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Mismatched ligand S,S,S-1 afforded 4a with 82% yield and 75% ee; b the introduction of substituents at the 3,3′-positions of the binaphthol moiety only marginally affected the enantioselectivities
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a) Mismatched ligand S,S,S-1 afforded 4a with 82% yield and 75% ee; b) the introduction of substituents at the 3,3′-positions of the binaphthol moiety only marginally affected the enantioselectivities.
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The spectral and analytical data for all new compounds were in agreement with the indicated structures
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The spectral and analytical data for all new compounds were in agreement with the indicated structures.
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a) For a catalytic asymmetric tandem Michael-aldol reaction, see T. Arai, H. Sasai, K. Aoe, K. Okamura, T. Date, M. Shibasaki, Angew. Chem. 1996, 108, 103; Angew. Chem. Int. Ed. Engl. 1996, 35, 104; b) M. Kitamura, T. Miki, K. Nakano, R. Noyori, Tetrahedron Lett. 1996, 37, 5141.
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a) For a catalytic asymmetric tandem Michael-aldol reaction, see T. Arai, H. Sasai, K. Aoe, K. Okamura, T. Date, M. Shibasaki, Angew. Chem. 1996, 108, 103; Angew. Chem. Int. Ed. Engl. 1996, 35, 104; b) M. Kitamura, T. Miki, K. Nakano, R. Noyori, Tetrahedron Lett. 1996, 37, 5141.
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85033284817
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The X-ray structural analysis of compound 6b was performed by Dr. A. L. Spek (Utrecht University). Details will be reported separately
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The X-ray structural analysis of compound 6b was performed by Dr. A. L. Spek (Utrecht University). Details will be reported separately.
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