Complement plays an important role in spinal cord injury and represents a therapeutic target for improving recovery following trauma

American Journal of Pathology

Volumn 169, Issue 3, 2006, Pages 1039-1047

  Qiao, Fei ^a   Atkinson, Carl ^a   Song, Hongbin ^a   Pannu, Ravinder ^a   Singh, Inderjit ^a   Tomlinson, Stephen ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT COMPONENT C3;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CONVALESCENCE; DEMYELINATION; HISTOPATHOLOGY; LOCOMOTION; MOUSE; NECROSIS; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; SCORING SYSTEM; SPINAL CORD INJURY;

EID: 33748802258     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.2353/ajpath.2006.060248     Document Type: Article

References (32)

1. Kwon BK, Tetzlaff W, Grauer JN, Beiner J, Vaccaro AR: Pathophysiology and pharmacologic treatment of acute spinal cord injury. Spine J 2004, 4:451-464
2. Taoka Y, Okajima K, Uchiba M, Murakami K, Kushimoto S, Johno M, Naruo M, Okabe H, Takatsuki K: Role of neutrophils in spinal cord injury in the rat. Neuroscience 1997, 79:1177-1182
3. Fiore C, Inman DM, Hirose S, Noble LJ, Igarashi T, Compagnone NA: Treatment with the neurosteroid dehydroepiandrosterone promotes recovery of motor behavior after moderate contusive spinal cord injury in the mouse. J Neurosci Res 2004, 75:391-400
4. Tsai EC, Tator CH: Neuroprotection and regeneration strategies for spinal cord repair. Curr Pharm Des 2005, 11:1211-1222
5. Hall ED, Springer JE: Neuroprotection and acute spinal cord injury: a reappraisal. NeuroRx 2004, 1:80-100
6. Anderson AJ, Najbauer J, Huang W, Young W, Robert S: Upregulation of complement inhibitors in association with vulnerable cells following contusion-induced spinal cord injury. J Neurotrauma 2005, 22:382-397
7. Anderson AJ, Robert S, Huang W, Young W, Cotman CW: Activation of complement pathways after contusion-induced spinal cord injury. J Neurotrauma 2004, 21:1831-1846
8. Reynolds DN, Smith SA, Zhang YP, Lahiri DK, Morassutti DJ, Shields CB, Kotwal GJ: Vaccinia virus complement control protein modulates inflammation following spinal cord injury. Ann NY Acad Sci 2003, 1010:534-539
9. Reynolds DN, Smith SA, Zhang YP, Mengsheng Q, Lahiri DK, Morassutti DJ, Shields CB, Kotwal GJ: Vaccinia virus complement control protein reduces inflammation and improves spinal cord integrity following spinal cord injury. Ann NY Acad Sci 2004, 1035:165-178
10. Atkinson C, Song H, Lu B, Qiao F, Burns TA, Holers VM, Tsokos GC, Tomlinson S: Targeted complement inhibition by C3d recognition ameliorates tissue injury without apparent increase in susceptibility to infection. J Clin Invest 2005, 115:2444-2453
11. Kuhn PL, Wrathall JR: A mouse model of graded contusive spinal cord injury. J Neurotrauma 1998, 15:125-140
12. Basso DM, Beattie MS, Bresnahan JC: Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection. Exp Neural 1996, 139:244-256
13. Noble LJ, Donovan F, Igarashi T, Goussev S, Werb Z: Matrix metalloproteinases limit functional recovery after spinal cord injury by modulation of early vascular events. J Neurosci 2002, 22:7526-7535
14. Mikami Y, Toda M, Watanabe M, Nakamura M, Toyama Y, Kawakami Y: A simple and reliable behavioral analysis of locomotor function after spinal cord injury in mice. Technical note. J Neurosurg 2002, 97:142-147
15. Wells JE, Rice TK, Nuttall RK, Edwards DR, Zekki H, Rivest S, Yong VW: An adverse role for matrix metalloproteinase 12 after spinal cord injury in mice. J Neurosci 2003, 23:10107-10115
