-
1
-
-
33846230449
-
Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: Are we ready for a prognostically prioritized molecular classification?
-
Mrozek K, Marcucci G, Paschka P, Whitman SP, Bloomfield CD. Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: are we ready for a prognostically prioritized molecular classification? Blood. 2007;109:431-448.
-
(2007)
Blood
, vol.109
, pp. 431-448
-
-
Mrozek, K.1
Marcucci, G.2
Paschka, P.3
Whitman, S.P.4
Bloomfield, C.D.5
-
2
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D, Weinberg RA. The hallmarks of cancer. Cell. 2000;100:57-70.
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
4
-
-
35348834097
-
Aberrant cytokine signaling in leukemia
-
Van Etten RA. Aberrant cytokine signaling in leukemia. Oncogene. 2007;26:6738-6749.
-
(2007)
Oncogene
, vol.26
, pp. 6738-6749
-
-
Van Etten, R.A.1
-
5
-
-
0028352734
-
Levels of retinoblastoma protein expression in newly diagnosed acute myelogenous leukemia
-
Kornblau SM, Xu H-J, Zhang W, et al. Levels of retinoblastoma protein expression in newly diagnosed acute myelogenous leukemia. Blood. 1994;84:256-261.
-
(1994)
Blood
, vol.84
, pp. 256-261
-
-
Kornblau, S.M.1
Xu, H.-J.2
Zhang, W.3
-
6
-
-
0033624762
-
BAX and PKCalpha modulate the prognostic impact of BCL2 expression in acute myelogenous leukemia
-
Kornblau SM, Vu HT, Ruvolo P, et al. BAX and PKCalpha modulate the prognostic impact of BCL2 expression in acute myelogenous leukemia. Clin Cancer Res. 2000;6:1401-1409.
-
(2000)
Clin Cancer Res
, vol.6
, pp. 1401-1409
-
-
Kornblau, S.M.1
Vu, H.T.2
Ruvolo, P.3
-
7
-
-
33749337234
-
Simultaneous activation of multiple signal transduction pathways confers poor prognosis in acute myelogenous leukemia
-
Kornblau SM,Womble M, Jackson CE, et al. Simultaneous activation of multiple signal transduction pathways confers poor prognosis in acute myelogenous leukemia. Blood. 2006;108:2358-2365.
-
(2006)
Blood
, vol.108
, pp. 2358-2365
-
-
Kornblau, S.M.1
Womble, M.2
Jackson, C.E.3
-
8
-
-
33750320436
-
Correlation of neuropilin-1 overexpression to survival in acute myeloid leukemia
-
Kreuter M,Woelke K, Bieker R, et al. Correlation of neuropilin-1 overexpression to survival in acute myeloid leukemia. Leukemia. 2006;20:1950-1954.
-
(2006)
Leukemia
, vol.20
, pp. 1950-1954
-
-
Kreuter, M.1
Woelke, K.2
Bieker, R.3
-
9
-
-
0035923722
-
BAALC, the human member of a novel mammalian neuroectoderm gene lineage, is implicated in hematopoiesis and acute leukemia
-
Tanner SM, Austin JL, Leone G, et al. BAALC, the human member of a novel mammalian neuroectoderm gene lineage, is implicated in hematopoiesis and acute leukemia. Proc Natl Acad Sci U S A. 2001;98:13901-13906.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 13901-13906
-
-
Tanner, S.M.1
Austin, J.L.2
Leone, G.3
-
10
-
-
0037097716
-
Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: Association with FAB subtypes and identification of subgroups with poor prognosis
-
Thiede C, Steudel C, Mohr B, et al. Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis. Blood. 2002;99:4326-4335.
-
(2002)
Blood
, vol.99
, pp. 4326-4335
-
-
Thiede, C.1
Steudel, C.2
Mohr, B.3
-
11
-
-
16544369516
-
Use of geneexpression profiling to identify prognostic subclasses in adult acute myeloid leukemia
-
Bullinger L, Dohner K, Bair E, et al. Use of geneexpression profiling to identify prognostic subclasses in adult acute myeloid leukemia. N Engl J Med. 2004;350:1605-1616.
