A small molecule modulator of prion protein increases human mesenchymal stem cell lifespan, exvivo expansion, and engraftment to bone marrow in NOD/SCID mice

Stem Cells

Volumn 30, Issue 6, 2012, Pages 1134-1143

  Mohanty, Sindhu T ^a   Cairney, Claire J ^b   Chantry, Andrew D ^a   Madan, Sanjeev ^c   Fernandes, James A ^c   Howe, Steven J ^d   Moore, Harry D ^e   Thompson, Mark J ^e   Chen, Beining ^e   Thrasher, Adrian ^d   Keith, W Nicol ^b   Bellantuono, Ilaria ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c SHEFFIELD CHILDREN S HOSPITAL   (United Kingdom)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

Adult stem cells; Aging; Marrow stromal cells; Mesenchymal stem cell; Osteoblast; Stem cell transplantation

Indexed keywords

MANGANESE SUPEROXIDE DISMUTASE; PRION PROTEIN; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MARROW; CELL COUNT; CELL CULTURE; CELL CYCLE PROGRESSION; CELL DIFFERENTIATION; CELL EXPANSION; CELL POPULATION; CELL PROLIFERATION; CELL REGENERATION; CELL SURVIVAL; CONTROLLED STUDY; DNA DAMAGE; ENZYME INDUCTION; EX VIVO STUDY; EXPERIMENTAL MODEL; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; HUMAN TISSUE; MESENCHYMAL STEM CELL; MESENCHYMAL STEM CELL TRANSPLANTATION; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; PROTEIN DEPLETION; PROTEIN EXPRESSION; SCAVENGING SYSTEM; SCID MOUSE;

ANIMALS; BONE MARROW CELLS; CELL DIFFERENTIATION; CELL GROWTH PROCESSES; CELLS, CULTURED; GENE KNOCKDOWN TECHNIQUES; HEK293 CELLS; HUMANS; LENTIVIRUS; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; MICE; MICE, INBRED NOD; MICE, SCID; PHOSPHORYLATION; PRIONS; TRANSFECTION;

MUS;

EID: 84861878496     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.1065     Document Type: Article

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