A single malaria merozoite serine protease mediates shedding of multiple surface proteins by juxtamembrane cleavage

Journal of Biological Chemistry

Volumn 278, Issue 26, 2003, Pages 23890-23898

  Howell, Steven A ^a   Wells, Isabelle ^a,c   Fleck, Suzanne L ^b   Kettleborough, Catherine ^b   Collins, Christine R ^a   Blackman, Michael J ^a  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^b MEDICAL RESEARCH COUNCIL   (United Kingdom)

^c F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ANTIGENS; BIOLOGICAL MEMBRANES; MALARIA CONTROL; MASS SPECTROMETRY;

MICRONEMES;

PROTEINS;

APICAL MEMBRANE ANTIGEN 1; GLYCOSYLPHOSPHATIDYLINOSITOL; MEMBRANE ANTIGEN; MEMBRANE PROTEIN; MEROZOITE SURFACE PROTEIN 1; SERINE PROTEINASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; APICAL MEMBRANE; ARTICLE; CELL INVASION; CELL ORGANELLE; ENZYME MECHANISM; ENZYME SPECIFICITY; ERYTHROCYTE; MALARIA; MASS SPECTROMETRY; MEROZOITE; MICRONEME; NONHUMAN; PARASITE VIRULENCE; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROCESSING;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, PROTOZOAN; MEMBRANE PROTEINS; MEROZOITE SURFACE PROTEIN 1; MOLECULAR SEQUENCE DATA; PLASMODIUM FALCIPARUM; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN TRANSPORT; PROTOZOAN PROTEINS; SERINE ENDOPEPTIDASES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

PLASMODIUM FALCIPARUM; PROTOZOA;

EID: 0038267453     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M302160200     Document Type: Article

References (45)

