Apoptosis inhibitor of macrophage (AIM) diminishes lipid droplet-coating proteins leading to lipolysis in adipocytes

Biochemical and Biophysical Research Communications

Volumn 422, Issue 3, 2012, Pages 476-481

  Iwamura, Yoshihiro ^a   Mori, Mayumi ^a   Nakashima, Katsuhiko ^a   Mikami, Toshiyuki ^b   Murayama, Katsuhisa ^b   Arai, Satoko ^a   Miyazaki, Toru ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

Author keywords

Apoptosis inhibitor of macrophage (AIM); Fatty acid synthase (FASN); Lipid droplet coating proteins; Lipolysis; PPAR

Indexed keywords

CARRIER PROTEIN; CARRIER PROTEIN AIM; FAT DROPLET; FATTY ACID SYNTHASE; HORMONE SENSITIVE LIPASE; MEMBRANE PROTEIN; MEMBRANE PROTEIN FSP27; PERILIPIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA ANTAGONIST; SATURATED FATTY ACID; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; UNSATURATED FATTY ACID;

ADIPOCYTE; ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENE EXPRESSION; LIPID STORAGE; LIPOLYSIS; NONHUMAN; PRIORITY JOURNAL; RAT;

ADIPOCYTES; ANIMALS; APOPTOSIS REGULATORY PROTEINS; CARRIER PROTEINS; FATTY ACIDS; LIPOLYSIS; MICE; PHOSPHOPROTEINS; PHOSPHORYLATION; PPAR GAMMA; PROTEINS; RECEPTORS, IMMUNOLOGIC; STEROL ESTERASE;

MUS;

EID: 84861943080     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.05.018     Document Type: Article

References (43)

