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Volumn 8, Issue 5, 2012, Pages 559-573

New oral multitargeted antiangiogenics in non-small-cell lung cancer treatment

Author keywords

angiogenesis; antiangiogenic therapy; biomarker; non small cell lung cancer; oral tyrosine kinase inhibitor; targeted agent

Indexed keywords

ANGIOGENESIS INHIBITOR; AXITINIB; BEVACIZUMAB; CARBOPLATIN; CEDIRANIB; DOCETAXEL; ERLOTINIB; GROWTH FACTOR; MOTESANIB; NINTEDANIB; PACLITAXEL; PAZOPANIB; PEMETREXED; PROTEIN TYROSINE KINASE INHIBITOR; SORAFENIB; SUNITINIB; VANDETANIB; VASCULOTROPIN ANTIBODY; VASCULOTROPIN INHIBITOR;

EID: 84861738322     PISSN: 14796694     EISSN: 17448301     Source Type: Journal    
DOI: 10.2217/fon.12.48     Document Type: Review
Times cited : (5)

References (77)
  • 1
    • 0034648765 scopus 로고    scopus 로고
    • Angiogenesis in cancer and other diseases
    • Carmeliet P, Jain RK. Angiogenesis in cancer and other diseases. Nature 407, 249-257 (2000).
    • (2000) Nature , vol.407 , pp. 249-257
    • Carmeliet, P.1    Jain, R.K.2
  • 2
    • 0023157363 scopus 로고
    • Angiogenic factors
    • Folkman J, Klagsbrun M. Angiogenic factors. Science 235, 442-447 (1987). (Pubitemid 17009577)
    • (1987) Science , vol.235 , Issue.4787 , pp. 442-447
    • Folkman, J.1    Klagsbrun, M.2
  • 3
    • 35548947467 scopus 로고    scopus 로고
    • Inhibition of angiogenesis in the treatment of non-small cell lung cancer
    • DOI 10.1111/j.1349-7006.2007.00620.x
    • Keedy VL, Sandler AB. Inhibition of angiogenesis in the treatment of non-small cell lung cancer. Cancer Sci. 98, 1825-1830 (2007). (Pubitemid 350002185)
    • (2007) Cancer Science , vol.98 , Issue.12 , pp. 1825-1830
    • Keedy, V.L.1    Sandler, A.B.2
  • 4
    • 30744449235 scopus 로고    scopus 로고
    • Angiogenesis as a therapeutic target
    • DOI 10.1038/nature04483, PII NATURE04483
    • Ferrara N, Kerbel RS. Angiogenesis as a therapeutic target. Nature 438, 967-974 (2005). (Pubitemid 43093963)
    • (2005) Nature , vol.438 , Issue.7070 , pp. 967-974
    • Ferrara, N.1    Kerbel, R.S.2
  • 5
    • 63749125392 scopus 로고    scopus 로고
    • VEGFs and receptors involved in angiogenesis versus lymphangiogenesis
    • Lohela M, Bry M, Tammela T, Alitalo K. VEGFs and receptors involved in angiogenesis versus lymphangiogenesis. Curr. Opin Cell Biol. 21, 154-165 (2009).
    • (2009) Curr. Opin Cell Biol. , vol.21 , pp. 154-165
    • Lohela, M.1    Bry, M.2    Tammela, T.3    Alitalo, K.4
  • 6
    • 46149087993 scopus 로고    scopus 로고
    • Regulation of tumor angiogenesis and metastasis by FGF and PDGF signaling pathways
    • Cao Y, Cao R, Hedlund EM. Regulation of tumor angiogenesis and metastasis by FGF and PDGF signaling pathways. J. Mol. Med. 86, 785-789 (2008).
    • (2008) J. Mol. Med. , vol.86 , pp. 785-789
    • Cao, Y.1    Cao, R.2    Hedlund, E.M.3
  • 7
    • 18144364350 scopus 로고    scopus 로고
    • Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis
    • DOI 10.1016/j.cytogfr.2005.01.004
    • Presta M, Dell'Era P, Mitola S, Moroni E, Ronca R, Rusnati M. Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis. Cytokine Growth Factor Rev. 16, 159-178 (2005). (Pubitemid 40616114)
    • (2005) Cytokine and Growth Factor Reviews , vol.16 , Issue.2 , pp. 159-178
    • Presta, M.1    Dell'Era, P.2    Mitola, S.3    Moroni, E.4    Ronca, R.5    Rusnati, M.6
  • 8
    • 70349304196 scopus 로고    scopus 로고
    • Phase II, multicenter, uncontrolled trial of single-Agent sorafenib in patients with relapsed or refractory, advanced non-small-cell lung cancer
    • Blumenschein GR Jr, Gatzemeier U, Fossella F et al. Phase II, multicenter, uncontrolled trial of single-Agent sorafenib in patients with relapsed or refractory, advanced non-small-cell lung cancer. J. Clin. Oncol. 27, 4274-4280 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , pp. 4274-4280
    • Blumenschein Jr., G.R.1    Gatzemeier, U.2    Fossella, F.3
  • 10
    • 84861759319 scopus 로고    scopus 로고
    • Nexavar® (sorafenib) tablets, oral, package insert, Inc., Wayne, NJ, USA
    • Nexavar® (sorafenib) tablets, oral, package insert. Bayer Health-Care Pharmaceuticals, Inc., Wayne, NJ, USA.
