Antileukemia component, dehydroeburicoic acid from Antrodia camphorata induces DNA damage and apoptosis in vitro and in vivo models

Phytomedicine

Volumn 19, Issue 8-9, 2012, Pages 788-796

  Du, Ying Chi ^a   Chang, Fang Rong ^a,b,c   Wu, Tung Ying ^a   Hsu, Yu Ming ^a   El Shazly, Mohamed ^a,d   Chen, Chieh Fu ^e   Sung, Ping Jyun ^f,g   Lin, Yan Yu ^a   Lin, Yi Hsin ^a   Wu, Yang Chang ^a,h,i   Lu, Mei Chin ^a,f,g  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

^d African Union Organization St Abbassia   (Egypt)

^e Chih Ying Plant Research and Development Foundation   (Taiwan)

^f NATIONAL DONG HWA UNIVERSITY   (Taiwan)

^g NATIONAL MUSEUM OF MARINE BIOLOGY AND AQUARIUM   (Taiwan)

^h CHINA MEDICAL UNIVERSITY   (Taiwan)

ⁱ CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Antrodia camphorata; Apoptosis; Dehydroeburicoic acid (DeEA); DNA damage; Topoisomerase II inhibitor

Indexed keywords

ACTIN; ALCOHOL; ANTCIN C; ANTCIN K; ANTILEUKEMIC AGENT; ANTRODIA CAMPHORATA EXTRACT; BIOLOGICAL MARKER; CASPASE 3; CASPASE 7; CASPASE 9; CHECKPOINT KINASE 2; DEHYDROEBURICOIC ACID; DNA TOPOISOMERASE (ATP HYDROLYSING); HISTONE H2AX; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PLANT EXTRACT; PLANT MEDICINAL PRODUCT; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL X; PROTEIN BID; TRITERPENOID; UNCLASSIFIED DRUG; ZHANKUIC ACID A; ZHANKUIC ACID C;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ANTRODIA CAMPHORATA; APOPTOSIS; ARTICLE; BODY WEIGHT; CANCER INHIBITION; CELL STRAIN HL 60; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; ENZYME ACTIVATION; ENZYME INHIBITION; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN PHOSPHORYLATION; TREATMENT DURATION; TUMOR VOLUME; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTRODIA; APOPTOSIS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA DAMAGE; DRUG SCREENING ASSAYS, ANTITUMOR; ERGOSTEROL; FEMALE; HISTONES; HL-60 CELLS; HUMANS; LANOSTEROL; LEUKEMIA; MEDICINE, CHINESE TRADITIONAL; MICE; MICE, NUDE; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; TOPOISOMERASE II INHIBITORS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

ANIMALIA; BASIDIOMYCOTA; MUS; TAIWANOFUNGUS CAMPHORATUS;

EID: 84861827593     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2012.03.014     Document Type: Article

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