-
1
-
-
0027459878
-
Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance
-
Hotamisligil GS, Shargill N-S, Spiegelman B-M (1993) Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance. Science 259:87-91. (Pubitemid 23036092)
-
(1993)
Science
, vol.259
, Issue.5091
, pp. 87-91
-
-
Hotamisligil, G.S.1
Shargill, N.S.2
Spiegelman, B.M.3
-
2
-
-
0347985272
-
Obesity-induced inflammatory changes in adipose tissue
-
DOI 10.1172/JCI200320514
-
Wellen KE, Hotamisligil GS (2003) Obesity-induced inflammatory changes in adipose tissue. J Clin Invest 112:1785-1788. (Pubitemid 38063699)
-
(2003)
Journal of Clinical Investigation
, vol.112
, Issue.12
, pp. 1785-1788
-
-
Wellen, K.E.1
Hotamisligil, G.S.2
-
3
-
-
20044387026
-
IKK-beta links inflammation to obesity-induced insulin resistance
-
DOI 10.1038/nm1185
-
Arkan MC, et al. (2005) IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med 11:191-198. (Pubitemid 40321355)
-
(2005)
Nature Medicine
, vol.11
, Issue.2
, pp. 191-198
-
-
Arkan, M.C.1
Hevener, A.L.2
Greten, F.R.3
Maeda, S.4
Li, Z.-W.5
Long, J.M.6
Wynshaw-Boris, A.7
Poli, G.8
Olefsky, J.9
Karin, M.10
-
5
-
-
0348230958
-
Obesity is associated with macrophage accumulation in adipose tissue
-
DOI 10.1172/JCI200319246
-
Weisberg SP, et al. (2003) Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112:1796-1808. (Pubitemid 38063703)
-
(2003)
Journal of Clinical Investigation
, vol.112
, Issue.12
, pp. 1796-1808
-
-
Weisberg, S.P.1
McCann, D.2
Desai, M.3
Rosenbaum, M.4
Leibel, R.L.5
Ferrante Jr., A.W.6
-
6
-
-
9144223683
-
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
-
DOI 10.1172/JCI200319451
-
Xu H, et al. (2003) Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 112:1821-1830. (Pubitemid 38063705)
-
(2003)
Journal of Clinical Investigation
, vol.112
, Issue.12
, pp. 1821-1830
-
-
Xu, H.1
Barnes, G.T.2
Yang, Q.3
Tan, G.4
Yang, D.5
Chou, C.J.6
Sole, J.7
Nichols, A.8
Ross, J.S.9
Tartaglia, L.A.10
Chen, H.11
-
7
-
-
35548943962
-
JNK1 in Hematopoietically Derived Cells Contributes to Diet-Induced Inflammation and Insulin Resistance without Affecting Obesity
-
DOI 10.1016/j.cmet.2007.09.011, PII S1550413107002926
-
Solinas G, et al. (2007) JNK1 in hematopoietically derived cells contributes to dietinduced inflammation and insulin resistance without affecting obesity. Cell Metab 6:386-397. (Pubitemid 350012000)
-
(2007)
Cell Metabolism
, vol.6
, Issue.5
, pp. 386-397
-
-
Solinas, G.1
Vilcu, C.2
Neels, J.G.3
Bandyopadhyay, G.K.4
Luo, J.-L.5
Naugler, W.6
Grivennikov, S.7
Wynshaw-Boris, A.8
Scadeng, M.9
Olefsky, J.M.10
Karin, M.11
-
8
-
-
28544446111
-
Monocyte and macrophage heterogeneity
-
DOI 10.1038/nri1733
