Airway hyperresponsiveness and airway obstruction in transgenic mice: Morphologic correlates in mice overexpressing interleukin (IL)-11 and IL-6 in the lung

American Journal of Respiratory Cell and Molecular Biology

Volumn 22, Issue 3, 2000, Pages 289-295

  Kuhn III, Charles ^a,b,c   Homer, Robert J ^a,b,c   Zhu, Zhou ^a,b,c   Ward, Nicholas ^a,b,c   Flavell, Richard A ^a,b,c   Geba, Gregory P ^a,b,c   Elias, Jack A ^a,b,c,d  

^a BROWN UNIVERSITY   (United States)

^b Section of Immunobiology   (United States)

^c VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AIRWAY HYPERRESPONSIVENESS; AIRWAY OBSTRUCTION; ASTHMA; BRONCHIOLE; INTERLEUKIN 11; INTERLEUKIN 6; LUNG; METHACHOLINE; MONONUCLEAR CELL; MORPHOLOGY; PARENCHYMA; PROTEIN EXPRESSION; REACTION MECHANISM; TRANSGENIC MOUSE;

ANIMALIA; MUS MUSCULUS;

EID: 0034038544     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/ajrcmb.22.3.3690     Document Type: Article

References (32)

1. 1. Boushey, H. A., M. J. Holzman, J. R. Sheller, and J. A. Nadel. 1980. Bronchial hyperreactivity. Am. Rev. Respir. Dis. 121:389-413.
2. 2. Sterk, P. J. 1993. Bronchial hyperresponsiveness today. Respir. Med. 87(Suppl. B):27-29.
3. 3. International Symposium of Airway Hyperreactivity. 1991. Airway hyperreactivity. Am. Rev. Respir. Dis. 143(Suppl.):S1-S82.
4. 4. DiCosmo, B. F., G. P. Geba, D. Picarella, J. A. Elias, J. A. Rankin, B. R. Stripp, J. A. Whitsett, and R. A. Flavell. 1994. Airway epithelial cell expression or interleukin-6 in transgenic mice: uncoupling of airway inflammation and bronchial hyperreactivity. J. Clin. Invest. 94:2028-2035.
5. 5. Tang, W., G. P. Geba, T. Zheng, P. Ray, R. J. Homer, C. Kuhn, R. A. Flavell, and J. A. Elias. 1996. Targeted expression of IL-11 in the murine airway causes lymphocytic inflammation, bronchial remodeling and airways obstruction. J. Clin. Invest. 98:2845-2853.
6. 6. Czupryn, M. S., J. M. McCoy, and H. A. Scoble. 1995. Structure-function relationships in human interleukin-11.J. Biol. Chem. 170:978-985.
7. 7. Akira, S., T. Taga, and T. Kishimoto. 1993. Interleukin-6 in biology and medicine. Adv. Immunol. 54:1-78.
8. 8. Du, X., and D. A. Williams. 1997. Interleukin-11: review of molecular cell biology and clinical use. Blood 89:3897-3908.
9. 9. Ray, P., W. Tang, P. Wang, R. Homer, C. Kuhn, R. A. Flavell, and J. A. Elias. 1997. Regulated overexpression of interleukin-11 in the lung: use to dissociate development and independent phenotypes. J. Clin. Invest. 100:2501-2511.
10. 10. James, A. L., J. C. Hogg, L. A. Dunn, and P. D. Pare. 1988. The use of the internal perimeter to compare airway size and to calculate smooth muscle shortening. Am. Rev. Respir. Dis. 138:136-139.
11. 11. Moreno, R. H., J. C. Hogg, and P. D. Pare. 1986. Mechanics of airway narrowing. Am. Rev. Respir. Dis. 133:1171-1180.
12. 12. James, A. L., P. D. Pare, and J. C. Hogg. 1989. The mechanics of airway narrowing in asthma. Am. Rev. Respir. Dis. 139:242-246.
13. 13. Wiggs, B. R., R. Moreno, J. C. Hogg, C. William, and P. D. Pare. 1990. A model of the mechanics of airway narrowing. J. Appl. Physiol. 69:849-860.
14. 14. Wiggs, B. R., C. Bosken, P. D. Pare, A. James, and J. C. Hogg. 1992. A model of airway narrowing in asthma and in chronic obstructive pulmonary disease. Am. Rev. Respir. Dis. 145:1251-1258.
15. 15. Lambert, R. K., B. R. Wiggs, K. Kuwano, J. C. Hogg, and P. D. Pare. 1993. Functional significance of increased airway smooth muscle in asthma and COPD. J. Appl. Physiol. 74:2771-2781.
