메뉴 건너뛰기




Volumn 14, Issue 3, 2005, Pages 126-135

Age-related increase of kynurenic acid in human cerebrospinal fluid - IgG and β2-microglobulin changes

Author keywords

2 microglobulin; Ageing; Cerebrospinal fluid; IgG; Kynurenic acid

Indexed keywords

BETA 2 MICROGLOBULIN; BIOLOGICAL MARKER; IMMUNOGLOBULIN G; KYNURENIC ACID; KYNURENINE AMINOTRANSFERASE;

EID: 23844467167     PISSN: 1424862X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000086295     Document Type: Article
Times cited : (74)

References (68)
  • 1
    • 0024093449 scopus 로고
    • Glutamate neurotoxicity and diseases of the nervous system
    • Choi DW: Glutamate neurotoxicity and diseases of the nervous system. Neuron 1988;1:623-634.
    • (1988) Neuron , vol.1 , pp. 623-634
    • Choi, D.W.1
  • 2
    • 0025063609 scopus 로고
    • Excitatory amino acid neurotoxicity and neurodegenerative disease
    • Meldrum B, Garthwaite J: Excitatory amino acid neurotoxicity and neurodegenerative disease. Trends Pharmacol Sci 1990;11:379-387.
    • (1990) Trends Pharmacol Sci , vol.11 , pp. 379-387
    • Meldrum, B.1    Garthwaite, J.2
  • 3
    • 0034125843 scopus 로고    scopus 로고
    • On neurodegenerative diseases, models, and treatment strategies: Lessons learned and lessons forgotten a generation following the cholinergic hypothesis
    • Bartus RT: On neurodegenerative diseases, models, and treatment strategies: Lessons learned and lessons forgotten a generation following the cholinergic hypothesis. Exp Neurol 2000;163:495-529.
    • (2000) Exp Neurol , vol.163 , pp. 495-529
    • Bartus, R.T.1
  • 4
    • 0027486072 scopus 로고
    • Neuropharmacology of quinolinic and kynurenic acids
    • Stone TW: Neuropharmacology of quinolinic and kynurenic acids. Pharmacol Rev 1993;45:309-379.
    • (1993) Pharmacol Rev , vol.45 , pp. 309-379
    • Stone, T.W.1
  • 5
    • 0035478066 scopus 로고    scopus 로고
    • The brain metabolite kynurenic acid inhibits α7 nicotinic receptor activity and increases non-α7 nicotinic receptor expression: Physiopathological implications
    • Hilmas C, Pereira EFR, Alkondon M, Rassoulpour A, Schwarcz R, Albuquerque EX: The brain metabolite kynurenic acid inhibits α7 nicotinic receptor activity and increases non-α7 nicotinic receptor expression: Physiopathological implications. J Neurosci 2001;21:7463-7473.
    • (2001) J Neurosci , vol.21 , pp. 7463-7473
    • Hilmas, C.1    Pereira, E.F.R.2    Alkondon, M.3    Rassoulpour, A.4    Schwarcz, R.5    Albuquerque, E.X.6
  • 6
    • 0021186590 scopus 로고
    • Kynurenic acid blocks neurotoxicity and seizures induced in rats by the related brain metabolite quinolinic acid
    • Foster AC, Vezzani A, French ED, Schwarcz R: Kynurenic acid blocks neurotoxicity and seizures induced in rats by the related brain metabolite quinolinic acid. Neurosci Lett 1984;48:273-278.
    • (1984) Neurosci Lett , vol.48 , pp. 273-278
    • Foster, A.C.1    Vezzani, A.2    French, E.D.3    Schwarcz, R.4
  • 7
    • 0035123904 scopus 로고    scopus 로고
    • Kynurenines in the CNS: From endogenous obscurity to therapeutic importance
    • Stone TW: Kynurenines in the CNS: From endogenous obscurity to therapeutic importance. Prog Neurobiol 2001;64:185-218.
