Synthesis and cancer cell cytotoxicity of substituted xanthenes

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 4, 2010, Pages 1456-1463

  Giri, Rajan ^a   Goodell, John R ^b   Xing, Chenguo ^a   Benoit, Adam ^a   Kaur, Harneet ^a   Hiasa, Hiroshi ^a   Ferguson, David M ^a,c  

^a UNIVERSITY OF MINNESOTA   (United States)

^b Boston University   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Cancer cells; Cytotoxicity; DNA binding; Drug design; DU 145; HeLa; Intercalation; MCF 7; Molecular modeling; SAR; Topoisomerase; Xanthene; Xanthone

Indexed keywords

(N,N DIETHYL) 9 HYDROXY 9 (3 METHOXYPHENYL) 9H XANTHENE 3 CARBOXAMIDE; (N,N DIETHYL) 9 HYDROXY PHENYL 9H XANTHENE CARBOXAMIDE; 2 CHLORO 6 (4 METHYLPIPERAZINE 1 CARBONYL) 9 ETHYL 9 HYDROXY XANTHENE; 2 CHLORO 6 (4 METHYLPIPERAZINE 1 CARBONYL) 9 HYDROXY (3 METHOXYPHENYL) 9H XANTHENE; 2 CHLORO 6 (4 METHYLPIPERAZINE 1 CARBONYL) 9 HYDROXY 9 METHYL 9H XANTHENE; 2 CHLORO 6 (4 METHYLPIPERAZINE 1 CARBONYL) 9 HYDROXY 9 PHENYL 9H XANTHENE; 2 CHLORO 6 (4 METHYLPIPERAZINE 1 CARBONYL) 9 HYDROXY 9 VINYL 9H XANTHENE; 2 FLUORO 6 (4 METHYLPIPERAZINE 1 CARBONYL) 9 ETHYL 9 HYDROXY 9H XANTHENE; 2 FLUORO 6 (4 METHYLPIPERAZINE 1 CARBONYL) 9 HYDROXY (3 METHOXYPHENYL) 9H XANTHENE; 2 FLUORO 6 (4 METHYLPIPERAZINE 1 CARBONYL) 9 HYDROXY METHYL 9H XANTHENE; 2 FLUORO 6 (4 METHYLPIPERAZINE 1 CARBONYL) 9 HYDROXY PHENYL 9H XANTHENE; 2 FLUORO 6 (4 METHYLPIPERAZINE 1 CARBONYL) 9 HYDROXY VINYL 9H XANTHENE; 3 (4 METHYLPIPERAZINE 1 CARBONYL) 9 ETHYL 9 HYDROXY 9H XANTHENE; 3 (4 METHYLPIPERAZINE 1 CARBONYL) 9 HYDROXY 9 (3 METHOXYPHENYL) 9H XANTHENE; 3 (4 METHYLPIPERAZINE 1 CARBONYL) 9 HYDROXY 9 METHYL 9H XANTHENE; 3 (4 METHYLPIPERAZINE 1 CARBONYL) 9 HYDROXY 9 PHENYL 9H XANTHENE; 3 (4 METHYLPIPERAZINE 1 CARBONYL) 9 HYDROXY 9 VINYL 9H XANTHENE; 3 (MORPHOLINO 4 CARBONYL) 9 HYDROXY (3 METHOXYPHENYL) 9H XANTHENE; 3 (MORPHOLINO 4 CARBONYL) 9 HYDROXY 9 PHENYL 9H XANTHENE; 9 (3 METHOXYPHENYL) XANTHEN 9 OL; 9 PHENYL XANTHEN 9 OL; ANTINEOPLASTIC AGENT; UNCLASSIFIED DRUG; XANTHEN 9 ONE; XANTHENE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CONTROLLED STUDY; CYCLIZATION; CYTOTOXICITY; DRUG CONFORMATION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; IC 50; MALE; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

DRUG SCREENING ASSAYS, ANTITUMOR; HELA CELLS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; XANTHENES;

EID: 75849127526     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.01.018     Document Type: Article

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