Sodium dependent multivitamin transporter (SMVT): A potential target for drug delivery

Current Drug Targets

Volumn 13, Issue 7, 2012, Pages 994-1003

  Vadlapudi, Aswani Dutt ^a   Vadlapatla, Ramya Krishna ^a   Mitra, Ashim K ^a  

^a UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

Author keywords

SMVT; Substrate specificity; Tissue distribution; Transporter targeted drug delivery

Indexed keywords

ANTINEOPLASTIC AGENT; ANTIVIRUS AGENT; BIOTIN; BIOTIN GANCICLOVIR; BIOTIN SAQUINAVIR; CISPLATIN; DENDRIMER; DOXORUBICIN; GANCICLOVIR; MACROGOL; MEMBRANE PROTEIN; N (2 HYDROXYPROPYL)METHACRYLAMIDE; NANOCARRIER; POLYAMIDOAMINE; POLYAMIDOAMINE BIOTIN FLUORESCEIN ISOTHIOCYANATE; SAQUINAVIR; SODIUM DEPENDENT MULTIVITAMIN TRANSPORTER; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; AREA UNDER THE CURVE; BIOCHEMISTRY; BIOTINYLATION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG ELIMINATION; DRUG HALF LIFE; DRUG PROTEIN BINDING; DRUG TARGETING; FEASIBILITY STUDY; HUMAN; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PERMEABILITY BARRIER; PHYSIOLOGY; PROTEIN GLYCOSYLATION; PROTEIN MOTIF; REVIEW; TISSUE DISTRIBUTION;

EID: 84861709697     PISSN: 13894501     EISSN: 18735592     Source Type: Journal    
DOI: 10.2174/138945012800675650     Document Type: Review

References (73)