    • Bayer Health-Care Pharmaceuticals
  • 12
    • 44449142019 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of sorafenib, an oral multikinase inhibitor, in Japanese patients with advanced refractory solid tumors
    • DOI 10.1111/j.1349-7006.2008.00837.x
    • Minami H, Kawada K, Ebi H et al. Phase I and pharmacokinetic study of sorafenib, an oral multikinase inhibitor, in Japanese patients with advanced refractory solid tumors. Cancer Sci. 99, 1492-1498 (2008). (Pubitemid 351761743)
    • (2008) Cancer Science , vol.99 , Issue.7 , pp. 1492-1498
    • Minami, H.1    Kawada, K.2    Ebi, H.3    Kitagawa, K.4    Kim, Y.-I.5    Araki, K.6    Mukai, H.7    Tahara, M.8    Nakajima, H.9    Nakajima, K.10
  • 13
    • 65349161533 scopus 로고    scopus 로고
    • A randomized discontinuation Phase II study of sorafenib versus placebo in patients with non-small cell lung cancer who have failed at least two prior chemotherapy regimens
    • Abstract 8014
    • Schiller JH, Lee JW, Hanna NH, Traynor AM, Carbone DP. A randomized discontinuation Phase II study of sorafenib versus placebo in patients with non-small cell lung cancer who have failed at least two prior chemotherapy regimens: E2501. J. Clin. Oncol. 26 (2008) (Abstract 8014).
    • (2008) J. Clin. Oncol. , vol.26
    • Schiller, J.H.1    Lee, J.W.2    Hanna, N.H.3    Traynor, A.M.4    Carbone, D.P.5
  • 14
    • 33748901860 scopus 로고    scopus 로고
    • Sorafenib combined with carboplatin/ paclitaxel for advanced non-small cell lung cancer: A Phase I subset analysis
    • Abstract 7194
    • Schiller JH, Flaherty KT, Redlinger M et al. Sorafenib combined with carboplatin/ paclitaxel for advanced non-small cell lung cancer: A Phase I subset analysis. J. Clin. Oncol. 24, Abstract 7194 (2006).
    • (2006) J. Clin. Oncol. , vol.24
    • Schiller, J.H.1    Flaherty, K.T.2    Redlinger, M.3
  • 15
    • 77951639655 scopus 로고    scopus 로고
    • Phase III study of carboplatin and paclitaxel alone or with sorafenib in advanced non-small-cell lung cancer
    • Scagliotti G, Novello S, Von PJ, Reck M et al. Phase III study of carboplatin and paclitaxel alone or with sorafenib in advanced non-small-cell lung cancer. J. Clin. Oncol. 28, 1835-1842 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , pp. 1835-1842
    • Scagliotti, G.1    Novello, S.2    Von, P.J.3    Reck, M.4
  • 16
    • 20244381389 scopus 로고    scopus 로고
    • Phase I/II trial evaluating the anti-vascular endothelial growth factor monoclonal antibody bevacizumab in combination with the HER-1/epidermal growth factor receptor tyrosine kinase inhibitor erlotinib for patients with recurrent non-small cell lung cancer
    • Herbst RS, Johnson DH, Mininberg E et al. Phase I/II trial evaluating the anti-vascular endothelial growth factor monoclonal antibody bevacizumab in combination with the HER-1/epidermal growth factor receptor tyrosine kinase inhibitor erlotinib for patients with recurrent non-small cell lung cancer. J. Clin. Oncol. 23, 2544-2555 (2005).
    • (2005) J. Clin. Oncol. , vol.23 , pp. 2544-2555
    • Herbst, R.S.1    Johnson, D.H.2    Mininberg, E.3
  • 17
    • 33646227448 scopus 로고    scopus 로고
    • Synergistic antitumor effects of combined epidermal growth factor receptor and vascular endothelial growth factor receptor-2 targeted therapy
    • Tonra JR, Deevi DS, Corcoran E et al. Synergistic antitumor effects of combined epidermal growth factor receptor and vascular endothelial growth factor receptor-2 targeted therapy. Clin. Cancer Res. 12, 2197-2207 (2006).
    • (2006) Clin. Cancer Res. , vol.12 , pp. 2197-2207
    • Tonra, J.R.1    Deevi, D.S.2    Corcoran, E.3
  • 18
    • 77953114837 scopus 로고    scopus 로고
    • A multicenter Phase II study of erlotinib and sorafenib in chemotherapy-naive patients with advanced non-small cell lung cancer
    • Lind JS, Dingemans AM, Groen HJ et al. A multicenter, Phase II study of erlotinib and sorafenib in chemotherapy-naive patients with advanced non-small cell lung cancer. Clin. Cancer Res. 16, 3078-3087 (2010).
    • (2010) Clin. Cancer Res. , vol.16 , pp. 3078-3087
    • Lind, J.S.1    Dingemans, A.M.2    Groen, H.J.3
  • 19
    • 79952257687 scopus 로고    scopus 로고
    • Sorafenib treatment efficacy and KRAS biomarker status in the Biomarker- Integrated Approaches of Targeted Therapy for Lung Cancer Elimination (BATTLE) trial
    • Abstract 7609
    • Herbst RS, Blumenschein GR Jr, Kim ES et al. Sorafenib treatment efficacy and KRAS biomarker status in the Biomarker- Integrated Approaches of Targeted Therapy for Lung Cancer Elimination (BATTLE) trial. J. Clin. Oncol. 28, Abstract 7609 (2010).