    • (2001) Prog Neurobiol , vol.64 , pp. 185-218
    • Stone, T.W.1
  • 8
    • 0033058001 scopus 로고    scopus 로고
    • Kynurenine metabolism in Alzheimer's disease
    • Baran H, Jellinger K, Deecke L: Kynurenine metabolism in Alzheimer's disease. J Neural Transm 1999;106:165-181.
    • (1999) J Neural Transm , vol.106 , pp. 165-181
    • Baran, H.1    Jellinger, K.2    Deecke, L.3
  • 10
    • 0025161567 scopus 로고
    • Kynurenine pathway measurements in Huntington's disease striatum. Evidence for reduced formation of kynurenic acid
    • Beal MF, Matson WR, Swartz KJ, Gamache PH, Bird ED: Kynurenine pathway measurements in Huntington's disease striatum. Evidence for reduced formation of kynurenic acid. J Neurochem 1990;55:1327-1339.
    • (1990) J Neurochem , vol.55 , pp. 1327-1339
    • Beal, M.F.1    Matson, W.R.2    Swartz, K.J.3    Gamache, P.H.4    Bird, E.D.5
  • 11
    • 0024538348 scopus 로고
    • Increase in kynurenic acid in Huntington's disease motor cortex
    • Connick JH, Carla V, Moroni F, Stone TW: Increase in kynurenic acid in Huntington's disease motor cortex. J Neurochem 1989;52:958-987.
    • (1989) J Neurochem , vol.52 , pp. 958-987
    • Connick, J.H.1    Carla, V.2    Moroni, F.3    Stone, T.W.4
  • 15
    • 0027162254 scopus 로고
    • Regional differences in the ontogenetic pattern of kynurenine aminotransferase in the rat brain
    • Baran H, Schwarcz R: Regional differences in the ontogenetic pattern of kynurenine aminotransferase in the rat brain. Dev Brain Res 1993;74:283-286.
    • (1993) Dev Brain Res , vol.74 , pp. 283-286
    • Baran, H.1    Schwarcz, R.2
  • 16
    • 0026684818 scopus 로고
    • Developmental changes in brain kynurenic acid concentrations
    • Beal MF, Swartz KJ, Isacson O: Developmental changes in brain kynurenic acid concentrations. Dev Brain Res 1992;68:136-139.
    • (1992) Dev Brain Res , vol.68 , pp. 136-139
    • Beal, M.F.1    Swartz, K.J.2    Isacson, O.3
  • 19
    • 0029125893 scopus 로고
    • Kynurenic acid and 5,7-dichlorokynurenic acids improve social and object recognition in male rats
    • Hlinak Z, Krejci I: Kynurenic acid and 5,7-dichlorokynurenic acids improve social and object recognition in male rats. Psychopharmacology 1995;120:463-469.
    • (1995) Psychopharmacology , vol.120 , pp. 463-469
    • Hlinak, Z.1    Krejci, I.2
  • 20
    • 0027361921 scopus 로고
    • 7-Chlorokynurenate, an antagonist of the glycine binding site on the NMDA receptor, inhibits memory formation in day-old chicks (Gallus domesticus)
    • Steele RJ, Stewart MG: 7-Chlorokynurenate, an antagonist of the glycine binding site on the NMDA receptor, inhibits memory formation in day-old chicks (Gallus domesticus). Behav Neural Biol 1993;60:89-92.
    • (1993) Behav Neural Biol , vol.60 , pp. 89-92
    • Steele, R.J.1    Stewart, M.G.2
  • 21
    • 0029946164 scopus 로고    scopus 로고
    • Increased kynurenic acid levels and decreased brain kynurenine aminotransferase I in patients with DOWN syndrome
    • Baran H, Cairns N, Lubec B, Lubec G: Increased kynurenic acid levels and decreased brain kynurenine aminotransferase I in patients with DOWN syndrome. Life Sci 1996; 58:1891-1899.