-
Gordon S, Taylor PR (2005) Monocyte and macrophage heterogeneity. Nat Rev Immunol 5:953-964. (Pubitemid 41746764)
-
(2005)
Nature Reviews Immunology
, vol.5
, Issue.12
, pp. 953-964
-
-
Gordon, S.1
Taylor, P.R.2
-
9
-
-
33846026712
-
Obesity induces a phenotypic switch in adipose tissue macrophage polarization
-
DOI 10.1172/JCI29881
-
Lumeng CN, Bodzin JL, Saltiel AR (2007) Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest 117:175-184. (Pubitemid 46048464)
-
(2007)
Journal of Clinical Investigation
, vol.117
, Issue.1
, pp. 175-184
-
-
Lumeng, C.N.1
Bodzin, J.L.2
Saltiel, A.R.3
-
10
-
-
5644231992
-
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
-
DOI 10.1126/science.1103160
-
Ozcan U, et al. (2004) Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 306:457-461. (Pubitemid 39372439)
-
(2004)
Science
, vol.306
, Issue.5695
, pp. 457-461
-
-
Ozcan, U.1
Cao, Q.2
Yilmaz, E.3
Lee, A.-H.4
Iwakoshi, N.N.5
Ozdelen, E.6
Tuncman, G.7
Gorgun, C.8
Glimcher, L.H.9
Hotamisligil, G.S.10
-
11
-
-
33845881411
-
Mechanisms linking obesity to insulin resistance and type 2 diabetes
-
DOI 10.1038/nature05482, PII NATURE05482
-
Kahn SE, Hull RL, Utzschneider KM (2006) Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 444:840-846. (Pubitemid 46024990)
-
(2006)
Nature
, vol.444
, Issue.7121
, pp. 840-846
-
-
Kahn, S.E.1
Hull, R.L.2
Utzschneider, K.M.3
-
12
-
-
77957838795
-
Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue
-
Kosteli A, et al. (2010) Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue. J Clin Invest 120:3466-3479.
-
(2010)
J Clin Invest
, vol.120
, pp. 3466-3479
-
-
Kosteli, A.1
-
13
-
-
0033579824
-
Increased susceptibility of thymocytes to apoptosis in mice lacking AIM, a novel murine macrophage-derived soluble factor belonging to the scavenger receptor cysteine-rich domain superfamily
-
DOI 10.1084/jem.189.2.413
-
Miyazaki T, Hirokami Y, Matsuhashi N, Takatsuka H, Naito M (1999) Increased susceptibility of thymocytes to apoptosis in mice lacking AIM, a novel murine macrophagederived soluble factor belonging to the scavenger receptor cysteine-rich domain superfamily. J Exp Med 189:413-422. (Pubitemid 29063262)
-
(1999)
Journal of Experimental Medicine
, vol.189
, Issue.2
, pp. 413-422
-
-
Miyazaki, T.1
Hirokami, Y.2
Matsuhashi, N.3
Takatsuka, H.4
Naito, M.5
-
14
-
-
77953818554
-
Macrophage-derived AIM is endocytosed into adipocytes and decreases lipid droplets via inhibition of fatty acid synthase activity
-
Kurokawa J, et al. (2010) Macrophage-derived AIM is endocytosed into adipocytes and decreases lipid droplets via inhibition of fatty acid synthase activity. Cell Metab 11:479-492.
