Expression and Characterization of the C345C/NTR Domains of Complement Components C3 and C5

Journal of Immunology

Volumn 171, Issue 12, 2003, Pages 6565-6573

  Thai, Chuong Thu ^a   Ogata, Ronald T ^a  

^a TORREY PINES INSTITUTE FOR MOLECULAR STUDIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 MACROGLOBULIN; CELL SURFACE RECEPTOR; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C345C; COMPLEMENT COMPONENT C4; COMPLEMENT COMPONENT C5; COMPLEMENT COMPONENT C6; COMPLEMENT COMPONENT C7; COMPLEMENT INHIBITOR; COMPLEMENT MEMBRANE ATTACK COMPLEX; CYSTEINE; DISULFIDE; FIBRINOGEN; NETRIN; NETRIN RECEPTORS; PROTEIN SUBUNIT; RECOMBINANT PROTEIN; THIOESTER; TISSUE INHIBITOR OF METALLOPROTEINASE; UNCLASSIFIED DRUG;

ALPHA CHAIN; AMINO ACID SEQUENCE; ARTICLE; BETA SHEET; BINDING AFFINITY; BINDING COMPETITION; BIOSYNTHESIS; C345C NTR DOMAIN; CARBOXY TERMINAL SEQUENCE; CELL LYSATE; CHEMISTRY; COMPLEMENT HEMOLYSIS TEST; COMPLEX FORMATION; DISSOCIATION CONSTANT; DISULFIDE BOND; ESCHERICHIA COLI; GENETICS; HEMOLYSIS; HUMAN; IMMUNOLOGY; METABOLISM; METHODOLOGY; MOLECULAR GENETICS; PLASMID; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN MOTIF; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SURFACE PLASMON RESONANCE;

EID: 0345735840     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.171.12.6565     Document Type: Article

References (56)

