Recombinant C345C and factor I modules of complement components C5 and C7 inhibit C7 incorporation into the complement membrane attack complex

Journal of Immunology

Volumn 174, Issue 10, 2005, Pages 6227-6232

  Thai, Chuong Thu ^a   Ogata, Ronald T ^a  

^a TORREY PINES INSTITUTE FOR MOLECULAR STUDIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT COMPONENT C5; COMPLEMENT COMPONENT C7; COMPLEMENT COMPONENT C8; COMPLEMENT COMPONENT C9; COMPLEMENT MEMBRANE ATTACK COMPLEX; RECOMBINANT COMPLEMENT C345C; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; COMPLEMENT CLASSICAL PATHWAY; COMPLEMENT DEPOSITION; COMPLEMENT FIXATION; COMPLEX FORMATION; CONTROLLED STUDY; ERYTHROCYTE; HEMOLYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DOMAIN; PROTEIN FUNCTION; SENSOR; SURFACE PLASMON RESONANCE;

EID: 18644370595     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.174.10.6227     Document Type: Article

References (20)

1. Müller-Eberhard, H. J. 1986. The membrane attack complex of complement. Annu. Rev. Immunol. 4: 503-528.
2. Morgan, B. P. 2000. Inhibition of complement in the membrane attack pathway. In Therapeutic Interventions in the Complement System. J. D. Lambris and V. M. Holers, eds. Humana Press, Totowa, p. 205.
3. Hobart, M. J., B. A. Fernie, and R. G. DiScipio. 1995. Structure of the human C7 gene and comparison with the C6, C8A, C8B, and C9 genes. J. Immunol. 154: 5188-5194.
4. Thai, C.-T., and R. T. Ogata. 2003. Expression and characterization of the C345C/NTR domains of complement components C3 and C5. J. Immunol. 171: 6565-6573.
5. Arroyave, C. M., and H. J. Müller-Eberhard. 1973. Interactions between human C5, C6, and C7 and their functional significance in complement-dependent cytolysis. J. Immunol. 111: 536-545.
6. DiScipio, R. G. 1992. Formation and structure of the C5b-7 complex of the lytic pathway of complement. J. Biol. Chem. 267: 17087-17094.
7. Thai, C.-T., and R. T. Ogata. 2004. Complement components C5 and C7: recombinant factor I modules of C7 bind to the C345C domain of C5. J. Immunol. 173: 4547-4552.
8. Kolb, W. P., J. A. Haxby, C. M. Arroyave, and H. J. Muller-Eberhard. 1973. The membrane attack mechanism of complement: reversible interactions among the five native components in free solution. J. Exp. Med. 138: 428-437.
9. Würzner, R., M. J. Hobart, B. A. Fernie, D. Mewar, P. C. Potter, A. Orren, and P. J. Lachmann. 1995. Molecular basis of subtotal complement C6 deficiency. J. Clin. Invest. 95: 1877-1883.
10. DiScipio, R. G., S. M. Union, and N. K. Rushmere. 1999. Function of the factor I modules (FIMS) of human complement component C6. J. Biol. Chem. 274: 31811-31818.
11. Yu, J. X., B. M. Bradt, and N. R. Cooper. 2000. Molecular cloning of the C6A form cDNA of the mouse sixth complement component: functional integrity despite the absence of factor I modules. Immunogenetics. 51: 779-787.
12. Thompson, R. A., and P. J. Lachmann. 1970. Reactive lysis: the complement-mediated lysis of unsensitized cells. I. The characterization of the indicator factor and its identification as C7. J. Exp. Med. 131: 629-641.
13. Lachmann, P. J., and R. A. Thompson. 1970. Reactive lysis: the complement-mediated lysis of unsensitized cells. II. The characterization of activated reactor as C56 and the participation of C8 and C9. J. Exp. Med. 131: 643-657.
14. Mollnes, T. E., A. Klos, and J. Tschopp. 1988. Identification of a human C5 β-chain epitope exposed in the native complement component but concealed in the SC5b-9 complex. Scand. J. Immunol. 28: 307-312.
15. Podack, E. R., G. Biesecker, W. P. Kolb, and H. 3. Müller-Eberhard. 1978. The C5b-6 complex: reaction with C7, C8, C9. J. Immunol. 121: 484-490.
16. Law, S. K. A., and K. B. M. Reid. 1995. Complement, 2nd Ed. IRL Press, Oxford.
17. Bhakdi, S., B. Bhakdi-Lehnen, and J. Tranum-Jensen. 1979. Proteolytic transformation of SC5b-9 into an amphiphilic macromolecule resembling the C5b-9 membrane attack complex of complement. Immunology 37: 901-912.
18. Podack, E. R., and H. J. Muller-Eberhard. 1980. SC5b-9 complex of complement: formation of the dimeric membrane attack complex by removal of S-protein. J. Immunol. 124: 1779-1783.
19. Marshall, P., A. Hasegawa, E. A. Davidson, V. Nussenzweig, and E. A. Whitlow. 1996. Interaction between complement proteins C5b-7 and erythrocyte membrane sialic acid. J. Exp. Med. 184: 1225-1232.
20. Liu, C., P. Marshall, I. Schreibmann, A. Vu, W. Gai, and M. Whitlow. 1999. Interaction between terminal complement proteins C5b-7 and anionic phospholipids. Blood 93: 2297-2301.