1. Pachebat, J. A., Ling, I. T., Grainger, M., Trucco, C., Howell, S., Fernandez-Reyes, D., Gunaratne, R., and Holder, A. A. (2001) Mol. Biochem. Parasitol. 117, 83-89
2. Blackman, M. J. (2000) Curr. Drug Targets 1, 59-83
3. Tomley, F., and Soldati, D. (2001) Trends Parasitol. 17, 81-86
4. Blackman, M. J., and Bannister, L. H. (2001) Mol. Biochem. Parasitol. 117, 11-25
5. Brossier, F., Jewett, T. J., Lovett, J. L., and Sibley, L. D. (2003) J. Biol. Chem. 278, 6229-6234
6. Deans, J. A., Alderson, T., Thomas, A. W., Mitchell, G. H., Lennox, E. S., and Cohen, S. (1982) Clin. Exp. Immunol. 49, 297-309
7. Triglia, T., Healer, J., Caruana, S. R., Hodder, A. N., Anders, R. F., Crabb, B. S., and Cowman, A. F. (2000) Mol. Microbiol. 38, 706-718
8. Hehl, A. B., Lekutis, C., Grigg, M. E., Bradley, P. J., Dubremetz, J. F., Ortega-Barria, E., and Boothroyd, J. C. (2000) Infect. Immun. 68, 7078-7086
9. Kocken, C. H., Withers-Martinez, C., Dubbeld, M. A., van der Wel, A., Hackett, F., Blackman, M. J., and Thomas, A. W. (2002) Infect. Immun. 70, 4471-4476
10. Li, F., Dluzewski, A., Coley, A. M., Thomas, A. W., Tilley, L., Anders, R. F., and Foley, M. (2002) J. Biol. Chem. 277, 50303-50310
11. Donahue, C. G., Carruthers, V. B., Gilk, S. D., and Ward, G. E. (2000) Mol. Biochem. Parasitol. 111, 15-30
12. Hodder, A. N., Crewther, P. E., Matthew, M. L., Reid, G., E., Moritz, R. L., Simpson, R. J., and Anders, R. F. (1996) J. Biol. Chem. 271, 29446-29452
13. Nair, M., Hinds, M., Coley, A., Hodder, A., Foley, M., Anders, R., and Norton, R. (2002) J. Mol. Biol. 322, 741-753
14. Deans, J. A., Thomas, A. W., Alderson, T., and Cohen, S. (1984) Mol. Biochem. Parasitol. 11, 189-204
15. Healer, J., Crawford, S., Ralph, S., McFadden, G., and Cowman, A. F. (2002) Infect. Immun. 70, 5751-5758
16. Narum, D. L., and Thomas, A. W. (1994) Mol. Biochem. Parasitol. 67, 59-68
17. Howell, S. A., Withers-Martinez, C., Kocken, C. H., Thomas, A. W., and Blackman, M. J. (2001) J. Biol. Chem. 276, 31311-31320
18. Blackman, M. J. (1994) Methods Cell Biol. 45, 213-220
19. Powers, J. C. (1977) Methods Enzymol. 46, 197-208
20. Blackman, M. J., Chappel, J. A., Shai, S., and Holder, A. A. (1993) Mol. Biochem. Parasitol. 62, 103-114
21. Withers-Martinez, C., Saldanha, J. W., Ely, B., Hackett, F., O'Connor, T., and Blackman, M. J. (2002) J. Biol. Chem. 277, 29698-29709
22. Blackman, M. J., Fujioka, H., Stafford, W. H. L., Sajid, M., Clough, B., Fleck, S. L., Aikawa, M., Grainger, M., and Hackett, F. (1998) J. Biol. Chem. 273, 23398-23409
23. Kocken, C. H., van der Wel, A. M., Dubbeld, M. A., Narum, D. L., van de Rijke, F. M., van Gemert, G.-J., van der Linde, X., Bannister, L. H., Janse, C., Waters, A. P., and Thomas, A. W. (1998) J. Biol. Chem. 273, 15119-15124
24. Blackman, M. J., Dennis, E. D., Hirst, E. M., Kocken, C. H., Scott-Finnigan, T. J., and Thomas, A. W. (1996) Exp. Parasitol. 83, 229-239
25. Schnolzer, M., Jedrzejewski, P., and Lehmann, W. D. (1996) Electrophoresis 17, 945-953
26. Rabenau, K. E., Sohrabi, A., Tripathy, A., Reitter, C., Ajioka, J. W., Tomley, F. M., and Carruthers, V. B. (2001) Mol. Microbiol. 41, 537-547
27. Ridley, R. G., Lahm, H.-W., Takacs, B., and Scaife, J. G. (1991) Mol. Biochem. Parasitol. 47, 245-246
28. Miller, L. H., Aikawa, M., Johnson, J. G., and Shiroishi, T. (1979) J. Exp. Med. 149, 172-184
29. Field, S. J., Pinder, J. C., Clough, B., Dluzewski, A. R., Wilson, R. J., and Gratzer, W. B. (1993) Cell Motil. Cytoskeleton 25, 43-48
30. Carruthers, V. B., and Sibley, L. D. (1999) Mol. Microbiol. 31, 421-428
31. Bumstead, J., and Tomley, F. (2000) Mol. Biochem. Parasitol. 110, 311-321
32. Schwager, S. L. U., Chubb, A. J., Woodman, Z. L., Yan, L., Mentele, R., Ehlers, M. R. W., and Sturrock, E. D. (2001) Biochemistry 40, 15624-15630
33. Morgan, W. D., Birdsall, B., Frenkiel, T. A., Gradwell, M. G., Burghaus, P. A., Syed, S. E. H., Uthaipibull, C., Holder, A. A., and Feeney, J. (1999) J. Mol. Biol. 289, 113-122
34. Chitarra, V., Holm, I., Bentley, G. A., Pêtres, S., and Longacre, S. (1999) Mol. Cell 3, 457-464
35. Pizarro, J. C., Chitarra, V., Calvet, C., Verger, D., and Bentley, G. A. (2002) Acta Crystallogr. D Biol. Crystallogr, 58, 1246-1248
36. Garman, S. C., Simcoke, W. N., Stowers, A. W., and Garboczi, D. N. (2003) J. Biol. Chem. 278, 7264-7269
37. O'Donnell, R. A., Saul, A., Cowman, A. F., and Crabb, B. S. (2000) Nature Med. 6, 91-95
38. Carruthers, V. B., Sherman, G. D., and Sibley, L. D. (2000) J. Biol. Chem. 275, 14346-14353
39. Opitz, C., Di Cristina, M., Reiss, M., Ruppert, T., Crisanti, A., and Soldati, D. (2002) EMBO J. 21, 1577-1585
40. Pinder, J. C., Fowler, R. E., Bannister, L. H., Dluzewski, A. R. and Mitchell, G. H. (2000) Parasitol. Today 16, 240-245
41. Fowler, R. E., Smith, A. M. C., Whitehorn, J., Williams, I. T., Bannister, L. H., and Mitchell, G. H. (2001) Mol. Biochem. Parasitol. 117, 187-200
42. Gantt, S., Persson, C., Rose, K., Birkett, A. J., Abagyan, R., and Nussenzweig, V. (2000) Infect. Immun. 68, 3667-3673
43. Fraser, T. S., Kappe, S. H. I., Narum, D. L., VanBuskirk, K. M., and Adams, J. H. (2001) Mol. Biochem. Parasitol. 117, 49-59
44. Gardner, M. J., Hall, N., Fung, E., White, O., Berriman, M., Hyman, R. W., Carlton, J. M., Pain, A., Nelson, K. E., Bowman, S., et al. (2002) Nature 419, 498-511
45. Guevara Patiño, J. A., Holder, A. A., McBride, J. S., and Blackman, M. J. (1997) J. Exp. Med. 186, 1689-1699