Longitudinal changes of peripheral blood DC subsets and regulatory t cells in chinese chronic HIV-1-infected patients during antiretroviral therapy

PLoS ONE

Volumn 7, Issue 5, 2012, Pages

  Zhang, Mei ^a   Zhang, Hongwei ^a   Zhang, Tong ^a   Ji, Yunxia ^a   Jiao, Yanmei ^a   Wu, Hao ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; ANTIRETROVIRUS AGENT; CD4 ANTIGEN; LAMIVUDINE PLUS NEVIRAPINE PLUS STAVUDINE; LAMIVUDINE PLUS NEVIRAPINE PLUS ZIDOVUDINE;

ADULT; ARTICLE; ASYMPTOMATIC INFECTION; BLOOD CELL COUNT; CD4 LYMPHOCYTE COUNT; CHINESE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; LYMPHOCYTE FUNCTION; MALE; MYELOID DENDRITIC CELL; PLASMACYTOID DENDRITIC CELL; PROTEIN BLOOD LEVEL; REGULATORY T LYMPHOCYTE; ASIAN; CELL CULTURE; DENDRITIC CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOLOGY; LONGITUDINAL STUDY; VIRUS LOAD;

HUMAN IMMUNODEFICIENCY VIRUS 1;

ADULT; ANTI-RETROVIRAL AGENTS; ASIAN CONTINENTAL ANCESTRY GROUP; CELLS, CULTURED; DENDRITIC CELLS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HIV INFECTIONS; HUMANS; LONGITUDINAL STUDIES; T-LYMPHOCYTES, REGULATORY; VIRAL LOAD;

EID: 84861663319     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0037966     Document Type: Article

References (40)

