A High-resolution ion mobility : Mass spectrometry platform for breakthrough discoveries in life science research and the pharmaceutical industry

American Laboratory

Volumn 42, Issue 6, 2010, Pages 13-17

  Wallace, Alistair ^a  

^a WATERS CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANALYTICAL TECHNOLOGY; ATMOSPHERIC PRESSURE CHEMICAL IONIZATION; BIO-MARKER DISCOVERY; DIVERSE RANGE; DYNAMIC RANGE; HIGH RESOLUTION; ION MOBILITY; LIFE SCIENCE RESEARCH; LIFE-SCIENCES; MASS ACCURACY; MATRIX-ASSISTED LASER DESORPTION IONIZATION; PERFORMANCE CHARACTERISTICS; PHARMACEUTICAL INDUSTRY; SOLIDS ANALYSIS;

ATMOSPHERIC CHEMISTRY; ATMOSPHERIC IONIZATION; ATMOSPHERIC PRESSURE; DESORPTION; DRUG PRODUCTS PLANTS; GAS CHROMATOGRAPHY; MASS SPECTROMETRY; PARTICLE DETECTORS;

IONIZATION OF SOLIDS;

EID: 77955298383     PISSN: 00447749     EISSN: None     Source Type: Trade Journal    
DOI: None     Document Type: Article

References (10)

1. Makarov, A.; Denisov, E.; Kholomeev, A.; Balschun, W.; Lange, O.; Stupat, K.; Horning, S. Performance evaluation of a hybrid linear ion trap/orbitrap mass spectrometer. Anal. Chem. 2006, 78(7), 2113-20.
2. Bateman, R.H.; Carruthers, R.; Hoyes, J.B.; Jones, C.; Langridge, J.I.; Millar, A.; Vissers, J.P. A novel precursor ion discovery method on a hybrid quadrupole orthogonal acceleration time-of-fl ight (Q-TOF) mass spectrometer for studying protein phosphorylation. J. Am. Soc. Mass Spectrom. 2002, 13(7), 792-803.
3. Pringle, S.D.; Giles, K.; Wildgoose, J.L.; Williams, J.P.; Slade, S.E.; Thalassinos, K.; Bateman, R.H.; Bowers, M.T.; Scrivens, J.H. An investigation of the mobility separation of some peptide and protein ions using a new hybrid quadrupole/traveling wave IMS/oa-TOF instrument. Int. J. Mass Spectrom. 2007, 261, 1-12.
4. Williams, J.P.; Bugarcic, T.; Habtemariam, A.; Giles, K.; Campuzano, I.; Rodger, P.M.; Sadler, P.J. Isomer separation and gasphase confi gurations of organoruthenium anticancer complexes: ion mobility mass spectrometry and modeling. J. Am. Soc. Mass Spectrom. 2009, 20(6), 1119-22.
5. Ruotolo, B.T.; Giles, K.; Campuzano, I.; Sandercock, A.M.; Bateman, R.H.; Robinson, C.V. Evidence for macromolecular protein rings in the absence of bulk water. Science 2005, 310, 1658-61.
6. Eckers, C.; Laures, A.M.; Giles, K.; Major, H.; Pringle, S. Evaluating the utility of ion mobility separation in combination with high-pressure liquid chromatography/mass spectrometry to facilitate detection of trace impurities in formulated drug products. Rapid Commun. Mass Spectrom. 2007, 21, 1255-63.
7. Trim, P.J.; Henson, C.M.; Avery, J.L.; McEwen, A.; Snel, M.F.; Claude, E.; Marshall, P.S.; West, A.; Princivalle, A.P.; Clench, M.R. Matrix-assisted laser desorption/ ionization-ion mobility separationmass spectrometry imaging of vinblastine in whole body tissue sections. Anal. Chem. 2008, 80(22), 8628-34.
8. Olivova, P.; Chen, W.; Chakraborty, A.B.; Gebler, J.C. Determination of N-glycosylation sites and site heterogeneity in a monoclonal antibody by electrospray quadrupole ion-mobility time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom. 2008, 22, 29-40.
9. Chan, E.C.; New, L.S.; Yap, C.W.; Goh, L.T. Pharmaceutical metabolite profiling using quadrupole/ion mobility spectrometry/ time-of-fl ight mass spectrometry. Rapid Commun. Mass Spectrom. 2009, 23, 384- 94.
10. Wu, C.; Siems,W.F.; Klasmeier, J.; Hill, H.H., Jr. Separation of isomeric peptides using electrospray ionization/high-resolution ion mobility spectrometry. Anal. Chem. 2000, 72, 391-5.