Thermal analysis and dissolution characteristics of nifedipine solid dispersions

Journal of Food and Drug Analysis

Volumn 20, Issue 1, 2012, Pages

  Wu, Jui Yu ^a   Ho, Hsiu O ^b   Chen, Ying Chen ^b   Chen, Chi Chia ^b   Sheu, Ming Thau ^b  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Dissolution; Fusion; Nifedipine; Solid dispersion; Thermal analysis

Indexed keywords

GELUCIRE; NIFEDIPINE; POLYETHYLENE;

ARTICLE; CRYSTALLIZATION; DRUG SOLUBILITY; MELTING POINT; SOLVENT EFFECT; TEMPERATURE; THERMAL ANALYSIS;

EID: 84861746000     PISSN: 10219498     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Fincher, J. H. 1968. Particle size of drugs and its relationship to absorption and activity. J. Pharm. Sci. 57: 1825-1835.
2. Shah, J. C., Chen, J. R. and Chow, D. 1999. Metastable polymorph of etoposide with higher dissolution rate. Drug Dev. Ind. Pharm. 25: 63-67. (Pubitemid 29071486)
3. Rabel, S. R., Jona, J. A. and Maurin, M. B. 1999. Applications of modulated differential scanning calorimetry in preformulation studies. J. Pharm. Biomed. Anal. 21: 339-345. (Pubitemid 29502571)
4. Pan, R. N., Chen, J. H. and Chen, R. R. L. 2000. Enhancement of dissolution and bioavailability of piroxicam in solid dispersion systems. Drug Dev. Ind. Pharm. 26: 989-994.
5. Ofoefule, S. I. 1997. Effect of polyethyleneglycol 4000 (PEG4000) solution on the in vitro release profile of nifedipine from polymer matrices. Biol. Pharm. Bull. 20: 574-576. (Pubitemid 27250648)
6. Ford, J. L. 1986. The current status of solid dispersions. Pharm. Acta Helv. 61: 69-88. (Pubitemid 16134014)
7. Aoki, K., Sato, K., Kawaguchi, Y. and Yamamoto, M. 1982. Acute and long-term hypotensive effects and plasma concentrations of nifedipine in patients with essential hypertension. Eur. J. Clin. Pharmacol. 23: 197-201. (Pubitemid 12028453)
8. Sugimoto, I., Sasaki, K. and Kuchiki, A. 1982. Stability and bioavailability of nifedipine in fine granules. Chem. Pharm. Bull. 30: 4479-4488. (Pubitemid 13185657)
9. Lin, C. W. and Cham, T. M. 1996. Effect of particle size on the available surface area of nifedipine from nifedipine-polyethylene glycol 6000 solid dispersions. Int. J. Pharm. 127: 261-272.
10. Suzuki, H. and Sunada, H. 1997. Comparison of nicotin-amide, ethylurea and polyethylene glycol as carriers for nifedipine solid dispersion systems. Chem. Pharm. Bull. 45: 1688-1693. (Pubitemid 27488434)
11. Ntawukulilyayo, J. D., Bouckaert, S. and Remon, J. P. 1993. Enhancement of dissolution rate of nifedipine using sucrose ester coprecipitates. Int. J. Pharm. 93: 209-214. (Pubitemid 23181298)
12. Chutimaworapan, S., Ritthidej, G. C., Yonemochi, E., Oguchi, T. and Yamamoto, K. 2000. Effect of water-soluble carriers on dissolution characteristics of nifedipine solid dispersions. Drug Dev. Ind. Pharm. 26: 1141-1150.
13. Rajebahadur, M., Zia, H., Nues, A. and Lee, C. 2006. Mechanistic study of solubility enhancement of nifedipine using vitamin E TPGS or solutol HS-15. Drug Deliv. 13: 201-206.
14. Bley, H., Fussnegger, B. and Bodmeier, R. 2010. Characterization and stability of solid dispersions based on PEG/polymer blends. Int. J. Pharm. 390: 165-173.
15. Sugimoto, I., Kuchiki, A. and Nakagawa, H. 1981. Stability of nifedipine-polyvinylpyrrolidone coprecipitate. Chem. Pharm. Bull. 29: 1715-1723. (Pubitemid 11053876)