    • (2010) J. Clin. Oncol. , vol.28
    • Herbst, R.S.1    Blumenschein Jr., G.R.2    Kim, E.S.3
  • 20
    • 36049026182 scopus 로고    scopus 로고
    • Role of anti-Angiogenesis agents in treating NSCLC: Focus on bevacizumab and VEGFR tyrosine kinase inhibitors
    • Cabebe E, Wakelee H. Role of anti-Angiogenesis agents in treating NSCLC: Focus on bevacizumab and VEGFR tyrosine kinase inhibitors. Curr. Treat. Options Oncol. 8, 15-27 (2007).
    • (2007) Curr. Treat. Options Oncol. , vol.8 , pp. 15-27
    • Cabebe, E.1    Wakelee, H.2
  • 21
    • 78650874372 scopus 로고    scopus 로고
    • SU11248 inhibits KIT and platelet-derived growth factor receptor beta in preclinical models of human small cell lung cancer
    • Abrams TJ, Lee LB, Murray LJ, Pryer NK, Cherrington JM. SU11248 inhibits KIT and platelet-derived growth factor receptor beta in preclinical models of human small cell lung cancer. Mol. Cancer Ther. 2, 471-478 (2003).
    • (2003) Mol. Cancer Ther. , vol.2 , pp. 471-478
    • Abrams, T.J.1    Lee, L.B.2    Murray, L.J.3    Pryer, N.K.4    Cherrington, J.M.5
  • 22
    • 70350655546 scopus 로고    scopus 로고
    • Phase II study of continuous daily sunitinib dosing in patients with previously treated advanced non-small cell lung cancer
    • Novello S, Scagliotti GV, Rosell R et al. Phase II study of continuous daily sunitinib dosing in patients with previously treated advanced non-small cell lung cancer. Br. J. Cancer 101, 1543-1548 (2009).
    • (2009) Br. J. Cancer , vol.101 , pp. 1543-1548
    • Novello, S.1    Scagliotti, G.V.2    Rosell, R.3
  • 24
    • 77955700137 scopus 로고    scopus 로고
    • Sunitinib in combination with gemcitabine plus cisplatin for advanced non-small cell lung cancer: A Phase I dose-escalation study
    • Reck M, Frickhofen N, Cedres S et al. Sunitinib in combination with gemcitabine plus cisplatin for advanced non-small cell lung cancer: A Phase I dose-escalation study. Lung Cancer 70(2), 180-187 (2010).
    • (2010) Lung Cancer , vol.70 , Issue.2 , pp. 180-187
    • Reck, M.1    Frickhofen, N.2    Cedres, S.3
  • 25
    • 78149356321 scopus 로고    scopus 로고
    • Sunitinib in combination with docetaxel in patients with advanced solid tumors: A Phase I dose-escalation study
    • Robert F, Sandler A, Schiller JH et al. Sunitinib in combination with docetaxel in patients with advanced solid tumors: A Phase I dose-escalation study. Cancer Chemother. Pharmacol. 66(4), 669-680 (2010).
    • (2010) Cancer Chemother. Pharmacol. , vol.66 , Issue.4 , pp. 669-680
    • Robert, F.1    Sandler, A.2    Schiller, J.H.3
  • 27
    • 0037102369 scopus 로고    scopus 로고
    • ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration
    • Wedge SR, Ogilvie DJ, Dukes M et al. ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration. Cancer Res. 62, 4645-4655 (2002).
    • (2002) Cancer Res. , vol.62 , pp. 4645-4655
    • Wedge, S.R.1    Ogilvie, D.J.2    Dukes, M.3
  • 29
    • 66349087009 scopus 로고    scopus 로고
    • Vandetanib versus gefitinib in patients with advanced non-small cell lung cancer: Results from a two-part, double-blind, randomized Phase II trial
    • Natale RB, Bodkin D, Govindan R et al. Vandetanib versus gefitinib in patients with advanced non-small cell lung cancer: Results from a two-part, double-blind, randomized Phase II trial. J. Clin. Oncol. 27, 2523-2529 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , pp. 2523-2529
    • Natale, R.B.1    Bodkin, D.2    Govindan, R.3
  • 31
    • 56749102822 scopus 로고    scopus 로고
    • Randomized Phase II study of vandetanib alone or with paclitaxel and carboplatin as first-line treatment for advanced non-small-cell lung cancer
    • Heymach V, Paz-Ares L, De Braud F et al. Randomized Phase II study of vandetanib alone or with paclitaxel and carboplatin as first-line treatment for advanced non-small-cell lung cancer. J. Clin. Oncol. 26, 5407-5415 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , pp. 5407-5415
    • Heymach, V.1    Paz-Ares, L.2    De Braud, F.3
  • 32
    • 77954035012 scopus 로고    scopus 로고
    • Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-small-cell lung cancer (ZODIAC): A double-blind, randomised, Phase 3 trial
    • Herbst RS, Sun Y, Eberhardt WE et al. Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-small-cell lung cancer (ZODIAC): A double-blind, randomised, Phase 3 trial. Lancet Oncol. 11(7), 619-626 (2010).