16. 16. Okazawa, M., S. Vedal, L. Verburgt, R. K. Lambert, and P. D. Pare. 1995. Determinants of airway smooth muscle shortening in excised canine lobes. J. Appl. Physiol. 78:608-614.
17. 17. Pare, P. D., and T. R. Bai. 1996. Airway wall remodelling in chronic obstructive pulmonary disease. Eur. Respir. Rev. 6:259-263.
18. 18. Riess, A., B. Wiggs, L. Verburgt, J. L. Wright, J. C. Hogg, and P. D. Pare. 1996. Morphologic determinants of airway responsiveness in chronic smokers. Am. J. Respir. Crit. Care Med. 154:1444-1449.
19. 19. Pare, P. D., C. R. Roberts, T. R. Bai, and B. J. Wiggs. 1997. The functional consequences of airway remodeling in asthma. Monaldi Arch. Chest Dis. 52:589-596.
20. 20. Macklem, P. T. 1996. A theoretical analysis of the effect of airway smooth muscle load on airway narrowing. Am. J. Respir. Crit. Care Med. 153:83-89.
21. 21. Bellofiore, S., D. H. Eidelman, P. T. Maclem, and J. G. Martin. 1989. Effects of elastase-induced emphysema on airway responsiveness to methacholine in rats. J. Appl. Physiol. 66:606-612.
22. 22. Mullen, J. D. M., B. R. Wiggs, J. L. Wright, J. C. Hogg, and P. D. Pare. 1986. Nonspecific airway reactivity in cigarette smokers: relationship to airway pathology and baseline lung function. Am. Rev. Respir. Dis. 133:120-125.
23. 23. Koyama, H., N. Nishimura, A. Ikeda, N. Sakai, M. Mishima, and T. Izumi. 1996. Influence of baseline airway caliber and pulmonary emphysema on bronchial responsiveness in patients with chronic obstructive pulmonary disease. Respir. Med. 90:323-328.
24. 24. Kanner, R. E., J. E. Connett, M. D. Altrose, A. S. Buist, W. W. Lee, D. P. Tashkin, and R. A. Wise. 1994. Gender differences in airway hyperresponsiveness in smokers with mild COPD. Am. J. Respir. Crit. Care Med. 150: 956-961.
25. 25. Castleman, W. L., R. L. Sorkness, R. F. Lemanske, G. Grasee, and M. M. Suyemoto. 1988. Neonatal pneumonia induces bronchiolar hypoplasia and alveolar dysplasia in rats. Lab. Invest. 59:387-396.
26. 26. Busse, W., S. P. Banks-Schlegel, and G. L. Larsen. 1995. NHLBI Workshop Summary: childhood-versus adult-onset asthma. Am. J. Respir. Crit. Care Med. 151:1294-1295.
27. 27. Ohkawa, F., U. Ikeda, T. Kanabe, K. Kawasaki, and K. Shimada. 1995. Effects of inflammatory cytokines on vascular tone. Cardiovasc. Res. 30:711-715.
28. 28. Paul, S., F. Bennett, J. Calvetti, K. Kelleher, C. Wood, R. O'Hara, A. Leary, B. Sibley, S. Clark, D. Williams, and Y.-C. Yang. 1990. Molecular cloning of a cDNA encoding interleukin-11, a stromal cell-derived lymphopoietic and hematopoietic cytokine. Proc. Natl. Acad. Sci. USA 87:7512-7516.
29. 29. Hirano, T., T. Taga, N. Nakano, K. Yosukawa, S. Kashiwamura, K. Shimizu, K. Nakajima, K. H. Pyun, and T. Kishimoto. 1985. Purification to homogeneity and characterization of human B cell differentiation factor (BCDF or BSFp2). Proc. Natl. Acad. Sci. USA 92:5490-5494.
30. 30. Coyle, A. J., S. J. Ackerman, and C. G. Irvin. 1993. Cationic proteins induce airway hyperresponsiveness dependent on charge interactions. Am. Rev. Respir. Dis. 147:896-900.
31. 31. Uchida, D. A., S. J. Ackerman, A. J. Coyle, G. L. Larsen, P. F. Weller, J. Freed, and C. G. Irvin. 1993. The effect of human eosinophil granule major basic protein on airway responsiveness in the rat in vivo: a comparison with polycations. Am. Rev. Respir. Dis. 147:982-988.
32. 32. Fann, M., and P. H. Patterson. 1994. Neuropoietic cytokines and activin A differentially regulate the phenotype of cultured sympathetic neurons. Proc. Natl. Acad. Sci. USA 91:43-47.