1. Ford ES, Puronen CE, Sereti I, (2009) Immunopathogenesis of asymptomatic chronic HIV Infection: the calm before the storm. Current opinion in HIV and AIDS 4: 206-214.
2. Lore K, Larsson M, (2003) The role of dendritic cells in the pathogenesis of HIV-1 infection. APMIS: acta pathologica, microbiologica, et immunologica Scandinavica 111: 776-788.
3. Vignali DA, Collison LW, Workman CJ, (2008) How regulatory T cells work. Nature reviews Immunology 8: 523-532.
4. Smed-Sorensen A, Lore K, (2011) Dendritic cells at the interface of innate and adaptive immunity to HIV-1. Current opinion in HIV and AIDS 6: 405-410.
5. Banchereau J, Steinman RM, (1998) Dendritic cells and the control of immunity. Nature 392: 245-252.
6. Liu YJ, (2005) IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. Annual review of immunology 23: 275-306.
7. Chatila TA, (2005) Role of regulatory T cells in human diseases. The Journal of allergy and clinical immunology 116: 949-959; quiz 960.
8. Fazekas de St Groth B, Landay AL, (2008) Regulatory T cells in HIV infection: pathogenic or protective participants in the immune response? AIDS 22: 671-683.
9. Barron MA, Blyveis N, Palmer BE, MaWhinney S, Wilson CC, (2003) Influence of plasma viremia on defects in number and immunophenotype of blood dendritic cell subsets in human immunodeficiency virus 1-infected individuals. The Journal of infectious diseases 187: 26-37.
10. Pacanowski J, Kahi S, Baillet M, Lebon P, Deveau C, et al. (2001) Reduced blood CD123+ (lymphoid) and CD11c+ (myeloid) dendritic cell numbers in primary HIV-1 infection. Blood 98: 3016-3021.
11. Finke JS, Shodell M, Shah K, Siegal FP, Steinman RM, (2004) Dendritic cell numbers in the blood of HIV-1 infected patients before and after changes in antiretroviral therapy. Journal of clinical immunology 24: 647-652.
12. Sabado RL, O'Brien M, Subedi A, Qin L, Hu N, et al. (2010) Evidence of dysregulation of dendritic cells in primary HIV infection. Blood 116: 3839-3852.
13. Fontaine J, Coutlee F, Tremblay C, Routy JP, Poudrier J, et al. (2009) HIV infection affects blood myeloid dendritic cells after successful therapy and despite nonprogressing clinical disease. The Journal of infectious diseases 199: 1007-1018.
14. Azzoni L, Chehimi J, Zhou L, Foulkes AS, June R, et al. (2007) Early and delayed benefits of HIV-1 suppression: timeline of recovery of innate immunity effector cells. AIDS 21: 293-305.
15. Chehimi J, Campbell DE, Azzoni L, Bacheller D, Papasavvas E, et al. (2002) Persistent decreases in blood plasmacytoid dendritic cell number and function despite effective highly active antiretroviral therapy and increased blood myeloid dendritic cells in HIV-infected individuals. Journal of immunology 168: 4796-4801.
16. Epple HJ, Loddenkemper C, Kunkel D, Troger H, Maul J, et al. (2006) Mucosal but not peripheral FOXP3+ regulatory T cells are highly increased in untreated HIV infection and normalize after suppressive HAART. Blood 108: 3072-3078.
17. Presicce P, Orsborn K, King E, Pratt J, Fichtenbaum CJ, et al. (2011) Frequency of circulating regulatory T cells increases during chronic HIV infection and is largely controlled by highly active antiretroviral therapy. PloS one 6: e28118.
18. Gaardbo JC, Nielsen SD, Vedel SJ, Ersboll AK, Harritshoj L, et al. (2008) Regulatory T cells in human immunodeficiency virus-infected patients are elevated and independent of immunological and virological status, as well as initiation of highly active anti-retroviral therapy. Clinical and experimental immunology 154: 80-86.
19. Bi X, Suzuki Y, Gatanaga H, Oka S, (2009) High frequency and proliferation of CD4+ FOXP3+ Treg in HIV-1-infected patients with low CD4 counts. European journal of immunology 39: 301-309.
20. Jiao Y, Fu J, Xing S, Fu B, Zhang Z, et al. (2009) The decrease of regulatory T cells correlates with excessive activation and apoptosis of CD8+ T cells in HIV-1-infected typical progressors, but not in long-term non-progressors. Immunology 128: e366-375.
21. Weiss L, Piketty C, Assoumou L, Didier C, Caccavelli L, et al. (2010) Relationship between regulatory T cells and immune activation in human immunodeficiency virus-infected patients interrupting antiretroviral therapy. PloS one 5: e11659.
22. Sachdeva N, Asthana V, Brewer TH, Garcia D, Asthana D, (2008) Impaired restoration of plasmacytoid dendritic cells in HIV-1-infected patients with poor CD4 T cell reconstitution is associated with decrease in capacity to produce IFN-alpha but not proinflammatory cytokines. Journal of immunology 181: 2887-2897.
23. Fitzgerald-Bocarsly P, Jacobs ES, (2010) Plasmacytoid dendritic cells in HIV infection: striking a delicate balance. Journal of leukocyte biology 87: 609-620.
24. Wijewardana V, Soloff AC, Liu X, Brown KN, Barratt-Boyes SM, (2010) Early myeloid dendritic cell dysregulation is predictive of disease progression in simian immunodeficiency virus infection. PLoS pathogens 6: e1001235.
25. Barratt-Boyes SM, Wijewardana V, (2011) A divergent myeloid dendritic cell response at virus set-point predicts disease outcome in SIV-infected rhesus macaques. Journal of medical primatology 40: 206-213.
26. Schmidt B, Fujimura SH, Martin JN, Levy JA, (2006) Variations in plasmacytoid dendritic cell (PDC) and myeloid dendritic cell (MDC) levels in HIV-infected subjects on and off antiretroviral therapy. Journal of clinical immunology 26: 55-64.
27. Geng W, Fan X, Diao Y, Cui H, Sun H, et al. (2011) Rapid disease progression in HIV-1-infected men who have sex with men is negatively correlated with peripheral plasmacytoid dendritic cell counts at the early stage of primary infection. Journal of clinical immunology 31: 882-890.
28. Chehimi J, Azzoni L, Farabaugh M, Creer SA, Tomescu C, et al. (2007) Baseline viral load and immune activation determine the extent of reconstitution of innate immune effectors in HIV-1-infected subjects undergoing antiretroviral treatment. Journal of immunology 179: 2642-2650.
29. Killian MS, Fujimura SH, Hecht FM, Levy JA, (2006) Similar changes in plasmacytoid dendritic cell and CD4 T-cell counts during primary HIV-1 infection and treatment. AIDS 20: 1247-1252.
30. Brenchley JM, Price DA, Schacker TW, Asher TE, Silvestri G, et al. (2006) Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nature medicine 12: 1365-1371.
31. Zhang Z, Jiang Y, Zhang M, Shi W, Liu J, et al. (2008) Relationship of frequency of CD4+CD25+Foxp3+ regulatory T cells with disease progression in antiretroviral-naive HIV-1 infected Chinese. Japanese journal of infectious diseases 61: 391-392.
32. Ndhlovu LC, Loo CP, Spotts G, Nixon DF, Hecht FM, (2008) FOXP3 expressing CD127lo CD4+ T cells inversely correlate with CD38+ CD8+ T cell activation levels in primary HIV-1 infection. Journal of leukocyte biology 83: 254-262.
33. Hunt PW, Landay AL, Sinclair E, Martinson JA, Hatano H, et al. (2011) A low T regulatory cell response may contribute to both viral control and generalized immune activation in HIV controllers. PloS one 6: e15924.
34. Robertson SJ, Hasenkrug KJ, (2006) The role of virus-induced regulatory T cells in immunopathology. Springer seminars in immunopathology 28: 51-62.
35. Krathwohl MD, Schacker TW, Anderson JL, (2006) Abnormal presence of semimature dendritic cells that induce regulatory T cells in HIV-infected subjects. The Journal of infectious diseases 193: 494-504.
36. Hubert P, Jacobs N, Caberg JH, Boniver J, Delvenne P, (2007) The cross-talk between dendritic and regulatory T cells: good or evil? Journal of leukocyte biology 82: 781-794.
37. Mahnke K, Bedke T, Enk AH, (2007) Regulatory conversation between antigen presenting cells and regulatory T cells enhance immune suppression. Cellular immunology 250: 1-13.
38. Manches O, Munn D, Fallahi A, Lifson J, Chaperot L, et al. (2008) HIV-activated human plasmacytoid DCs induce Tregs through an indoleamine 2,3-dioxygenase-dependent mechanism. The Journal of clinical investigation 118: 3431-3439.
39. Yonezawa A, Morita R, Takaori-Kondo A, Kadowaki N, Kitawaki T, et al. (2003) Natural alpha interferon-producing cells respond to human immunodeficiency virus type 1 with alpha interferon production and maturation into dendritic cells. Journal of virology 77: 3777-3784.
40. Donaghy H, Pozniak A, Gazzard B, Qazi N, Gilmour J, et al. (2001) Loss of blood CD11c(+) myeloid and CD11c(-) plasmacytoid dendritic cells in patients with HIV-1 infection correlates with HIV-1 RNA virus load. Blood 98: 2574-2576.