Evidence of antibody production in the rat cervical lymph nodes after antigen administration into the cerebrospinal fluid

Archives of Histology and Cytology

Volumn 69, Issue 1, 2006, Pages 37-47

  Walter, Beatriz A ^a   Valera, Vladimir A ^a   Takahashi, Sugata ^a   Matsuno, Kenjiro ^b   Ushiki, Tatsuo ^a  

^a NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^b DOKKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; FLUORESCEIN ISOTHIOCYANATE; KEYHOLE LIMPET HEMOCYANIN;

ANIMAL CELL; ANIMAL TISSUE; ANTIBODY PRODUCING CELL; ANTIBODY PRODUCTION; ANTIGEN SPECIFICITY; ARTICLE; CELLULAR DISTRIBUTION; CENTRAL NERVOUS SYSTEM; CEREBROSPINAL FLUID; CERVICAL LYMPH NODE; HISTOLOGY; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; LYMPH VESSEL; MALE; NONHUMAN; NOSE MUCOSA; RAT; SUBARACHNOID SPACE;

ANIMALS; ANTIBODY FORMATION; ANTIBODY-PRODUCING CELLS; ANTIGENS; CEREBROSPINAL FLUID; FLUORESCEIN-5-ISOTHIOCYANATE; HEMOCYANIN; LYMPH NODES; MALE; RATS; SPLEEN; SUBARACHNOID SPACE;

EID: 33645817328     PISSN: 09149465     EISSN: 13491717     Source Type: Journal    
DOI: 10.1679/aohc.69.37     Document Type: Article

References (28)