1. Dorkoosh FA, Setyaningsih D, Borchard G, Rafiee-Tehrani M, Verhoef JC, Junginger HE. Effects of superporous hydrogels on paracellular drug permeability and cytotoxicity studies in Caco-2 cell monolayers. Int J Pharm 2002; 241(1): 35-45.
2. Kotze AF, Luessen HL, de Leeuw BJ, de Boer AG, Verhoef JC, Junginger HE. Comparison of the effect of different chitosan salts and N-trimethyl chitosan chloride on the permeability of intestinal epithelial cells (Caco-2). J Control Release 1998; 51(1): 35-46.
3. Kuchimanchi KR, Gandhi MD, Sheta RR, et al. Intestinal absorption and biodistribution of cosalane and its amino acid conjugates: novel anti-HIV agents. Int J Pharm 2002; 231(2): 197-211.
4. Tengamnuay P, Sahamethapat A, Sailasuta A, Mitra AK. Chitosans as nasal absorption enhancers of peptides: comparison between free amine chitosans and soluble salts. Int J Pharm 2000; 197(1-2): 53-67.
5. Shao Z, Li Y, Chermak T, Mitra AK. Cyclodextrins as mucosal absorption promoters of insulin. II. Effects of beta-cyclodextrin derivatives on alpha-chymotryptic degradation and enteral absorption of insulin in rats. Pharm Res 1994; 11(8): 1174-9.
6. Ward PD, Tippin TK, Thakker DR. Enhancing paracellular permeability by modulating epithelial tight junctions. Pharm Sci Technolo Today 2000; 3(10): 346-58.
7. Anderson JM, Van Itallie CM. Tight junctions and the molecular basis for regulation of paracellular permeability. Am J Physiol 1995; 269(4 Pt 1): G467-75.
8. Powell DW. Barrier function of epithelia. Am J Physiol 1981; 241(4): G275-88.
9. Pal D, Kwatra D, Minocha M, Paturi DK, Budda B, Mitra AK. Efflux transporters-and cytochrome P-450-mediated interactions between drugs of abuse and antiretrovirals. Life Sci 2011; 88(21-22): 959-71.
10. Kwatra D, Vadlapatla RK, Vadlapudi AD, Pal D, Mitra AK. Interaction of gatifloxacin with efflux transporters: a possible mechanism for drug resistance. Int J Pharm 2010; 395(1-2): 114-21.
11. Pal D, Mitra AK. MDR-and CYP3A4-mediated drug-drug interactions. J Neuroimmune Pharmacol 2006; 1(3): 323-39.
12. Pal D, Mitra AK. MDR-and CYP3A4-mediated drug-herbal interactions. Life Sci 2006; 78(18): 2131-45.
13. McKeegan KS, Borges-Walmsley MI, Walmsley AR. The structure and function of drug pumps: an update. Trends Microbiol 2003; 11(1): 21-9.
14. Saier MH, Jr., Paulsen IT. Phylogeny of multidrug transporters. Semin Cell Dev Biol 2001; 12(3): 205-13.
15. Putman M, van Veen HW, Konings WN. Molecular properties of bacterial multidrug transporters. Microbiol Mol Biol Rev 2000; 64(4): 672-93.
16. Gottesman MM, Fojo T, Bates SE. Multidrug resistance in cancer: role of ATP-dependent transporters. Nat Rev Cancer 2002; 2(1): 48-58.
17. Gaudana R, Ananthula HK, Parenky A, Mitra AK. Ocular drug delivery. AAPS J 2010; 12(3): 348-60.
18. Gaudana R, Jwala J, Boddu SH, Mitra AK. Recent perspectives in ocular drug delivery. Pharm Res 2009; 26(5): 1197-216.
19. Yang C, Tirucherai GS, Mitra AK. Prodrug based optimal drug delivery via membrane transporter/receptor. Expert Opin Biol Ther 2001; 1(2): 159-75.
20. Vadlapudi AD, Vadlapatla RK, Mitra AK. Current and emerging antivirals for the treatment of cytomegalovirus (CMV) retinitis: an update on recent patents. Recent Pat Antiinfect Drug Discov 2011; in press.
21. Janoria KG, Boddu SH, Wang Z, et al. Vitreal pharmacokinetics of biotinylated ganciclovir: role of sodium-dependent multivitamin transporter expressed on retina. J Ocul Pharmacol Ther 2009; 25(1): 39-49.
22. Talluri RS, Samanta SK, Gaudana R, Mitra AK. Synthesis, metabolism and cellular permeability of enzymatically stable dipeptide prodrugs of acyclovir. Int J Pharm 2008; 361(1-2): 118-24.
23. Anand BS, Dey S, Mitra AK. Current prodrug strategies via membrane transporters/receptors. Expert Opin Biol Ther 2002; 2(6): 607-20.
24. Vadlapatla RK, Vadlapudi AD, Kwatra D, Pal D, Mitra AK. Differential effect of P-gp and MRP2 on cellular translocation of gemifloxacin. Int J Pharm 2011; 420(1): 26-33.
25. Luo S, Wang Z, Patel M, et al. Targeting SVCT for enhanced drug absorption: synthesis and in vitro evaluation of a novel vitamin C conjugated prodrug of saquinavir. Int J Pharm 2011; 414(1-2): 77-85.
26. Prasad PD, Wang H, Huang W, et al. Molecular and functional characterization of the intestinal Na+-dependent multivitamin transporter. Arch Biochem Biophys 1999; 366(1): 95-106.