-
(2004)
N Engl J Med
, vol.350
, pp. 1605-1616
-
-
Bullinger, L.1
Dohner, K.2
Bair, E.3
-
12
-
-
11144358111
-
Prognostically useful gene-expression profiles in acute myeloid leukemia
-
Valk PJ, Verhaak RG, Beijen MA, et al. Prognostically useful gene-expression profiles in acute myeloid leukemia. N Engl J Med. 2004;350:1617-1628.
-
(2004)
N Engl J Med
, vol.350
, pp. 1617-1628
-
-
Valk, P.J.1
Verhaak, R.G.2
Beijen, M.A.3
-
13
-
-
27644506613
-
Integrative genomic and proteomic analysis of prostate cancer reveals signatures of metastatic progression
-
Varambally S, Yu J, Laxman B, et al. Integrative genomic and proteomic analysis of prostate cancer reveals signatures of metastatic progression. Cancer Cell. 2005;8:393-406.
-
(2005)
Cancer Cell
, vol.8
, pp. 393-406
-
-
Varambally, S.1
Yu, J.2
Laxman, B.3
-
14
-
-
20144368638
-
Integrated genomic and proteomic analyses of gene expression in mammalian cells
-
Tian Q, Stepaniants SB, Mao M, et al. Integrated genomic and proteomic analyses of gene expression in mammalian cells. Mol Cell Proteomics. 2004;3:960-969.
-
(2004)
Mol Cell Proteomics
, vol.3
, pp. 960-969
-
-
Tian, Q.1
Stepaniants, S.B.2
Mao, M.3
-
15
-
-
10744226821
-
Proteomic profiling of the NCI-60 cancer cell lines using new high-density reverse-phase lysate microarrays
-
Nishizuka S, Charboneau L, Young L, et al. Proteomic profiling of the NCI-60 cancer cell lines using new high-density reverse-phase lysate microarrays. Proc Natl Acad Sci U S A. 2003;100: 14229-14234.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 14229-14234
-
-
Nishizuka, S.1
Charboneau, L.2
Young, L.3
-
16
-
-
0037097716
-
Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: Association with FAB subtypes and identification of subgroups with poor prognosis
-
Thiede C, Steudel C, Mohr B, et al. Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis. Blood. 2002;99:4326-4335.
-
(2002)
Blood
, vol.99
, pp. 4326-4335
-
-
Thiede, C.1
Steudel, C.2
Mohr, B.3
-
17
-
-
32444446461
-
Assay of Rab25 function in ovarian and breast cancers
-
Cheng KW, Lu Y, Mills GB. Assay of Rab25 function in ovarian and breast cancers. Methods Enzymol. 2005;403:202-215.
-
(2005)
Methods Enzymol
, vol.403
, pp. 202-215
-
-
Cheng, K.W.1
Lu, Y.2
Mills, G.B.3
-
18
-
-
33750456480
-
Reverse phase protein array (RPPA): Validation of a novel proteomic technology and utility for analysis of primary leukemia specimens and hematopoetic stem cells (HSC)
-
Tibes R, Qiu YH, Lu Y, et al. Reverse phase protein array (RPPA): validation of a novel proteomic technology and utility for analysis of primary leukemia specimens and hematopoetic stem cells (HSC). Mol Cancer Ther. 2006;5:2512-2521.
-
(2006)
Mol Cancer Ther
, vol.5
, pp. 2512-2521
-
-
Tibes, R.1
Qiu, Y.H.2
Lu, Y.3
-
19
-
-
0035848705
-
Reverse phase protein microarrays which capture disease progression show activation of prosurvival pathways at the cancer invasion front
-
Paweletz CP, Charboneau L, Bichsel VE, et al. Reverse phase protein microarrays which capture disease progression show activation of prosurvival pathways at the cancer invasion front. Oncogene. 2001;20:1981-1989.
-
(2001)
Oncogene
, vol.20
, pp. 1981-1989
-
-
Paweletz, C.P.1
Charboneau, L.2
Bichsel, V.E.3
-
20
-
-
17844377553
-
Use of reverse phase protein microarrays and reference standard development for molecular network analysis of metastatic ovarian carcinoma
-
Sheehan K, Calvert VS, Kay E, et al. Use of reverse phase protein microarrays and reference standard development for molecular network analysis of metastatic ovarian carcinoma. Mol Cell Proteomics. 2005;4:346-355.
