Exploring key parameters to detect subtle ligand-induced protein conformational changes using traveling wave ion mobility mass spectrometry

Analytical Chemistry

Volumn 84, Issue 11, 2012, Pages 4703-4710

  Atmanene, Cédric ^a   Petiot Bécard, Stéphanie ^b,c   Zeyer, Denis ^a   Van Dorsselaer, Alain ^b,c   Vivat Hannah, Valérie ^a   Sanglier Cianférani, Sarah ^b,c  

^a NovAliX Structural Biology   (France)

^b UNIVERSITÉ DE STRASBOURG   (France)

^c CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ATOMIC RESOLUTION; BIO-MOLECULAR; CALIBRATION METHOD; COLLISION CROSS SECTIONS; CONFORMATIONAL CHANGE; CONFORMATIONAL TRANSITIONS; DATA INTERPRETATION; FLOWRATE RATIO; ION MOBILITY; ION MOBILITY-MASS SPECTROMETRY; KEY PARAMETERS; MODULATOR BINDING; NITROGEN FLOW RATES; PROTEIN MODELS; STRUCTURAL CHARACTERIZATION; TRAVELING WAVE; WAVE HEIGHTS;

DATA PROCESSING; FLOW RATE; HELIUM; LIGANDS; MASS SPECTROMETRY; PROTEINS; X RAY CRYSTALLOGRAPHY;

THREE DIMENSIONAL;

4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 NITROBENZENESULFONYL]BENZAMIDE; ABT-737; BCL2L1 PROTEIN, HUMAN; BIPHENYL DERIVATIVE; HELIUM; HYBRID PROTEIN; ION; LIGAND; NITROGEN; NITROPHENOL; PIPERAZINE DERIVATIVE; PROTEIN BCL X; SULFONAMIDE;

AMINO ACID SEQUENCE; ARTICLE; CHEMISTRY; HUMAN; INSTRUMENTATION; MASS SPECTROMETRY; METHODOLOGY; MOLECULAR GENETICS; PROTEIN CONFORMATION; SENSITIVITY AND SPECIFICITY; SEQUENCE ALIGNMENT; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; BCL-X PROTEIN; BIPHENYL COMPOUNDS; CRYSTALLOGRAPHY, X-RAY; HELIUM; HUMANS; IONS; LIGANDS; MASS SPECTROMETRY; MOLECULAR SEQUENCE DATA; NITROGEN; NITROPHENOLS; PIPERAZINES; PROTEIN CONFORMATION; RECOMBINANT FUSION PROTEINS; SENSITIVITY AND SPECIFICITY; SEQUENCE ALIGNMENT; SULFONAMIDES;

EID: 84861861298     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac203223h     Document Type: Article

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