Synthesis and biological evaluations of condensed pyridine and condensed pyrimidine-based HMG-CoA reductase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 10, 2001, Pages 1285-1288

  Suzuki, Mikio ^a   Iwasaki, Hiroshi ^a   Fujikawa, Yoshihiro ^a   Sakashita, Mitsuaki ^a   Kitahara, Masaki ^a   Sakoda, Ryozo ^a  

^a NISSAN CHEMICAL INDUSTRIES LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3,5 DIHYDROXYHEPTENOIC ACID DERIVATIVE; 5 HYDROXYKETONE; CHOLESTEROL; ESTER DERIVATIVE; HEXAHYDRONAPHTALENE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ISOXAZOLOPYRIDINE; KETONE DERIVATIVE; NAPHTHALENE DERIVATIVE; PYRAZOLOPYRIDINE; PYRAZOLOPYRIMIDINE; PYRIDINE DERIVATIVE; THIENOPYRIDINE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; POLYMERIZATION; REACTION ANALYSIS; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ADMINISTRATION, ORAL; ANIMALS; CHOLESTEROL; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LIVER; MALE; PYRIDINES; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0035927241     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00203-7     Document Type: Article

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