Up-regulation of mitofusin-2 protects CD4 + T cells from HMGB1-mediated immune dysfunction partly through Ca 2+-NFAT signaling pathway

Cytokine

Volumn 59, Issue 1, 2012, Pages 79-85

  Zhao, Guang ju ^a,b   Yao, Yong ming ^b   Lu, Zhong qiu ^a   Hong, Guang liang ^a   Zhu, Xiao mei ^b   Wu, Yao ^b   Wang, Da wei ^b   Dong, Ning ^b   Yu, Yan ^b   Sheng, Zhi yong ^b  

^a THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIVERSITY   (China)

^b CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

High mobility group box 1 protein; Immune suppression; Mitofusin 2; Sepsis; T lymphocyte

Indexed keywords

CALCIUM ION; GAMMA INTERFERON; HIGH MOBILITY GROUP B1 PROTEIN; INTERLEUKIN 2; INTERLEUKIN 4; MITOFUSIN 2; TRANSCRIPTION FACTOR NFAT;

ADAPTIVE IMMUNITY; ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CD4+ T LYMPHOCYTE; CELL PROTECTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNE DYSFUNCTION; IMMUNOPATHOLOGY; LENTIVIRINAE; LYMPHOCYTE ACTIVATION; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; MALE; MOUSE; NONHUMAN; POLARIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TH2 CELL; UPREGULATION; WESTERN BLOTTING;

ANIMALS; CALCIUM SIGNALING; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL PROLIFERATION; CONCANAVALIN A; CYTOPROTECTION; GREEN FLUORESCENT PROTEINS; GTP PHOSPHOHYDROLASES; HMGB1 PROTEIN; HUMANS; INTERLEUKIN-2; MALE; MICE; MICE, INBRED BALB C; NFATC TRANSCRIPTION FACTORS; TIME FACTORS; TRANSFECTION; UP-REGULATION;

EID: 84861691555     PISSN: 10434666     EISSN: 10960023     Source Type: Journal    
DOI: 10.1016/j.cyto.2012.03.026     Document Type: Article

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