Cytosine-phosphate-guanosine-DNA induces CD274 expression in human B cells and suppresses T helper type 2 cytokine production in pollen antigen-stimulated CD4-positive cells

Clinical and Experimental Immunology

Volumn 169, Issue 1, 2012, Pages 1-9

  Kubo, S ^a   Yamada, T ^a   Osawa, Y ^a   Ito, Y ^a   Narita, N ^a   Fujieda, S ^a  

^a UNIVERSITY OF FUKUI   (Japan)

Author keywords

CD274; CpG; Cry j 1; Human B cells; Th2 cytokine

Indexed keywords

BETA ACTIN; CD30 LIGAND; CD4 ANTIGEN; CPG OLIGODEOXYNUCLEOTIDE; CRY J 1 ANTIGEN; CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE T CELL COSTIMULATOR LIGAND; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 5; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; POLLEN ANTIGEN; PROGRAMMED DEATH 1 LIGAND 1; STRESS ACTIVATED PROTEIN KINASE; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ALLERGIC RHINITIS; ANTIGEN EXPRESSION; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOMODULATION; IMMUNOREGULATION; INFLAMMATION; INTERFERON PRODUCTION; JAPANESE CEDAR; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH2 CELL;

ADJUVANTS, IMMUNOLOGIC; ANTIGENS, CD274; ANTIGENS, PLANT; B-LYMPHOCYTES; CELL COMMUNICATION; CELLS, CULTURED; CYTOKINES; HUMANS; INDUCIBLE T-CELL CO-STIMULATOR LIGAND; INTERFERON-GAMMA; INTERLEUKIN-12; INTERLEUKIN-13; INTERLEUKIN-5; LYMPHOCYTE ACTIVATION; NF-KAPPA B P50 SUBUNIT; OLIGODEOXYRIBONUCLEOTIDES; PLANT PROTEINS; POLLEN; PROGRAMMED CELL DEATH 1 RECEPTOR; RHINITIS, ALLERGIC, SEASONAL; TH2 CELLS;

EID: 84861760054     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2012.04585.x     Document Type: Article

References (27)