1. Walport, M. J. 2001. Complement: first of two parts. N. Engl. J. Med. 344:1058.
2. Walport, M. J. 2001. Complement: second of two parts., N. Engl. J. Med. 344:1140.
3. Law, S. K. A., and K. B. M. Reid. 1995. Complement, 2nd Ed. IRL Press, Oxford.
4. Sahu, A., and J. D. Lambris. 2001. Structure and biology of complement protein C3, a connecting link between innate and acquired immunity. Immunol. Rev. 180:35.
5. DiScipio, R. G. 1992. Formation and structure of the C5b-7 complex of the lytic pathway of complement. J. Biol. Chem. 267:17087.
6. Stewart, J. L., W. P. Kolb, and J. M. Sodetz. 1987. Evidence that C5b recognizes and mediates C8 incorporation in the cytolytic complex of complement. J. Immunol. 139:1960.
7. Sottrup-Jensen, L. 1989. α-Macroglobulins: structure, shape, and mechanism of proteinase complex formation. J. Biol. Chem. 264:11539.
8. Lagueux, M., E. Perrodou, E. A. Levashina, M. Capovilla, and J. A. Hoffman. 2000. Constitutive expression of a complement-like protein in Toll and JAK gain-of-function mutants of Drosophila. Proc. Natl. Acad. Sci. USA 87:11427.
9. Levashina, E. A., L. F. Moita, S. Blandin, G. Vriend, M. Lagneux, and F. C. Kafatos. 2001. Conserved role of a complement-like protein in phagocytosis revealed by dsRNA knockout in cultured cells of the mosquito, Anopheles gambiae. Cell 104:709.
10. Lin, M., D. R. Sutherland, W. Horsfall, N. Totty, E. Yeo, R. Nayar, X. F. Wu, and A. C. Schuh. 2002. Cell surface antigen CD109 is a novel member of the a2 macroglobulin/C3, C4, C5 family of thioester-containing proteins. Blood 99:1683.
11. Law, S. K. A., and A. W. Dodds. 1997. The internal thioester and the covalent binding properties of the complement proteins C3 and C4. Protein Sci. 6:263.
12. Sottrup-Jensen, L., O. Sand, L. Kristensen, and G. H. Fey. 1989. The α-macroglobulin bait region. J. Biol. Chem. 264:15781.
13. Ishii. N., W. G. Wadsworth, B. D. Stern, J. G. Culotti. and E. M. Hedgecock. 1992. UNC-6, a laminin-related protein, guides cell and pioneer axon rnigrafions in C. elegans. Neuron 9:873.
14. Dickson, B. J. 2002. Molecular mechanism of axon guidance. Science 298:1959.
15. Bork, P., and A. Bairoch. 1995. Extracellular protein modules: a proposed nomenclature. Trends Biochem. Sci. 20:(poster suppl.).
16. Bányai, L., and L. Patthy. 1999. The NTR module: domains of netrins, secreted frizzled related proteins, and type I procollagen C-proteinase enhancer protein are homologous with tissue inhibitors of metalloproteinases. Protein Sci. 8:1636.
17. Chong, J. M., A. Üren, J. S. Rubin, and D. W. Speicher. 2002. Disulfide bond assignments of secreted frizzled-related protein-I provide insights about frizzled homology and netrin modules. J. Biol. Chem. 277:5134.
18. Stetefeld, J., M. Jenny, T. Schulthess. R. Landwehr, B. Schumacher, S. Frank, M. A. Rüegg, J. Engel, and R. A. Kammerer. 2001. The laminin-binding domain of agrin is related to N-TIMP-I. Nat. Struct. Biol. 8:705.
19. Liepinsh, E., L. Bányai, G. Pintacuda, M. Trexler, L. Patthy, and G. Otting. 2003. NMR structure of the netrin-like domain of human type I procollagen C-proteinase enhancer defines structural consensus of NTR domains and assesses potential proteinase inhibitory activity and ligand binding. J. Biol. Chem. 278:25982.
20. Gomis-Rüth, F.-X., K. Maskos, M. Betz, A. Bergner, R. Huber, K. Suzuki, N. Yoshida, H. Nagase, K. Brew, G. P. Bourenkov, et al. 1997. Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1. Nature 389:77.
21. Muskett, F. W., T. A. Frenkiel, J. Feeney, R. B. Freedman, M. D. Carr, and R. A. Williamson. 1998. High resolution structure of the N-terminal domain of tissue inhibitor of metalloproteinases-2 and characterization of its interaction site with matrix metalloproteinase-3. J. Biol. Chem. 273:21736.
22. Low, P. J., R. Ai, and R. T. Ogata. 1999. Active sites in complement components C5 and C3 identified by proximity to indels in the C3/4/5 protein family. J. Immunol. 162:6580.
23. Sandoval, A., R. Ai, J. M. Ostresh, and R. T. Ogata. 2000. Distal recognition site for classical pathway convertase located in the C345C/netrin module of complement component C5. J. Immunol. 165:1066.
24. Müller-Eberhard, H. J. 1988. Molecular organization and function of the complement system. Annu. Rev. Biochem. 57:321.
25. DeBruijn, M. H. L., and G. H. Fey. 1985. Human complement component C3: cDNA coding sequence and derived primary structure. Proc. Natl. Acad. Sci. USA 82:708.
26. Haviland, D. L., J. C. Haviland. D. T. Fleischer, A. Hunt, and R. A. Wetsel. 1991. Complete cDNA sequence of human complement pro-C5: evidence of truncated transcripts derived from a single copy gene. J. Immunol. 146:362.
27. Taniguchi-Sidle, A., and D. E. Isenman. 1992. Mutagenesis of the Arg-Gly-Asp triplet in human complement component C3 does not abolish binding of iC3b to the leukocyte integrin complement receptor type III (CR3, CD11b/CD18). J. Immunol. 267:635.
28. Ogata, R. T., and P. J. Low. 1995. Complement component C5: engineering of a mutant that is specifically cleaved by the C4-specific C1s protease. J. Immunol. 155:2642.
29. Miller, J. H. 1972. Experiments in Molecular Genetics. Cold Spring Harbor Lab., Cold Spring Harbor.
30. DiScipio, R. G., C. A. Smith, H. J. Müller-Eberhard, and T. E. Hugli. 1983. The activation of human complement component C5 by a fluid phase C5 convertase. J. Biol. Chem. 258:10629.