-
(2010)
Cell Metab
, vol.11
, pp. 479-492
-
-
Kurokawa, J.1
-
15
-
-
5444235922
-
LXR-dependent gene expression is important for macrophage survival and the innate immune response
-
DOI 10.1016/j.cell.2004.09.032, PII S0092867404009419
-
Joseph SB, et al. (2004) LXR-dependent gene expression is important for macrophage survival and the innate immune response. Cell 119:299-309. (Pubitemid 39360910)
-
(2004)
Cell
, vol.119
, Issue.2
, pp. 299-309
-
-
Joseph, S.B.1
Bradley, M.N.2
Castrillo, A.3
Bruhn, K.W.4
Mak, P.A.5
Pei, L.6
Hogenesch, J.7
O'Connell, R.M.8
Cheng, G.9
Saez, E.10
Miller, J.F.11
Tontonoz, P.12
-
16
-
-
11144221176
-
Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosis
-
DOI 10.1073/pnas.0407749101
-
Valledor AF, et al. (2004) Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosis. Proc Natl Acad Sci USA 101:17813-17818. (Pubitemid 40051969)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.51
, pp. 17813-17818
-
-
Valledor, A.F.1
Hsu, L.-C.2
Ogawa, S.3
Sawka-Verhelle, D.4
Karin, M.5
Glass, C.K.6
-
17
-
-
0030996654
-
Molecular cloning, mapping to human chromosome 1 q21-q23, and cell binding characteristics of Spalpha, a new member of the scavenger receptor cysteine-rich (SRCR) family of proteins
-
DOI 10.1074/jbc.272.10.6151
-
Gebe JA, et al. (1997) Molecular cloning, mapping to human chromosome 1 q21-q23, and cell binding characteristics of Spalpha, a new member of the scavenger receptor cysteine-rich (SRCR) family of proteins. J Biol Chem 272:6151-6158. (Pubitemid 27118082)
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.10
, pp. 6151-6158
-
-
Gebe, J.A.1
Kiener, P.A.2
Ring, H.Z.3
Li, X.4
Francke, U.5
Aruffo, A.6
-
18
-
-
61849102357
-
Glycoproteomic analysis of plasma from patients with atopic dermatitis: CD5L and ApoE as potential biomarkers
-
Kim WK, et al. (2008) Glycoproteomic analysis of plasma from patients with atopic dermatitis: CD5L and ApoE as potential biomarkers. Exp Mol Med 40:677-685.
-
(2008)
Exp Mol Med
, vol.40
, pp. 677-685
-
-
Kim, W.K.1
-
19
-
-
69249148700
-
A proteomic strategy to identify novel serum biomarkers for liver cirrhosis and hepatocellular cancer in individuals with fatty liver disease
-
Gray J, et al. (2009) A proteomic strategy to identify novel serum biomarkers for liver cirrhosis and hepatocellular cancer in individuals with fatty liver disease. BMC Cancer 9:271.
-
(2009)
BMC Cancer
, vol.9
, pp. 271
-
-
Gray, J.1
-
20
-
-
23244462754
-
A role for the apoptosis inhibitory factor AIM/Spalpha/Api6 in atherosclerosis development
-
DOI 10.1016/j.cmet.2005.02.002, PII S1550413105000550
-
Arai S, et al. (2005) A role for the apoptosis inhibitory factor AIM/Spalpha/Api6 in atherosclerosis development. Cell Metab 1:201-213. (Pubitemid 43960602)
-
(2005)
Cell Metabolism
, vol.1
, Issue.3
, pp. 201-213
-
-
Arai, S.1
Shelton, J.M.2
Chen, M.3
Bradley, M.N.4
Castrillo, A.5
Bookout, A.L.6
Mak, P.A.7
Edwards, P.A.8
Mangelsdorf, D.J.9
Tontonoz, P.10
Miyazaki, T.11
-
21
-
-
33750584214
-
TLR4 links innate immunity and fatty acid-induced insulin resistance
-
DOI 10.1172/JCI28898
-
Shi H, et al. (2006) TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest 116:3015-3025. (Pubitemid 44684486)
-
(2006)
Journal of Clinical Investigation
, vol.116
, Issue.11
, pp. 3015-3025
-
-
Shi, H.1
Kokoeva, M.V.2
Inouye, K.3
Tzameli, I.4
Yin, H.5
Flier, J.S.6
