Determination of permeability and lipophilicity of pyrazolo-pyrimidine tyrosine kinase inhibitors and correlation with biological data

European Journal of Medicinal Chemistry

Volumn 44, Issue 9, 2009, Pages 3712-3717

  Dreassi, Elena ^a   Zizzari, Alessandra Tania ^a   Falchi, Federico ^a   Schenone, Silvia ^b   Santucci, Annalisa ^a   Maga, Giovanni ^c   Botta, Maurizio ^a  

^a UNIVERSITY OF SIENA   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

^c CNR   (Italy)

Author keywords

Abl; PAMPA; Physico chemical property; Src; Tyrosine kinase inhibitor

Indexed keywords

ABELSON KINASE; CAFFEINE; CARBAMAZEPINE; CEFALEXIN; CHLORAMPHENICOL; FUROSEMIDE; KETOPROFEN; PARACETAMOL; PROPRANOLOL; PROTEIN TYROSINE KINASE INHIBITOR; PYRAZOLOPYRIMIDINE DERIVATIVE; THEOPHYLLINE; WARFARIN;

ARTICLE; ARTIFICIAL MEMBRANE; COMPUTER ANALYSIS; CORRELATION ANALYSIS; DRUG DESIGN; DRUG PENETRATION; ENZYME INHIBITOR INTERACTION; LIPOPHILICITY; MEMBRANE PERMEABILITY;

HUMANS; LIPIDS; MEMBRANES, ARTIFICIAL; PERMEABILITY; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-ABL; PYRAZOLES; PYRIMIDINES;

EID: 67650427149     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.03.039     Document Type: Article

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