    • (2010) Lancet Oncol. , vol.11 , Issue.7 , pp. 619-626
    • Herbst, R.S.1    Sun, Y.2    Eberhardt, W.E.3
  • 33
    • 79959371861 scopus 로고    scopus 로고
    • Tumor biomarker analyses from the Phase III ZODIAC study of docetaxel D) plus or minus vandetanib (VAN) in second-line advanced NSCLC
    • Abstract 7516
    • Johnson E, Ryan AJ, Heymach J et al. Tumor biomarker analyses from the Phase III ZODIAC study of docetaxel (D) plus or minus vandetanib (VAN) in second-line advanced NSCLC. J. Clin. Oncol. 28, Abstract 7516 (2010).
    • (2010) J. Clin. Oncol. , pp. 28
    • Johnson, E.1    Ryan, A.J.2    Heymach, J.3
  • 34
    • 79952742483 scopus 로고    scopus 로고
    • Vandetanib plus pemetrexed versus pemetrexed as second-line therapy in patients with advanced non-small cell lung cancer (NSCLC): A randomized, double-blind Phase III trial (ZEAL)
    • De Boer R, Arrieta O, Yang CH et al. Vandetanib plus pemetrexed versus pemetrexed as second-line therapy in patients with advanced non-small cell lung cancer (NSCLC): A randomized, double-blind Phase III trial (ZEAL). J. Clin. Oncol. 1067-1074 (2011).
    • (2011) J. Clin. Oncol. , pp. 1067-1074
    • De Boer, R.1    Arrieta, O.2    Yang, C.H.3
  • 35
    • 70349476412 scopus 로고    scopus 로고
    • Vandetanib versus erlotinib in patients with advanced non-small cell lung cancer (NSCLC) after failure of at least one prior cytotoxic chemotherapy: A randomized, double-blind Phase III trial (ZEST)
    • Abstract 8009
    • Natale RB, Thongprasert S, Greco FA et al. Vandetanib versus erlotinib in patients with advanced non-small cell lung cancer (NSCLC) after failure of at least one prior cytotoxic chemotherapy: A randomized, double-blind Phase III trial (ZEST). J. Clin. Oncol. 27, Abstract 8009 (2009).
    • (2009) J. Clin. Oncol. , vol.27
    • Natale, R.B.1    Thongprasert, S.2    Greco, F.A.3
  • 36
    • 78049395323 scopus 로고    scopus 로고
    • Vandetanib versus placebo in patients with advanced non-small cell lung cancer (NSCLC) after prior therapy with an EGFR tyrosine kinase inhibitor (TKI): A randomized, double-blind Phase III trial (ZEPHYR)
    • Abstract 7525
    • Lee J, Hirsch V, Park K et al. Vandetanib versus placebo in patients with advanced non-small cell lung cancer (NSCLC) after prior therapy with an EGFR tyrosine kinase inhibitor (TKI): A randomized, double-blind Phase III trial (ZEPHYR). J. Clin. Oncol. 28, Abstract 7525 (2010).
    • (2010) J. Clin. Oncol. , vol.28
    • Lee, J.1    Hirsch, V.2    Park, K.3
  • 37
    • 49649123154 scopus 로고    scopus 로고
    • BIBF1120: Triple angiokinase inhibitor with sustained receptor blockade and good anti-Tumor efficacy
    • Hilberg F, Roth GJ, Krssak M et al. BIBF1120: Triple angiokinase inhibitor with sustained receptor blockade and good anti-Tumor efficacy. Cancer Res. 68(12), 4774-4782 (2008).
    • (2008) Cancer Res. , vol.68 , Issue.12 , pp. 4774-4782
    • Hilberg, F.1    Roth, G.J.2    Krssak, M.3
  • 38
    • 77952413832 scopus 로고    scopus 로고
    • In vitro and in vivo efficacy of BIBF 1120, a small molecule triple angiokinase inhibitor, in combination with taxanes Proceedings AACR-NCI-EORTC
    • Hilberg F, Brandstetter I, Roth GJ. In vitro and in vivo efficacy of BIBF 1120, a small molecule triple angiokinase inhibitor, in combination with taxanes. Proceedings AACR-NCI-EORTC. Int. Conf. Mol. Targets Cancer Ther. 59, A19 (2005).
    • (2005) Int. Conf. Mol. Targets Cancer Ther. , Issue.59
    • Hilberg, F.1    Brandstetter, I.2    Roth, G.J.3
  • 39
    • 77951466584 scopus 로고    scopus 로고
    • Pharmacokinetic characterization of BIBF 1120, an orally active triple angiokinase inhibitor (VEGFR, PDGFR, FGFR) inadvanced cancer patients
    • Stopfer P, Roth W, Mross KB et al. Pharmacokinetic characterization of BIBF 1120, an orally active triple angiokinase inhibitor (VEGFR, PDGFR, FGFR) inadvanced cancer patients. Eur. J. Cancer Suppl. 4(12), 26 (2006).