-
22
-
-
33846323706
-
Role of the Toll-like receptor 4/NF-kappaB pathway in saturated fatty acid-induced inflammatory changes in the interaction between adipocytes and macrophages
-
DOI 10.1161/01.ATV.0000251608.09329.9a, PII 0004360520070100000014
-
Suganami T, et al. (2007) Role of the Toll-like receptor 4/NF-kappaB pathway in saturated fatty acid-induced inflammatory changes in the interaction between adipocytes and macrophages. Arterioscler Thromb Vasc Biol 27:84-91. (Pubitemid 46370478)
-
(2007)
Arteriosclerosis, Thrombosis, and Vascular Biology
, vol.27
, Issue.1
, pp. 84-91
-
-
Suganami, T.1
Tanimoto-Koyama, K.2
Nishida, J.3
Itoh, M.4
Yuan, X.5
Mizuarai, S.6
Kotani, H.7
Yamaoka, S.8
Miyake, K.9
Aoe, S.10
Kamei, Y.11
Ogawa, Y.12
-
23
-
-
34247884376
-
C3H/HeJ mice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet
-
DOI 10.1007/s00125-007-0654-8
-
Poggi M, et al. (2007) C3H/HeJ mice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet. Diabetologia 50:1267-1276. (Pubitemid 46701560)
-
(2007)
Diabetologia
, vol.50
, Issue.6
, pp. 1267-1276
-
-
Poggi, M.1
Bastelica, D.2
Gual, P.3
Iglesias, M.A.4
Gremeaux, T.5
Knauf, C.6
Peiretti, F.7
Verdier, M.8
Juhan-Vague, I.9
Tanti, J.F.10
Burcelin, R.11
Alessi, M.C.12
-
24
-
-
34547602916
-
Loss-of-function mutation in toll-like receptor 4 prevents diet-induced obesity and insulin resistance
-
DOI 10.2337/db06-1595
-
Tsukumo DM, et al. (2007) Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance. Diabetes 56:1986-1998. (Pubitemid 47195825)
-
(2007)
Diabetes
, vol.56
, Issue.8
, pp. 1986-1998
-
-
Tsukumo, D.M.L.1
Carvalho-Filho, M.A.2
Carvalheira, J.B.C.3
Prada, P.O.4
Hirabara, S.M.5
Schenka, A.A.6
Araujo, E.P.7
Vassallo, J.8
Curi, R.9
Velloso, L.A.10
Saad, M.J.A.11
-
25
-
-
44449110675
-
Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat
-
DOI 10.1038/oby.2008.210, PII OBY2008210
-
Davis JE, Gabler NK, Walker-Daniels J, Spurlock ME (2008) Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat. Obesity (Silver Spring) 16:1248-1255. (Pubitemid 351770507)
-
(2008)
Obesity
, vol.16
, Issue.6
, pp. 1248-1255
-
-
Davis, J.E.1
Gabler, N.K.2
Walker-Daniels, J.3
Spurlock, M.E.4
-
26
-
-
33748750917
-
Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance
-
DOI 10.1074/jbc.M601284200
-
Kamei N, et al. (2006) Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance. J Biol Chem 281:26602-26614. (Pubitemid 44401869)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.36
, pp. 26602-26614
-
-
Kamei, N.1
Tobe, K.2
Suzuki, R.3
Ohsugi, M.4
Watanabe, T.5
Kubota, N.6
Ohtsuka-Kowatari, N.7
Kumagai, K.8
Sakamoto, K.9
Kobayashi, M.10
Yamauchi, T.11
Ueki, K.12
Oishi, Y.13
Nishimura, S.14
Manabe, I.15
Hashimoto, H.16
Ohnishi, Y.17
Ogata, H.18
Tokuyama, K.19
Tsunoda, M.20
Ide, T.21
Murakami, K.22
Nagai, R.23
Kadowaki, T.24
more..
-
27
-
-
33745216724
-
MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity
-
Kanda H, et al. (2006) MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J Clin Invest 116:1494-1505.
-
(2006)
J Clin Invest
, vol.116
, pp. 1494-1505
-
-
Kanda, H.1
-
28
-
-
73849125378
-
CCL5 promotes macrophage recruitment and survival in human adipose tissue
-
Keophiphath M, Rouault C, Divoux A, Clément K, Lacasa D (2010) CCL5 promotes macrophage recruitment and survival in human adipose tissue. Arterioscler Thromb Vasc Biol 30:39-45.
