Quantitative imaging of cartilage and bone morphology, reactive oxygen species, and vascularization in a rodent model of osteoarthritis

Arthritis and Rheumatism

Volumn 64, Issue 6, 2012, Pages 1899-1908

  Xie, Liqin ^a   Lin, Angela S P ^a   Kundu, Kousik ^a   Levenston, Marc E ^b   Murthy, Niren ^a   Guldberg, Robert E ^a  

^a GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^b STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IODOACETIC ACID; LEAD CHROMATE; PROTEOGLYCAN; REACTIVE OXYGEN METABOLITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ARTICULAR CARTILAGE; BONE EROSION; CONTRAST ENHANCEMENT; CONTROLLED STUDY; FEMUR; FLUORESCENCE IMAGING; IN VIVO STUDY; KNEE OSTEOARTHRITIS; MALE; MICRO-COMPUTED TOMOGRAPHY; MORPHOLOGY; NONHUMAN; OSTEOLYSIS; PRIORITY JOURNAL; QUANTITATIVE STUDY; RAT; TRABECULAR BONE; VASCULARIZATION;

ANIMALS; ARTHRITIS, EXPERIMENTAL; BONE AND BONES; CARTILAGE, ARTICULAR; KNEE JOINT; MALE; NEOVASCULARIZATION, PATHOLOGIC; OSTEOARTHRITIS, KNEE; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES;

EID: 84861829988     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.34370     Document Type: Article

References (58)