    • (2006) Eur. J. Cancer Suppl. , vol.4 , Issue.12 , pp. 26
    • Stopfer, P.1    Roth, W.2    Mross, K.B.3
  • 40
    • 33845315778 scopus 로고    scopus 로고
    • A Phase I study of BIBF 1120, an orally active triple angiokinase inhibitor (VEGFR, PDGFR, FGFR) given continuously to patients with advanced solid tumours, incorporating dynamic contrast enhanced magnetic resonance imaging (DCE-MRI)
    • Lee CP, Taylor NJ, Attard G et al. A Phase I study of BIBF 1120, an orally active triple angiokinase inhibitor (VEGFR, PDGFR, FGFR) given continuously to patients with advanced solid tumours, incorporating dynamic contrast enhanced magnetic resonance imaging (DCE-MRI). J. Clin. Oncol. 24(18S), 3015 (2006).
    • (2006) J. Clin. Oncol. , vol.24 , Issue.18 S , pp. 3015
    • Lee, C.P.1    Taylor, N.J.2    Attard, G.3
  • 41
    • 77952356430 scopus 로고    scopus 로고
    • Phase I dose-escalation study of continuous oral treatment with the angiokinase inhibitor BIBF 1120 in patients with advanced solid tumours (and presentation)
    • Abstract 1243
    • Kaneda H, Okamoto I, Satoh T et al. Phase I dose-escalation study of continuous oral treatment with the angiokinase inhibitor BIBF 1120 in patients with advanced solid tumours (and presentation). Eur. J. Cancer Suppl. 7(2), Abstract 1243 (2009).
    • (2009) Eur. J. Cancer Suppl. , vol.7 , Issue.2
    • Kaneda, H.1    Okamoto, I.2    Satoh, T.3
  • 42
    • 77951457663 scopus 로고    scopus 로고
    • A Phase I study of continuous oral treatment with the triple angiokinase inhibitor BIBF 1120 together with carboplatin and paclitaxel in patients with advanced non-small cell lung cancer (NSCLC)
    • Camidge DR, Conkling P, Stephenson J, Shapiro D. A Phase I study of continuous oral treatment with the triple angiokinase inhibitor BIBF 1120 together with carboplatin and paclitaxel in patients with advanced non-small cell lung cancer (NSCLC). J. Thoracic Oncol. 2(8), S730 (2007).
    • (2007) J. Thoracic Oncol. , vol.2 , Issue.8
    • Camidge, D.R.1    Conkling, P.2    Stephenson, J.3    Shapiro, D.4
  • 43
    • 69349105666 scopus 로고    scopus 로고
    • A Phase I study of continuous oral treatment with the triple angiokinase inhibitor BIBF 1120 together with pemetrexed in previously treated patients with non-small cell lung cancer
    • Hanna N, Ellis P, Stopfer P et al. A Phase I study of continuous oral treatment with the triple angiokinase inhibitor BIBF 1120 together with pemetrexed in previously treated patients with non-small cell lung cancer. J. Thoracic Oncol. 2(8), S717 (2007).
    • (2007) J. Thoracic Oncol. , vol.2 , Issue.8
    • Hanna, N.1    Ellis, P.2    Stopfer, P.3
  • 44
    • 77951463394 scopus 로고    scopus 로고
    • Efficacy, safety and pharmacokinetic (PK) results of a Phase II study with the triple angiokinase inhibitor BIBF 1120 in patients suffering from advanced non small cell lung cancer (NSCLC)
    • Von Pawel J, Kaiser R, Eschbach C et al. Efficacy, safety and pharmacokinetic (PK) results of a Phase II study with the triple angiokinase inhibitor BIBF 1120 in patients suffering from advanced non small cell lung cancer (NSCLC). J. Thoracic Oncol. 3(4), S61 (2008).
    • (2008) J. Thoracic Oncol. , vol.3 , Issue.4
    • Von Pawel, J.1    Kaiser, R.2    Eschbach, C.3
  • 45
    • 79957452054 scopus 로고    scopus 로고
    • A Phase II double-blind study to investigate efficacy and safety of two doses of the triple angiokinase inhibitor BIBF 1120 in patients with relapsed advanced non-small-cell lung cancer
    • Reck M, Kaiser R, Eschbach C et al. A Phase II double-blind study to investigate efficacy and safety of two doses of the triple angiokinase inhibitor BIBF 1120 in patients with relapsed advanced non-small-cell lung cancer. Ann. Oncol. 22(6), 1374-1381 (2011).
    • (2011) Ann. Oncol. , vol.22 , Issue.6 , pp. 1374-1381
    • Reck, M.1    Kaiser, R.2    Eschbach, C.3
  • 46
    • 49649083397 scopus 로고    scopus 로고
    • The tyrosine kinase inhibitor cediranib blocks ligand-induced vascular endothelial growth factor receptor-3 activity and lymphangiogenesis
    • Heckman CA, Holopainen T, Wirzenius M et al. The tyrosine kinase inhibitor cediranib blocks ligand-induced vascular endothelial growth factor receptor-3 activity and lymphangiogenesis. Cancer Res. 68, 4754-4762 (2008).