    • (1996) Life Sci , vol.58 , pp. 1891-1899
    • Baran, H.1    Cairns, N.2    Lubec, B.3    Lubec, G.4
  • 22
    • 0023783911 scopus 로고
    • Kynurenic acid antagonizes responses to NMDA via an action at the strychnine-insensitive glycine receptor
    • Birch PJ, Grossman CJ, Hayes AG: Kynurenic acid antagonizes responses to NMDA via an action at the strychnine-insensitive glycine receptor. Eur J Pharmacol 1988;154:85-87.
    • (1988) Eur J Pharmacol , vol.154 , pp. 85-87
    • Birch, P.J.1    Grossman, C.J.2    Hayes, A.G.3
  • 23
    • 0024409242 scopus 로고
    • The induction of intercellular adhesion molecule 1 (ICAM-1) expression on human fetal astrocytes by interferon-gamma, tumor necrosis factor alpha, lymphotoxin, and interleukin-1: Relevance to intracerebral antigen presentation
    • Frohman EM, Frohman TC, Dustin ML, Vayuvegula B, Choi B, Gupta A, van den Noort S, Gupta S: The induction of intercellular adhesion molecule 1 (ICAM-1) expression on human fetal astrocytes by interferon-gamma, tumor necrosis factor alpha, lymphotoxin, and interleukin-1: Relevance to intracerebral antigen presentation. J Neuroimmunol 1989;23:117-124.
    • (1989) J Neuroimmunol , vol.23 , pp. 117-124
    • Frohman, E.M.1    Frohman, T.C.2    Dustin, M.L.3    Vayuvegula, B.4    Choi, B.5    Gupta, A.6    Van Den Noort, S.7    Gupta, S.8
  • 24
    • 0026489478 scopus 로고
    • Effects of immune activation on quinolinic acid and neuroactive kynurenines in the mouse
    • Saito K, Markey SP, Heyes MP: Effects of immune activation on quinolinic acid and neuroactive kynurenines in the mouse. Neuroscience 1992;1:25-39.
    • (1992) Neuroscience , vol.1 , pp. 25-39
    • Saito, K.1    Markey, S.P.2    Heyes, M.P.3
  • 26
    • 0003022066 scopus 로고
    • Astrocyte-microglia interactions
    • Murphy S (ed): San Diego, Academic Press
    • Benveniste EN: Astrocyte-microglia interactions; in Murphy S (ed): Astrocytes: Pharmacology and Function. San Diego, Academic Press, 1993, pp 355-382.
    • (1993) Astrocytes: Pharmacology and Function , pp. 355-382
    • Benveniste, E.N.1
  • 30
    • 84991176657 scopus 로고
    • Production of beta 2-microglobulin by normal and malignant human cell lines and peripheral lymphocytes
    • Nilsson K, Evrin PE, Welsh KI: Production of beta 2-microglobulin by normal and malignant human cell lines and peripheral lymphocytes. Transpl Rev 1974;21:53-84.
    • (1974) Transpl Rev , vol.21 , pp. 53-84
    • Nilsson, K.1    Evrin, P.E.2    Welsh, K.I.3
  • 31
    • 0027333253 scopus 로고
    • Relationship of interleukin-1 beta and beta 2-microglobulin with neuropeptides in cerebrospinal fluid od patients with dementia of the Alzheimer type
    • Martinez M, Frank A, Hernanz A: Relationship of interleukin-1 beta and beta 2-microglobulin with neuropeptides in cerebrospinal fluid od patients with dementia of the Alzheimer type. J Neuroimmunol 1993;48:235-240.
    • (1993) J Neuroimmunol , vol.48 , pp. 235-240
    • Martinez, M.1    Frank, A.2    Hernanz, A.3
  • 32
    • 0018247055 scopus 로고
    • Cerebrospinal fluid beta 2-microglobulin in neurological disorders
    • Tenhunen R, Iivanainen M, Kovanen J: Cerebrospinal fluid beta 2-microglobulin in neurological disorders. Acta Neurol Scand 1978;58:366-373.