16. Wells JE, Hurlbert RJ, Fehlings MG, Yong VW: Neuroprotection by minocycline facilitates significant recovery from spinal cord injury in mice. Brain 2003, 126:1628-1637
17. Carlson SL, Parrish ME, Springer JE, Doty K, Dossett L: Acute inflammatory response in spinal cord following impact injury. Exp Neurol 1998, 151:77-88
18. Gonzalez R, Glaser J, Liu MT, Lane TE, Keirstead HS: Reducing inflammation decreases secondary degeneration and functional deficit after spinal cord injury. Exp Neurol 2003, 184:456-463
19. Li LM, Zhu Y, Fan GY: Effects of recombinant sCR1 on the immune inflammatory reaction in acute spinal cord injury tissue of rats. Chin J Traumatol 2005, 8:49-53
20. de Castro R, Jr, Hughes MG, Xu GY, Clifton C, Calingasan NY, Gelman BB, McAdoo DJ: Evidence that infiltrating neutrophils do not release reactive oxygen species in the site of spinal cord injury. Exp Neurol 2004, 190:414-424
21. Saville LR, Pospisil CH, Mawhinney LA, Bao F, Simedrea FC, Peters AA, O'Connell PJ, Weaver LC, Dekaban GA: A monoclonal antibody to CD11d reduces the inflammatory infiltrate into the injured spinal cord: a potential neuroprotective treatment. J Neuroimmunol 2004, 156:42-57
22. Oatway MA, Chen Y, Bruce JC, Dekaban GA, Weaver LC: Anti-CD11d integrin antibody treatment restores normal serotonergic projections to the dorsal, intermediate, and ventral horns of the injured spinal cord. J Neurosci 2005, 25:637-647
23. Collard CD, Agah A, Reenstra W, Buras J, Stahl GL: Endothelial nuclear factor-kappaB translocation and vascular cell adhesion molecule-1 induction by complement: inhibition with anti-human C5 therapy or cGMP analogues. Arterioscler Thromb Vasc Biol 1999, 19:2623-2629
24. Foreman KE, Vaporciyan AA, Bonish BK, Jones ML, Johnson KJ, Glovsky MM, Eddy SM, Ward PA: C5a-induced expression of P-selectin in endothelial cells. J Clin Invest 1994, 94:1147-1155
25. Mulligan MS, Schmid E, Till GO, Hugli TE, Friedl HP, Roth RA, Ward PA: C5a-dependent up-regulation in vivo of lung vascular P-selectin. J Immunol 1997, 158:1857-1861
26. Vaporciyan AA, Mulligan MS, Warren JS, Barton PA, Miyasaka M, Tamatani T, Ward PA: Up-regulation of lung vascular ICAM-1 in rats is complement dependent. J Immunol 1995, 155:1442-1150
27. Sewell DL, Nacewicz B, Liu F, Macvilay S, Erdei A, Lambris JD, Sandor M, Fabry Z: Complement C3 and C5 play critical roles in traumatic brain cryoinjury: blocking effects on neutrophil extravasation by C5a receptor antagonist. J Neuroimmunol 2004, 155:55-63
28. Rus H, Cudrici C, Niculescu F: C5b-9 complement complex in autoimmune demyelination and multiple sclerosis: dual role in neuroinflammation and neuroprotection. Ann Med 2005, 37:97-104
29. Tran GT, Hodgkinson SJ, Carter N, Killingsworth M, Spicer ST, Hall BM: Attenuation of experimental allergic encephalomyelitis in complement component 6-deficient rats is associated with reduced complement C9 deposition, P-selectin expression, and cellular infiltrate in spinal cords. J Immunol 2002, 168:4293-4300
30. Mead RJ, Singhrao SK, Neal JW, Lassmann H, Morgan BP: The membrane attack complex of complement causes severe demyelination associated with acute axonal injury. J Immunol 2002, 168:458-465
31. Mead RJ, Neal JW, Griffiths MR, Linington C, Botto M, Lassmann H, Morgan BP: Deficiency of the complement regulator CD59a enhances disease severity, demyelination and axonal injury in murine acute experimental allergic encephalomyelitis. Lab Invest 2004, 84:21-28
32. Dyer JK, Bourque JA, Sleeves JD: The role of complement in immunological demyelination of the mammalian spinal cord. Spinal Cord 2005, 43:417-425