    • (2008) Cancer Res. , vol.68 , pp. 4754-4762
    • Heckman, C.A.1    Holopainen, T.2    Wirzenius, M.3
  • 48
    • 42949105645 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of daily oral AZD2171, an inhibitor of vascular endothelial growth factor tyrosine kinases, in combination with carboplatin and paclitaxel in patients with advanced non-small-cell lung cancer: The National Cancer Institute of Canada clinical trials group
    • Laurie SA, Gauthier I, Arnold A et al. Phase I and pharmacokinetic study of daily oral AZD2171, an inhibitor of vascular endothelial growth factor tyrosine kinases, in combination with carboplatin and paclitaxel in patients with advanced non-small-cell lung cancer: The National Cancer Institute of Canada clinical trials group. J. Clin. Oncol. 26, 1871-1878 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , pp. 1871-1878
    • Laurie, S.A.1    Gauthier, I.2    Arnold, A.3
  • 49
    • 61349124193 scopus 로고    scopus 로고
    • A Phase I and pharmacokinetic study of daily oral cediranib, an inhibitor of vascular endothelial growth factor tyrosine kinases, in combination with cisplatin and gemcitabine in patients with advanced non-small cell lung cancer: A study of the national cancer institute of canada clinical trials group
    • Goss G, Shepherd FA, Laurie S et al. A Phase I and pharmacokinetic study of daily oral cediranib, an inhibitor of vascular endothelial growth factor tyrosine kinases, in combination with cisplatin and gemcitabine in patients with advanced non-small cell lung cancer: A study of the National Cancer Institute of Canada Clinical Trials Group. Eur. J. Cancer 45, 782-788 (2009).
    • (2009) Eur. J. Cancer , vol.45 , pp. 782-788
    • Goss, G.1    Shepherd, F.A.2    Laurie, S.3
  • 50
    • 73949092851 scopus 로고    scopus 로고
    • Randomized, double-blind trial of carboplatin and paclitaxel with either daily oral cediranib or placebo in advanced non-small-cell lung cancer: NCIC Clinical Trials Group BR24 study
    • Goss GD, Arnold A, Shepherd FA et al. Randomized, double-blind trial of carboplatin and paclitaxel with either daily oral cediranib or placebo in advanced non-small-cell lung cancer: NCIC Clinical Trials Group BR24 study. J. Clin. Oncol. 28, 49-55 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , pp. 49-55
    • Goss, G.D.1    Arnold, A.2    Shepherd, F.A.3
  • 51
    • 77957092171 scopus 로고    scopus 로고
    • Cediranib a VEGF receptor 1 2, and 3 inhibitor, and pemetrexed in patients (pts) with recurrent non-small cell lung cancer (NSCLC)
    • (Abstract e19007
    • Gadgeel SM, Wozniak A, Edelman MJ et al. Cediranib, a VEGF receptor 1, 2, and 3 inhibitor, and pemetrexed in patients (pts) with recurrent non-small cell lung cancer (NSCLC). J. Clin. Oncol. 27 (2009) (Abstract e19007).
    • (2009) J. Clin. Oncol. , pp. 27
    • Gadgeel, S.M.1    Wozniak, A.2    Edelman, M.J.3
  • 52
    • 78049411804 scopus 로고    scopus 로고
    • A randomized Phase II study of gemcitabine (G) and carboplatin C) with or without cediranib (AZD2171 [CED]) as first-line therapy in advanced non-small cell lung cancer (NSCLC)
    • Dy GK, Mandrekar SJ, Nelson GD et al. A randomized Phase II study of gemcitabine (G) and carboplatin (C) with or without cediranib (AZD2171 [CED]) as first-line therapy in advanced non-small cell lung cancer (NSCLC). J. Clin. Oncol. (Meeting Abstracts) 28, 7603 (2010).
    • (2010) J. Clin. Oncol. (Meeting Abstracts) , Issue.28 , pp. 7603
    • Dy, G.K.1    Mandrekar, S.J.2    Nelson, G.D.3
  • 53
    • 44649151405 scopus 로고    scopus 로고
    • Axitinib, a novel anti-angiogenic drug with promising activity in various solid tumors
    • Choueiri TK. Axitinib, a novel anti-Angiogenic drug with promising activity in various solid tumors. Curr. Opin Investig. Drugs 9, 658-671 (2008). (Pubitemid 351777169)
    • (2008) Current Opinion in Investigational Drugs , vol.9 , Issue.6 , pp. 658-671
    • Choueiri, T.K.1
  • 55
    • 78651105332 scopus 로고    scopus 로고
    • Axitinib (AG-013736; AG) combined with chemotherapy in patients (pts) with advanced non-small cell lung cancer (NSCLC) and other solid tumors
    • S15 Abstract 3559
    • Martin LP, Kozloff MF, Krzakowski M et al. Axitinib (AG-013736; AG) combined with chemotherapy in patients (pts) with advanced non-small cell lung cancer (NSCLC) and other solid tumors. J. Clin. Oncol. 27, S15 Abstract 3559 (2009).
    • (2009) J. Clin. Oncol. , vol.27
    • Martin, L.P.1    Kozloff, M.F.2    Krzakowski, M.3
  • 56
    • 24944453855 scopus 로고    scopus 로고
    • Phase I trial of the oral antiangiogenesis agent AG-013736 in patients with advanced solid tumors: Pharmacokinetic and clinical results
    • Rugo HS, Herbst RS, Liu G et al. Phase I trial of the oral antiangiogenesis agent AG-013736 in patients with advanced solid tumors: Pharmacokinetic and clinical results. J. Clin. Oncol. 23, 5474-5483 (2005).