27. Wang H, Huang W, Fei YJ, et al. Human placental Na+-dependent multivitamin transporter. Cloning, functional expression, gene structure, and chromosomal localization. J Biol Chem 1999; 274(21): 14875-83.
28. Chatterjee NS, Kumar CK, Ortiz A, Rubin SA, Said HM. Molecular mechanism of the intestinal biotin transport process. Am J Physiol 1999; 277(4 Pt 1): C605-13.
29. Ghosal A, Said HM. Structure-function activity of the human sodium-dependent multivitamin transporter: role of His¹ ¹ ⁵ and His(2). Am J Physiol Cell Physiol 2011; 300(1): C97-104.
30. Ghosal A, Subramanian VS, Said HM. Role of the putative Nglycosylation and PKC-phosphorylation sites of the human sodiumdependent multivitamin transporter (hSMVT) in function and regulation. Biochim Biophys Acta 2011; 1808(8): 2073-80.
31. Said HM, Ma TY, Kamanna VS. Uptake of biotin by human hepatoma cell line, Hep G2: a carrier-mediated process similar to that of normal liver. J Cell Physiol 1994; 161(3): 483-9.
32. Said HM, Mohammadkhani R. Involvement of histidine residues and sulfhydryl groups in the function of the biotin transport carrier of rabbit intestinal brush-border membrane. Biochim Biophys Acta 1992; 1107(2): 238-44.
33. Ghosal A, Said HM. Cys(294) is essential for the function of the human sodium-dependent multivitamin transporter. Biochim Biophys Acta 2011; 1818(1): 97-102.
34. Grassl SM. Human placental brush-border membrane Na(+)-biotin cotransport. J Biol Chem 1992; 267(25): 17760-5.
35. Park S, Sinko PJ. The blood-brain barrier sodium-dependent multivitamin transporter: a molecular functional in vitro-in situ correlation. Drug Metab Dispos 2005; 33(10): 1547-54.
36. Said HM, Ortiz A, McCloud E, Dyer D, Moyer MP, Rubin S. Biotin uptake by human colonic epithelial NCM460 cells: a carriermediated process shared with pantothenic acid. Am J Physiol 1998; 275(5 Pt 1): C1365-71.
37. Baur B, Wick H, Baumgartner ER. Na(+)-dependent biotin transport into brush-border membrane vesicles from rat kidney. Am J Physiol 1990; 258(4 Pt 2): F840-7.
38. Prasad PD, Srinivas SR, Wang H, Leibach FH, Devoe LD, Ganapathy V. Electrogenic nature of rat sodium-dependent multivitamin transport. Biochem Biophys Res Commun 2000; 270(3): 836-40.
39. Zempleni J, Mock DM. Marginal biotin deficiency is teratogenic. Proc Soc Exp Biol Med 2000; 223(1): 14-21.
40. Dakshinamurti K, Chauhan J. Regulation of biotin enzymes. Annu Rev Nutr 1988; 8: 211-33.
41. Sweetman L, Nyhan WL. Inheritable biotin-treatable disorders and associated phenomena. Annu Rev Nutr 1986; 6: 317-43.
42. Bonjour JP. Biotin. In: Machlin LJ, editor. Handbook of Vitamins; Nutritional Biochemical and Clinical Aspects. New York: Dekker; 1984: pp. 403-35.
43. Luo S, Kansara VS, Zhu X, Mandava NK, Pal D, Mitra AK. Functional characterization of sodium-dependent multivitamin transporter in MDCK-MDR1 cells and its utilization as a target for drug delivery. Mol Pharm 2006; 3(3): 329-39.
44. Prasad PD, Ganapathy V. Structure and function of mammalian sodium-dependent multivitamin transporter. Curr Opin Clin Nutr Metab Care 2000; 3(4): 263-6.
45. Grassl SM. Human placental brush-border membrane Na(+)-pantothenate cotransport. J Biol Chem 1992; 267(32): 22902-6.
46. Grafe F, Wohlrab W, Neubert RH, Brandsch M. Transport of biotin in human keratinocytes. J Invest Dermatol 2003; 120(3): 428-33.
47. Zempleni J, Mock DM. Uptake and metabolism of biotin by human peripheral blood mononuclear cells. Am J Physiol 1998; 275(2 Pt 1): C382-8.
48. Said HM, Redha R, Nylander W. Biotin transport in the human intestine: site of maximum transport and effect of pH. Gastroenterology 1988; 95(5): 1312-7.
49. Kansara V, Luo S, Balasubrahmanyam B, Pal D, Mitra AK. Biotin uptake and cellular translocation in human derived retinoblastoma cell line (Y-79): a role of hSMVT system. Int J Pharm 2006; 312(1-2): 43-52.
50. Janoria KG, Hariharan S, Paturi D, Pal D, Mitra AK. Biotin uptake by rabbit corneal epithelial cells: role of sodium-dependent multivitamin transporter (SMVT). Curr Eye Res 2006; 31(10): 797-809.
51. Ramanathan S, Pooyan S, Stein S, et al. Targeting the sodiumdependent multivitamin transporter (SMVT) for improving the oral absorption properties of a retro-inverso Tat nonapeptide. Pharm Res 2001; 18(7): 950-6.