    • (1978) Acta Neurol Scand , vol.58 , pp. 366-373
    • Tenhunen, R.1    Iivanainen, M.2    Kovanen, J.3
  • 34
    • 0017592811 scopus 로고
    • Principles of albumin and IgG analyses in neurological disorders. I. Establishment of reference values
    • Tibbling G, Link H, Öhman S: Principles of albumin and IgG analyses in neurological disorders. I. Establishment of reference values. Scand J Clin Lab Invest 1977;37:385-390.
    • (1977) Scand J Clin Lab Invest , vol.37 , pp. 385-390
    • Tibbling, G.1    Link, H.2    Öhman, S.3
  • 35
    • 0021670537 scopus 로고
    • Improved detection of oligoclonal IgG in cerebrospinal fluid by isoelectric focusing in agarose, double-antibody peroxidase labeling, and avidin-biotin amplification
    • Olsson T, Kostulas V, Link H: Improved detection of oligoclonal IgG in cerebrospinal fluid by isoelectric focusing in agarose, double-antibody peroxidase labeling, and avidin-biotin amplification. Clin Chem 1984;30:1246-1249.
    • (1984) Clin Chem , vol.30 , pp. 1246-1249
    • Olsson, T.1    Kostulas, V.2    Link, H.3
  • 36
    • 0023810583 scopus 로고
    • Fluorimetric microdetermination of kynurenic acid, an endogenous blocker of neurotoxicity, by high performance liquid chromatography
    • Shibata K: Fluorimetric microdetermination of kynurenic acid, an endogenous blocker of neurotoxicity, by high performance liquid chromatography. J Chromat 1988;430:376-380.
    • (1988) J Chromat , vol.430 , pp. 376-380
    • Shibata, K.1
  • 37
    • 0025236518 scopus 로고
    • Measurement of kynurenic acid in mammalian brain extracts and cerebrospinal fluid by high-performance liquid chromatography with fluorometric and coulometric electrode assay detection
    • Swartz KJ, Matson WR, MacGarvey U, Ryan EA, Beal MF: Measurement of kynurenic acid in mammalian brain extracts and cerebrospinal fluid by high-performance liquid chromatography with fluorometric and coulometric electrode assay detection. Analyt Biochem 1990;85:363-376.
    • (1990) Analyt Biochem , vol.85 , pp. 363-376
    • Swartz, K.J.1    Matson, W.R.2    MacGarvey, U.3    Ryan, E.A.4    Beal, M.F.5
  • 38
    • 0024536479 scopus 로고
    • Rat brain slices produce and liberate kynurenic acid upon expose to L-kynurenine
    • Turski WA, Gramsbergen JBP, Traitler H, Schwarcz R: Rat brain slices produce and liberate kynurenic acid upon expose to L-kynurenine. J Neurochem 1989;52:1629-1636.
    • (1989) J Neurochem , vol.52 , pp. 1629-1636
    • Turski, W.A.1    Gramsbergen, J.B.P.2    Traitler, H.3    Schwarcz, R.4
  • 41
    • 0023940187 scopus 로고
    • Cerebrospinal fluid IgG in childhood: The establishment of reference value
    • Rust RS Jr, Dodson WE, Trotter JL: Cerebrospinal fluid IgG in childhood: The establishment of reference value. Ann Neurol 1988;23: 406-410.
    • (1988) Ann Neurol , vol.23 , pp. 406-410
    • Rust Jr., R.S.1    Dodson, W.E.2    Trotter, J.L.3
  • 42
    • 0033008956 scopus 로고    scopus 로고
    • Kynurenic acid in brain and cerebrospinal fluid of fetal, new born, and adult sheep and effects of placental emboliation
    • Walker DW, Curtis B, Lacey B, Nitsos I: Kynurenic acid in brain and cerebrospinal fluid of fetal, new born, and adult sheep and effects of placental emboliation. PediatriC Res 1999;45:820-826.