1. Goldring MB, Goldring SR,. Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis. Ann N Y Acad Sci 2010; 1192: 230-7.
2. Blair-Levy JM, Watts CE, Fiorentino NM, Dimitriadis EK, Marini JC, Lipsky PE,. A type I collagen defect leads to rapidly progressive osteoarthritis in a mouse model. Arthritis Rheum 2008; 58: 1096-106.
3. Mrosek EH, Lahm A, Erggelet C, Uhl M, Kurz H, Eissner B, et al. Subchondral bone trauma causes cartilage matrix degeneration: an immunohistochemical analysis in a canine model. Osteoarthritis Cartilage 2006; 14: 171-8.
4. Radin EL, Rose RM,. Role of subchondral bone in the initiation and progression of cartilage damage. Clin Orthop Relat Res 1986; 213: 34-40.
5. Lajeunesse D, Reboul P,. Subchondral bone in osteoarthritis: a biologic link with articular cartilage leading to abnormal remodeling. Curr Opin Rheumatol 2003; 15: 628-33.
6. Antoniades L, MacGregor AJ, Matson M, Spector TD,. A cotwin control study of the relationship between hip osteoarthritis and bone mineral density. Arthritis Rheum 2000; 43: 1450-5.
7. Hayami T, Pickarski M, Zhuo Y, Wesolowski GA, Rodan GA, le Duong T,. Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis. Bone 2006; 38: 234-43.
8. Bettica P, Cline G, Hart DJ, Meyer J, Spector TD,. Evidence for increased bone resorption in patients with progressive knee osteoarthritis: longitudinal results from the Chingford study. Arthritis Rheum 2002; 46: 3178-84.
9. Brandt KD, Dieppe P, Radin E,. Etiopathogenesis of osteoarthritis. Med Clin North Am 2009; 93: 1-24, xv.
10. Calvo E, Palacios I, Delgado E, Sanchez-Pernaute O, Largo R, Egido J, et al. Histopathological correlation of cartilage swelling detected by magnetic resonance imaging in early experimental osteoarthritis. Osteoarthritis Cartilage 2004; 12: 878-86.
11. Ashraf S, Walsh DA,. Angiogenesis in osteoarthritis. Curr Opin Rheumatol 2008; 20: 573-80.
12. Bonnet CS, Walsh DA,. Osteoarthritis, angiogenesis and inflammation. Rheumatology (Oxford) 2005; 44: 7-16.
13. Sutton S, Clutterbuck A, Harris P, Gent T, Freeman S, Foster N, et al. The contribution of the synovium, synovial derived inflammatory cytokines and neuropeptides to the pathogenesis of osteoarthritis. Vet J 2009; 179: 10-24.
14. Case JP, Baliunas AJ, Block JA,. Lack of efficacy of acetaminophen in treating symptomatic knee osteoarthritis: a randomized, double-blind, placebo-controlled comparison trial with diclofenac sodium. Arch Intern Med 2003; 163: 169-78.
15. Hellio Le Graverand-Gastineau MP,. OA clinical trials: current targets and trials for OA. Choosing molecular targets: what have we learned and where we are headed? Osteoarthritis Cartilage 2009; 17: 1393-401.
16. Costa C, Incio J, Soares R,. Angiogenesis and chronic inflammation: cause or consequence? Angiogenesis 2007; 10: 149-66.
17. Imhof H, Breitenseher M, Kainberger F, Trattnig S,. Degenerative joint disease: cartilage or vascular disease? Skeletal Radiol 1997; 26: 398-403.
18. Haywood L, McWilliams DF, Pearson CI, Gill SE, Ganesan A, Wilson D, et al. Inflammation and angiogenesis in osteoarthritis. Arthritis Rheum 2003; 48: 2173-7.
19. Mapp PI, Avery PS, McWilliams DF, Bowyer J, Day C, Moores S, et al. Angiogenesis in two animal models of osteoarthritis. Osteoarthritis Cartilage 2008; 16: 61-9.
20. Guingamp C, Gegout-Pottie P, Philippe L, Terlain B, Netter P, Gillet P,. Mono-iodoacetate-induced experimental osteoarthritis: a dose-response study of loss of mobility, morphology, and biochemistry. Arthritis Rheum 1997; 40: 1670-9.
21. Palmer AW, Guldberg RE, Levenston ME,. Analysis of cartilage matrix fixed charge density and three-dimensional morphology via contrast-enhanced microcomputed tomography. Proc Natl Acad Sci U S A 2006; 103: 19255-60.
22. Xie L, Lin AS, Levenston ME, Guldberg RE,. Quantitative assessment of articular cartilage morphology via EPIC-microCT. Osteoarthritis Cartilage 2009; 17: 313-20.
23. Duvall CL, Taylor WR, Weiss D, Guldberg RE,. Quantitative microcomputed tomography analysis of collateral vessel development after ischemic injury. Am J Physiol Heart Circ Physiol 2004; 287: H302-10.
24. Xie L, Lin AS, Guldberg RE, Levenston ME,. Nondestructive assessment of sGAG content and distribution in normal and degraded rat articular cartilage via EPIC-microCT. Osteoarthritis Cartilage 2010; 18: 65-72.
25. Gerwin N, Bendele AM, Glasson S, Carlson CS,. The OARSI histopathology initiative: recommendations for histological assessments of osteoarthritis in the rat. Osteoarthritis Cartilage 2010; 18 Suppl 3: S24-34.
26. Glasson SS, Chambers MG, van den Berg WB, Little CB,. The OARSI histopathology initiative: recommendations for histological assessments of osteoarthritis in the mouse. Osteoarthritis Cartilage 2010; 18 Suppl 3: S17-23.
27. Xia Y,. The total volume and the complete thickness of articular cartilage determined by MRI. Osteoarthritis Cartilage 2003; 11: 473-4.
28. Uchiyama T, Tanizawa T, Muramatsu H, Endo N, Takahashi HE, Hara T,. A morphometric comparison of trabecular structure of human ilium between microcomputed tomography and conventional histomorphometry. Calcif Tissue Int 1997; 61: 493-8.
29. Millington SA, Grabner M, Wozelka R, Anderson DD, Hurwitz SR, Crandall JR,. Quantification of ankle articular cartilage topography and thickness using a high resolution stereophotography system. Osteoarthritis Cartilage 2007; 15: 205-11.
30. Laib A, Barou O, Vico L, Lafage-Proust MH, Alexandre C, Rugsegger P,. 3D micro-computed tomography of trabecular and cortical bone architecture with application to a rat model of immobilisation osteoporosis. Med Biol Eng Comput 2000; 38: 326-32.
