In utero and early-life exposure of rats to a Wi-Fi signal: Screening of immune markers in sera and gestational outcome

Bioelectromagnetics

Volumn 33, Issue 5, 2012, Pages 410-420

  Aït Aïssa, Saliha ^a,b   Billaudel, Bernard ^a   Poulletier de Gannes, Florence ^a   Ruffié, Gilles ^a   Duleu, Sébastien ^c   Hurtier, Annabelle ^a   Haro, Emmanuelle ^a   Taxile, Murielle ^a   Athané, Axel ^b   Geffard, Michel ^a,c   Wu, Tongning ^d   Wiart, Joe ^e   Bodet, Dominique ^f   Veyret, Bernard ^a,b   Lagroye, Isabelle ^a,b  

^a UNIVERSITÉ BORDEAUX 1   (France)

^b PSL RESEARCH UNIVERSITY   (France)

^c Institute for Development of Human and Therapeutic Pathology Research   (France)

^d China Academy of Telecommunication Research of MIIT   (China)

^e ORANGE LABS   (France)

^f Gemacbio   (France)

Author keywords

Circulating antibodies; Delivery outcome; Immune biomarkers; In utero exposure; Perinatal exposure; Toxicity markers; Wi Fi; Young animals

Indexed keywords

BIOMARKERS; RATS; REVERBERATION;

CIRCULATING ANTIBODY; DELIVERY OUTCOME; EARLIEST LIFE; EXPERIMENTAL APPROACHES; IMMUNE BIOMARKERS; IN UTERO EXPOSURE; PERINATAL EXPOSURE; SPECIFIC ABSORPTION RATE; TOXICITY MARKER; YOUNG ANIMAL;

ANTIBODIES;

ANIMALIA; RATTUS;

ANTIBODY; BIOLOGICAL MARKER;

ANIMAL; ARTICLE; BLOOD; BODY SIZE; DELIVERY; ENVIRONMENTAL EXPOSURE; FEMALE; FOLLOW UP; GROWTH, DEVELOPMENT AND AGING; IMMUNOLOGY; LITTER SIZE; PREGNANCY; PREGNANCY OUTCOME; RADIATION EXPOSURE; RADIOFREQUENCY RADIATION; RAT; WIRELESS COMMUNICATION; WISTAR RAT;

ANIMALS; ANTIBODIES; BIOLOGICAL MARKERS; BODY SIZE; DELIVERY, OBSTETRIC; FEMALE; FOLLOW-UP STUDIES; GROWTH AND DEVELOPMENT; LITTER SIZE; MATERNAL EXPOSURE; PREGNANCY; PREGNANCY OUTCOME; RADIO WAVES; RATS; RATS, WISTAR; WIRELESS TECHNOLOGY;

EID: 84861741210     PISSN: 01978462     EISSN: 1521186X     Source Type: Journal    
DOI: 10.1002/bem.21699     Document Type: Article

References (51)