    • (1999) PediatriC Res , vol.45 , pp. 820-826
    • Walker, D.W.1    Curtis, B.2    Lacey, B.3    Nitsos, I.4
  • 43
    • 0035798252 scopus 로고    scopus 로고
    • Kynurenic acid levels are elevated in the cerebrospinal fluid of patients with schizophrenia
    • Erhardt S, Blennow K, Nordin C, Skogh E, Lindström LH, Engberg G: Kynurenic acid levels are elevated in the cerebrospinal fluid of patients with schizophrenia. Neurosci Lett 2001;313:96-98.
    • (2001) Neurosci Lett , vol.313 , pp. 96-98
    • Erhardt, S.1    Blennow, K.2    Nordin, C.3    Skogh, E.4    Lindström, L.H.5    Engberg, G.6
  • 46
    • 20944441781 scopus 로고    scopus 로고
    • Prostaglandine-mediated control of rat brain kynurenic acid synthesis - Opposite actions by COX-1 and COX-2 isoforms
    • DOI 10.1007/s00702-004-0231-y
    • Schwieler L, Erhardt S, Erhardt C, Engberg G: Prostaglandine-mediated control of rat brain kynurenic acid synthesis - opposite actions by COX-1 and COX-2 isoforms. J Neural Transm DOI 10.1007/s00702-004-0231-y.
    • J Neural Transm
    • Schwieler, L.1    Erhardt, S.2    Erhardt, C.3    Engberg, G.4
  • 47
    • 33645248859 scopus 로고
    • The Neurochemistry of quinolinic acid and kynurenate: Current Concepts
    • Meldrum BS, Moroni F, Simon RP, Woods JH (eds): New York, Raven Press
    • Schwarcz R, Baran H, Wu H-Q, Du F, McMaster O: The Neurochemistry of quinolinic acid and kynurenate: Current Concepts; in Meldrum BS, Moroni F, Simon RP, Woods JH (eds): Excitatory Amino Acids. New York, Raven Press, 1991, pp 365-375.
    • (1991) Excitatory Amino Acids , pp. 365-375
    • Schwarcz, R.1    Baran, H.2    Wu, H.-Q.3    Du, F.4    McMaster, O.5
  • 48
    • 0033795994 scopus 로고    scopus 로고
    • Eletrophysiological effects of exogenous and endogenous kynurenic acid in the rat brain: In vivo and in vitro
    • Sharfman HE, Goodman JH, Schwarcz R: Eletrophysiological effects of exogenous and endogenous kynurenic acid in the rat brain: in vivo and in vitro. Amino Acids 2000;19:283-297.
    • (2000) Amino Acids , vol.19 , pp. 283-297
    • Sharfman, H.E.1    Goodman, J.H.2    Schwarcz, R.3
  • 49
    • 0026076136 scopus 로고
    • Blood-brain barrier transport of kynurenines: Implications for brain synthesis and metabolism
    • Fukui S, Schwarcz R, Rapoport SI, Takada Y, Smith QR: Blood-brain barrier transport of kynurenines: Implications for brain synthesis and metabolism. J Neurochem 1991;56:2007-2015.
    • (1991) J Neurochem , vol.56 , pp. 2007-2015
    • Fukui, S.1    Schwarcz, R.2    Rapoport, S.I.3    Takada, Y.4    Smith, Q.R.5
  • 50
    • 0025738589 scopus 로고
    • Age-related changes in cerebrospinal fluid protein concentrations
    • Garton MJ, Keir G, Lakshmi MV, Thompson EJ: Age-related changes in cerebrospinal fluid protein concentrations. J Neurol Sci 1991;104:74-80.