1. Bradbury MW, Westrop RJ: Factors influencing exit of substances from cerebrospinal fluid into deep cervical lymph of the rabbit. J Physiol 339: 519-534 (1983).
2. Brighenti A, Andrulis M, Geissinger E, Roth S, Muller-Hermelink HK, Rudiger T: Extrafollicular proliferation of B cells in the absence of follicular hyperplasia: a distinct reaction pattern in lymph nodes correlated with primary or recall type responses. Histopathology 47: 90-100 (2005).
3. Cserr HF, DePasquale M, Harling-Berg CJ, Park JT, Knopf PM: Afferent and efferent arms of the humoral immune response to CSF-administered albumins in a rat model with normal blood-brain barrier permeability. J Neuroimmunol 41: 195-202 (1992a).
4. Cserr HF, Harling-Berg CJ, Knopf PM: Drainage of brain extracellular fluid into blood and deep cervical lymph and its immunological significance. Brain Pathol 2: 269-276 (1992b).
5. Delemarre FG, Claassen E, Van Rooijen N: Primary in situ immune response in popliteal lymph nodes and spleen of mice after subcutaneous immunization with thymus-dependent or thymus-independent (type 1 and 2) antigens. Anat Rec 223: 152-157 (1989).
6. Erlich SS, McComb JG, Hyman S, Weiss MH: Ultrastructural morphology of the olfactory pathway for cerebrospinal fluid drainage in the rabbit. J Neurosurg 64: 466-473 (1986).
7. Geldof AA, van der Ende MB, Langevoort HL: Lymph node involvement in a humoral immune response. Anat Rec 209: 541-546 (1984).
8. Gretz JE, Anderson AO, Shaw S: Cords, channels, corridors and conduits: critical architectural elements facilitating cell interactions in the lymph node cortex. Immunol Rev 156: 11-24 (1997).
9. Harling-Berg C, Knopf PM, Merriam J, Cserr HF: Role of cervical lymph nodes in the systemic humoral immune response to human serum albumin microinfused into rat cerebrospinal fluid. J Neuroimmunol 25: 185-193 (1989).
10. Harling-Berg CJ, Park TJ, Knopf PM: Role of the cervical lymphatics in the Th2-type hierarchy of CNS immune regulation. J Neuroimmunol 101: 111-127 (1999).
11. Hatterer E, Davoust N, Didier-Bazes M, Vuaillat C, Malcus C, et al: How to drain without lymphatics? Dendritic cells migrate from the cerebrospinal fluid to the B-cell follicles of cervical lymph nodes. Blood 107: 806-812 (2006).
12. Johnston M, Zakharov A, Papaiconomou C, Salmasi G, Armstrong D: Evidence of connections between cerebrospinal fluid and nasal lymphatic vessels in humans, non-human primates and other mammalian species. Cerebrospinal Fluid Res 1: 2 (2004).
13. Kida S, Pantazis A, Weller RO: CSF drains directly from the subarachnoid space into nasal lymphatics in the rat. Anatomy, histology and immunological significance. Neuropathol Appl Neurobiol 19: 480-488 (1993).
14. Knopf PM, Harling-Berg CJ, Cserr HF, Basu D, Sirulnick EJ, et al: Antigen-dependent intrathecal antibody synthesis in the normal rat brain: tissue entry and local retention of antigen-specific B cells. J Immunol 161:692-701 (1998).
15. Koh L, Zakharov A, Johnston M: Integration of the subarachnoid space and lymphatics: is it time to embrace a new concept of cerebrospinal fluid absorption? Cerebrospinal Fluid Res 2: 6 (2005).
16. Ling C, Sandor M, Fabry Z: In situ processing and distribution of intracerebrally injected OVA in the CNS. J Neuroimmunol 141: 90-98 (2003).
17. Matsuno K, Ezaki T, Kotani M: Splenic outer periarterial lymphoid sheath (PALS): an immunoproliferative microenvironment constituted by antigen-laden marginal metallophils and ED2-positive macrophages in the rat. Cell Tissue Res 257: 459-470 (1989).
18. Matsuno K, Ezaki T Kudo S, Uehara Y: A life stage of particle-laden rat dendritic cells in vivo: Their terminal division, active phagogytosis and translocation fro the liver to the draining lymph. J Exp Med 183:1865-1878 (1996).
19. Ohtani O, Ohtani Y, Carati CJ, Gannon BJ: Fluid and cellular pathways of rat lymph nodes in relation to lymphatic labyrinths and Aquaporin-1 expression. Arch Histol Cytol 66: 261-272 (2003).
20. Rhodes JM, Lind I: Antigen uptake in vivo peritoneal macrophages from normal mice, and those undergoing primary or secondary response. Immunology 14: 511-525 (1968).
21. Pabst O, Peters T, Czeloth N, Bernhardt G, Scharffetter-Kochanek K, Forster R: Cutting edge: egress of newly generated plasma cells from peripheral lymph nodes depends on beta 2 integrin. J Immunol 174: 7492-7495 (2005).
22. Straus W: Location of antibody to horseradish peroxidase in popliteal lymph nodes of rabbits during the primary and early secondary response. J Histochem Cytochem 18:120-130 (1970).
23. Thorne RG, Pronk GJ, Padmanabhan V, Frey WH, 2nd: Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration. Neuroscience 127:481-496 (2004).
24. Ushiki T, Ohtani O, Abe K: Scanning electron microscopic studies of reticular framework in the rat mesenteric lymph node. Anat Rec 241: 113-122 (1995).
25. van Rooijen N: The "in situ" immune response in lymph nodes: a review. Anat Rec 218: 359-364 (1987).
26. Walter B, Valera V, Takahashi S, Ushiki T: The olfactory route for cerebrospinal fluid drainage into the peripheral lymphatic system. Neuropathol Appl Neurobiol (2006, in press).
27. Wehrli N, Legler DF, Finke D, Toellner KM, Loetscher P, et al: Changing responsiveness to chemokines allows medullary plasmablasts to leave lymph nodes. Eur J Immunol 31: 609-616 (2001).
28. Weller RO, Kida S, Zhang ET: Pathways of fluid drainage from the brain-morphological aspects and immunological significance in rat and man. Brain Pathol 2: 277-284 (1992).