The role of activin A in regulation of hemopoiesis

Stem Cells

Volumn 20, Issue 6, 2002, Pages 493-500

  Shav Tal, Yaron ^a   Zipori, Dov ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

B lymphopoiesis; Bone marrow stroma; Erythropoiesis; Hemopoietic stem cells; Inhibin; TGF

Indexed keywords

ACTIVIN A; CYTOKINE; INHIBIN; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; ACTIVIN;

APOPTOSIS; B LYMPHOCYTE; CANCER CELL CULTURE; CELL CYCLE; CELL DIFFERENTIATION; CELL LINEAGE; ERYTHROPOIESIS; GENE EXPRESSION; GENE EXPRESSION REGULATION; HEMATOPOIESIS; HEMATOPOIETIC CELL; HEMATOPOIETIC STEM CELL; LEUKEMIA; LYMPHOMA; LYMPHOPOIESIS; MEGAKARYOCYTE; MESENCHYME; MYELOMONOCYTIC LEUKEMIA; PROTEIN EXPRESSION; SHORT SURVEY; STROMA CELL; T LYMPHOCYTE; ANIMAL; HUMAN; PHYSIOLOGY; REVIEW;

ACTIVINS; ANIMALS; HEMATOPOIESIS; HEMATOPOIETIC STEM CELLS; HUMANS; INHIBIN-BETA SUBUNITS;

EID: 0036459180     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1634/stemcells.20-6-493     Document Type: Short Survey

References (87)