-
(2005)
Mol Cell Proteomics
, vol.4
, pp. 346-355
-
-
Sheehan, K.1
Calvert, V.S.2
Kay, E.3
-
21
-
-
0242523651
-
Signal pathway profiling of prostate cancer using reverse phase protein arrays
-
Grubb RL, Calvert VS, Wulkuhle JD, et al. Signal pathway profiling of prostate cancer using reverse phase protein arrays. Proteomics. 2003;3: 2142-2146.
-
(2003)
Proteomics
, vol.3
, pp. 2142-2146
-
-
Grubb, R.L.1
Calvert, V.S.2
Wulkuhle, J.D.3
-
22
-
-
3242829141
-
Immunohistochemical signal amplification by catalyzed reporter deposition and its application in double immunostaining
-
Hunyady B, Krempels K, Harta G, Mezey E. Immunohistochemical signal amplification by catalyzed reporter deposition and its application in double immunostaining. J Histochem Cytochem. 1996;44:1353-1362.
-
(1996)
J Histochem Cytochem
, vol.44
, pp. 1353-1362
-
-
Hunyady, B.1
Krempels, K.2
Harta, G.3
Mezey, E.4
-
23
-
-
0242406333
-
Utility of reverse phase protein arrays: Applications to signalling pathways and human body arrays
-
Charboneau L, Scott H, Chen T, et al. Utility of reverse phase protein arrays: applications to signalling pathways and human body arrays. Brief Funct Genomic Proteomic. 2002;1:305-315.
-
(2002)
Brief Funct Genomic Proteomic
, vol.1
, pp. 305-315
-
-
Charboneau, L.1
Scott, H.2
Chen, T.3
-
24
-
-
33744461054
-
Nonlinear modeling of protein expression in protein arrays
-
Tabus I, Hategan A, Mircean C, et al. Nonlinear modeling of protein expression in protein arrays. IEEE Trans Signal Process. 2006;54:2394-2407.
-
(2006)
IEEE Trans Signal Process
, vol.54
, pp. 2394-2407
-
-
Tabus, I.1
Hategan, A.2
Mircean, C.3
-
25
-
-
0035979259
-
Bootstrapping cluster analysis: Assessing the reliability of conclusions from microarray experiments
-
Kerr MK, Churchill G. Bootstrapping cluster analysis: assessing the reliability of conclusions from microarray experiments. Proc Natl Acad Sci U S A. 2001;98:8961-8965.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 8961-8965
-
-
Kerr, M.K.1
Churchill, G.2
-
26
-
-
0035532141
-
Estimating the number of clusters in a data set via the gap statistic
-
Tibshirani R, Walther G, Hastie, T. Estimating the number of clusters in a data set via the gap statistic. J R Stat Soc Series. 2001;63:411-423.
-
(2001)
J R Stat Soc Series
, vol.63
, pp. 411-423
-
-
Tibshirani, R.1
Walther, G.2
Hastie, T.3
-
27
-
-
26944498714
-
Comparative analysis of the effects of sample source and test methodology on the assessment of protein expression in acute myelogenous leukemia
-
Kornblau SM, Womble M, Cade JS, Lemker EM, Qiu YH. Comparative analysis of the effects of sample source and test methodology on the assessment of protein expression in acute myelogenous leukemia. Leukemia. 2005;19:1550-1557.
-
(2005)
Leukemia
, vol.19
, pp. 1550-1557
-
-
Kornblau, S.M.1
Womble, M.2
Cade, J.S.3
Lemker, E.M.4
Qiu, Y.H.5
-
28
-
-
0024501380
-
Prognostic impact of cytogenetic abnormalities in patients with de novo acute nonlymphocytic leukemia
-
Schiffer CA, Lee E, Tomiyasu T, Wiernik P, Testa J. Prognostic impact of cytogenetic abnormalities in patients with de novo acute nonlymphocytic leukemia. Blood. 1989;73:263-270.