52. Balamurugan K, Ortiz A, Said HM. Biotin uptake by human intestinal and liver epithelial cells: role of the SMVT system. Am J Physiol Gastrointest Liver Physiol 2003; 285(1): G73-7.
53. Nabokina SM, Subramanian VS, Said HM. Comparative analysis of ontogenic changes in renal and intestinal biotin transport in the rat. Am J Physiol Renal Physiol 2003; 284(4): F737-42.
54. Chatterjee NS, Rubin SA, Said HM. Molecular characterization of the 5' regulatory region of rat sodium-dependent multivitamin transporter gene. Am J Physiol Cell Physiol 2001; 280(3): C548-55.
55. Said HM. Cellular uptake of biotin: mechanisms and regulation. J Nutr 1999; 129(2S Suppl): 490S-3S.
56. Said HM, Redha R, Nylander W. A carrier-mediated, Na+ gradientdependent transport for biotin in human intestinal brush-border membrane vesicles. Am J Physiol 1987; 253(5 Pt 1): G631-6.
57. Balamurugan K, Vaziri ND, Said HM. Biotin uptake by human proximal tubular epithelial cells: cellular and molecular aspects. Am J Physiol Renal Physiol 2005; 288(4): F823-31.
58. Baur B, Baumgartner ER. Na(+)-dependent biotin transport into brush-border membrane vesicles from human kidney cortex. Pflugers Arch 1993; 422(5): 499-505.
59. Ohkura Y, Akanuma S, Tachikawa M, Hosoya K. Blood-to-retina transport of biotin via Na+-dependent multivitamin transporter (SMVT) at the inner blood-retinal barrier. Exp Eye Res 2010; 91(3): 387-92.
60. Minko T, Paranjpe PV, Qiu B, et al. Enhancing the anticancer efficacy of camptothecin using biotinylated poly(ethylene glycol) conjugates in sensitive and multidrug-resistant human ovarian carcinoma cells. Cancer Chemother Pharmacol 2002; 50(2): 143-50.
61. Bildstein L, Dubernet C, Couvreur P. Prodrug-based intracellular delivery of anticancer agents. Adv Drug Deliv Rev 2011; 63(1-2): 3-23.
62. Russell-Jones G, McTavish K, McEwan J, Rice J, Nowotnik D. Vitamin-mediated targeting as a potential mechanism to increase drug uptake by tumours. J Inorg Biochem 2004; 98(10): 1625-33.
63. Yang W, Cheng Y, Xu T, Wang X, Wen LP. Targeting cancer cells with biotin-dendrimer conjugates. Eur J Med Chem 2009; 44(2): 862-8.
64. Yellepeddi VK, Kumar A, Palakurthi S. Biotinylated poly(amido)amine (PAMAM) dendrimers as carriers for drug delivery to ovarian cancer cells in vitro. Anticancer Res 2009; 29(8): 2933-43.
65. Yellepeddi VK, Kumar A, Maher DM, Chauhan SC, Vangara KK, Palakurthi S. Biotinylated PAMAM dendrimers for intracellular delivery of cisplatin to ovarian cancer: role of SMVT. Anticancer Res 2011; 31(3): 897-906.
66. Ramanathan S, Qiu B, Pooyan S, et al. Targeted PEG-based bioconjugates enhance the cellular uptake and transport of a HIV-1 TAT nonapeptide. J Control Release 2001; 77(3): 199-212.
67. Choudhury I, Wang J, Rabson AB, Stein S, Pooyan S, Leibowitz MJ. Inhibition of HIV-1 replication by a Tat RNA-binding domain peptide analog. J Acquir Immune Defic Syndr Hum Retrovirol 1998; 17(2): 104-11.
68. Chen LL, Frankel AD, Harder JL, Fawell S, Barsoum J, Pepinsky B. Increased cellular uptake of the human immunodeficiency virus-1 Tat protein after modification with biotin. Anal Biochem 1995; 227(1): 168-75.
69. Wan L, Zhang X, Gunaseelan S, et al. Novel multi-component nanopharmaceuticals derived from poly(ethylene) glycol, retroinverso-Tat nonapeptide and saquinavir demonstrate combined anti-HIV effects. AIDS Res Ther 2006; 3: 12.
70. Macha S, Mitra AK. Ocular disposition of ganciclovir and its monoester prodrugs following intravitreal administration using microdialysis. Drug Metab Dispos 2002; 30(6): 670-5.
71. Gunaseelan S, Debrah O, Wan L, et al. Synthesis of poly(ethylene glycol)-based saquinavir prodrug conjugates and assessment of release and anti-HIV-1 bioactivity using a novel protease inhibition assay. Bioconjug Chem 2004; 15(6): 1322-33.
72. Said HM, Hoefs J, Mohammadkhani R, Horne DW. Biotin transport in human liver basolateral membrane vesicles: a carriermediated, Na+ gradient-dependent process. Gastroenterology 1992; 102(6): 2120-5.
73. Ma TY, Dyer DL, Said HM. Human intestinal cell line Caco-2: a useful model for studying cellular and molecular regulation of biotin uptake. Biochim Biophys Acta 1994; 1189(1): 81-8.