1. Zechner R., Strauss J.G., Haemmerle G., et al. Lipolysis: pathway under construction. Curr. Opin. Lipidol. 2005, 16:333-340.
2. Lafontan M. Advances in adipose tissue metabolism. Int. J. Obes. 2008, 32(Suppl. 7):S39-S51.
3. Lass A., Zimmermann R., Oberer M., et al. Lipolysis - a highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores. Prog. Lipid Res. 2011, 50:14-27.
4. Morris D.L., Singer K., Lumeng C.N. Adipose tissue macrophages: phenotypic plasticity and diversity in lean and obese states. Curr. Opin. Clin. Nutr. Metab. Care 2011, 14:341-346.
5. Duncan R.E., Ahmadian M., Jaworski K., et al. Regulation of lipolysis in adipocytes. Annu. Rev. Nutr. 2007, 27:79-101.
6. Holm C. Molecular mechanisms regulating hormone-sensitive lipase and lipolysis. Biochem. Soc. Trans. 2003, 31:1120-1124.
7. Lass A., Zimmermann R., Haemmerle G., et al. Cell Metab. 2006, 3:309-319.
8. Girousse A., Langin D. Adipocyte lipases and lipid droplet-associated proteins: insight from transgenic mouse models. Curr. Opin. Lipidol. 2011, 16:333-340.
9. Kurokawa J., Arai S., Nakashima K., et al. AIM is endocytosed into adipocytes and decreases lipid droplets via inhibition of fatty acid synthase activity. Cell Metab. 2010, 11:479-492.
10. Miyazaki T., Hirokami Y., Matsuhashi N., et al. Increased susceptibility of thymocytes to apoptosis in mice lacking AIM, a novel murine macrophage-derived soluble factor belonging to the scavenger receptor cysteine-rich domain superfamily. J. Exp. Med. 1999, 189:413-422.
11. Joseph S.B., Bradley M.N., Castrillo A. LXR-dependent gene expression is important for macrophage survival and the innate immune response. Cell 2004, 119:299-309.
12. Valledor A.F., Hsu L.C., Ogawa S., et al. Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosis. Proc. Natl. Acad. Sci. USA 2004, 101:17813-17818.
13. Arai S., Shelton J.M., Chen M., et al. A role of the apoptosis inhibitory factor AIM/Sp/Api6 in atherosclerosis development. Cell Metab. 2005, 1:201-213.
14. Gebe J.A., Kiener P.A., Ring H.Z. Molecular cloning, mapping to human chromosome 1 q21-q23 and cell binding characteristics of Spalpha, a new member of the scavenger receptor cysteine-rich (SRCR) family of proteins. J. Biol. Chem. 2007, 272:6151-6158.
15. Gebe J.A., Llewellyn M., Hoggatt H., et al. Molecular cloning, genomic organization and cell-binding characteristics of mouse Spalpha. Immunology 2000, 99:78-86.
16. Gangadharan B., Antrobus R., Dwek R.A., et al. Novel serum biomarker candidates for liver fibrosis in hepatitis C patients. Clin. Chem. 2007, 53:1792-1799.
17. Kim W.K., Hwang H.R., Kim do H. Glycoproteomic analysis of plasma from patients with atopic dermatitis: CD5L and ApoE as potential biomarkers. Exp. Mol. Med. 2009, 40:677-685.
18. Gray J., Chattopadhyay D., Beale G.S. A proteomic strategy to identify novel serum biomarkers for liver cirrhosis and hepatocellular cancer in individuals with fatty liver disease. BMC Cancer 2009, 9:271.
19. Kurokawa J., Nagano H., Ohara O., et al. AIM is required for obesity-associated recruitment of inflammatory macrophages into adipose tissue. Proc. Natl. Acad. Sci. USA 2011, 108:12072-12077.
20. Miyazaki T., Kurokawa J., Arai S. AIMing at metabolic syndrome - towards the development of novel therapies for metabolic diseases via apoptosis inhibitor of macrophage (AIM)- Circ. J. 2011, 75:2522-2531.
21. Hotamisligil G.S., Shargill N.S., Spiegelman B.M. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 1993, 259:87-91.
22. Wellen K.E., Hotamisligil G.S. Obesity-induced inflammatory changes in adipose tissue. J. Clin. Invest. 2003, 112:1785-1788.
23. Arkan M.C., Hevener A.L., Greten F.R., et al. IKK-beta links inflammation to obesity-induced insulin resistance. Nat. Med. 2005, 11:191-198.
24. Shoelson S.E., Lee J., Goldfine A.B. Inflammation and insulin resistance. J. Clin. Invest. 2006, 116:1793-1801.
25. Neels J.G., Olefsky J.M. Inflamed fat: what starts the fire?. J. Clin. Invest. 2006, 116:33-35.
26. Kuhajda F.P., Pizer E.S., Li J.N., et al. Synthesis and antitumor activity of an inhibitor of fatty acid synthase. Proc. Natl. Acad. Sci. USA 2007, 97:3450-3454.
27. Ducharme N.A., Bickel P.E. Lipid droplets in lipogenesis and lipolysis. Endocrinology 2008, 149:942-949.
28. Puri V., Czech M.P. Lipid droplets: FSP27 knockout enhances their sizzle. J. Clin. Invest. 2008, 118:2693-2696.
29. Brasaemle D.L. Thematic review series: adipocyte biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis. J. Lipid Res. 2007, 48:2547-2559.
30. Nishino N., Tamori Y., Tateya S., et al. FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets. J. Clin. Invest. 2008, 118:2693-2696.
31. Puri V., Ranjit S., Konda S., et al. Cidea is associated with lipid droplets and insulin sensitivity in humans. Proc. Natl. Acad. Sci. USA 2008, 105:7833-7838.
32. Martinez-Bota J., Anderson J.B., Tessier D., et al. Absence of perilipin results in leanness and reverses obesity in Lepr(db/db) mice. Nat. Genet. 2000, 26:474-479.
33. Sztalryd C., Gruia-Gray J., Roush D.L., et al. Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity. Proc. Natl. Acad. Sci. USA 2001, 98:6494-6499.
34. Matsusue K. A physiological role for fat specific protein 27/cell death-inducing DFF45-like effector C in adipose and liver. Biol. Pharm. Bull. 2010, 33:346-350.
35. Matsusue K., Kusakabe T., Noguchi T., et al. Hepatic steatosis in leptin-deficient mice is promoted by the PPARgamma target gene Fsp27. Cell Metab. 2008, 7:302-311.
36. Dalen K.T., Schoonjans K., Ulven S.M., et al. Adipose tissue expression of the lipid droplet-associating proteins S3-12 and perilipin is controlled by peroxisome proliferator-activated receptor-gamma. Diabetes 2007, 53:1243-1252.
37. Tontonoz P., Spiegelman B.M. Fat and beyond: the diverse biology of PPARgamma. Annu. Rev. Biochem. 2008, 77:289-312.
38. Tzameli I., Fang H., Ollero M., et al. Regulated production of a peroxisome proliferator-activated receptor-gamma ligand during an early phase of adipocyte differentiation in 3T3-L1 adipocytes. J. Biol. Chem. 2000, 279:36093-36102.
39. Forman B.M., Chen J., Evans R.M. Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta. Proc. Natl. Acad. Sci. USA 1997, 94:4312-4317.
40. Vance D., Goldberg I., Mitsuhashi O., et al. Inhibition of fatty acid synthetases by the antibiotic cerulenin. Biochem. Biophys. Res. Commun. 1972, 48:649-656.
41. Schmid B., Rippmann J.F., Tadayyon M., et al. Inhibition of fatty acid synthase prevents preadipocyte differentiation. Biochem. Biophys. Res. Commun. 2005, 328:1073-1082.
42. Rosen E.D., Sarraf P., Troy A.E., et al. PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro. Mol. Cell 1999, 4:611-617.
43. Wu Z., Puigserver P., Spiegelman B.M. Transcriptional activation of adipogenesis. Curr. Opin. Cell Biol. 1999, 11:689-694.