Loss of Shp2-mediated mitogen-activated protein kinase signaling in Müller glial cells results in retinal degeneration

Molecular and Cellular Biology

Volumn 31, Issue 14, 2011, Pages 2973-2983

  Cai, Zhigang ^a   Simons, David L ^b   Fu, Xin Yuan ^a   Feng, Gen Sheng ^c   Wu, Samuel M ^b   Zhang, Xin ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CULLEN EYE INSTITUTE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

K RAS PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; PROTEIN TYROSINE PHOSPHATASE SHP 2; STAT3 PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL COUNT; CELL FUNCTION; CONTROLLED STUDY; ELECTRORETINOGRAM; ENZYME ACTIVATION; MOUSE; MUELLER CELL; NONHUMAN; PHOTORECEPTOR; PRIORITY JOURNAL; RETINA CELL; RETINA DEGENERATION; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CELL SURVIVAL; ELECTRORETINOGRAPHY; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; MAP KINASE SIGNALING SYSTEM; MICE; MICE, TRANSGENIC; MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 11; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS P21(RAS); PTEN PHOSPHOHYDROLASE; RAS PROTEINS; RETINA; RETINAL DEGENERATION; STAT3 TRANSCRIPTION FACTOR;

EID: 79960353847     PISSN: 02707306     EISSN: 10985549     Source Type: Journal    
DOI: 10.1128/MCB.05054-11     Document Type: Article

References (37)