1. Amara A, Chaugier C, Ragnaud JM, Geffard M. 1994. Circulating autoantibodies directed against conjugated fatty acids in sera of HIV-1-infected patients. Clin Exp Immunol 96: 379-383.
2. Baran H, Jellinger K, Deecke L. 1999. Kynurenine metabolism in Alzheimer's disease. J Neural Transm 106: 165-181.
3. Berman E, Carter HB, House D. 1984. Growth and development of mice offspring after irradiation in utero with 2450-MHz microwaves. Teratology 30: 393-402.
4. Boullerne A, Petry KG, Geffard M. 1996. Circulating antibodies directed against conjugated fatty acids in sera of patients with multiple sclerosis. J Neuroimmunol 65: 75-81.
5. Capri M, Mesirca P, Remondini D, Carosella S, Pasi S, Castellani G, Franceschi C, Bersani F. 2004. 50Hz sinusoidal magnetic fields do not affect human lymphocyte activation and proliferation in vitro. Phys Biol 1: 211-219.
6. Chagnaud JL, Veyret B. 1999. In vivo exposure of rats to GSM-modulated microwaves: Flow cytometry analysis of lymphocyte subpopulations and of mitogen stimulation. Int J Radiat Biol 75: 111-113.
7. Chahoud I, Paumgartten FJ. 2009. Influence of litter size on the postnatal growth of rat pups: Is there a rationale for litter-size standardization in toxicity studies? Environ Res 109: 1021-1027.
8. Duleu S, Van Der Velden C, Poulletier de Gannes F, Tranchant MC, Geffard M. 2007. Circulating antibodies to NO- and ONOO-modified antigens in amyotrophic lateral sclerosis, Alzheimer's disease and multiple sclerosis. Immuno-Anal Biol Spéc 22(5): 273-281.
9. Ema M, Miyawaki E, Hirose A, Kamata E. 2003. Decreased anogenital distance and increased incidence of undescended testes in fetuses of rats given monobenzyl phthalate, a major metabolite of butyl benzyl phthalate. Reprod Toxicol 17: 407-412.
10. Faiderbe S, Chagnaud JL, Geffard M. 1992. Identification and characterization of a specific auto antiphosphatidylinositol immune response during the time course of benzo(a)pyrene-induced malignant tumors in female Sprague-Dawley rats. Cancer Res 52: 2862-2865.
11. Faiderbe S, Chagnaud JL, Geffard M. 1995. Chemically induced sarcomas in Sprague-Dawley rats: Dose effects on autoantibody levels and tumor progression. Cancer Detect Prev 19: 274-277.
12. Ferreira AR, Knakievicz T, Pasquali MA, Gelain DP, Dal-Pizzol F, Fernández CE, de Salles AA, Ferreira HB, Moreira JC. 2006. Ultra high frequency-electromagnetic field irradiation during pregnancy leads to an increase in erythrocytes micronuclei incidence in rat offspring. Life Sci 80: 43-50.
13. Finnie JW, Blumbergs PC, Cai Z, Manavis J, Kuchel TR. 2006. Effect of mobile telephony on blood-brain barrier permeability in the fetal mouse brain. Pathology 38: 63-65.
14. Finnie JW, Chidlow G, Blumbergs PC, Manavis J, Cai Z. 2009. Heat shock protein induction in fetal mouse brain as a measure of stress after whole of gestation exposure to mobile telephony radiofrequency fields. Pathology 41: 276-279.
15. Gallavan RH, Holson JF, Stump DG, Knapp JF, Reynolds VL. 1999. Interpreting the toxicologic significance of alterations in anogenital distance: Potential for confounding effects of progeny body weights. Reprod Toxicol 13: 383-390.
16. Galler JR, Turkewitz G. 1975. Variability of the effects of rearing in a large litter on the development of the rat. Dev Psychobiol 8: 325-331.
17. Galvin MJ, MacNichols G, McRee DI. 1983. Effects of 2450MHz microwave radiation during the gestational period on the postnatal hematology of rats. Cell Biophys 5: 33-41.