-
(1989)
Blood
, vol.73
, pp. 263-270
-
-
Schiffer, C.A.1
Lee, E.2
Tomiyasu, T.3
Wiernik, P.4
Testa, J.5
-
29
-
-
0037838661
-
Overexpression and constitutive activation of FLT3 induces STAT5 activation in primary acute myeloid leukemia blast cells
-
Spiekermann K, Bagrintseva K, Schwab R, Schmieja K, Hiddemann W. Overexpression and constitutive activation of FLT3 induces STAT5 activation in primary acute myeloid leukemia blast cells. Clin Cancer Res. 2003;9:2140-2150.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 2140-2150
-
-
Spiekermann, K.1
Bagrintseva, K.2
Schwab, R.3
Schmieja, K.4
Hiddemann, W.5
-
30
-
-
0034598830
-
Tandemduplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines
-
Hayakawa F, Towatari M, Kiyoi H, et al. Tandemduplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines. Oncogene. 2000;19:624-631.
-
(2000)
Oncogene
, vol.19
, pp. 624-631
-
-
Hayakawa, F.1
Towatari, M.2
Kiyoi, H.3
-
31
-
-
22044448746
-
AMLassociated Flt3 kinase domain mutations show signal transduction differences compared with Flt3 ITD mutations
-
Choudhary C, Schwable J, Brandts C, et al. AMLassociated Flt3 kinase domain mutations show signal transduction differences compared with Flt3 ITD mutations. Blood. 2005;106:265-273.
-
(2005)
Blood
, vol.106
, pp. 265-273
-
-
Choudhary, C.1
Schwable, J.2
Brandts, C.3
-
32
-
-
0004012196
-
-
2nd ed, Boca Raton, FL: Chapman & Hall/CRC;
-
Gelman A, Carlin JB, Stern HS, Rubin DR. Bayesian Data Analysis (2nd ed). Boca Raton, FL: Chapman & Hall/CRC; 2004.
-
(2004)
Bayesian Data Analysis
-
-
Gelman, A.1
Carlin, J.B.2
Stern, H.S.3
Rubin, D.R.4
-
33
-
-
61849166016
-
Mutations of the Tp53 gene occur in 13.4% of acute myeloid leukemia and are strongly associated with a complex aberrant karyotype [abstract]
-
Schoch C, Dicker F, Herholz H, et al. Mutations of the Tp53 gene occur in 13.4% of acute myeloid leukemia and are strongly associated with a complex aberrant karyotype [abstract]. Blood. 2006; 108.
-
(2006)
Blood
, pp. 108
-
-
Schoch, C.1
Dicker, F.2
Herholz, H.3
-
34
-
-
32444449180
-
Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: Implications for therapy
-
Tovar C, Rosinski J, Filipovic Z, et al. Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy. Proc Natl Acad Sci U S A. 2006;103:1888-1893.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 1888-1893
-
-
Tovar, C.1
Rosinski, J.2
Filipovic, Z.3
-
35
-
-
0033768666
-
Expression and prognostic significance of survivin in de novo acute myeloid leukaemia
-
Adida C, Recher C, Raffoux E, et al. Expression and prognostic significance of survivin in de novo acute myeloid leukaemia. Br J Haematol. 2000; 111:196-203.
-
(2000)
Br J Haematol
, vol.111
, pp. 196-203
-
-
Adida, C.1
Recher, C.2
Raffoux, E.3
-
36
-
-
0026528809
-
Mutations of the p53 gene in acute myeloid leukaemia
-
Fenaux P, Preudhomme C, Quiquandon I, et al. Mutations of the p53 gene in acute myeloid leukaemia. Br J Haematol. 1992;80:178-183.
-
(1992)
Br J Haematol
, vol.80
, pp. 178-183
-
-
Fenaux, P.1
Preudhomme, C.2
Quiquandon, I.3
-
37
-
-
0028172868
-
p53 mutations are associated with resistance to chemotherapy and short survival in hematologic malignancies
-
Wattel E, Preudhomme C, Hecquet B, et al. p53 mutations are associated with resistance to chemotherapy and short survival in hematologic malignancies. Blood. 1994;84:3148-3157.
