Optimization of important early ADME(T) parameters of NADPH oxidase-4 inhibitor molecules

Medicinal Chemistry

Volumn 8, Issue 2, 2012, Pages 174-181

  Borbély, Gábor ^a   Huszár, Mónika ^a   Varga, Attila ^a   Futosi, Krisztina ^a   Mócsai, Attila ^a   Orfi, László ^a,b   Idei, Miklós ^a   Mandl, József ^a   Kéri, György ^a,b   Vántus, Tibor ^a  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b Vichem Chemie Research Ltd   (Hungary)

Author keywords

ADME(T); Characterization; Compounds; Disease; Inhibitor; NADPH oxidase 4; Relationship

Indexed keywords

CHROMAN DERIVATIVE; NADPH OXIDASE INHIBITOR; OXIDOREDUCTASE INHIBITOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; UNCLASSIFIED DRUG;

ADME(T) PARAMETER; ARTICLE; CALCULATION; CHEMICAL STRUCTURE; CONTROLLED STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LIPOPHILICITY; MEMBRANE PERMEABILITY; NEUTROPHIL; PHARMACOLOGICAL PARAMETERS; PHOSPHOLIPOPHILICITY; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROCESS OPTIMIZATION; STRUCTURE ACTIVITY RELATION;

EID: 84861950592     PISSN: 15734064     EISSN: 18756638     Source Type: Journal    
DOI: 10.2174/157340612800493674     Document Type: Article

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