18. Gatta L, Pinto R, Ubaldi V, Pace L, Galloni P, Lovisolo GA, Marino C, Pioli C. 2003. Effects of in vivo exposure to GSM-modulated 900MHz radiation on mouse peripheral lymphocytes. Radiat Res 160: 600-605.
19. Geffard M, Seguela P, Heinrich-Rock AM. 1984. Antisera against catecholamines: Specificity studies and physicochemical data for anti-dopamine and anti-P-tyramine antibodies. Mol Immunol 21: 515-522.
20. Grune T, Michel P, Sitte N, Eggert W, Albrecht-Nebe H, Esterbauer H, Siems WG. 1997. Increased levels of 4-hydroxynonenal modified proteins in plasma of children with autoimmune diseases. Free Radic Biol Med 23: 357-360.
21. Holladay SD, Smialowicz RJ. 2000. Development of the murine and human immune system: Differential effects of immunotoxicants depend on time of exposure. Environ Health Perspect 108(SUPPL 3): S463-S473.
22. Huang PC, Kuo PL, Chou YY, Lin SJ, Lee CC. 2009. Association between prenatal exposure to phthalates and the health of newborns. Environ Int 35: 14-20.
23. Iguchi T, Uesugi Y, Takasugi N, Petrow V. 1991. Quantitative analysis of the development of genital organs from the urogenital sinus of the fetal male mouse treated prenatally with a 5 alpha-reductase inhibitor. J Endocrinol 128: 395-401.
24. Jaswal S, Mehta HC, Sood AK, Kaur J. 2003. Antioxidant status in rheumatoid arthritis and role of antioxidant therapy. Clin Chim Acta 338: 123-129.
25. Jauch D, Urbańska EM, Guidetti P, Bird ED, Vonsattel JP, Whetsell WO, Schwarcz R. 1995. Dysfunction of brain kynurenic acid metabolism in Huntington's disease: Focus on kynurenine aminotransferases. J Neurol Sci 130: 39-47.
26. Jen KC, Wehmer F, Morofski J. 1978. Effects of undernutrition and litter size on material variables and pup development. Dev Psychobiol 11: 279-287.
27. Jensh RP. 1997. Behavioral teratologic studies using microwave radiation: Is there an increased risk from exposure to cellular phones and microwave ovens? Reprod Toxicol 11: 601-611.
28. Kepplinger B, Baran H, Kainz A, Ferraz-Leite H, Newcombe J, Kalina P. 2005. Age-related increase of kynurenic acid in human cerebrospinal fluid-IgG and beta2-microglobulin changes. Neurosignals 14: 126-135.
29. Kuribayashi M, Wang J, Fujiwara O, Doi Y, Nabae K, Tamano S, Ogiso T, Asamoto M, Kurien BT, Hensley K, Bachmann M, Scofield RH. 2006. Oxidatively modified autoantigens in autoimmune diseases. Free Radic Biol Med 41: 549-556.
30. Kurimoto C, Kawano S, Tsuji G, Hatachi S, Jikimoto T, Sugiyama D, Kasagi S, Komori T, Nakamura H, Yodoi J, Kumagai S. 2007. Thioredoxin may exert a protective effect against tissue damage caused by oxidative stress in salivary glands of patients with Sjögren's syndrome. J Rheumatol 34: 2035-2043.
31. Luster MI, Dean JH, Germolec DR. 2003. Consensus workshop on methods to evaluate developmental immunotoxicity. Environ Health Perspect 111(4): 579-583.
32. Maneta-Peyret L, Daverat P, Geffard M, Cassagne C, Orgogozo JM. 1987. Natural seric anti-fatty acid antibodies in multiple sclerosis. Neurosci Lett 80: 235-239.
33. Mangas A, Coveñas R, Bodet D, De León M, Duleu S, Geffard M. 2008. Evaluation of the effects of a new drug candidate (GEMSP) in a chronic EAE model. Int J Biol Sci 4: 150-160.
34. Nasta F, Prisco MG, Pinto R, Lovisolo GA, Marino C, Pioli C. 2006. Effects of GSM-modulated radiofrequency electromagnetic fields on B-cell peripheral differentiation and antibody production. Radiat Res 165: 664-670.
35. Ogawa T, Matson WR, Beal MF, Myers RH, Bird ED, Milbury P, Saso S. 1992. Kynurenine pathway abnormalities in Parkinson's disease. Neurology 42: 1702-1706.
