TH17 cells are critical for skin-specific pathological injury in acute graft-versus-host disease

Transplantation Proceedings

Volumn 44, Issue 5, 2012, Pages 1412-1418

  Cheng, H ^a   Tian, J ^b   Li, Z ^a   Zeng, L ^a   Pan, B ^a   Song, G ^a   Chen, W ^a   Xu, K ^a  

^a XUZHOU MEDICAL UNIVERSITY   (China)

^b XUZHOU CHILDREN S HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; HALOFUGINONE; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 6; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ACUTE GRAFT VERSUS HOST DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW TRANSPLANTATION; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL EXPANSION; CELL INFILTRATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; FEMALE; FLUORESCENCE ACTIVATED CELL SORTER; HISTOPATHOLOGY; INFLAMMATION; INFLAMMATORY INFILTRATE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN INJURY; TH17 CELL;

ACUTE DISEASE; ANIMALS; BONE MARROW TRANSPLANTATION; CELL DIFFERENTIATION; CELL SEPARATION; CELLS, CULTURED; DISEASE MODELS, ANIMAL; FEMALE; FLOW CYTOMETRY; GRAFT VS HOST DISEASE; INFLAMMATION MEDIATORS; INTERLEUKIN-17; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; PIPERIDINES; QUINAZOLINONES; SKIN; TH1 CELLS; TH17 CELLS; TIME FACTORS;

EID: 84861899216     PISSN: 00411345     EISSN: 18732623     Source Type: Journal    
DOI: 10.1016/j.transproceed.2011.12.078     Document Type: Article

References (49)

