Tandem transformations of nitriles into N-heterocyclic compounds by electrophilic trapping of Blaise reaction intermediates

Synthesis (Germany)

Volumn 44, Issue 12, 2012, Pages 1809-1817

  Kim, Juhyun ^a   Chun, Yusung ^a   Shin, Hyunik ^b   Lee, Sang Gi ^a  

^a Ewha Womans University   (South Korea)

^b LG Chemical Ltd   (South Korea)

Author keywords

catalysis; cyclizations; heterocycles; nitriles; tandem reactions

Indexed keywords

2-PYRIDONES; ARYLATIONS; CHEMOSELECTIVE; CROSS COUPLING REACTIONS; CYCLIZATIONS; ELECTROPHILES; HETEROCYCLES; IN-SITU; INDOLE DERIVATIVES; INTRAMOLECULAR ALKYLATION; N-HETEROCYCLES; N-HETEROCYCLIC COMPOUNDS; NITRILES; PALLADIUM-CATALYZED; TANDEM REACTION;

ADDITION REACTIONS; ALKYLATION; CATALYSIS; CYANIDES;

REACTION INTERMEDIATES;

1,3 ENYNE DERIVATIVE; 2 METHYLBENZONITRILE; 2 PYRIDONE DERIVATIVE; 4 PHENYL 2 PYRIDONE DERIVATIVE; COPPER; ELECTROPHILE; ETHYL 2 PHENYL 1H INDOLE 3 CARBOXYLIC ACID; ETHYL 4 METHYL 2 PHENYL 5,6,7,8 TETRAHYDROQUINOLINE 3 CARBOXYLIC ACID; ETHYL 6 OXO 2,4 DIPHENYL 1,6 DIHYDROPYRIDINE 3 CARBOXYLIC ACID; ETHYL PYRROLIDIN 2 YLIDENEACETIC ACID; HETEROCYCLIC COMPOUND; INDOLE DERIVATIVE; N HETEROCYCLIC COMPOUND; NITRILE; OMEGA CHOLORALKYL NITRILE DERIVATIVE; PALLADIUM; PYRIDINE DERIVATIVE; PYRIDONE DERIVATIVE; UNCLASSIFIED DRUG; ZINC BROMIDE;

ADDITION REACTION; ALKYLATION; AROMATIZATION; ARTICLE; ARYLATION; BLAISE REACTION INTERMEDIATE; CATALYSIS; CHEMICAL ANALYSIS; CHEMICAL MODIFICATION; CHEMICAL REACTION; CHEMICAL STRUCTURE; CROSS COUPLING REACTION; CYCLIZATION; ELECTROCYCLIZATION; ELECTROPHILIC TRAPPING; ELECTROPHILICITY; NUCLEOPHILICITY; ONE POT SYNTHESIS; PROTON TRANSPORT; TANDEM TRANSFORMATION;

EID: 84861847435     PISSN: 00397881     EISSN: 1437210X     Source Type: Journal    
DOI: 10.1055/s-0031-1290814     Document Type: Article

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