31. Janatova, J., P. E. Lorenz, A. N. Schechter, J. W. Prahl, and B. F. Tack. 1980. Third component of human complement: appearance of a sulfhydryl group following chemical or enzymatic inactivation. Biochemistry 19:4471.
32. Wright, S. K., and R. E. Viola. 1998., Evaluation of methods for the quantitation of cysteines in proteins. Anal. Biochem. 265:8.
33. Ogata, R. T., and P. J. Low. 1997. Complement-inhibiting peptides identified by proximity to indels in the C3/4/5 protein family. J. Immunol. 158:3852.
34. Dolmer, K., and L. Sottrup-Jensen. 1993. Disulfide bridges in human complement component C3b. FEBS Lett. 315:85.
35. Huang, W., K. Suzuki, H. Nagase, S. Arumugam, S. R. Van Doren, and K. Brew. 1996. Folding and characterization of the amino-terminal domain of human tissue inhibitor of metalloproteinases-1 (TIMP-1) expressed at high yield in E. coli. FEBS Lett. 384:155.
36. Williamson, R. A., D. Natalia, C. K. Gee, G. Murphy, M. D. Carr, and R. B. Freedman. 1996. Chemically and conformationally authentic active domain of human tissue inhibitor of metalloproteinase-2 refolded from bacteria inclusion bodies. Eur. J. Biochem. 241:476.
37. Bessette. P. H., F. Åslund, J. Beckwith, and G. Georgiou. 1999. Efficient folding of proteins with multiple disulfide bonds in the Escherichia coli cytoplasm. Proc. Natl. Acad. Sci. USA 96:13703.
38. Williamson, R. A., G. Martorell, M. D. Carr, G. Murphy, A. J. P. Docherty, R. B. Freedman, and J. Feeney. 1994. Solution structure of the active domain of tissue inhibitor of metalloproteinases-2: a new member of the OB fold protein family. Biochemistry 33:11745.
39. Arroyave, C. M., and H. J. Müller-Eberhard. 1973. Interactions between human C5, C6, and C7 and their functional significance in complement-dependent cytolysis. J. Immunol. 111:536.
40. DiScipio, R. G., S. M. Linton, and N. K. Rushmere. 1999. Function of the factor I modules (FIMS) of human complement component C6. J. Biol. Chem. 274:31811.
41. Kolb, W. P., J. A. Haxby, C. M. Arroyave, and H. J. Müller-Eberhard. 1973. The membrane attack mechanism of complement: reversible interactions among the five native components in free solution. J. Exp. Med. 138:428.
42. Preissner, K. T., E. R. Podack, and H. M. Müller-Eberhard. 1985. Self-association of the seventh component of human complement (C7): dimerization and polymerization. J. Immunol. 135:452.
43. Zutshi, R., M. Brickner, and J. Chmielewski. 1998. Inhibiting the assembly of protein-protein interfaces. Curr. Opin. Chem. Biol. 2:62.
44. Oran, A. E., and D. E. Isenman. 1999. Identification of residues within the 727-767 segment of human complement component C3 important for its interaction with factor H and with complement receptor 1 (CR1, CD35). J. Biol. Chem. 274:5120.
45. Clemenza, L., and D. E. Isenman. 2000. Structure-guided identification of C3d residues essential for its binding to complement receptor CR2 (CD21). J. Immunol. 165:3839.
46. Szakonyi, G., J. M. Guthridge. D. Li, K. Young, V. M. Holers, and X. S. Chen. 2001. Structure of complement receptor 2 in complex with its C3d ligand. Science 292:1725.
47. Taniguchi-Sidle, A., and D. E. Isenman. 1994. Interactions of human complement component C3 with factor B and with complement receptor type 1 (CR1, CD35) and type 3 (CR3, CD11b/CD18) involve an acidic sequence at the N-terminus of the C3 α-chain. J. Immunol. 153:5285.
48. Lambris, J. D., Z. Lao, T. J. Oglesby, J. P. Atkinson, C. E. Hack, and J. D. Becherer. 1996. Dissection of CR1, factor H, membrane cofactor protein, and factor B binding and functional sites in the third complement component. J. Immunol. 156:4821.
49. Kim, Y. U., M. C. Carroll, D. E. Isenman, M. Nonaka, P. Pramoonjago, J. Takeda, K. Inoue, and T. Kinoshita. 1992. Covalent binding of C3b to C4b within the classical complement pathway C5 convertases: determination of amino acid residues involved in ester linkage formation. J. Biol. Chem. 267:4171.
50. Ogata, R. T., R. Ai, and P. J. Low. 1998. Active sites in complement component C3 mapped by mutations at indels. J. Immunol. 161:4785.
51. Haefliger, J.-A., J. Tschopp, N. Vial, and D. E. Jenne. 1989. Complete primary structure and functional characterization of the sixth component of the human complement system: identification of the C5b-binding domain in complement C6. J. Biol. Chem. 264:18041.
52. Letunic, I., L. Goodstadt, N. J. Dickens, T. Doerks, J. Schultz, R. Mott, F. Ciccarelli. R. R. Copley, C. P. Ponting, and P. Bork. 2002. Recent improvements to the SMART domain-based sequence annotation resource (smart.emblheidelberg.de). Nucleic Acids Res. 30:242.
53. Podack, E. R., W. P. Kolb, and H. J. Müller-Eberhard. 1978. The C5b-6 complex: formation, isolation, and inhibition of its activity by lipoprotein and the S-protein of human serum. J. Immunol. 120:1841.
54. Würzner, R., M. J. Hobart, B. A. Femie, D. Mewar, P. C. Potter. A. Orren, and P. J. Lachmann. 1995. Molecular basis of subtotal complement C6 deficiency. J. Clin. Invest. 95:1877.
55. Würzner, R., V. C. Joycey, and P. J. Lachmann. 1994. Complement component C7: assessment of in vivo synthesis after liver transplantation reveals that hepatocytes do not synthesize the majority of human C7. J. Immunol. 152:4624.
56. Morgan, B. P. 2000. Inhibition of complement in the membrane attack complex. In Therapeutic Interventions in the Complement System. J. D. Lambris and V. M. Holers, eds. Humana Press, Totowa, p. 205,