    • (2005) J. Clin. Oncol. , vol.23 , pp. 5474-5483
    • Rugo, H.S.1    Herbst, R.S.2    Liu, G.3
  • 57
    • 68949127256 scopus 로고    scopus 로고
    • Efficacy and safety of axitinib in patients with advanced non-small-cell lung cancer: Results from a Phase II study
    • Schiller JH, Larson T, Ou SH et al. Efficacy and safety of axitinib in patients with advanced non-small-cell lung cancer: Results from a Phase II study. J. Clin. Oncol. 27, 3836-3841 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , pp. 3836-3841
    • Schiller, J.H.1    Larson, T.2    Ou, S.H.3
  • 59
    • 67449164582 scopus 로고    scopus 로고
    • Phase I trial of pazopanib in patients with advanced cancer
    • Hurwitz HI, Dowlati A, Saini S et al. Phase I trial of pazopanib in patients with advanced cancer. Clin. Cancer Res. 15, 4220-4227 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , pp. 4220-4227
    • Hurwitz, H.I.1    Dowlati, A.2    Saini, S.3
  • 60
    • 67449133343 scopus 로고    scopus 로고
    • Preoperative treatment with pazopanib (GW786034) a multikinase angiogenesis inhibitor in early stage non-small cell lung cancer (NSCLC): A proof-of-concept Phase II study
    • Abstract 7557
    • Altorki N, Guarino M, Lee P et al. Preoperative treatment with pazopanib (GW786034) a multikinase angiogenesis inhibitor in early stage non-small cell lung cancer (NSCLC): A proof-of-concept Phase II study. J. Clin. Oncol. 26, Abstract 7557 (2008).
    • (2008) J. Clin. Oncol. , vol.26
    • Altorki, N.1    Guarino, M.2    Lee, P.3
  • 62
    • 55849108694 scopus 로고    scopus 로고
    • Safety and pharmacokinetics (PK) of AMG 706 in combination with panitumumab and gemcitabine-cisplatin in patients (pts) with advanced cancer
    • Abstract 14057
    • Crawford J, Burris H, Stephenson J Jr et al. Safety and pharmacokinetics (PK) of AMG 706 in combination with panitumumab and gemcitabine-cisplatin in patients (pts) with advanced cancer. J. Clin. Oncol. 25, Abstract 14057 (2007).
    • (2007) J. Clin. Oncol. , vol.25
    • Crawford, J.1    Burris, H.2    Stephenson Jr., J.3
  • 63
    • 74949088883 scopus 로고    scopus 로고
    • Phase 1b study of motesanib, an oral angiogenesis inhibitor, in combination with carboplatin/paclitaxel and/or panitumumab for the treatment of advanced non-small cell lung cancer
    • Blumenschein GR Jr, Reckamp K, Stephenson GJ et al. Phase 1b study of motesanib, an oral angiogenesis inhibitor, in combination with carboplatin/paclitaxel and/or panitumumab for the treatment of advanced non-small cell lung cancer. Clin. Cancer Res. 16, 279-290 (2010).
    • (2010) Clin. Cancer Res. , vol.16 , pp. 279-290
    • Blumenschein Jr., G.R.1    Reckamp, K.2    Stephenson, G.J.3
  • 64
    • 78049392715 scopus 로고    scopus 로고
    • Randomized, open-label Phase II study of motesanib or bevacizumab in combination with paclitaxel and carboplatin (P/C) for advanced nonsquamous non-small cell lung cancer (NSCLC)
    • Abstract 7528
    • Blumenschein GR, Kabbinavar FF, Menon H et al. Randomized, open-label Phase II study of motesanib or bevacizumab in combination with paclitaxel and carboplatin (P/C) for advanced nonsquamous non-small cell lung cancer (NSCLC). J. Clin. Oncol. 28, Abstract 7528 (2010).