1. Ying SY, Zhang Z, Furst B et al. Activins and activin receptors in cell growth. Proc Soc Exp Biol Med 1997;214:114-122.
2. Phillips DJ. Regulation of activin's access to the cell: Why is mother nature such a control freak? Bioessays 2000;22:689-696.
3. Mathews LS. Activin receptors and cellular signaling by the receptor serine kinase family. Endocr Rev 1994;15:310-325.
4. Gaddy-Kurten D, Tsuchida K, Vale W. Activins and the receptor serine kinase superfamily. Recent Prog Horm Res 1995;50:109-129.
5. Shav-Tal Y, Lapter S, Parameswaran R et al. Activin receptors. In: Oppenheim JJ, Feldman M, eds. Cytokine Reference (Online book edition). Academic Press, 2001 http://www.aca demicpress.com/cytokinereference.
6. Pangas SA, Woodruff TK. Activin signal transduction pathways. Trends Endocrinol Metab 2000;11:309-314.
7. Tsukazaki T, Chiang TA, Davison AF et al. SARA, a FYVE domain protein that recruits Smad2 to the TGFβ receptor. Cell 1998;95:779-791.
8. Takagi T, Harada J, Ishii S. Murine Schnurri-2 is required for positive selection of thymocytes. Nat Immunol 2001;2:1048-1053.
9. Woodruff TK. Activin. In: Oppenheim JJ, Feldman M, eds. Cytokine Reference (Online Book Edition). Academic Press, 2000 http://www.academicpress.com/cytokinereference.
10. Johansson BM, Wiles MV. Evidence for involvement of activin A and bone morphogenetic protein 4 in mammalian mesoderm and hematopoietic development. Mol Cell Biol 1995;15:141-151.
11. Zipori D. In vitro proliferation of mouse lymphoblastoid cell lines: Growth modulation by various populations of adherent cells. Cell Tissue Kinet 1980;13:287-298.
12. Zipori D. Conditions required for the inhibition of in vitro growth of a mouse myeloma cell line by adherent bone-marrow cells. Cell Tissue Kinet 1981;14:479-488.
13. Zipori D, Tamir M, Toledo J et al. Differentiation stage and lineage-specific inhibitor from the stroma of mouse bone marrow that restricts lymphoma cell growth. Proc Natl Acad Sci USA 1986;83:4547-4551.
14. Brosh N, Stemberg D, Honigwachs-Sha'anani J et al. The plasmacytoma growth inhibitor restrictin-P is an antagonist of interleukin 6 and interleukin 11. Identification as a stromaderived activin A. J Biol Chem 1995;270:29594-29600.
15. Uchimaru K, Motokura T, Takahashi S et al. Bone marrow stromal cells produce and respond to activin A: Interactions with basic fibroblast growth factor and platelet-derived growth factor. Exp Hematol 1995;23:613-618.
16. Yu AW, Shao LE, Frigon Jr NL et al. Detection of functional and dimeric activin A in human marrow microenvironment. Implications for the modulation of erythropoiesis. Ann NY Acad Sci 1994;718:285-298.
17. Shao L, Frigon Jr NL, Sehy DW et al. Regulation of production of activin A in human marrow stromal cells and monocytes. Exp Hematol 1992;20:1235-1242.
18. Shao LE, Frigon Jr NL, Yu A et al. Contrasting effects of inflammatory cytokines and glucocorticoids on the production of activin A in human marrow stromal cells and their implications. Cytokine 1998;10:227-235.
19. Takahashi S, Uchimaru K, Harigaya K et al. Tumor necrosis factor and interleukin-1 induce activin A gene expression in a human bone marrow stromal cell line. Biochem Biophys Res Commun 1992;188:310-317.
20. Yamashita T, Takahashi S, Ogata E. Expression of activin A/erythroid differentiation factor in murine bone marrow stromal cells. Blood 1992;79:304-307.
21. Sternberg D, Peled A, Shezen E et al. Control of stroma-dependent hematopoiesis by basic fibroblast growth factor: Stromal phenotypic plasticity and modified myelopoietic functions. Cytokines Mol Ther 1996;2:29-38.
22. Yu EW, Dolter KE, Shao LE et al. Suppression of IL-6 biological activities by activin A and implications for inflammatory arthropathies. Clin Exp Immunol 1998;112:126-132.
23. Dolter KE, Palyash JC, Shao LE et al. Analysis of activin A gene expression in human bone marrow stromal cells. J Cell Biochem 1998;70:8-21.
24. Zipori D, Toledo J, von der Mark K. Phenotypic heterogeneity among stromal cell lines from mouse bone marrow disclosed in their extracellular matrix composition and interactions with normal and leukemic cells. Blood 1985;66:447-455.
25. Shoham T, Sternberg D, Brosh N et al. The promotion of plasmacytoma tumor growth by mesenchymal stroma is antagonized by basic fibroblast growth factor induced activin A. Leukemia 2001;15:1102-1110.
26. Hayette S, Gadoux M, Martel S et al. FLRG (follistatin-related gene), a new target of chromosomal rearrangement in malignant blood disorders. Oncogene 1998;16:2949-2954.
27. Maguer-Satta V, Bartholin L, Jeanpierre S et al. During hematopoiesis, expression of FLRG, a novel activin A ligand, is regulated by TGF-β. Exp Hematol 2001;29:301-308.
28. Broxmeyer HE, Lu L, Cooper S et al. Selective and indirect modulation of human multipotential and erythroid hematopoietic progenitor cell proliferation by recombinant human activin and inhibin. Proc Natl Acad Sci USA 1988;85:9052-9056.
29. Yu J, Shao L, Vaughan J et al. Characterization of the potentiation effect of activin on human erythroid colony formation in vitro. Blood 1989;73:952-960.
