Heat shock factor-1 knockout induces multidrug resistance gene, MDR1b, and enhances P-glycoprotein (ABCB1)-based drug extrusion in the heart

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 23, 2012, Pages 9023-9028

  Krishnamurthy, Karthikeyan ^a   Vedam, Kaushik ^a   Kanagasabai, Ragu ^a   Druhan, Lawrence J ^a   Ilangovan, Govindasamy ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

Chemotherapeutics; Dilated cardiomyopathy; Mouse model of cardioprotection; Oxidative stress

Indexed keywords

DOXORUBICIN; GLYCOPROTEIN P; HEAT SHOCK TRANSCRIPTION FACTOR 1; I KAPPA B; I KAPPA B KINASE ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 1B; UNCLASSIFIED DRUG; VERAPAMIL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING SITE; CARDIOTOXICITY; CONTROLLED STUDY; ENZYME ACTIVITY; GENE DELETION; GENE EXPRESSION; GENE INACTIVATION; GENE INDUCTION; HEART FAILURE; HEART FUNCTION; HEART LEFT VENTRICLE FAILURE; HEART MUSCLE CELL; KNOCKOUT MOUSE; LUMINESCENCE; MORTALITY; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN DNA BINDING; SURVIVAL;

ANALYSIS OF VARIANCE; ANIMALS; DOXORUBICIN; FLUORESCENCE; GENE EXPRESSION REGULATION; HEART FAILURE; HEAT-SHOCK PROTEINS; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; MYOCYTES, CARDIAC; NEOPLASM PROTEINS; P-GLYCOPROTEINS; VENTRICULAR FUNCTION, LEFT; VERAPAMIL;

MUS;

EID: 84861875551     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1200731109     Document Type: Article

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