    • (2010) J. Clin. Oncol. , vol.28
    • Blumenschein, G.R.1    Kabbinavar, F.F.2    Menon, H.3
  • 65
    • 40949111793 scopus 로고    scopus 로고
    • Cell adhesion molecules, vascular endothelial growth factor, and basic fibroblast growth factor in patients with non-small cell lung cancer treated with chemotherapy with or without bevacizumab - An Eastern Cooperative Oncology Group study
    • DOI 10.1158/1078-0432.CCR-07-1154
    • Dowlati A, Gray R, Sandler AB, Schiller JH, Johnson DH. Cell adhesion molecules, vascular endothelial growth factor, and basic fibroblast growth factor in patients with non-small cell lung cancer treated with chemotherapy with or without bevacizumab - An Eastern Cooperative Oncology Group Study. Clin. Cancer Res. 14, 1407-1412 (2008). (Pubitemid 351413922)
    • (2008) Clinical Cancer Research , vol.14 , Issue.5 , pp. 1407-1412
    • Dowlati, A.1    Gray, R.2    Sandler, A.B.3    Schiller, J.H.4    Johnson, D.H.5
  • 66
    • 3242796635 scopus 로고    scopus 로고
    • Soluble intercellular adhesion molecule-1 (sICAM-1): An overview
    • Witkowska AM, Borawska MH. Soluble intercellular adhesion molecule-1 (sICAM-1): An overview. Eur. Cytokine Netw. 15, 91-98 (2004). (Pubitemid 38980081)
    • (2004) European Cytokine Network , vol.15 , Issue.2 , pp. 91-98
    • Witkowska, A.M.1    Borawska, M.H.2
  • 67
    • 66149188254 scopus 로고    scopus 로고
    • Baseline vascular endothelial growth factor concentration as a potential predictive marker of benefit from vandetanib in non-small cell lung cancer
    • Hanrahan EO, Ryan AJ, Mann H et al. Baseline vascular endothelial growth factor concentration as a potential predictive marker of benefit from vandetanib in non-small cell lung cancer. Clin. Cancer Res. 15, 3600-3609 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , pp. 3600-3609
    • Hanrahan, E.O.1    Ryan, A.J.2    Mann, H.3
  • 68
    • 74949090109 scopus 로고    scopus 로고
    • Distinct patterns of cytokine and angiogenic factor modulationin and markers of benefit for vandetanib and/or chemotherapy in patients with non-small-cell lung cancer
    • Hanrahan EO, Lin HY, Kim ES et al. Distinct patterns of cytokine and angiogenic factor modulationin and markers of benefit for vandetanib and/or chemotherapy in patients with non-small-cell lung cancer. J. Clin. Oncol. 28, 193-201 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , pp. 193-201
    • Hanrahan, E.O.1    Lin, H.Y.2    Kim, E.S.3
  • 69
    • 66149188254 scopus 로고    scopus 로고
    • Baseline vascular endothelial growth factor concentration as a potential predictive marker of benefit from vandetanib in non-small cell lung cancer
    • Hanrahan EO, Ryan AJ, Mann H et al. Baseline vascular endothelial growth factor concentration as a potential predictive marker of benefit from vandetanib in non-small cell lung cancer. Clin. Cancer Res. 15, 3600-3609 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , pp. 3600-3609
    • Hanrahan, E.O.1    Ryan, A.J.2    Mann, H.3
  • 70
    • 24944440830 scopus 로고    scopus 로고
    • TRIBUTE: A Phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non-small-cell lung cancer
    • Herbst RS, Prager D, Hermann R et al. TRIBUTE: A Phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non-small-cell lung cancer. J. Clin. Oncol. 23, 5892-5899 (2005).
    • (2005) J. Clin. Oncol. , vol.23 , pp. 5892-5899
    • Herbst, R.S.1    Prager, D.2    Hermann, R.3
  • 72
    • 4444238981 scopus 로고    scopus 로고
    • Results of a Phase III trial of erlotinib (OSI-774) combined with cisplatin and gemcitabine (GC) chemotherapy in advanced non-small cell lung cancer (NSCLC)
    • for the TALENT study investigators
    • Gatzemeier U, Pluzanska A, Szczesna A et al. for the TALENT study investigators. Results of a Phase III trial of erlotinib (OSI-774) combined with cisplatin and gemcitabine (GC) chemotherapy in advanced non-small cell lung cancer (NSCLC). J. Clin. Oncol. 22, 7010 (2004).
    • (2004) J. Clin. Oncol. , vol.22 , pp. 7010
    • Gatzemeier, U.1    Pluzanska, A.2    Szczesna, A.3
  • 74
    • 33745897599 scopus 로고    scopus 로고
    • Pharmacodynamic separation of epidermal growth factor receptor tyrosine kinase inhibitors and chemotherapy in non-small-cell lung cancer
    • Davies AM, Ho C, Lara PN Jr, Mack P, Gumerlock PH, Gandara DR. Pharmacodynamic separation of epidermal growth factor receptor tyrosine kinase inhibitors and chemotherapy in nonsmall-cell lung cancer. Clin. Lung Cancer 7, 385-388 (2006). (Pubitemid 44043547)
    • (2006) Clinical Lung Cancer , vol.7 , Issue.6 , pp. 385-388
    • Davies, A.M.1    Ho, C.2    Lara Jr., P.N.3    Mack, P.4    Gumerlock, P.H.5    Gandara, D.R.6
  • 75
    • 75549091170 scopus 로고    scopus 로고
    • CD133+ circulating haematopoietic progenitor cells predict for response to sorafenib plus erlotinib in non-small cell lung cancer patients
    • Vroling L, Lind JS, De Haas RR et al. CD133+ circulating haematopoietic progenitor cells predict for response to sorafenib plus erlotinib in non-small cell lung cancer patients. Br. J. Cancer 102, 268-275 (2010).
    • (2010) Br. J. Cancer , vol.102 , pp. 268-275
    • Vroling, L.1    Lind, J.S.2    De Haas, R.R.3
  • 76
    • 8444239305 scopus 로고    scopus 로고
    • VEGF gene sequence variation defines VEGF gene expression status and angiogenic activity in non-small cell lung cancer
    • DOI 10.1016/j.lungcan.2004.04.037, PII S0169500204002053
    • Koukourakis MI, Papazoglou D, Giatromanolaki A, Bougioukas G, Maltezos E, Sivridis E. VEGF gene sequence variation defines VEGF gene expression status and angiogenic activity in non-small cell lung cancer. Lung Cancer 46, 293-298 (2004). (Pubitemid 39487303)
    • (2004) Lung Cancer , vol.46 , Issue.3 , pp. 293-298
    • Koukourakis, M.I.1    Papazoglou, D.2    Giatromanolaki, A.3    Bougioukas, G.4    Maltezos, E.5    Siviridis, E.6


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