Identification of berberine as a novel agonist of fatty acid receptor GPR40

Phytotherapy Research

Volumn 24, Issue 8, 2010, Pages 1260-1263

  Rayasam, Geetha Vani ^a   Tulasi, Vamshi Krishna ^a   Sundaram, Sindhuja ^a   Singh, Winny ^a   Kant, Rajiv ^a   Davis, Joseph Alex ^a   Saini, Kulvinder Singh ^a   Ray, Abhijit ^a  

^a Department of Pharmacology   (India)

Author keywords

Calcium mobilization; Diabetes; Insulin secretion

Indexed keywords

BERBERINE; CALCIUM; G PROTEIN COUPLED RECEPTOR 40; G PROTEIN COUPLED RECEPTOR 40 AGONIST; GLUCOSE; INSULIN; UNCLASSIFIED DRUG; ANTIDIABETIC AGENT; G PROTEIN COUPLED RECEPTOR; G-PROTEIN-COUPLED RECEPTOR 40, RAT;

AGONIST; ANIMAL CELL; ARTICLE; CALCIUM MOBILIZATION; CHO CELL; CONCENTRATION RESPONSE; DRUG EFFECT; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG RECEPTOR BINDING; INSULIN RELEASE; MAMMAL CELL; NONHUMAN; PANCREAS ISLET BETA CELL; PROTEIN EXPRESSION; RAT; AGONISTS; ANIMAL; CELL LINE; DRUG EFFECTS; METABOLISM; SECRETION (PROCESS);

MAMMALIA; RATTUS;

ANIMALS; BERBERINE; CALCIUM; CELL LINE; GLUCOSE; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN-SECRETING CELLS; RATS; RECEPTORS, G-PROTEIN-COUPLED;

EID: 77955614371     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.3165     Document Type: Article

References (16)

1. Gulfraz M, Mehmood S, Ahmad A, Fatima N, Praveen Z, Williamson EM. 2008. Comparison of the antidiabetic activity of Berberis lyceum root extract and berberine in alloxan-induced diabetic rats. Phytother Res 22: 1208-1212.
2. Itoh Y, Kawamata Y, Harada M et al. 2004. Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40. Nature 422(6928): 173-176. (Pubitemid 36362750)
3. Jhou JY, Zhou SW, Zhang KB et al. 2008. Chronic effects of berberine on blood, liver glucolipid metabolism and liver PPARs expression in diabetic hyperlipidemic rats. Biol Pharm Bull 31: 1169-1176.
4. Ko BS, Choi SB, Park SK, Jang JS, Kim YE, Park S. 2005. Insulin sensitizing and insulinotropic action of berberine from Cortidis rhizome. Biol Pharm Bull 28: 1431-1437. (Pubitemid 41379694)
5. Lee YS, Kim WS, Kim KH et al. 2006. Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states. Diabetes 55: 2256-2264.
6. Leng SH, Lu FE, Xu LJ. 2004. Therapeutic effects of berberine in impaired glucose tolerance rats and its influence on insulin secretion. Acta Pharmacol Sin 25: 496-502. (Pubitemid 38470422)
7. Poitout V. 2003. The ins and outs of fatty acids on the pancreatic beta cell. Trends Endocrinol Metab 14: 201-203.
8. Rayasam GV, Tulasi VK, Davis JA, Bansal VS. 2007. Fatty acid receptors as new therapeutic targets for diabetes. Expert Opin Ther Targets 11: 661-671. (Pubitemid 46758791)
9. Tang LQ, Wei W, Chen LM, Liu S. 2006. Effects of berberine on diabetes induced by alloxan and a high-fat/high-cholesterol diet in rats. J Ethnopharmacol 1: 109-115. (Pubitemid 44498992)
10. Wang ZS, Lu FE, Chen G, Xu LJ, Wang KF, Zou X. 2007. Effect of berberine on insulin secretion and glucokinase activity of NIT-1 cells. Yao Xue Xue Bao 42: 1045-1049.
11. Wang ZQ, Lu FE, Leng SH et al. 2008. Facilitating effects of berberine on rat pancreatic islets through modulating hepatic nuclear factor 4 alpha expression and glucokinase activity. World J Gastroenterol 14: 6004-6011.
12. Yin J, Hu R, Chen M et al. 2002. Effects of berberine on glucose metabolism in vitro. Metabolism 51: 1439-1443.
13. Yin J, Zhang H, Ye J. 2008a. Traditional Chinese medicine in treatment of metabolic syndrome. Endocr Metab Immune Disord Drug Targets 8: 99-111.
14. Yin J, Xing H, Ye J. 2008b. Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism 57: 712.
15. Zhou L, Wang X, Shao L et al. 2008. Berberine acutely inhibits insulin secretion from beta-cells through 3′,5′-cyclic adenosine 5′-monophosphate signaling pathway. Endocrinology 149: 4510-4518.
16. Zhou J, Zhou S, Tang J et al. 2009. Protective effect of berberine on beta cells in streptozotocin- and high carbohydrate/ high-fat diet-induced diabetic rats. Eur J Pharmacol 606: 262-268.