16. Suzuki, H. and Sunada, H. 1998. Influence of water-soluble polymers on the dissolution of Nifedipine solid dispersions with combined carriers. Chem. Pharm. Bull. 46: 482-487. (Pubitemid 28188567)
17. Ho, H. O., Su, H. L., Tsai, T. and Sheu, M. T. 1996. The preparation and characterization of solid dispersions on pellets using a fluidized-bed system. Int. J. Pharm. 139: 223-229. (Pubitemid 26276286)
18. Nakamichi, K., Nakano, T., Yasuura, H., Izumi, S. and Kawashima, Y. 2002. The role of the kneading paddle and the effects of screw revolution speed and water content on the preparation of solid dispersions using a twin-screw extruder. Int. J. Pharm. 241: 203-211. (Pubitemid 34718022)
19. Vippagunta, S. R., Maul, K. A., Tallavajhala, S. and Grant, D. J. W. 2002. Solid-state characterization of nifedipine solid dispersions. Int. J. Pharm. 236: 111-123. (Pubitemid 34219378)
20. Kanagale, P., Patel, V., Venkatesan, N., Jain, M., Patel, P. and Misra, A. 2008. Pharmaceutical development of solid dispersion based osmotic drug delivery system for nifedipine. Curr. Drug Deliv. 5: 306-311.
21. Li, L., AbuBaker, O. and Shao, Z. J. 2006. Characterization of poly(ethylene oxide) as a drug carrier in hot-melt extrusion. Drug Dev. Ind. Pharm. 32: 991-1002. (Pubitemid 44359761)
22. Sugamura, Y., Fujii, M., Nakanishi, S., Suzuki, A., Shibata, Y., Koizumi, N. and Watanabe, Y. 2011. Effect of particle size of drug on conversion of crystals to an amorphous state in a solid dispersion with crospovidone. Chem. Pharm. Bull. 59: 235-238.
23. Tanno, F., Nishiyama, Y., Kokubo, H. and Obara, S. 2004. Evaluation of hypromellose acetate succinate (HPMCAS) as a carrier in solid dispersions. Drug Dev. Ind. Pharm. 30: 9-17. (Pubitemid 38240471)
24. Aso, Y., Yoshioka, S., Miyazaki, T., Kawanishi, T., Tanaka, K., Kitamura, S., Takakura, A., Hayashi, T. and Muranushi, N. 2007. Miscibility of nifedipine and hydrophilic polymers as measured by 1H-NMR spin-lattice relaxation. Chem. Pharm. Bull. 55: 1227-1231. (Pubitemid 47344979)
25. Rumondor, A. C. F., Ivanisevic, I., Bates, S., Alonzo, D. E. and Taylor, L. S. 2009. Evaluation of drug-polymer miscibility in amorphous solid dispersion systems. Pharm. Res. 26: 2523-2534.
26. Srinarong, P., Kouwen, S., Visser, M. R., Hinrichs, W. L. J. and Frijlink, H. W. 2010. Effect of drug-carrier interaction on the dissolution behavior of solid dispersion tablets. Pharm. Dev. Technol. 15: 460-468.
27. Marsac, P. J., Konno, H., Rumondor, A. C. F. and Taylor, L. S. 2007. Recrystallization of nifedipine and felodipine from amorphous molecular level solid dispersions containing poly(vinylpyrrolidone) and sorbed water Pharm. Res. 25: 647-656. (Pubitemid 351357733)
28. Rumondor, A. C. F., Marsac, P. J., Stanford, L. A. and Taylor, L. S. 2009. Phase behavior of poly(vinylpyrrolidone) containing amorphous solid dispersions in the presence of moisture. Mol. Pharm. 6: 1492-1505.
29. Ho, H. O., Chen, C. N. and Sheu, M. T. 2000. Influence of pluronic F-68 on dissolution and bioavailability characteristics of multiple-layer pellets of nifedipine for controlled release delivery. J. Control Release. 68: 433-440.
30. Plato, C. and Glasgow, A. R. Jr. 1969. Differential scanning calorimetry as a general method for determining the purity and heat of fusion of high-purity organic chemicals. Application to 95 compounds. Anal. Chem. 41: 330-336.