1. Martin PJ, Schoch G, Fisher L, et al: A retrospective analysis of therapy for acute graft-versus-host disease: initial treatment. Blood 76:1464, 1990
2. Vogelsang GB, Lee L, Bensen-Kennedy DM: Pathogenesis and treatment of graft-versus-host disease after bone marrow transplant. Annu Rev Med 54:29, 2003
3. Shlomchik WD: Graft-versus-host disease. Nat Rev Immunol 7:340, 2007
4. Teshima T, Ordemann R, Reddy P, et al: Acute graft-versus-host disease does not require alloantigen expression on host epithelium. Nat Med 8:575, 2002
5. Macindoe I, Glockner L, Vukasin P, et al: Conformational stability and DNA binding specificity of the cardiac T-box transcription factor Tbx20. J Mol Biol 389:606, 2009
6. Abbas AK, Murphy KM, Sher A: Functional diversity of helper T lymphocytes. Nature 383:787, 1996
7. Murph KM, Reiner SL: The lineage decisions of helper T cells. Nat Rev Immunol 2:933, 2002
8. Bettelli E, Carrier Y, Gao W, et al: Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441:235, 2006
9. Miossec P, Korn T, Kuchroo VK: Interleukin-17 and type 17 helper T cells. N Engl J Med 361:888, 2009
10. Loong CC, Hsieh HG, Lui WY, et al: Evidence for the early involvement of interleukin 17 in human and experimental renal allograft rejection. J Pathol 197:322, 2002
11. Vanaudenaerde BM, DuPont LJ, Wuyts WA, et al: The role of interleukin-17 during acute rejection after lung transplantation. Eur Respir J 27:779, 2006
12. Yuan X, Paez-Cortez J, Schmitt-Knosalla I, et al: A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathy. J Exp Med 205:3133, 2008
13. Nikolic B, Lee S, Bronson RT, et al: Th1 and Th2 mediate acute graft-versus-host disease, each with distinct end-organ targets. J Clin Invest 105:1289, 2000
14. Hill GR, Olver SD, Kuns RD, et al: Stem cell mobilization with G-CSF induces type 17 differentiation and promotes scleroderma. Blood 116:819, 2010
15. Yi T, Zhao D, Lin C, et al: Absence of donor Th17 leads to augmented Th1 differentiation and exacerbated acute graft-versushost disease. Blood 112:2101, 2008
16. Carlson MJ, West ML, Coghill JM, et al: In vitro differentiated TH17 cells mediate lethal acute graft-versus-host disease with severe cutaneous and pulmonary pathologic manifestations. Blood 113:1365, 2009
17. Lexberg MH, Taubner A, Förster A, et al: Th memory for interleukin-17 expression is stable in vivo. Eur J Immunol 38:2654, 2008
18. Stark MA, Huo Y, Burcin TL, et al: Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17. Immunity 22:285, 2005
19. He D, Wu L, Kim HK, et al: CD8+ IL-17-producing T cells are important in effector functions for the elicitation of contact hypersensitivity responses. J Immunol 177:6852, 2006
20. Cupedo T, Crellin NK, Papazian N, et al: Human fetal lymphoid tissue-inducer cells are interleukin 17-producing precursors to RORC+ CD127+ natural killer-like cells. Nat Immunol 10:66, 2009
21. Michel ML, Keller AC, Paget C, et al: Identification of an IL-17-producing NK1.1neg iNKT cell population involved in airway neutrophilia. J Exp Med 204:995, 2007
22. Lee KA, Kang MH, Lee YS, et al: A distinct subset of natural killer T cells produces IL-17, contributing to airway infiltration of neutrophils but not to airway hyperreactivity. Cell Immunol 251:50, 2008
23. Mrabet-Dahbi S, Metz M, Dudeck A, et al: Murine mast cells secrete a unique profile of cytokines and prostaglandins in response to distinct TLR2 ligands. Exp Dermatol 18:437, 2009
24. Song C, Luo L, Lei Z, et al: IL-17-producing alveolar macrophages mediate allergic lung inflammation related to asthma. J Immunol 181:6117, 2008
25. Song C, Luo L, Lei Z, et al: IL-17 produced by neutrophils regulates IFN-γ-mediated neutrophil migration in mouse kidney ischemia-reperfusion injury. J Clin Invest 120:331, 2010
26. Pines M, Nagler A: Halofuginone: a novel antifibrotic therapy. Gen Pharmacol 30:445, 1998
27. Sundrud MS, Koralov SB, Feuerer M, et al: Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response. Science 324:1334, 2009
28. Spiegel A, Zcharia E, Vagima Y, et al: Heparanase regulates retention and proliferation of primitive Sca-1+/c-Kit+/Lin- cells via modulation of the bone marrow microenvironment. Blood 111:4934, 2008
29. Cooke KR, Kobzik L, Martin TR, et al: An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation: I. The roles of minor H antigens and endotoxin. Blood 88:3230, 1996
30. Lohr J, Knoechel B, Wang JJ, et al: Role of IL-17 and regulatory T lymphocytes in a systemic autoimmune disease. J Exp Med 13:2785, 2006
31. Anderson BE, McNiff JM, Jain D, et al: Distinct roles for donor- and host-derived antigen-presenting cells and costimulatory molecules in murine chronic graft-versus-host disease: requirements depend on target organ. Blood 105:2227, 2005
32. Borsotti C, Franklin AR, Lu SX, et al: Absence of donor T-cell-derived soluble TNF decreases graft-versus-host disease without impairing graft-versus-tumor activity. Blood 110:783, 2007
33. Harrington LE, Hatton RD, Mangan PR, et al: Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 6:1123, 2005
34. Schnyder-Candrian S, Togbe D, Couillin I, et al: Interleukin- 17 is a negative regulator of established allergic asthma. J Exp Med 203:2715, 2006
35. Nakae S, Iwakura Y, Suto H, et al: Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17. J Leukoc Biol 81:1258, 2007
36. Nair RP, Ruether A, Stuart PE, et al: Polymorphisms of the IL12B and IL23R genes are associated with psoriasis. J Invest Dermatol 7:1653, 2008
37. Lowes MA, Kikuchi T, Fuentes-Duculan J, et al: Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells. J Invest Dermatol 5:1207, 2008
38. Nishimori H, Sugiyama H, Kobayashi K, et al: Donor Th17 and Th1 contribute to chronic graft-versus-host disease. Biol Blood Marrow Transplant 17:S166, 2011
39. Yi T, Chen Y, Wang L, et al: Reciprocal differentiation and tissue-specific pathogenesis of Th1, Th2, and Th17 cells in graft versus host disease. Blood 114:3101, 2009
40. Iclozan C, Yu Y, Liu C, et al: T helper 17 cells are sufficient but not necessary to induce acute graft-versus-host disease. Biol Blood Marrow Transplant 16:170, 2010
41. Piguet PF, Grau GE, Allet B, et al: Tumor necrosis factor/ cachectin is an effector of skin and gut lesions of the acute phase of graft-versus-host disease. J Exp Med 166:1280, 1987
42. Wall DA, Sheehan KC: The role of tumor necrosis factor alpha and interferon gamma in graft-versus-host disease and related immunodeficiency. Transplantation 57:273, 1994
43. Gaffen SL: Structure and signaling in the IL-17 receptor family. Nat Rev Immunol 9:556, 2009
44. Fowler DH, Kurasawa K, Smith R, et al: Donor CD4- enriched cells of Th2 cytokine phenotype regulate graft-versus-host disease without impairing allogeneic engraftment in sublethally irradiated mice. Blood 84:3540, 1994
45. Rus V, Svetic A, Nguyen P, et al: Kinetics of Th1 and Th2 cytokine production during the early course of acute and chronic murine graft-versus-host disease. Regulatory role of donor CD8+T cells. J Immunol 155:2396, 1995
46. O'Connor W Jr, Kamanaka M, Booth CJ, et al: A protective function for interleukin 17A in T cell-mediated intestinal inflammation. Nat Immunol 10:603, 2009
47. Hirota K, Duarte JH, Veldhoen M, et al: Fate mapping of IL-17-producing T cells in inflammatory responses. Nat Immunol 12:255, 2011
48. Palmer MT, Weaver CT: Autoimmunity: Increasing suspects in the CD4+ T cell lineup. Nat Immunol 11:36, 2010
49. Kryczek I, Bruce AT, Gudjonsson JE, et al: Induction of IL-17+ T cell trafficking and development by IFNgamma: mechanism and pathological relevance in psoriasis. J Immunol 181:4733, 2008