Defective dopamine receptor function in proximal tubules of obese Zucker rats

Hypertension

Volumn 34, Issue 5, 1999, Pages 1091-1096

  Hussain, Tahir ^a   Beheray, Sucheta A ^b   Lokhandwala, Mustafa F ^b  

^a UNIVERSITY OF HOUSTON   (United States)

^b NONE

Author keywords

Hypertension, obesity; Insulin resistance; Kidney; Obesity; Sodium pump

Indexed keywords

2,3,4,5 TETRAHYDRO 7,8 DIHYDROXY 1 PHENYL 1H 3 BENZAZEPINE; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); DOPAMINE; DOPAMINE RECEPTOR; GLUCOSE; GUANOSINE 5' O (3 THIOTRIPHOSPHATE);

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BASOLATERAL MEMBRANE; BINDING SITE; INSULIN RESISTANCE; KIDNEY PROXIMAL TUBULE; MALE; NATRIURESIS; NONHUMAN; OBESITY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; RECEPTOR DENSITY; SODIUM ABSORPTION; SODIUM RETENTION;

EID: 0032750032     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.HYP.34.5.1091     Document Type: Article

References (32)

1. Wickelgren I. Obesity: how big a problem? Science. 1998;280: 1364-1367.
2. Berg FM, ed. Special report: health risks of obesity. Obesity and Health. 2nd ed. Hettinger, NC: Healthy Living Institute: 1993.
3. Wood JE, Cash JR. Obesity and hypertension: clinical and experimental observations. Ann Intern Med. 1939;13:922-928.
4. Hall JE, Branda MW, Dixon WN, Smith MJ. Obesity-induced hypertension: renal function and systemic hemodynamics. Hypertension. 1993; 22:292-299.
5. Alonso-Galicia M, Brands MW, Zappe DH, Hall JE. Hypertension in obese Zucker rats: role of angiotensin II and adrenergic activity. Hypertension. 1996;28:1047-1054.
6. O'Hare JP, Roland JM, Walters G, Corall RJM. Impaired sodium retention in response to volume expansion induced by water immersion in insulin-dependent diabetes mellitus. Diabetes Res. 1986;3:213-215.
7. deChatel R, Wiedmann P, Flammer J, Zeigler WH, Bererta-Piccoli C, Vetter W, Reubi FC. Sodium, renin, aldosterone, catecholamines and blood pressure in diabetes mellitus. Kidney Int. 1977;12:412-421.
8. Feldt-Rasmussen B, Mathiesen ER, Deckert T, Geise J, Chrislersen NJ, Bern-Hansen L, Nielsen MD. Central role for sodium in the pathogenesis of blood pressure changes independent of angiotensin, aldosterone and catecholamines in type 1 (insulin-dependent) diabetes mellitus. Diabetologia. 1987;30:610-617.
9. Lee MR. Dopamine and the kidney. Clin Sci. 1982;312:77-83.
10. Hegde SS, Jadhav AL, Lokhandwala MF. Role of kidney dopamine in the natriuretic response to volume expansion in rats. Hypertension. 1989; 13: 828-834.
11. Felder RA, Seikaly MG, Cody P, Eisner GM, Jose PA. Attenuated renal response to dopaminergic drugs in spontaneously hypertensive rats. Hypertension. 1990;15:560-569.
12. Chen CJ, Lokhandwala MF. An impairment of tubular DA-1 receptor function as a causative factor for diminished natriuresis to volume expansion in spontaneously hypertensive rats. Clin Exp Hypertens. 1992;14:615-628.
13. Kinoshita S, Sidhu A, Felder RA. Defective dopamine-1 receptor adenylate cyclase coupling in the proximal convoluted tubules from the spontaneously hypertensive rats. J Clin Invest. 1989;84:1849-1858.
14. Ohbu K, Felder RA. Nephron specificity of dopamine receptor-adenylyl cyclase defect in spontaneous hypertension. Am J Physiol. 1993;264: F274-F279.
15. Sanada H, Jose PA, Yu PY, Hazen-Martin D, Carey RM, Bruns D, Felder RA. Human hypertensive subjects have a renal proximal tubular defect in dopamine-1 receptor/adenylyl cyclase coupling. J Am Soc Nephrol. 1997; 8:307A. Abstract.
16. 1A dopamine receptor in the pathogenesis of genetic hypertension. J Clin Invest. 1996;97:2283-2288.
17. +-exchanger activity in renal BBMV by stimulation of adenylate cyclase. Am J Physiol. 1990;259:F297-F303.
18. Vyas SJ, Eichberg J, Lokhandwala MF. Characterization of receptors involved in dopamine induced activation of phospholipase-C in rat renal cortex. J Pharmacol Exp Ther. 1992;260:134-139.
19. 1-like dopamine receptor activation. Naunyn Schmiedebergs Arch Pharmacol. 1993;347:289-295.
20. Chen CJ, Vyas SJ, Eichberg J, Lokhandwala MF. Diminished phospholipase C activation by dopamine in spontaneously hypertensive rats. Hypertension. 1992;19:102-108.
21. Gesek FA, Schoolwerth AC. Hormone response to proximal Na, H-exchanger in spontaneously hypertensive rats. Am J Physiol. 1991;261: F526-F536.
22. Chen CJ, Beach RE, Lokhandwala MF. Dopamine fails to inhibit renal tubular sodium pump in hypertensive rats. Hypertension. 1993;21: 364-372.
23. Hall JE, Brandts MW, Henegar JR, Shek EW. Abnormal kidney function as a cause and a consequence of obesity hypertension. Clin Exp Pharmacol Physiol. 1998;25:58-64.
24. Chan JCN, Critchley JH, Ho CS, Nicholls MG, Cockram CS, Swaminathan R. Atrial natriuretic peptide and urinary dopamine output in non-insulin-dependent diabetes mellitus. Clin Sci. 1992;83:247-253.
25. Segers O, Anckaert E, Gerlo E, Dupont AG, Somers G. Dopamine-sodium relationship in type 2 diabetic patients. Diabetes Res Clin Pract. 1996;34:89-98.
26. Kurtz TW, Morris RC, Pershadsingh HA. The Zucker fatty rat as a genetic model of obesity and hypertension. Hypertension. 1989;13: 896-901.
27. Sacktor BL, Rosenbloom IL, Liang CT, Cheng L. Na-gradient and sodium plus potassium gradient-dependent glutamate uptake in renal basolateral membrane vesicles. J Membr Biol. 1981;60:63-71.
28. Kansra V, Hussain T, Lokhandwala MF. Alterations in dopamine DA1 receptor and G proteins in renal proximal tubules of old rats. Am J Physiol. 1997;273:F53-F59.
29. Hussain T, Lokhandwala MF. Renal dopamine-1 receptor coupling with Gs and Gq/11 proteins in spontaneously hypertensive rats. Am J Physiol. 1997;272:F339-F346.
30. Zeigler DW, Patel KP. Reduced renal responses to an acute saline load in obese Zucker rats. Am J Physiol. 1991;261:R712-R718.
31. Segers O, Dupont AG, Gerlo E, Somers G. Urinary sodium and dopamine excretion, II: role of hyperinsulinemia in renal dopamine production. Med Sci. 1996;24:571-572.
32. Felder RA, Kinoshita S, Ohbu K, Mouradian MM, Sibley DR, Monsma FJ Jr, Minowa T, Minowa MT, Canessa LM, Jose PA. Organ specificity of the dopamine receptor/adenylyl cyclase coupling defect in spontaneously hypertensive rats. Am J Physiol. 1993;264:R726-R732.