-
(2010)
Arterioscler Thromb Vasc Biol
, vol.30
, pp. 39-45
-
-
Keophiphath, M.1
Rouault, C.2
Divoux, A.3
Clément, K.4
Lacasa, D.5
-
29
-
-
0026736726
-
Triglyceride metabolism in 3T3-L1 cells. An in vivo 13C NMR study
-
Soma MR, Mims MP, Chari MV, Rees D, Morrisett JD (1992) Triglyceride metabolism in 3T3-L1 cells. An in vivo 13C NMR study. J Biol Chem 267:11168-11175.
-
(1992)
J Biol Chem
, vol.267
, pp. 11168-11175
-
-
Soma, M.R.1
Mims, M.P.2
Chari, M.V.3
Rees, D.4
Morrisett, J.D.5
-
30
-
-
70349239156
-
Fatty acids as metabolic mediators in innate immunity
-
Kopp A, et al. (2009) Fatty acids as metabolic mediators in innate immunity. Eur J Clin Invest 39:924-933.
-
(2009)
Eur J Clin Invest
, vol.39
, pp. 924-933
-
-
Kopp, A.1
-
31
-
-
58149310977
-
Fatty acid-induced induction of Toll-like receptor-4/nuclear factor-kappaB pathway in adipocytes links nutritional signalling with innate immunity
-
Schaeffler A, et al. (2009) Fatty acid-induced induction of Toll-like receptor-4/nuclear factor-kappaB pathway in adipocytes links nutritional signalling with innate immunity. Immunology 126:233-245.
-
(2009)
Immunology
, vol.126
, pp. 233-245
-
-
Schaeffler, A.1
-
32
-
-
75449093273
-
TIR-containing adaptors in Toll-like receptor signalling
-
Jenkins KA, Mansell A (2010) TIR-containing adaptors in Toll-like receptor signalling. Cytokine 49:237-244.
-
(2010)
Cytokine
, vol.49
, pp. 237-244
-
-
Jenkins, K.A.1
Mansell, A.2
-
33
-
-
20544452580
-
Lipolysis: Pathway under construction
-
Zechner R, Strauss JG, Haemmerle G, Lass A, Zimmermann R (2005) Lipolysis: Pathway under construction. Curr Opin Lipidol 16:333-340. (Pubitemid 40839763)
-
(2005)
Current Opinion in Lipidology
, vol.16
, Issue.3
, pp. 333-340
-
-
Zechner, R.1
Strauss, J.G.2
Haemmerle, G.3
Lass, A.4
Zimmermann, R.5
-
34
-
-
48749103552
-
FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets
-
Nishino N, et al. (2008) FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets. J Clin Invest 118:2693-2696.
-
(2008)
J Clin Invest
, vol.118
, pp. 2693-2696
-
-
Nishino, N.1
-
35
-
-
34548531751
-
Adipose tissue as an immunological organ: Toll-like receptors, C1q/TNFs and CTRPs
-
DOI 10.1016/j.it.2007.07.003, PII S1471490607001822
-
Schäffler A, Schölmerich J, Salzberger B (2007) Adipose tissue as an immunological organ: Toll-like receptors, C1q/TNFs and CTRPs. Trends Immunol 28:393-399. (Pubitemid 47385374)
-
(2007)
Trends in Immunology
, vol.28
, Issue.9
, pp. 393-399
-
-
Schaffler, A.1
Scholmerich, J.2
Salzberger, B.3
-
36
-
-
0033120081
-
Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide evidence for TLR4 as the Lps gene product
-
Hoshino K, et al. (1999) Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the Lps gene product. J Immunol 162:3749-3752. (Pubitemid 29314747)
-
(1999)
Journal of Immunology
, vol.162
, Issue.7
, pp. 3749-3752
-
-
Hoshino, K.1
Takeuchi, O.2
Kawai, T.3
Sanjo, H.4
Ogawa, T.5
Takeda, Y.6
Takeda, K.7
Akira, S.8
|