30. Mizuguchi T, Kosaka M, Saito S. Activin A suppresses proliferation of interleukin-3-responsive granulocyte-macrophage colony-forming progenitors and stimulates proliferation and differentiation of interleukin-3-responsive erythroid burst-forming progenitors in the peripheral blood. Blood 1993;81:2891-2897.
31. Nakamura K, Kosaka M, Mizuguchi T et al. Effect of erythroid differentiation factor on maintenance of human hematopoietic cells in co-cultures with allogenic stromal cells. Biochem Biophys Res Commun 1993;194:1103-1110.
32. Hangoc G, Carow CE, Schwall R et al. Effects in vivo of recombinant human inhibin on myelopoiesis in mice. Exp Hematol 1992;20:1243-1246.
33. Nishihara T, Okahashi N, Ueda N. Activin A induces apoptotic cell death. Biochem Biophys Res Commun 1993;197:985-991.
34. Nishihara T, Ohsaki Y, Ueda N et al. Induction of apoptosis in B lineage cells by activin A derived from macrophages. J Interferon Cytokine Res 1995;15:509-516.
35. Sternberg D, Honigwachs-sha'anani J, Brosh N et al. Restrictin-P/stromal activin A, kills its target cells via an apoptotic mechanism. Growth Factors 1995;12:277-287.
36. Phillips DJ, Brauman JN, Mason AJ et al. A sensitive and specific in vitro bioassay for activin using a mouse plasmacytoma cell line, MPC-11. J Endocrinol 1999;162:111-116.
37. Honigwachs-Sha'anani J, Brosh N, Kompier R et al. Restrictin-P: The first member of a putative family of novel inhibitors. Ann N Y Acad Sci 1991;628:287-297.
38. Yamato K, Koseki T, Ohguchi M et al. Activin A induction of cell-cycle arrest involves modulation of cyclin D2 and p21CIP1/WAF1 in plasmacytic cells. Mol Endocrinol 1997;11:1044-1052.
39. Ishisaki A, Yamato K, Nakao A et al. Smad7 is an activin-inducible inhibitor of activin-induced growth arrest and apoptosis in mouse B cells. J Biol Chem 1998;273:24293-24296.
40. Zauberman A, Oren M, Zipori D. Involvement of p21(WAF1/Cip1), CDK4 and Rb in activin A mediated signaling leading to hepatoma cell growth inhibition. Oncogene 1997;15:1705-1711.
41. Weinberg RA. The retinoblastoma protein and cell cycle control. Cell 1995;81:323-330.
42. Ishisaki A, Yamato K, Hashimoto S et al. Differential inhibition of Smad6 and Smad7 on bone morphogenetic protein- and activin-mediated growth arrest and apoptosis in B cells. J Biol Chem 1999;274:13637-13642.
43. Koseki T, Yamato K, Krajewski S et al. Activin A-induced apoptosis is suppressed by BCL-2. FEBS Lett 1995;376:247-250.
44. Koseki T, Yamato K, Ishisaki A et al. Correlation between Bcl-X expression and B-cell hybridoma apoptosis induced by activin A. Cell Signal 1998;10:517-521.
45. Zauberman A, Lapter S, Zipori D. Smad proteins suppress C/EBPβ and STAT3 mediated transcriptional activation of the haptoglobin promoter. J Biol Chem 2001;276:24719-24725.
46. Sakai R, Eto Y. Involvement of activin in the regulation of bone metabolism. Mol Cell Endocrinol 2001;180:183-188.
47. Shoham T, Yaniv E, Koren R et al. Reduced expression of activin A in focal lymphoid agglomerates within nasal polyps. J Histochem Cytochem 2001;49:1245-1252.
48. Shoham T, Zipori D. Molecular Evidence for the Critical Role of the Stroma in Regulation of Hemopoiesis: Stromal Activin A Restricts B Cell Lymphopoiesis. Internal Cytokine Society and the International Society for Interferon and Cytokine Research, Jerusalem, Israel 1998:30.
49. Zipori D, Kalai M, Tamir M. Restrictins: Stromal cell associated factors that control cell organization in hemopoietic tissues. Nat Immun Cell Growth Regul 1988;7:185-192.
50. Zipori D. Regulation of hemopoiesis by cytokines that restrict options for growth and differentiation. Cancer Cells 1990;2:205- 211.
51. Zipori D. The renewal and differentiation of hemopoietic stem cells. FASEB J 1992;6:2691-2697.
52. Zipori D, Barda-Saad M. Role of activin A in negative regulation of normal and tumor B lymphocytes. J Leuk Biol 2001;69:867-873.
53. Oritani K, Medina KL, Tomiyama Y et al. Limitin: An interferon-like cytokine that preferentially influences B-lymphocyte precursors. Nat Med 2000;6:659-666.
54. Ohneda O, Ohneda K, Nomiyama H et al. WECHE: A novel hematopoietic regulatory factor. Immunity 2000;12:141-150.
55. Yokota T, Oritani K, Takahashi I et al. Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages. Blood 2000;96:1723-1732.
56. 3H]thymidine uptake by rat thymocytes and 3T3 cells in vitro. Mol Cell Endocrinol 1989;61:133-138.
57. Robertson DM, Foulds LM, Prisk M et al. Inhibin/activin β-sub-unit monomer: Isolation and characterization. Endocrinology 1992;130:1680-1687.
58. Hedger MP, Clarke L. Isolation of rat blood lymphocytes using a two-step Percoll density gradient. Effect of activin (erythroid differentiation factor) on peripheral T lymphocyte proliferation in vitro. J Immunol Methods 1993;163:133-136.
59. Hedger MP, Phillips DJ, de Kretser DM. Divergent cell-specific effects of activin-A on thymocyte proliferation stimulated by phytohemagglutinin, and interleukin 1β or interleukin 6 in vitro. Cytokine 2000;12:595-602.