1. Bringmann, A., et al. 2009. Cellular signaling and factors involved in Müller cell gliosis: neuroprotective and detrimental effects. Prog. Retin. Eye Res. 28:423-451.
2. Bringmann, A., et al. 2006. Müller cells in the healthy and diseased retina. Prog. Retin. Eye Res. 25:397-424.
3. Cai, Z., G.-S. Feng, and X. Zhang. 2010. Temporal requirement of the protein tyrosine phosphatase Shp2 in establishing the neuronal fate in early retinal development. J. Neurosci. 30:4110-4119.
4. Donovan, M., F. Doonan, and T. G. Cotter. 2011. Differential roles of ERK1/2 and JNK in retinal development and degeneration. J. Neurochem. 116:33-42.
5. Dubois-Dauphin, M., et al. 2000. Early postnatal Müller cell death leads to retinal but not optic nerve degeneration in NSE-Hu-Bcl-2 transgenic mice. Neuroscience 95:9-21.
6. Furuta, Y., O. Lagutin, B. L. Hogan, and G. C. Oliver. 2000. Retina- and ventral forebrain-specific Cre recombinase activity in transgenic mice. Genesis 26:130-132.
7. Goldberg, J. L., and B. A. Barres. 2000. The relationship between neuronal survival and regeneration. Annu. Rev. Neurosci. 23:579-612.
8. Groszer, M., et al. 2001. Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo. Science 294:2186-2189.
9. Harada, C., et al. 2011. Glia- and neuron-specific functions of TrkB signalling during retinal degeneration and regeneration. Nat. Commun. 2:189.
10. Harada, T., et al. 2000. Modification of glial-neuronal cell interactions prevents photoreceptor apoptosis during light-induced retinal degeneration. Neuron 26:533-541.
11. Harada, T., C. Harada, and L. F. Parada. 2007. Molecular regulation of visual system development: more than meets the eye. Genes Dev. 21:367- 378.
12. Hartong, D. T., E. L. Berson, and T. P. Dryja. 2006. Retinitis pigmentosa. Lancet 368:1795-1809.
13. Jadhav, A. P., K. Roesch, and C. L. Cepko. 2009. Development and neurogenic potential of Müller glial cells in the vertebrate retina. Prog. Retin. Eye Res. 28:249-262.
14. Joly, S., C. Lange, M. Thiersch, M. Samardzija, and C. Grimm. 2008. Leukemia inhibitory factor extends the lifespan of injured photoreceptors in vivo. J. Neurosci. 28:13765-13774.
15. Kennan, A., A. Aherne, and P. Humphries. 2005. Light in retinitis pigmentosa. Trends Genet. 21:103-110.
16. Kinkl, N., G. Hageman, J. Sahel, and D. Hicks. 2002. Fibroblast growth factor receptor (FGFR) and candidate signaling molecule distribution within rat and human retina. Mol. Vis. 14:149-160.
17. Li, G., et al. 2007. Nonredundant role of Akt2 for neuroprotection of rod photoreceptor cells from light-induced cell death. J. Neurosci. 27:203-211.
18. Marquardt, T., R. Ashery-Padan, N. Andrejewski, R. Scardigli, F. Guillemot, and P. Gruss. 2001. Pax6 is required for the multipotent state of retinal progenitor cells. Cell 105:43-55.
19. Moh, A., et al. 2007. Role of STAT3 in liver regeneration: survival, DNA synthesis, inflammatory reaction and liver mass recovery. Lab Invest. 87: 1018-1028.
20. Neel, B. G., H. Gu, and L. Pao. 2003. The ′Shp'ing news: SH2 domaincontaining tyrosine phosphatases in cell signaling. Trends Biochem. Sci. 28:284-293.
21. Ohtani, T., et al. 2000. Dissection of signaling cascades through gp130 in vivo: reciprocal roles for STAT3-and SHP2-mediated signals in immune responses. Immunity 12:95-105.
22. Ozawa, Y., et al. 2004. Downregulation of STAT3 activation is required for presumptive rod photoreceptor cells to differentiate in the postnatal retina. Mol. Cell. Neurosci. 26:258-270.
23. Pan, Y., C. Carbe, A. Powers, G. S. Feng, and X. Zhang. 2010. Sprouty2-modulated Kras signaling rescues Shp2 deficiency during lens and lacrimal gland development. Development 137:1085-1093.
24. Pan, Y., et al. 2008. Bud specific N-sulfation of heparan sulfate regulates Shp2-dependent FGF signaling during lacrimal gland induction. Development 135:301-310.
25. Pimentel, B., et al. 2000. c-Raf regulates cell survival and retinal ganglion cell morphogenesis during neurogenesis. J. Neurosci. 20:3254-3262.
26. Rajala, A., M. Tanito, Y. Z. Le, C. R. Kahn, and R. V. S. Rajala. 2008. Loss of neuroprotective survival signal in mice lacking insulin receptor gene in rod photoreceptor cells. J. Biol. Chem. 283:19781-19792.
27. Rattner, A., and J. Nathans. 2005. The genomic response to retinal disease and injury: evidence for endothelin signaling from photoreceptors to glia. J. Neurosci. 25:4540-4549.
28. Samardzija, M., et al. 2006. Differential role of Jak-STAT signaling in retinal degenerations. FASEB J. 20:2411-2413.
29. Stone, J., et al. 1999. Mechanisms of photoreceptor death and survival in mammalian retina. Prog. Retin. Eye Res. 18:689-735.
30. Tuveson, D. A., et al. 2004. Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects. Cancer Cell 5:375-387.
31. Ueki, Y., Y.-Z. Le, S. Chollangi, W. Muller, and J. D. Ash. 2009. Preconditioning-induced protection of photoreceptors requires activation of the signal-transducing receptor gp130 in photoreceptors. Proc. Natl. Acad. Sci. U. S. A. 106:21389-21394.
32. Wahlin, K. J., P. A. Campochiaro, D. J. Zack, and R. Adler. 2000. Neurotrophic factors cause activation of intracellular signaling pathways in Muller cells and other cells of the inner retina, but not photoreceptors. Invest. Ophthalmol. Vis. Sci. 41:927-936.
33. Wright, A. F., C. F. Chakarova, M. M. Abd El-Aziz, and S. S. Bhattacharya. 2010. Photoreceptor degeneration: genetic and mechanistic dissection of a complex trait. Nat. Rev. Genet. 11:273-284.
34. Xu, D., Q. C. 2008. Protein tyrosine phosphatases in the JAK/STAT pathway. Front. Biosci. 13:4925-4932.
35. Yi, X., et al. 2005. Insulin receptor substrate 2 is essential for maturation and survival of photoreceptor cells. J. Neurosci. 25:1240-1248.
36. Zack, D. J. 2000. Neurotrophic rescue of photoreceptors: are Müller cells the mediators of survival? Neuron 26:285-286.
37. Zhang, E. E., E. Chapeau, K. Hagihara, and G. S. Feng. 2004. Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism. Proc. Natl. Acad. Sci. U. S. A. 101:16064-16069.