36. Ogawa K, Nabae K, Wang J, Wake K, Watanabe S, Kawabe M, Fujiwara O, Takahashi S, Ichihara T, Tamano S, Shirai T. 2009. Effects of gestational exposure to 1.95-GHz W-CDMA signals for IMT-2000 cellular phones: Lack of embryotoxicity and teratogenicity in rats. Bioelectromagnetics 30: 205-212.
37. Otto M, von Mühlendahl KE. 2007. Electromagnetic fields (EMF): Do they play a role in children's environmental health (CEH)? Int J Hyg Environ Health 210: 635-644.
38. Poulletier de Gannes F, Taxile M, Duleu S, Hurtier A, Haro E, Geffard M, Ruffié G, Billaudel B, Lévêque P, Dufour P, Lagroye I, Veyret B. 2009. A confirmation study of Russian and Ukrainian data on effects of 2450MHz microwave exposure on immunological processes and teratology in rats. Radiat Res 172: 617-624.
39. Prisco MG, Nasta F, Rosado MM, Lovisolo GA, Marino C, Pioli C. 2008. Effects of GSM-modulated radiofrequency electromagnetic fields on mouse bone marrow cells. Radiat Res 170: 803-810.
40. Salauze L, van der Velden C, Lagroye I, Veyret B, Geffard M. 2005. Circulating antibodies to cysteinyl catecholamines in amyotrophic lateral sclerosis and Parkinson's disease patients. Amyotroph Lateral Scler Other Motor Neuron Disord 6: 226-233.
41. Sambucci M, Laudisi F, Nasta F, Pinto R, Lodato R, Altavista P, Lovisolo GA, Marino C, Pioli C. 2010. Prenatal exposure to non-ionizing radiation: Effects of Wi-Fi signals on pregnancy outcome, peripheral B-cell compartment and antibody production. Radiat Res 174(6): 732-740.
42. Seneş M, Kazan N, Coşkun O, Zengi O, Inan L, Yücel D. 2007. Oxidative and nitrosative stress in acute ischaemic stroke. Ann Clin Biochem 44: 43-47.
43. Skakkebaek NE, Rajpert-De Meyts E, Main KM. 2001. Testicular dysgenesis syndrome: An increasingly common developmental disorder with environmental aspects. Hum Reprod 16: 972-978.
44. Smialowicz RJ. 2002. The rat as a model in developmental immunotoxicology. Hum Exp Toxicol 21(9-10): 513-519.
45. Sommer AM, Grote K, Reinhardt T, Streckert J, Hansen V, Lerchl A. 2009. Effects of radiofrequency electromagnetic fields (UMTS) on reproduction and development of mice: A multi-generation study. Radiat Res 171: 89-95.
46. Spencer JP, Whiteman M, Jenner P, Halliwell B. 2002. 5-s-Cysteinyl-conjugates of catecholamines induce cell damage, extensive DNA base modification and increases in caspase-3 activity in neurons. J Neurochem 81: 122-129.
47. Stankiewicz W, Dabrowski MP, Kubacki R, Sobiczewska E, Szmigielski S. 2006. Immunotropic influence of 900MHz microwave GSM signal on human blood immune cells activated in vitro. Electromagn Biol Med 25: 45-51.
48. Takahashi S, Imai N, Nabae K, Wake K, Kawai H, Wang J, Watanabe S, Kawabe M, Fujiwara O, Ogawa K, Tamano S, Shirai T. 2010. Lack of adverse effects of whole-body exposure to a mobile telecommunication electromagnetic field on the rat fetus. Radiat Res 173: 362-372.
49. Tuschl H, Novak W, Molla-Djafari H. 2006. In vitro effects of GSM modulated radiofrequency fields on human immune cells. Bioelectromagnetics 27: 188-196.
50. Wu T, Hadjem A, Wong MF, Gati A, Picon O, Wiart J. 2010. Whole-body new-born and young rats' exposure assessment in a reverberating chamber operating at 2.4GHz. Phys Med Biol 55: 1619-1630.
51. Yoshikawa T, Hara T, Tsurumi H, Goto N, Hoshi M, Kitagawa J, Kanemura N, Kasahara S, Ito H, Takemura M, Saito K, Seishima M, Takami T, Moriwaki H. 2009. Serum concentration of L-kynurenine predicts the clinical outcome of patients with diffuse large B-cell lymphoma treated with R-CHOP. Eur J Haematol 84: 304-309.