The newly identified K + channel blocker talatisamine attenuates beta-amyloid oligomers induced neurotoxicity in cultured cortical neurons

Neuroscience Letters

Volumn 518, Issue 2, 2012, Pages 122-127

  Wang, Yanxia ^a   Song, Mingke ^a   Hou, Lina ^a   Yu, Zhihua ^a   Chen, Hongzhuan ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Apoptosis; Beta amyloid (A ); Cell viability; Delayed rectifier K + currents (I K); Talatisamine; Tetraethylammonium (TEA)

Indexed keywords

AMYLOID BETA PROTEIN[1-40]; CASPASE 3; CASPASE 4; POTASSIUM CHANNEL BLOCKING AGENT; PROTEIN BAX; PROTEIN BCL 2; TALATISAMINE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN CELL; CELL DENSITY; CELL MEMBRANE PERMEABILITY; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; ENZYME ACTIVATION; MITOCHONDRIAL MEMBRANE POTENTIAL; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PREMEDICATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; VOLTAGE CLAMP;

ACONITINE; AMYLOID BETA-PEPTIDES; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELL SURVIVAL; CELLS, CULTURED; CEREBRAL CORTEX; FLUORESCENT ANTIBODY TECHNIQUE; NEURONS; NEUROPROTECTIVE AGENTS; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNEL BLOCKERS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84861665920     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2012.04.067     Document Type: Article

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