1. Lombardi V, Singh AK, Akbari O. The role of costimulatory molecules in allergic disease and asthma. Int Arch Allergy Immunol 2010; 151:179-89.
2. Folkl A, Bienzle D. Structure and function of programmed death (PD) molecules. Vet Immunol Immunopathol 2010; 134:33-8.
3. Heinecke L, Proud D, Sanders S, Schleimer R, Kim J. Induction of B7-H1 and B7-DC expression on airway epithelial cells by the Toll-like receptor 3 agonist double-stranded RNA and human rhinovirus infection: in vivo and in vitro studies. J Allergy Clin Immunol 2008; 121:1155-60.
4. Allam J, Peng W, Appel T etal. Toll-like receptor 4 ligation enforces tolerogenic properties of oral mucosal Langerhans cells. J Allergy Clin Immunol 2008; 121:368-74.
5. Liu N, Ohnishi N, Ni L, Akira S, Bacon K. CpG directly induces T-bet expression and inhibits IgG1 and IgE switching in B cells. Nat Immunol 2003; 4:687-93.
6. Fujieda S, Iho S, Kimura Y, Yamamoto H, Igawa H, Saito H. Synthetic oligodeoxynucleotides inhibit IgE induction in human lymphocytes. Am J Respir Crit Care Med 2000; 162:232-9.
7. Iskra S, Kalla M, Delecluse H, Hammerschmidt W, Moosmann A. Toll-like receptor agonists synergistically increase proliferation and activation of B cells by Epstein-Barr virus. J Virol 2010; 84:3612-23.
8. Carpenter EL, Mick R, Rüter J, Vonderheide RH. Activation of human B cells by the agonist CD40 antibody CP-870, 893 and augmentation with simultaneous Toll-like receptor 9 stimulation. J Transl Med 2009; 7:93.
9. Han SH, Kim YE, Park JA etal. Expression of human beta-defensin-2 gene induced by CpG-DNA in human B cells. Biochem Biophys Res Commun 2009; 389:443-8.
10. Osawa Y, Iho S, Takauji R etal. Collaborative action of NF-kappaB and p38 MAPK is involved in CpG DNA-induced IFN-alpha and chemokine production in human plasmacytoid dendritic cells. J Immunol 2006; 177:4841-52.
11. Yamamoto H, Yamada T, Takabayashi T etal. Platelet derived endothelial cell growth factor/thymidine phosphorylase enhanced human IgE production. Allergol Int 2011; 60:79-85.
12. Chen YQ, Shi HZ. CD28/CTLA-4-CD80/CD86 and ICOS-B7RP-1 costimulatory pathway in bronchial asthma. Allergy 2006; 61:15-26.
13. Fuchiwaki T, Sun X, Fujimura K etal. The central role of CD30L/CD30 interactions in allergic rhinitis pathogenesis in mice. Eur J Immunol 2011; 41:2947-54.
14. Klaschik S, Tross D, Shirota H, Klinman DM. Short- and long-term changes in gene expression mediated by the activation of TLR9. Mol Immunol 2010; 47:1317-24.
15. Crompton PD, Mircetic M, Weiss G etal. The TLR9 ligand CpG promotes the acquisition of Plasmodium falciparum-specific memory B cells in malaria-naive individuals. J Immunol 2009; 182:3318-26.
16. Eckl-Dorna J, Batista FD. BCR-mediated uptake of antigen linked to TLR9 ligand stimulates B-cell proliferation and antigen-specific plasma cell formation. Blood 2009; 113:3969-77.
17. San Román B, Irache JM, Gómez S, Gamazo C, Espuelas S. Co-delivery of ovalbumin and CpG motifs into microparticles protected sensitized mice from anaphylaxis. Int Arch Allergy Immunol 2009; 149:111-8.
18. Tan L, Rogers TJ, Hatzirodos N, Baker LM, Ooi E, Wormald PJ. Immunomodulatory effect of cytosine-phosphate-guanosine (CpG)-oligonucleotides in nonasthmatic chronic rhinosinusitis: an explant model. Am J Rhinol Allergy 2009; 23:123-9.
19. Yang W, Li H, Chen PW etal. PD-L1 expression on human ocular cells and its possible role in regulating immune-mediated ocular inflammation. Invest Ophthalmol Vis Sci 2009; 50:273-80.
20. Wilcox RA, Feldman AL, Wada DA etal. B7-H1 (PD-L1, CD274) suppresses host immunity in T-cell lymphoproliferative disorders. Blood 2009; 114:2149-58.
21. Xu W, Tamura T, Takatsu K. CpG ODN mediated prevention from ovalbumin-induced anaphylaxis in mouse through B cell pathway. Int Immunopharmacol 2008; 8:351-61.
22. Marzec M, Zhang Q, Goradia A etal. Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1). Proc Natl Acad Sci USA 2008; 105:20852-7.
23. Wölfle SJ, Strebovsky J, Bartz H etal. PD-L1 expression on tolerogenic APCs is controlled by STAT-3. Eur J Immunol 2011; 41:413-24.
24. Senti G, Johansen P, Haug S etal. Use of A-type CpG oligodeoxynucleotides as an adjuvant in allergen-specific immunotherapy in humans: a phase I/IIa clinical trial. Clin Exp Allergy 2009; 39:562-70.
25. Carnés J, Robinson DS. New strategies for allergen immunotherapy. Recent Pat Inflamm Allergy Drug Discov 2008; 2:92-101.
26. Okazaki T, Honjo T. PD-1 and PD-1 ligands: from discovery to clinical application. Int Immunol 2007; 19:813-24.
27. Kroczek R, Hamelmann E. T-cell costimulatory molecules: optimal targets for the treatment of allergic airway disease with monoclonal antibodies. J Allergy Clin Immunol 2005; 116:906-9.