60. Petraglia F, Sacerdote P, Cossarizza A et al. Inhibin and activin modulate human monocyte chemotaxis and human lymphocyte interferon-γ production. J Clin Endocrinol Metab 1991;72:496-502.
61. Eto Y, Tsuji T, Takezawa M et al. Purification and characterization of erythroid differentiation factor (EDF) isolated from human leukemia cell line THP-1. Biochem Biophys Res Commun 1987;142:1095-1103.
62. Murata M, Eto Y, Shibai H et al. Erythroid differentiation factor is encoded by the same mRNA as that of the inhibin βA chain. Proc Natl Acad Sci USA 1988;85:2434-2438.
63. Hilden K, Tuuri T, Eramaa M et al. Co-ordinate expression of activin A and its type I receptor mRNAs during phorbol esterinduced differentiation of human K562 erythroleukemia cells. Mol Cell Endocrinol 1999;153:137-145.
64. Yu J, Shao LE, Lemas V et al. Importance of FSH-releasing protein and inhibin in erythrodifferentiation. Nature 1987;330:765-767.
65. Frigon Jr NL, Shao L, Young AL et al. Regulation of globin gene expression in human K562 cells by recombinant activin A. Blood 1992;79:765-772.
66. Shiozaki M, Sakai R, Tabuchi M et al. In vivo treatment with erythroid differentiation factor (EDF/activin A) increases erythroid precursors (CFU-E and BFU-E) in mice. Biochem Biophys Res Commun 1989;165:1155-1161.
67. Schwall R, Schmelzer CH, Matsuyama E et al. Multiple actions of recombinant activin-A in vivo. Endocrinology 1989;125:1420-1423.
68. Broxmeyer HE, Hangoc G, Zucali JR et al. Effects in vivo of purified recombinant human activin and erythropoietin in mice. Int J Hematol 1991;54:447-454.
69. Shiozaki M, Sakai R, Tabuchi M et al. Evidence for the participation of endogenous activin A/erythroid differentiation factor in the regulation of erythropoiesis. Proc Natl Acad Sci USA 1992;89:1553-1556.
70. 1 phase. J Cell Biochem 1992;50:255-265.
71. Shiozaki M, Kosaka M, Eto Y. Activin A: A commitment factor in erythroid differentiation. Biochem Biophys Res Commun 1998;242:631-635.
72. Kitamura K, Aota S, Sakamoto R et al. Smad7 selectively interferes with different pathways of activin signaling and inhibits erythroid leukemia cell differentiation. Blood 2000;95:3371-3379.
73. Shao L, Frigon Jr NL, Young AL et al. Effect of activin A on globin gene expression in purified human erythroid progenitors. Blood 1992;79:773-781.
74. Nakao K, Kosaka M, Saito S. Effects of erythroid differentiation factor (EDF) on proliferation and differentiation of human hematopoietic progenitors. Exp Hematol 1991;19:1090-1095.
75. Scher W, Eto Y, Ejima D et al. Phorbol ester-treated human acute myeloid leukemia cells secrete G-CSF, GM-CSF and erythroid differentiation factor into serum-free media in primary culture. Biochim Biophys Acta 1990;1055:278-286.
76. Takahashi S, Yamashita T, Eto Y et al. Inducible gene expression of activin A/erythroid differentiation factor in HL-60 cells. Biochem Biophys Res Commun 1990;167:654-658.
77. Eramaa M, Hurme M, Stenman UH et al. Activin A/erythroid differentiation factor is induced during human monocyte activation. J Exp Med 1992;176:1449-1452.
78. Yu J, Shao LE, Frigon Jr NL et al. Induced expression of the new cytokine, activin A, in human monocytes: Inhibition by glucocorticoids and retinoic acid. Immunology 1996;88:368-374.
79. Yamashita N, Nakajima T, Takahashi H et al. Effects of activin A on IgE synthesis and cytokine production by human peripheral mononuclear cells. Clin Exp Immunol 1993;94:214-219.
80. Okabe-Kado J, Honma Y, Hayashi M et al. Effects of transforming growth factor β and activin A on vitamin D3-induced monocytic differentiation of myeloid leukemia cells. Anticancer Res 1991;11:181-186.
81. Yamada R, Suzuki T, Hashimoto M et al. Induction of differentiation of the human promyelocytic cell line HL-60 by activin/EDF. Biochem Biophys Res Commun 1992;187:79-85.
82. Saeki K, Yuo A, Kato M et al. Cell density-dependent apoptosis in HL-60 cells, which is mediated by an unknown soluble factor, is inhibited by transforming growth factor β1 and overexpression of Bcl-2. J Biol Chem 1997;272:20003-20010.
83. Ohguchi M, Yamato K, Ishihara Y et al. Activin A regulates the production of mature interleukin-1β and interleukin-1 receptor antagonist in human monocytic cells. J Interferon Cytokine Res 1998;18:491-498.
84. Fukuchi Y, Kizaki M, Yamato K et al. Mcl-1, an early-induction molecule, modulates activin A-induced apoptosis and differentiation of CML cells. Oncogene 2001;20:704-713.
85. Fujimoto K, Kawakita M, Kato K et al. Purification of megakaryocyte differentiation activity from a human fibrous histiocytoma cell line: N-terminal sequence homology with activin A. Biochem Biophys Res Commun 1991;174:1163-1168.
86. Nishimura M, Kaku K, Azuno Y et al. Effect of erythroid differentiation factor on megakaryocytic differentiation of L8057, a murine megakaryoblastic leukemia cell line. Biochem Biophys Res Commun 1991;181:1042-1047.
87. Okafuji K, Kaku K, Seguchi M et al. Effects of activin A/erythroid differentiation factor on erythroid and megakaryocytic differentiations of mouse erythroleukemia (Friend) cells: Evidence for two distinct modes of cell response. Exp Hematol 1995;23:210-216.