Discovery of novel disaccharide antibacterial agents using a combinatorial library approach

Journal of Medicinal Chemistry

Volumn 42, Issue 17, 1999, Pages 3193-3198

  Sofia, Michael J ^a,b   Allanson, Nigel ^a   Hatzenbuhler, Nicole T ^a   Jain, Rakesh ^a   Kakarla, Ramesh ^a   Kogan, Natan ^a   Liang, Rui ^a   Liu, Dashan ^a   Silva, Domingos J ^a   Wang, Huiming ^a   Gange, David ^a   Anderson, Jan ^a   Chen, Anna ^a   Chi, Feng ^a   Dulina, Richard ^a   Huang, Buwen ^a   Kamau, Muthoni ^a   Wang, Chunguang ^a   Baizman, Eugene ^a   Branstrom, Arthur ^a   Bristol, Neil ^a   Goldman, Robert ^a   Han, Kiho ^a   Longley, Clifford ^a   Midha, Sunita ^a   Axelrod, Helena R ^a   more..

^a Intercardia Inc   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; DISACCHARIDE;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; BACTERIAL CELL WALL; CHEMICAL BOND; DRUG CONFORMATION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; LETTER; REACTION ANALYSIS; STEREOCHEMISTRY;

ANTI-BACTERIAL AGENTS; BACTERIA; CELL WALL; DISACCHARIDES; DRUG RESISTANCE, MICROBIAL; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 13044269653     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990212a     Document Type: Letter

References (32)

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27. Based on the analysis of 10% of the library products, the average yield of the desired products was determined to be 22% and the average product purity was determined to be 78%. Product yield was calculated from standard curves developed with several HPLC-purified disaccharide products. The product purity was determined based on the relative HPLC peak areas using evaporative light scattering detection.
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31. 50 determination.
32. 600 media] x 100 > 90%.