-
(1994)
Blood
, vol.84
, pp. 3148-3157
-
-
Wattel, E.1
Preudhomme, C.2
Hecquet, B.3
-
38
-
-
61849183483
-
-
Kornblau SM, Barnett J, Qiu YH, et al. p53 protein expression levels are prognostic in AML and predict for mutational status [abstract]. Abstracts of the American Society of Hematology 40th Annual Meeting. December 8-11, 2007, Altanta, GA.
-
Kornblau SM, Barnett J, Qiu YH, et al. p53 protein expression levels are prognostic in AML and predict for mutational status [abstract]. Abstracts of the American Society of Hematology 40th Annual Meeting. December 8-11, 2007, Altanta, GA.
-
-
-
-
39
-
-
0032006805
-
Elevated expression of the apoptotic regulator Mcl-1 at the time of leukemic relapse
-
Kaufmann SH, Karp JE, Svingen PA, et al. Elevated expression of the apoptotic regulator Mcl-1 at the time of leukemic relapse. Blood. 1998;91:991-1000.
-
(1998)
Blood
, vol.91
, pp. 991-1000
-
-
Kaufmann, S.H.1
Karp, J.E.2
Svingen, P.A.3
-
40
-
-
0035845561
-
Inhibition of both paracrine and autocrine VEGF/ VEGFR-2 signaling pathways is essential to induce longterm remission of xenotransplanted human leukemias
-
Dias S, Hattori K, Heissig B, et al. Inhibition of both paracrine and autocrine VEGF/ VEGFR-2 signaling pathways is essential to induce longterm remission of xenotransplanted human leukemias. Proc Natl Acad Sci U S A. 2001;98:10857-10862.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 10857-10862
-
-
Dias, S.1
Hattori, K.2
Heissig, B.3
-
41
-
-
0037114642
-
In vivo administration of vascular endothelial growth factor (VEGF) and its antagonist, soluble neuropilin- 1, predicts a role of VEGF in the progression of acute myeloid leukemia in vivo
-
Schuch G, Machluf M, Bartsch G Jr, et al. In vivo administration of vascular endothelial growth factor (VEGF) and its antagonist, soluble neuropilin- 1, predicts a role of VEGF in the progression of acute myeloid leukemia in vivo. Blood. 2002; 100:4622-4628.
-
(2002)
Blood
, vol.100
, pp. 4622-4628
-
-
Schuch, G.1
Machluf, M.2
Bartsch Jr, G.3
-
42
-
-
0035896366
-
Protein kinase B (PKB/Akt): A key regulator of glucose transport?
-
Hajduch E, Litherland GJ, Hundal HS. Protein kinase B (PKB/Akt): a key regulator of glucose transport? FEBS Lett. 2001;492:199-203.
-
(2001)
FEBS Lett
, vol.492
, pp. 199-203
-
-
Hajduch, E.1
Litherland, G.J.2
Hundal, H.S.3
-
43
-
-
0033551070
-
New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
-
Cantley LC, Neel BG. New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc Natl Acad Sci U S A. 1999;96: 4240-4245.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 4240-4245
-
-
Cantley, L.C.1
Neel, B.G.2
-
44
-
-
0032431032
-
The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway
-
Wu X, Senechal K, Neshat MS, Whang YE, Sawyers CL. The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway. Proc Natl Acad Sci U S A. 1998;95:15587-15591.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 15587-15591
-
-
Wu, X.1
Senechal, K.2
Neshat, M.S.3
Whang, Y.E.4
Sawyers, C.L.5
-
45
-
-
61849090227
-
-
Kornblau SM, Qiu YH, Palla SL, et al. Patterns and prognostic impact of PI3K-AKT pathway activation, regulation and downstream activity in AML using reverse phase proteins arrays (RPPA) [abstract]. Abstracts of the American Society of Hematology 40th Annual Meeting. December 8-11, 2007, Atlanta, GA.
-
Kornblau SM, Qiu YH, Palla SL, et al. Patterns and prognostic impact of PI3K-AKT pathway activation, regulation and downstream activity in AML using reverse phase proteins arrays (RPPA) [abstract]. Abstracts of the American Society of Hematology 40th Annual Meeting. December 8-11, 2007, Atlanta, GA.
-
-
-
|