S, Joffe RT, Nahmias C, Young LT (2003): Course of illness, hippocampal function and hippocampal volume in major depression. Proc Natl Acad Sci USA 100:1387-1392.
42. Malberg JE, Eisch AJ, Nestler EJ, Duman RS (2000): Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. J Neurosci 20:9104-9110.
43. McEwen BS (2005): Glucocorticoids, depression and mood disorders: Structural remodeling in the brain. Metabolism 54(Suppl 1):20-23.
44. Nakata K, Ujike H, Sakai A, Uchida N, Nomura A, Imamura T (2003): Association study of the brain-derived neurotrophic factor (BDNF) gene in bipolar disorder. Neurosci Lett 337: 17-20.
45. Nemoto K, Ohnishi T, Mori T, Moriguchi Y, Hashimoto R, Asada T, Kunugi H (2006): The val66met polymorphism of the brainderived neurotrophic factor gene affects age-related brain morphology. Neurosci Lett 397:25-29.
46. Neves-Pereira M, Mundo E, Muglia P, King N, Macciardi F, Kennedy JL (2002): The brain-derived neurotrophic factor gene confers susceptibility to bipolar disorder: Evidence from a family-based association study. Am J Hum Genet 71:651-655.
47. Parker G, Roy K, Mitchell P, Wilhelm K, Malhi G, Hadzi-Pavlovic D (2002): Atypical depression: A reappraisal. Am J Psychiatry 159:1470-1479.
48. Pezawas L, Verchinski VA, Mattay VS, Callicott JH, Kolachana BS, Straub RE, Egan MF, Meyer-Lindenberg A, Weinberger DR (2004): The brain-derived neurotrophic factor val66 met polymorphism and variation in human cortical morphology. J Neurosci 24:10099-10102.
49. Sapolsky RM (2000a): Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. Arch Gen Psychiatry 57:925-935.
50. Sapolsky RM (2000b): The possibility of neurotoxicity in the hippocampus in major depression: A primer on neuron death. Biol Psychiatry 48:755-765.
51. Schofield PR, Williams LM, Paul RH, Gatt JM, Brown KJ, Luty A, Cooper N, Grieve SM, Dobsone-Stone C, Kuan SA, Gordon E (2008): Disturbances in selective information processing associated with the BDNF Val66Met polymorphism: Evidence from cognition, the P300 and fronto-hippocampal systems. Biol Psychol (in revision).
52. Sen S, Nesse RM, Stoltenberg SF, Li S, Gleiberman L, Chakravarti A, Weder AB, Burmeister M (2003): A BDNF coding variant is associated with NEO personality inventory domain neuroticism, a risk factor for depression. Neuropsychopharmacology 28:397-401.
53. Sheline YI, Shanghavi M, Mintum MA, Gado MH (1999): Depression duration but not age predicts hippocampal volume loss in medically healthy women with recurrent major depression. J Neurosci 19:5034-5043.
54. Sklar P, Gabriel SB, McInnis MG, Bennett P, Lin YM, Tsan G (2002): Family based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus. Mol Psychiatry 7:579-593.
55. Slade T, Andrews G (2005): Latent structure of depression in a community sample: A taxometric analysis. Psychol Med 35: 489-497.
56. Szeszko PR, Lipsky R, Mentschel C, Robinson D, Gunduz-Bruce H, Sevy S, AShtan M, Napolitano B, Bilder RM, Kane JM, Goldman D, Malhotra AK (2005): Brain-derived neurotrophic factor val66met polymorphism and volume of the hippocampal formation. Mol Psychaitry 10:631-636.
57. Tzourio-Mazoyer M, Landeau B, Papathanassiou D, Crivello F, Etard O, Delcroix N, Mazoyer B, Joliot M (2002): Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single subject brain. Neuroimage 15:273-289.
58. Van Praag H (1987): Monamine precursors in depression: Present state and prospects. In: Zohar J, Belmaker RH, editors. Treating Resistant Depression. New York: PMA Publishing. pp 279-306.
59. Videbech P, Ravnkilde B (2004): Hippocampal volume and depression: A meta-analysis of MRI studies. Am J Psychiatry 161: 1957-1966.
60. Viken RJ, Rose RJ, Kaprio J, Kaskenvuo NA (1994): Developmental genetic analysis of adult personality: Extraversion and neuroticism from 18 to 59 years of age. J Pers Soc Psychol 66: 722-730.
61. Whitford TJ, Farrow TFD, Gomes L, Brennan J, Harris AWF, Williams LM (2005): Grey matter deficits and symptom profile in first episode schizophrenia. Psych Research: Neuroimaging 139:229-238.
62. Williams LM (2006): An integrative neuroscience model of 'significance' processing. J Integr Neurosci 5:1-47.
63. Willis-Owen SA, Fullerton J, Surtees PG, Wainwright NW, Miller S, Flint J (2005): The val66met coding variant of the brainderived neurotrophic factor (BDNF) gene does not contribute toward variation in the personality trait neuroticism. Biol Psychiatry 58:738-742.