    • (1991) J Neurol Sci , vol.104 , pp. 74-80
    • Garton, M.J.1    Keir, G.2    Lakshmi, M.V.3    Thompson, E.J.4
  • 51
    • 0018901290 scopus 로고
    • L-Kynurenine: Its synthesis and possible regulatory function in brain
    • Gal EM, Sherman AD: L-Kynurenine: Its synthesis and possible regulatory function in brain. Neurochem Res 1980;5:223-239.
    • (1980) Neurochem Res , vol.5 , pp. 223-239
    • Gal, E.M.1    Sherman, A.D.2
  • 52
    • 0028279905 scopus 로고
    • Kynurenine specifically increases in the cerebrospinal fluid of the aged rats
    • Wada H, Ito H, Orimo H, Sato A: Kynurenine specifically increases in the cerebrospinal fluid of the aged rats. Biog Amines 1994;3:221-225.
    • (1994) Biog Amines , vol.3 , pp. 221-225
    • Wada, H.1    Ito, H.2    Orimo, H.3    Sato, A.4
  • 53
    • 0026507973 scopus 로고
    • Human macrophages convert L-tryptophan into the neurotoxin quinolinic acid
    • Heyes MP, Saito K, Markey SP: Human macrophages convert L-tryptophan into the neurotoxin quinolinic acid. Biochem J 1992;283:633-635.
    • (1992) Biochem J , vol.283 , pp. 633-635
    • Heyes, M.P.1    Saito, K.2    Markey, S.P.3
  • 54
    • 0030832112 scopus 로고    scopus 로고
    • Different kynurenine pathway enzymes limit quinolinic acid formation by various human cell types
    • Heyes MP, Chen CY, Major EO, Saito K: Different kynurenine pathway enzymes limit quinolinic acid formation by various human cell types. Biochem J 1997;326:351-356.
    • (1997) Biochem J , vol.326 , pp. 351-356
    • Heyes, M.P.1    Chen, C.Y.2    Major, E.O.3    Saito, K.4
  • 55
    • 0025972897 scopus 로고
    • Two kynurenine aminotransferases in human brain
    • Okuno E, Nakamura M, Schwarcz R: Two kynurenine aminotransferases in human brain. Brain Res 1991;542:307-312.
    • (1991) Brain Res , vol.542 , pp. 307-312
    • Okuno, E.1    Nakamura, M.2    Schwarcz, R.3
  • 56
    • 0028008608 scopus 로고
    • Purification and characterisation of kynurenine aminotransferase I from human brain
    • Baran H, Okuno E, Kido R, Schwarcz R: Purification and characterisation of kynurenine aminotransferase I from human brain. J Neurochem 1994;62:730-738.
    • (1994) J Neurochem , vol.62 , pp. 730-738
    • Baran, H.1    Okuno, E.2    Kido, R.3    Schwarcz, R.4
  • 57
    • 0026476185 scopus 로고
    • Immunocytochemical localization of kynurenine aminotransferase in the rat striatum: A light and electron microscopic study
    • Roberts RC, Du F, McCarthy KE, Okuno E, Schwarcz R: Immunocytochemical localization of kynurenine aminotransferase in the rat striatum: A light and electron microscopic study. J Comp Neurol 1992;326:82-90.
    • (1992) J Comp Neurol , vol.326 , pp. 82-90
    • Roberts, R.C.1    Du, F.2    McCarthy, K.E.3    Okuno, E.4    Schwarcz, R.5
  • 58
    • 0033580079 scopus 로고    scopus 로고
    • Kynurenine aminotransferase I (KAT I) isoform gene expression in the rat brain: An in situ hybridization study
    • Tamburin M, Mostardini M, Benatti L: Kynurenine aminotransferase I (KAT I) isoform gene expression in the rat brain: An in situ hybridization study. Neuroreport 1999;10:61-65.
