KATP channel-deficient pancreatic β-cells are streptozotocin resistant because of lower GLUT2 activity

American Journal of Physiology - Endocrinology and Metabolism

Volumn 294, Issue 2, 2008, Pages

  Xu, Jin ^a   Zhang, Li ^a   Chou, Andrew ^a   Allaby, Tim ^a   Bélanger, Guy ^a   Radziuk, Jerry ^a,b   Jasmin, Bernard J ^a,b   Miki, Takashi ^c   Seino, Susumo ^c   Renaud, Jean Marc ^a  

^a UNIVERSITY OF OTTAWA   (Canada)

^b OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^c KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Diabetic model; Glucose tolerance; Glucose transporter; Insulin; Knockout; Liver

Indexed keywords

GLUCOSE; GLUCOSE TRANSPORTER 2; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; POTASSIUM CHANNEL; STREPTOZOCIN; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; ANTINEOPLASTIC ANTIBIOTIC; INSULIN; INWARDLY RECTIFYING POTASSIUM CHANNEL; SLC2A2 PROTEIN, MOUSE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DISEASE MODEL; DRUG BLOOD LEVEL; DRUG LIVER LEVEL; DRUG RESPONSE; DRUG TISSUE LEVEL; DRUG TRANSPORT; IMMUNOFLUORESCENCE; MOUSE; MOUSE STRAIN; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN DEFECT; PROTEIN EXPRESSION; SINGLE DRUG DOSE; STREPTOZOCIN DIABETES; SYMPTOMATOLOGY; ANIMAL; BLOOD; C57BL MOUSE; CYTOSOL; DRUG EFFECT; DRUG RESISTANCE; EXPERIMENTAL DIABETES MELLITUS; FLUORESCENCE MICROSCOPY; GENETICS; GLUCOSE BLOOD LEVEL; IN VITRO STUDY; LIVER; METABOLISM; MOUSE MUTANT; PANCREAS; PANCREAS ISLET; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; WESTERN BLOTTING;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; BLOOD GLUCOSE; BLOTTING, WESTERN; CYTOSOL; DIABETES MELLITUS, EXPERIMENTAL; DRUG RESISTANCE; GLUCOSE TRANSPORTER TYPE 2; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; KATP CHANNELS; LIVER; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSCOPY, FLUORESCENCE; PANCREAS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; STREPTOZOCIN;

EID: 38949207551     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00296.2007     Document Type: Article

References (26)

1. Berger NA. Poly(ADP-ribose) in the cellular response to DNA damage. Radiation Research 101: 4-15, 1985.
2. Brosky G, Logothetopoulos J. Streptozotocin diabetes in the mouse and guinea pig. Diabetes 18: 606-611, 1969.
3. Burkart V, Wang ZQ, Radons J, Heller B, Herceg Z, Stingl L, Wagner EF, Kolb H. Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozotocin. Nat Med 5: 314-319, 1999.
4. Elsner M, Guldbakke B, Tiedge M, Munday R, Lenzen S. Relative importance of transport and alkylation for pancreatic beta-cell toxicity of streptozotocin. Diabetologia 43: 1528-1533, 2000.
5. Hosokawa M, Dolci W, Thorens B. Differential sensitivity of GLUT1-and GLUT2-expressing β cells to streptozotocin. Biochem Biophys Res Commun 289: 1114-1117, 2001.
6. KATP: an inward rectifier subunit plus the sulfonylurea receptor. Science 270: 1166-1170, 1995.
7. Junod A, Lambert AE, Stauffacher W, Renold AE. Diabetogenic action of streptozotocin: relationship of dose to metabolic response. J Clin Invest 48: 2129-2139, 1969.
8. max and Km of transport activity. J Biol Chem 267: 22550-22555, 1992.
9. ATP channel openers protect rat islets against the toxic effect of streptozotocin. Diabetes 49: 1131-1136, 2000.
10. Like AA, Rossini AA. Streptozotocin-induced pancreatic insulitis: new model of diabetes mellitus. Science 193: 415-417, 1976.
11. Marette A, Richardson JM, Ramlal T, Balon TW, Vranic M, Pessin JE, Klip A. Abundance, localization, and insulin-induced translocation of glucose transporters in red and white muscle. Am J Physiol Cell Physiol 263: C443-C452, 1992.
12. + channels in cell survival and differentiation in the endocrine pancreas. Diabetes 50, Suppl 1: S48-S51, 2001.
13. Miki T, Minami K, Zhang L, Morita M, Gonoi T, Shiuchi T, Minokoshi Y, Renaud JM, Seino S. ATP-sensitive potassium channels participate in glucose uptake in skeletal muscle and adipose tissue. Am J Physiol Endocrinol Metab 283: E1178-E1184, 2002.
14. ATP channel-deficient mice. Proc Natl Acad Sci USA 95: 10402-10406, 1998.
15. Oka Y, Asano T, Shibasaki Y, Lin JL, Tsukuda K, Katagiri H, Akanuma Y, Takaku F. C-terminal truncated glucose transporter is locked into an inward-facing form without transport activity. Nature 354: 550-553, 1990.
16. Pieper AA, Brat DJ, Krug DK, Watkins CC, Gupta A, Blackshaw S, Verma A, Wang ZQ, Snyder SH. Poly(ADP-ribose) polymerase-deficient mice are protected from streptozotocin-induced diabetes. Proc Natl Acad Sci USA 96: 3059-3064, 1999.
17. Renaud JM, Moon TW. Characterization of gluconeogenesis in hepatocytes isolated from the American eel, Anguilla rostrata LeSueur. J Comp Physiol 135: 115-125, 1980.
18. Robertson RP, Harmon J, Tran PO, Tanaka Y, Takahashi H. Glucose toxicity in β-cells: type 2 diabetes, good radicals gone bad, and the glutathione connection. Diabetes 52: 581-587, 2003.
19. Schnedl WJ, Ferber S, Johnson J, Newgard CB. STZ transport and cytotoxicity: specific enhancement of GLUT2-expressing cells. Diabetes 43: 1326-1333, 1994.
20. Seino S. ATP-sensitive potassium channels: a model of heteromultimeric potassium channel/receptor assemblies. Annu Rev Physiol 61: 637-662, 1999.
21. ATP channels learned from Kir62 genetically engineered mice. Diabetes 49: 311-318, 2002.
22. Steel RGD, Torrie JH. Principles and procedures of statistics. A biometrical approach. New York: McGraw-Hill, 1980.
23. Thorens B. A gene knockout approach in mice to identify glucose sensors controlling glucose homeostasis. Pflügers Arch 445: 482-490, 2003.
24. Thorens B, Sarker HK, Kaback HR, Lodish HF. Cloning and functional expression in bacteria of a novel glucose transporter present in liver, intestine, kidney, and pancreatic islet cells. J Cell Biol 55: 281-290, 1988.
25. Wollheim C, Meda P, Halban PA. Establishment and culture of insulin-secreting beta cell lines. Methods Enzymol 192: 223-235, 1990.
26. Zhao L, Li Z, Borg LA, Karlsson FA. Alterations in net glucose uptake in the pancreatic B-cell GLUT2 transporter induced by diazoxide and by secretory stimuli. J Endocr 185: 291-299, 2005.