31. Morenko BJ, Bove SE, Chen L, Guzman RE, Juneau P, Bocan TM, et al. In vivo micro computed tomography of subchondral bone in the rat after intra-articular administration of monosodium iodoacetate. Contemp Top Lab Anim Sci 2004; 43: 39-43.
32. Anderson-MacKenzie JM, Quasnichka HL, Starr RL, Lewis EJ, Billingham ME, Bailey AJ,. Fundamental subchondral bone changes in spontaneous knee osteoarthritis. Int J Biochem Cell Biol 2005; 37: 224-36.
33. Fahlgren A, Messner K, Aspenberg P,. Meniscectomy leads to an early increase in subchondral bone plate thickness in the rabbit knee. Acta Orthop Scand 2003; 74: 437-41.
34. Wachsmuth L, Engelke K,. High-resolution imaging of osteoarthritis using microcomputed tomography. Methods Mol Med 2004; 101: 231-48.
35. Ding M, Odgaard A, Hvid I,. Changes in the three-dimensional microstructure of human tibial cancellous bone in early osteoarthritis. J Bone Joint Surg Br 2003; 85: 906-12.
36. Hochberg MC, Lethbridge-Cejku M, Tobin JD,. Bone mineral density and osteoarthritis: data from the Baltimore Longitudinal Study of Aging. Osteoarthritis Cartilage 2004; 12 Suppl A: S45-8.
37. Botter SM, van Osch GJ, Waarsing JH, van der Linden JC, Verhaar JA, Pols HA, et al. Cartilage damage pattern in relation to subchondral plate thickness in a collagenase-induced model of osteoarthritis. Osteoarthritis Cartilage 2008; 16: 506-14.
38. Koh YH, Hong SH, Kang HS, Chung CY, Koo KH, Chung HW, et al. The effects of bone turnover rate on subchondral trabecular bone structure and cartilage damage in the osteoarthritis rat model. Rheumatol Int 2010; 30: 1165-71.
39. Beyreuther B, Callizot N, Stohr T,. Antinociceptive efficacy of lacosamide in the monosodium iodoacetate rat model for osteoarthritis pain. Arthritis Res Ther 2007; 9: R14.
40. Armstrong CG, Mow VC,. Variations in the intrinsic mechanical properties of human articular cartilage with age, degeneration, and water content. J Bone Joint Surg Am 1982; 64: 88-94.
41. Williamson AK, Chen AC, Sah RL,. Compressive properties and function-composition relationships of developing bovine articular cartilage. J Orthop Res 2001; 19: 1113-21.
42. Rieppo J, Toyras J, Nieminen MT, Kovanen V, Hyttinen MM, Korhonen RK, et al. Structure-function relationships in enzymatically modified articular cartilage. Cells Tissues Organs 2003; 175: 121-32.
43. LeRoux MA, Arokoski J, Vail TP, Guilak F, Hyttinen MM, Kiviranta I, et al. Simultaneous changes in the mechanical properties, quantitative collagen organization, and proteoglycan concentration of articular cartilage following canine meniscectomy. J Orthop Res 2000; 18: 383-92.
44. Regan E, Flannelly J, Bowler R, Tran K, Nicks M, Carbone BD, et al. Extracellular superoxide dismutase and oxidant damage in osteoarthritis. Arthritis Rheum 2005; 52: 3479-91.
45. Kundu K, Knight SF, Willett N, Lee S, Taylor WR, Murthy N,. Hydrocyanines: a class of fluorescent sensors that can image reactive oxygen species in cell culture, tissue, and in vivo. Angew Chem Int Ed Engl 2009; 48: 299-303.
46. Lee D, Khaja S, Velasquez-Castano JC, Dasari M, Sun C, Petros J, et al. In vivo imaging of hydrogen peroxide with chemiluminescent nanoparticles. Nat Mater 2007; 6: 765-9.
47. Garcia-Sanz A, Rodriguez-Barbero A, Bentley MD, Ritman EL, Romero JC,. Three-dimensional microcomputed tomography of renal vasculature in rats. Hypertension 1998; 31: 440-4.
48. Jorgensen SM, Demirkaya O, Ritman EL,. Three-dimensional imaging of vasculature and parenchyma in intact rodent organs with X-ray micro-CT. Am J Physiol 1998; 275: H1103-14.
49. Paulus MJ, Gleason SS, Kennel SJ, Hunsicker PR, Johnson DK,. High resolution X-ray computed tomography: an emerging tool for small animal cancer research. Neoplasia 2000; 2: 62-70.
50. Bentley MD, Ortiz MC, Ritman EL, Romero JC,. The use of microcomputed tomography to study microvasculature in small rodents. Am J Physiol Regul Integr Comp Physiol 2002; 282: R1267-79.
51. Shibakawa A, Yudoh K, Masuko-Hongo K, Kato T, Nishioka K, Nakamura H,. The role of subchondral bone resorption pits in osteoarthritis: MMP production by cells derived from bone marrow. Osteoarthritis Cartilage 2005; 13: 679-87.
52. Fay J, Varoga D, Wruck CJ, Kurz B, Goldring MB, Pufe T,. Reactive oxygen species induce expression of vascular endothelial growth factor in chondrocytes and human articular cartilage explants. Arthritis Res Ther 2006; 8: R189.
53. Hayami T, Funaki H, Yaoeda K, Mitui K, Yamagiwa H, Tokunaga K, et al. Expression of the cartilage derived anti-angiogenic factor chondromodulin-I decreases in the early stage of experimental osteoarthritis. J Rheumatol 2003; 30: 2207-17.
54. Henrotin Y, Kurz B, Aigner T,. Oxygen and reactive oxygen species in cartilage degradation: friends or foes? Osteoarthritis Cartilage 2005; 13: 643-54.
55. Koo S, Gold GE, Andriacchi TP,. Considerations in measuring cartilage thickness using MRI: factors influencing reproducibility and accuracy. Osteoarthritis Cartilage 2005; 13: 782-9.
56. Eckstein F, Reiser M, Englmeier KH, Putz R,. In vivo morphometry and functional analysis of human articular cartilage with quantitative magnetic resonance imaging: from image to data, from data to theory. Anat Embryol (Berl) 2001; 203: 147-73.
57. Guzman RE, Evans MG, Bove S, Morenko B, Kilgore K,. Mono-iodoacetate- induced histologic changes in subchondral bone and articular cartilage of rat femorotibial joints: an animal model of osteoarthritis. Toxicol Pathol 2003; 31: 619-24.
58. Piscaer TM, Waarsing JH, Kops N, Pavljasevic P, Verhaar JA, van Osch GJ, et al. In vivo imaging of cartilage degeneration using microCT-arthrography. Osteoarthritis Cartilage 2008; 16: 1011-7.