    • (1999) Neuroreport , vol.10 , pp. 61-65
    • Tamburin, M.1    Mostardini, M.2    Benatti, L.3
  • 60
    • 0021797084 scopus 로고
    • Free and conjugated amino acids in human CSF: Influence of age and sex
    • Ferraro TN, Hare TA: Free and conjugated amino acids in human CSF: Influence of age and sex. Brain Res 1985;338:53-60.
    • (1985) Brain Res , vol.338 , pp. 53-60
    • Ferraro, T.N.1    Hare, T.A.2
  • 61
    • 0032806355 scopus 로고    scopus 로고
    • Increased microglial activation and protein nitration in white matter of the aging monkey
    • Sloane JA, Hollander W, Moss MB, Rosene DL, Abraham CR: Increased microglial activation and protein nitration in white matter of the aging monkey. Neurobiol Aging 1999;20:395-405.
    • (1999) Neurobiol Aging , vol.20 , pp. 395-405
    • Sloane, J.A.1    Hollander, W.2    Moss, M.B.3    Rosene, D.L.4    Abraham, C.R.5
  • 62
    • 0028104020 scopus 로고
    • Glial fibrillary acidic protein: Regulation by hormones, cytokines, and growth factors
    • Laping NJ, Teter B, Nichols NR, Rozovsky I, Finch CE: Glial fibrillary acidic protein: Regulation by hormones, cytokines, and growth factors. Brain Pathol 1994;4:259-275.
    • (1994) Brain Pathol , vol.4 , pp. 259-275
    • Laping, N.J.1    Teter, B.2    Nichols, N.R.3    Rozovsky, I.4    Finch, C.E.5
  • 63
    • 0035212257 scopus 로고    scopus 로고
    • Drug transporters in the central nervous system: Brain barriers and brain parenchyma considerations
    • Lee G, Dallas S, Hong M, Bendayan R: Drug transporters in the central nervous system: Brain barriers and brain parenchyma considerations. Pharmacol Rev 2001;53:569-596.
    • (2001) Pharmacol Rev , vol.53 , pp. 569-596
    • Lee, G.1    Dallas, S.2    Hong, M.3    Bendayan, R.4
  • 65
    • 0030995379 scopus 로고    scopus 로고
    • Increased transcription of the astrocyte gene GFAP during middle-age is attenuated by food restriction: Implications for the role of oxidative stress
    • Morgan TE, Rozovsky I, Golgsmith SK, Stone DJ, Yoshida T, Finch CE: Increased transcription of the astrocyte gene GFAP during middle-age is attenuated by food restriction: Implications for the role of oxidative stress. Free Radic Biol Med 1997;23:524-528.
    • (1997) Free Radic Biol Med , vol.23 , pp. 524-528
    • Morgan, T.E.1    Rozovsky, I.2    Golgsmith, S.K.3    Stone, D.J.4    Yoshida, T.5    Finch, C.E.6
  • 66
    • 0032168690 scopus 로고    scopus 로고
    • Aging of glutamate receptors: Correlation between binding and spatial memory performance in mice
    • Magnusson KR: Aging of glutamate receptors: Correlation between binding and spatial memory performance in mice. Mech Ageing Dev 1998;104:227-248.
    • (1998) Mech Ageing Dev , vol.104 , pp. 227-248
    • Magnusson, K.R.1
  • 67
    • 0027513688 scopus 로고
    • Effects of aging on NMDA and MK801 binding sites in mice
    • Magnusson KR, Cotman CW: Effects of aging on NMDA and MK801 binding sites in mice. Brain Res 1993;604:334-337.
    • (1993) Brain Res , vol.604 , pp. 334-337
    • Magnusson, K.R.1    Cotman, C.W.2
  • 68
    • 0027905017 scopus 로고
    • Modulation of neuronal migration by NMDA receptors
    • Kumoro H, Rakic P: Modulation of neuronal migration by NMDA receptors. Science 1993;260:95-97.
    • (1993) Science , vol.260 , pp. 95-97
    • Kumoro, H.1    Rakic, P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.